Improved insulin sensitivity 3 months after RYGB surgery is associated with increased subcutaneous adipose tissue AMPK activity and decreased oxidative stress

Diabetes

Volumn 64, Issue 9, 2015, Pages 3155-3159

  Julia Xu, X ^a   Apovian, Caroline ^a   Hess, Donald ^a   Carmine, Brian ^a   Saha, Asish ^a   Ruderman, Neil ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; GLUCOSE; HEMOGLOBIN A1C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; MALONYL COENZYME A; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; ENZYME ACTIVITY; FEMALE; GLUCOSE BLOOD LEVEL; HIP CIRCUMFERENCE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MIDDLE AGED; MORBID OBESITY; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RELAPSE; REMISSION; ROUX EN Y GASTRIC BYPASS; STOMACH BYPASS; SUBCUTANEOUS FAT; WAIST CIRCUMFERENCE; COMPLICATION; ENZYMOLOGY; GENETICS; METABOLISM; OBESITY, MORBID; TREATMENT OUTCOME;

ADIPONECTIN; ADULT; AMP-ACTIVATED PROTEIN KINASES; CYTOKINES; DIABETES MELLITUS, TYPE 2; FEMALE; GASTRIC BYPASS; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY, MORBID; OXIDATIVE STRESS; RNA, MESSENGER; SUBCUTANEOUS FAT; TREATMENT OUTCOME;

EID: 84957075059     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-1765     Document Type: Article

References (24)

1. Furuya CK Jr, de Oliveira CP, de Mello ES, et al. Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years. J Gastro-enterol Hepatol 2007;22:510-514
2. Buchwald H, Estok R, Fahrbach K et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 2009;122: 248.e5-256.e5
3. Sjöström L, Peltonen M, Jacobson P, et al. Bariatric surgery and long-term cardiovascular events. JAMA 2012;307:56-65
4. Salehi M, Prigeon RL, D'Alessio DA. Gastric bypass surgery enhances glucagon-like peptide 1-stimulated postprandial insulin secretion in humans. Diabetes 2011;60:2308-2314
5. Clément K. Bariatric surgery, adipose tissue and gut microbiota. Int J Obes (Lond) 2011;35(Suppl. 3):S7-S15
6. Le Roux CW, Aylwin SJ, Batterham RL, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 2006;243:108-114
7. Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012;13:251-262
8. Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest 2013;123:2764-2772
9. Xu XJ, Gauthier MS, Hess DT, et al. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res 2012;53:792-801
10. Gauthier MS, O'Brien EL, Bigornia S, et al. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Bio-chem Biophys Res Commun 2011;404:382-387
11. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28: 412-419
12. Lara-Castro C, Doud EC, Tapia PC, et al. Adiponectin multimers and metabolic syndrome traits: relative adiponectin resistance in African Americans. Obesity (Silver Spring) 2008;16:2616-2623
13. McGarry JD, Stark MJ, Foster DW. Hepatic malonyl-CoA levels of fed, fasted and diabetic rats as measured using a simple radioisotopic assay. J Biol Chem 1978;253:8291-8293
14. Gregor MF, Yang L, Fabbrini E, et al. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 2009;58:693-700
15. Tomas E, Tsao TS, Saha AK, et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA 2002;99: 16309-16313
16. Ruderman N, Prentki M. AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov 2004;3:340-351
17. Salminen A, Hyttinen JM, Kaarniranta K. AMP-activated protein kinase inhibits NF-kB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl) 2011;89:667-676
18. Xu XJ, Pories WJ, Dohm LG, Ruderman NB. What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant? Curr Opin Lipidol 2013;24:49-56
19. Kola B, Christ-Crain M, Lolli F, et al. Changes in adenosine 59-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome. J Clin Endocrinol Metab 2008;93:4969-4973
20. Laferrère B, Heshka S, Wang K, et al. Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes. Diabetes Care 2007;30:1709-1716
21. Krasner NM, Ido Y, Ruderman NB, Cacicedo JM. Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. PLoS ONE 2014;9:e97554
22. Bell LN, Temm CJ, Saxena R, et al. Bariatric surgery-induced weight loss reduces hepatic lipid peroxidation levels and affects hepatic cytochrome P-450 protein content. Ann Surg 2010;251:1041-1048
23. Gletsu-Miller N, Hansen JM, Jones DP, et al. Loss of total and visceral adipose tissue mass predicts decreases in oxidative stress after weight-loss surgery. Obesity (Silver Spring) 2009;17:439-446
24. Arterburn DE, Bogart A, Sherwood NE, et al. A multisite study of long-term remission and relapse of type 2 diabetes mellitus following gastric bypass. Obes Surg 2013;23:93-102