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Volumn 310, Issue 1, 2016, Pages R33-R40

ZnT4 (SLC30A4)-null (“lethal milk”) mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation

Author keywords

Lactation; Mammary gland; SLC30A4; Zinc; ZnT4

Indexed keywords

ADIPOPHILIN; BETA ACTIN; CYTOKERATIN 8; PROTEIN KINASE B; STAT3 PROTEIN; STAT5 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UVOMORULIN; ZINC ION; ZINC TRANSPORTER; ZNT4 PROTEIN; CADHERIN; CATION TRANSPORT PROTEIN; SLC30A4 PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR;

EID: 84956965658     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00315.2014     Document Type: Article
Times cited : (15)

References (53)
  • 1
    • 0026693126 scopus 로고
    • The murine mutation, lethal milk, results in production of zinc-deficient milk
    • Ackland ML, Mercer JF. The murine mutation, lethal milk, results in production of zinc-deficient milk. J Nutr 122: 1214–1218, 1992.
    • (1992) J Nutr , vol.122 , pp. 1214-1218
    • Ackland, M.L.1    Mercer, J.F.2
  • 2
    • 34248226985 scopus 로고    scopus 로고
    • Key stages in mammary gland development. Secretory activation in the mammary gland: It’s not just about milk protein synthesis!
    • Anderson SM, Rudolph MC, McManaman JL, Neville MC. Key stages in mammary gland development. Secretory activation in the mammary gland: it’s not just about milk protein synthesis! Breast Cancer Res 9: 204, 2007.
    • (2007) Breast Cancer Res , vol.9 , pp. 204
    • Anderson, S.M.1    Rudolph, M.C.2    McManaman, J.L.3    Neville, M.C.4
  • 3
    • 84905122223 scopus 로고    scopus 로고
    • Impact of obesity on mammary gland inflammation and local estrogen production
    • Brown K. Impact of obesity on mammary gland inflammation and local estrogen production. J Mammary Gland Biol Neoplasia 19: 183–189, 2014.
    • (2014) J Mammary Gland Biol Neoplasia , vol.19 , pp. 183-189
    • Brown, K.1
  • 4
    • 33845969541 scopus 로고    scopus 로고
    • Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency
    • Chowanadisai W, Lonnerdal B, Kelleher SL. Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. J Biol Chem 281: 39,699–39,707, 2006.
    • (2006) J Biol Chem , vol.281 , Issue.39 , pp. 699-739
    • Chowanadisai, W.1    Lonnerdal, B.2    Kelleher, S.L.3
  • 5
    • 84861113372 scopus 로고    scopus 로고
    • Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition
    • Dempsey C, McCormick NH, Croxford TP, Seo YA, Grider A, Kelleher SL. Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition. J Nutr 142: 655–660, 2012.
    • (2012) J Nutr , vol.142 , pp. 655-660
    • Dempsey, C.1    McCormick, N.H.2    Croxford, T.P.3    Seo, Y.A.4    Grider, A.5    Kelleher, S.L.6
  • 6
    • 0021751131 scopus 로고
    • Grider A. Zinc metabolism in lethal-milk mice: Otolith, lactation, and aging effects
    • Erway LC, Grider A. Zinc metabolism in lethal-milk mice: Otolith, lactation, and aging effects. J Hered 75: 480–484, 1984.
    • (1984) J Hered , vol.75 , pp. 480-484
    • Erway, L.C.1
  • 7
    • 33749593508 scopus 로고    scopus 로고
    • Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation
    • Green KA, Nielsen BS, Castellino FJ, Romer J, Lund LR. Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation. Dev Biol 299: 164–175, 2006.
    • (2006) Dev Biol , vol.299 , pp. 164-175
    • Green, K.A.1    Nielsen, B.S.2    Castellino, F.J.3    Romer, J.4    Lund, L.R.5
  • 8
    • 77649239656 scopus 로고    scopus 로고
    • STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells
    • Guo L, Lichten LA, Ryu MS, Liuzzi JP, Wang F, Cousins RJ. STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells. Proc Natl Acad Sci USA 107: 2818–2823, 2010.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2818-2823
    • Guo, L.1    Lichten, L.A.2    Ryu, M.S.3    Liuzzi, J.P.4    Wang, F.5    Cousins, R.J.6
  • 9
    • 84932621659 scopus 로고    scopus 로고
    • TNFpost-translationally targets ZnT2 to accumulate zinc in lysosomes
    • Hennigar SR, Kelleher SL. TNFpost-translationally targets ZnT2 to accumulate zinc in lysosomes. J Cell Physiol 230: 2345–2350, 2015.
    • (2015) J Cell Physiol , vol.230 , pp. 2345-2350
    • Hennigar, S.R.1    Kelleher, S.L.2
  • 10
    • 84923012081 scopus 로고    scopus 로고
    • ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution
    • Hennigar SR, Seo YA, Sharma S, Soybel DI, Kelleher SL. ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution. Sci Rep 5: 8033, 2015.
    • (2015) Sci Rep , vol.5 , pp. 8033
    • Hennigar, S.R.1    Seo, Y.A.2    Sharma, S.3    Soybel, D.I.4    Kelleher, S.L.5
  • 11
    • 84941106879 scopus 로고    scopus 로고
    • Obesity-induced inflammation is associated with alterations in subcellular zinc pools and premature mammary gland involution in lactating mice
    • Hennigar SR, Velasquez V, Kelleher SL. Obesity-induced inflammation is associated with alterations in subcellular zinc pools and premature mammary gland involution in lactating mice. J Nutr 145: 1999–2005, 2015.
    • (2015) J Nutr , vol.145 , pp. 1999-2005
    • Hennigar, S.R.1    Velasquez, V.2    Kelleher, S.L.3
  • 12
    • 29244451536 scopus 로고    scopus 로고
    • Key stages in mammary gland development: The mammary end bud as a motile organ
    • Hinck L, Silberstein GB. Key stages in mammary gland development: the mammary end bud as a motile organ. Breast Cancer Res 7: 245–251, 2005.
    • (2005) Breast Cancer Res , vol.7 , pp. 245-251
    • Hinck, L.1    Silberstein, G.B.2
  • 13
    • 0030724951 scopus 로고    scopus 로고
    • A novel gene involved in zinc transport is deficient in the lethal milk mouse
    • Huang L, Gitschier J. A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat Genet 17: 292–297, 1997.
    • (1997) Nat Genet , vol.17 , pp. 292-297
    • Huang, L.1    Gitschier, J.2
  • 14
    • 84878579262 scopus 로고    scopus 로고
    • Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: A novel mechanism for zinc deficiency in a breast-fed infant
    • Itsumura N, Inamo Y, Okazaki F, Teranishi F, Narita H, Kambe T, Kodama H. Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant. PLoS One 8: e64045.
    • Plos One , vol.8
    • Itsumura, N.1    Inamo, Y.2    Okazaki, F.3    Teranishi, F.4    Narita, H.5    Kambe, T.6    Kodama, H.7
  • 15
    • 0035949696 scopus 로고    scopus 로고
    • The identification of secreted carbonic anhydrase VI as a constitutive glycoprotein of human and rat milk
    • Karhumaa P, Leinonen J, Parkkila S, Kaunisto K, Tapanainen J, Rajaniemi H. The identification of secreted carbonic anhydrase VI as a constitutive glycoprotein of human and rat milk. Proc Natl Acad Sci USA 98: 11,604–11,608, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.11 , pp. 604-611
    • Karhumaa, P.1    Leinonen, J.2    Parkkila, S.3    Kaunisto, K.4    Tapanainen, J.5    Rajaniemi, H.6
  • 16
    • 17644396710 scopus 로고    scopus 로고
    • Zip3 plays a major role in zinc uptake into mammary epithelial cells and is regulated by prolactin
    • Kelleher SL, Lonnerdal B. Zip3 plays a major role in zinc uptake into mammary epithelial cells and is regulated by prolactin. Am J Physiol Cell Physiol 288: C1042–C1047, 2005.
    • (2005) Am J Physiol Cell Physiol , vol.288 , pp. C1042-C1047
    • Kelleher, S.L.1    Lonnerdal, B.2
  • 17
    • 0242661897 scopus 로고    scopus 로고
    • Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells
    • Kelleher SL, Lonnerdal B. Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells. J Nutr 133: 3378–3385, 2003.
    • (2003) J Nutr , vol.133 , pp. 3378-3385
    • Kelleher, S.L.1    Lonnerdal, B.2
  • 18
    • 84862306310 scopus 로고    scopus 로고
    • Zinc in specialized secretory tissues: Roles in the pancreas, prostate, and mammary gland
    • Kelleher SL, McCormick NH, Velasquez V, Lopez V. Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary gland. Adv Nutr 2: 101–111, 2011.
    • (2011) Adv Nutr , vol.2 , pp. 101-111
    • Kelleher, S.L.1    McCormick, N.H.2    Velasquez, V.3    Lopez, V.4
  • 19
    • 84855724443 scopus 로고    scopus 로고
    • Mapping the zinc-transporting system in mammary cells: Molecular analysis reveals a phenotype-dependent zinc-transporting network during lactation
    • Kelleher SL, Velasquez V, Croxford TP, McCormick NH, Lopez V, MacDavid J. Mapping the zinc-transporting system in mammary cells: molecular analysis reveals a phenotype-dependent zinc-transporting network during lactation. J Cell Physiol 227: 1761–1770, 2012.
    • (2012) J Cell Physiol , vol.227 , pp. 1761-1770
    • Kelleher, S.L.1    Velasquez, V.2    Croxford, T.P.3    McCormick, N.H.4    Lopez, V.5    Macdavid, J.6
  • 21
    • 84930225048 scopus 로고    scopus 로고
    • Essential role for zinc transporter 2 (ZnT2)-mediated zinc transport in mammary gland development and function during lactation
    • Lee S, Hennigar SR, Alam S, Nishida K, Kelleher SL. Essential role for zinc transporter 2 (ZnT2)-mediated zinc transport in mammary gland development and function during lactation. J Biol Chem 290: 13,064–13,078, 2015.
    • (2015) J Biol Chem , vol.290 , Issue.13 , pp. 064-113
    • Lee, S.1    Hennigar, S.R.2    Alam, S.3    Nishida, K.4    Kelleher, S.L.5
  • 22
    • 41149101031 scopus 로고    scopus 로고
    • Zinc toxicity alters mitochondrial metabolism and leads to decreased ATP production in hepatocytes
    • Lemire J, Mailloux R, Appanna VD. Zinc toxicity alters mitochondrial metabolism and leads to decreased ATP production in hepatocytes. J Appl Toxicol 28: 175–182, 2008.
    • (2008) J Appl Toxicol , vol.28 , pp. 175-182
    • Lemire, J.1    Mailloux, R.2    Appanna, V.D.3
  • 23
    • 79952250472 scopus 로고    scopus 로고
    • ZnT2-overexpression represses the cytotoxic effects of zinc hyper-accumulation in malignant metallothionein- null T47D breast tumor cells
    • Lopez V, Foolad F, Kelleher SL. ZnT2-overexpression represses the cytotoxic effects of zinc hyper-accumulation in malignant metallothionein- null T47D breast tumor cells. Cancer Lett 304: 41–51, 2011.
    • (2011) Cancer Lett , vol.304 , pp. 41-51
    • Lopez, V.1    Foolad, F.2    Kelleher, S.L.3
  • 24
    • 84879446511 scopus 로고    scopus 로고
    • Zinc biochemistry: From a single zinc enzyme to a key element of life
    • Maret W. Zinc biochemistry: from a single zinc enzyme to a key element of life. Adv Nutr 4: 82–91, 2013.
    • (2013) Adv Nutr , vol.4 , pp. 82-91
    • Maret, W.1
  • 26
    • 4644269107 scopus 로고    scopus 로고
    • MCMN. Regulation of milk lipid formation and secretion in the mouse mammary gland
    • McManaman J, Palmer C, Anderson S, Schwertfeger K, MCMN. Regulation of milk lipid formation and secretion in the mouse mammary gland. Adv Exp Med Biol 554: 263–279, 2004.
    • (2004) Adv Exp Med Biol , vol.554 , pp. 263-279
    • McManaman, J.1    Palmer, C.2    Anderson, S.3    Schwertfeger, K.4
  • 28
    • 0033369167 scopus 로고    scopus 로고
    • Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells
    • Murgia C, Vespignani I, Cerase J, Nobili F, Perozzi G. Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells. Am J Physiol Gastrointest Liver Physiol 277: G1231–G1239, 1999.
    • (1999) Am J Physiol Gastrointest Liver Physiol , vol.277 , pp. G1231-G1239
    • Murgia, C.1    Vespignani, I.2    Cerase, J.3    Nobili, F.4    Perozzi, G.5
  • 29
    • 33847026229 scopus 로고    scopus 로고
    • The ZnT4 mutation inlethal milk mice affects intestinal zinc homeostasis through the expression of other Zn transporters
    • Murgia C, Vespignani I, Rami R, Perozzi G. The ZnT4 mutation inlethal milk mice affects intestinal zinc homeostasis through the expression of other Zn transporters. Genes Nutr 1: 61–70, 2006.
    • (2006) Genes Nutr , vol.1 , pp. 61-70
    • Murgia, C.1    Vespignani, I.2    Rami, R.3    Perozzi, G.4
  • 30
    • 16844380139 scopus 로고    scopus 로고
    • Modulation of the interleukin- 6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction
    • Novotny-Diermayr V, Lin B, Gu L, Cao X. Modulation of the interleukin- 6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction. J Biol Chem 280: 12,747–12,757, 2005.
    • (2005) J Biol Chem , vol.280 , Issue.12 , pp. 747-812
    • Novotny-Diermayr, V.1    Lin, B.2    Gu, L.3    Cao, X.4
  • 31
    • 34247551118 scopus 로고    scopus 로고
    • The alveolar switch: Coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium
    • Oakes S, Hilton H, Ormandy C. The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium. Breast Cancer Res 8: 207, 2006.
    • (2006) Breast Cancer Res , vol.8 , pp. 207
    • Oakes, S.1    Hilton, H.2    Ormandy, C.3
  • 32
    • 84905852377 scopus 로고    scopus 로고
    • Making milk: A new link between STAT5 and Akt1
    • Oliver CH, Watson CJ. Making milk: A new link between STAT5 and Akt1. JAK-STAT 2: e23228, 2013.
    • (2013) JAK-STAT , vol.2
    • Oliver, C.H.1    Watson, C.J.2
  • 33
    • 0029873677 scopus 로고    scopus 로고
    • ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration
    • Palmiter RD, Cole TB, Findley SD. ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J 15: 1784–1791, 1996.
    • (1996) EMBO J , vol.15 , pp. 1784-1791
    • Palmiter, R.D.1    Cole, T.B.2    Findley, S.D.3
  • 34
    • 36649038999 scopus 로고    scopus 로고
    • Initiation of human lactation: Secretory differentiation and secretory activation
    • Pang W, Hartmann P. Initiation of human lactation: secretory differentiation and secretory activation. J Mammary Gland Biol Neoplasia 12: 211–221, 2007.
    • (2007) J Mammary Gland Biol Neoplasia , vol.12 , pp. 211-221
    • Pang, W.1    Hartmann, P.2
  • 35
    • 84904309258 scopus 로고    scopus 로고
    • Characterization of Golgi scaffold proteins and their roles in compartmentalizing cell signaling
    • Peng W, Lei Q, Jiang Z, Hu Z. Characterization of Golgi scaffold proteins and their roles in compartmentalizing cell signaling. J Mol Histol 45: 435–445, 2014.
    • (2014) J Mol Histol , vol.45 , pp. 435-445
    • Peng, W.1    Lei, Q.2    Jiang, Z.3    Hu, Z.4
  • 36
    • 0017959169 scopus 로고
    • Lethal milk mutation results in dietary zinc deficiency in nursing mice
    • Piletz JA, Ganschow RE. Lethal milk mutation results in dietary zinc deficiency in nursing mice. Am J Clin Nutr 31: 560–562, 1978.
    • (1978) Am J Clin Nutr , vol.31 , pp. 560-562
    • Piletz, J.A.1    Ganschow, R.E.2
  • 37
    • 0017870725 scopus 로고
    • Zinc deficiency in murine milk underlies expression of the lethal milk (Lm) mutation
    • Piletz JE, Ganschow RE. Zinc deficiency in murine milk underlies expression of the lethal milk (lm) mutation. Science 199: 181–183, 1978.
    • (1978) Science , vol.199 , pp. 181-183
    • Piletz, J.E.1    Ganschow, R.E.2
  • 38
    • 36649025517 scopus 로고    scopus 로고
    • Translational regulation of milk protein synthesis at secretory activation
    • Rhoads RE, Grudzien-Nogalska E. Translational regulation of milk protein synthesis at secretory activation. J Mammary Gland Biol Neoplasia 12: 283–292, 2007.
    • (2007) J Mammary Gland Biol Neoplasia , vol.12 , pp. 283-292
    • Rhoads, R.E.1    Grudzien-Nogalska, E.2
  • 39
    • 80054020618 scopus 로고    scopus 로고
    • Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands
    • Russell TD, Schaack J, Orlicky DJ, Palmer C, Chang BH, Chan L, McManaman JL. Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands. J Cell Sci 124: 3247–3253, 2011.
    • (2011) J Cell Sci , vol.124 , pp. 3247-3253
    • Russell, T.D.1    Schaack, J.2    Orlicky, D.J.3    Palmer, C.4    Chang, B.H.5    Chan, L.6    McManaman, J.L.7
  • 40
    • 0142042372 scopus 로고    scopus 로고
    • Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation
    • Schwertfeger KL, McManaman JL, Palmer CA, Neville MC, Anderson SM. Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation. J Lipid Res 44: 1100–1112, 2003.
    • (2003) J Lipid Res , vol.44 , pp. 1100-1112
    • Schwertfeger, K.L.1    McManaman, J.L.2    Palmer, C.A.3    Neville, M.C.4    Anderson, S.M.5
  • 41
    • 84906572321 scopus 로고    scopus 로고
    • Prolactin (PRL)-stimulated ubiquitination of ZnT2 mediates a transient increase in zinc secretion followed by ZnT2 degradation in mammary epithelial cells
    • Seo YA, Lee S, Hennigar SR, Kelleher SL. Prolactin (PRL)-stimulated ubiquitination of ZnT2 mediates a transient increase in zinc secretion followed by ZnT2 degradation in mammary epithelial cells. J Biol Chem 289: 23,653–23,661, 2014.
    • (2014) J Biol Chem , vol.289 , Issue.23 , pp. 653-723
    • Seo, Y.A.1    Lee, S.2    Hennigar, S.R.3    Kelleher, S.L.4
  • 42
    • 79957660884 scopus 로고    scopus 로고
    • A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function
    • Seo YA, Lopez V, Kelleher SL. A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function. Am J Physiol Cell Physiol 300: C1479–C1489, 2011.
    • (2011) Am J Physiol Cell Physiol , vol.300 , pp. C1479-C1489
    • Seo, Y.A.1    Lopez, V.2    Kelleher, S.L.3
  • 43
    • 33750470097 scopus 로고    scopus 로고
    • CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/ basal and non-epithelial cells
    • Sleeman KE, Kendrick H, Ashworth A, Isacke CM, Smalley MJ. CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/ basal and non-epithelial cells. Breast Cancer Res 8: R7, 2006.
    • (2006) Breast Cancer Res , vol.8 , pp. 7
    • Sleeman, K.E.1    Kendrick, H.2    Ashworth, A.3    Isacke, C.M.4    Smalley, M.J.5
  • 45
    • 69849084075 scopus 로고    scopus 로고
    • Key stages in mammary gland development: The cues that regulate ductal branching morphogenesis
    • Sternlicht MD. Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis. Breast Cancer Res 8: 201, 2006.
    • (2006) Breast Cancer Res , vol.8 , pp. 201
    • Sternlicht, M.D.1
  • 47
    • 84874718742 scopus 로고    scopus 로고
    • Essential role of the zinc transporter ZIP9/SLC39A9 in regulating the activations of Akt and Erk in B-cell receptor signaling pathway in DT40 cells
    • Taniguchi M, Fukunaka A, Hagihara M, Watanabe K, Kamino S, Kambe T, Enomoto S, Hiromura M. Essential role of the zinc transporter ZIP9/SLC39A9 in regulating the activations of Akt and Erk in B-cell receptor signaling pathway in DT40 cells. PLoS One 8: e58022, 2013.
    • (2013) Plos One , vol.8
    • Taniguchi, M.1    Fukunaka, A.2    Hagihara, M.3    Watanabe, K.4    Kamino, S.5    Kambe, T.6    Enomoto, S.7    Hiromura, M.8
  • 48
    • 0034603079 scopus 로고    scopus 로고
    • Truncation of the -catenin binding domain of E-cadherin precedes epithelial apoptosis during prostate and mammary involution
    • Vallorosi CJ, Day KC, Zhao X, Rashid MG, Rubin MA, Johnson KR, Wheelock MJ, Day ML. Truncation of the -catenin binding domain of E-cadherin precedes epithelial apoptosis during prostate and mammary involution. J Biol Chem 275: 3328–3334, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 3328-3334
    • Vallorosi, C.J.1    Day, K.C.2    Zhao, X.3    Rashid, M.G.4    Rubin, M.A.5    Johnson, K.R.6    Wheelock, M.J.7    Day, M.L.8
  • 50
    • 79952705948 scopus 로고    scopus 로고
    • Cytokine signalling in mammary gland development
    • Watson CJ, Oliver CH, Khaled WT. Cytokine signalling in mammary gland development. J Reprod Immunol 88: 124–129, 2011.
    • (2011) J Reprod Immunol , vol.88 , pp. 124-129
    • Watson, C.J.1    Oliver, C.H.2    Khaled, W.T.3
  • 51
    • 84861478959 scopus 로고    scopus 로고
    • Involvement of TNF-and MAPK pathway in the intramammary MMP-9 release via degranulation of cow neutrophils during acute mammary gland involution
    • Yu TC, Chen SE, Ho TH, Peh HC, Liu WB, Tiantong A, Nagahata H, Chang CJ. Involvement of TNF-and MAPK pathway in the intramammary MMP-9 release via degranulation of cow neutrophils during acute mammary gland involution. Vet Immunol Immunopathol 147: 161–169, 2012.
    • (2012) Vet Immunol Immunopathol , vol.147 , pp. 161-169
    • Yu, T.C.1    Chen, S.E.2    Ho, T.H.3    Peh, H.C.4    Liu, W.B.5    Tiantong, A.6    Nagahata, H.7    Chang, C.J.8
  • 53
    • 84928386773 scopus 로고    scopus 로고
    • Effect of zinc on high glucose-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells
    • Zhang X, Liang D, Chi ZH, Chu Q, Zhao C, Ma RZ, Zhao Y, Li H. Effect of zinc on high glucose-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells. Int J Mol Med 35: 1747–1754, 2015.
    • (2015) Int J Mol Med , vol.35 , pp. 1747-1754
    • Zhang, X.1    Liang, D.2    Chi, Z.H.3    Chu, Q.4    Zhao, C.5    Ma, R.Z.6    Zhao, Y.7    Li, H.8


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