A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function

American Journal of Physiology - Cell Physiology

Volumn 300, Issue 6, 2011, Pages

  Seo, Young Ah ^a   Lopez, Veronica ^a   Kelleher, Shannon L ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Adenosine 5' triphosphate biogenesis; Apoptosis; Mitochondrial targeting; Zinc transporter

Indexed keywords

ADENOSINE TRIPHOSPHATE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; SMALL INTERFERING RNA; ZINC; ZINC TRANSPORTER;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOENERGY; CELL CULTURE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; FEMALE; FEMALE GENITAL SYSTEM; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; MAMMARY GLAND; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; OVARY; PLACENTA; PRIORITY JOURNAL; PROTEIN MOTIF; UTERUS;

AMINO ACID MOTIFS; ANIMALS; CATION TRANSPORT PROTEINS; CELLS, CULTURED; EPITHELIAL CELLS; FEMALE; HISTIDINE; MAMMARY GLANDS, ANIMAL; MICE; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PREGNANCY; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; ZINC;

EID: 79957660884     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00420.2010     Document Type: Article

References (37)

1. Besecker B, Bao S, Bohacova B, Papp A, Sadee W, Knoell DL. Thehuman zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia. Am J Physiol Lung Cell Mol Physiol 294: L1127-L1136, 2008.
2. Chacinska A, Pfanner N, Meisinger C. How mitochondria import hydrophilic and hydrophobic proteins. Trends Cell Biol 12: 299-303, 2002.
3. Chowanadisai W, Lonnerdal B, Kelleher SL. Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. J Biol Chem 281: 39699-39707, 2006.
4. Costello LC, Franklin RB, Liu Y, Kennedy MC. Zinc causes a shift toward citrate equilibrium of the m-aconitase reaction of prostate mitochondria. J Inorg Biol 78: 161-165, 2000.
5. Costello LC, Guan Z, Franklin RB, Feng P. Metallothionein can function as a chaperone for zinc uptake transport into prostate and liver mitochondria. J Inorg Biochem 98: 664-666, 2004.
6. Deane EE, Kelly SP, Lo CK, Woo NY. Effects of GH, prolactin and cortisol on hepatic heat shock protein 70 expression in a marine teleost Sparus sarba. J Endocrinol 161: 413-421, 1999.
7. Dinur-Mills M, Tal M, Pines O. Dual targeted mitochondrial proteins are characterized by lower MTS parameters and total net charge. PLoS One 3: e2161, 2008.
8. Falcon-Perez JM, Dell'Angelica EC. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res 313: 1473-1483, 2007.
9. Feng P, Liang JY, Li TL, Guan ZX, Zou J, Franklin R, Costello LC. Zinc induces mitochondria apoptogenesis in prostate cells. Mol Urol 4: 31-36, 2000.
10. Franklin B, Costello L. The important role of the apoptotic effects of zinc in the development of cancers. J Cell Biochem 106: 750-757, 2009.
11. Guan Z, Kukoyi B, Feng P, Kennedy MC, Franklin RB, Costello LC. Kinetic identification of a mitochondrial zinc uptake transport process in prostate cells. J Inorg Biochem 97: 199-206, 2003.
12. He L, Girijashanker K, Dalton TP, Reed J, Li H, Soleimani M, Nebert DW. ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties. Mol Pharmacol 70: 171-180, 2006.
13. Iguchi K, Usui S, Inoue T, Sugimura Y, Tatematsu M, Hirano K. High-level expression of zinc transporter-2 in the rat lateral and dorsal prostate. J Androl 23: 819-824, 2002.
14. Jackson KA, Helston RM, McKay JA, O'Neill ED, Mathers JC, Ford D. Splice variants of the human zinc transporter ZnT5 (SLC30A5) are differentially localised and regulated by zinc through transcription and mRNA stability. J Biol Chem 282: 10423-10431, 2007.
15. 2+ induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria. J Biol Chem 276: 47524-47529, 2001.
16. Kambe T, Yamaguchi-Iwai Y, Sasaki R, Nagao M. Overview of mammalian zinc transporters. Cell Mol Life Sci 61: 49-68, 2004.
17. Kelleher SL, Lonnerdal B. Zinc transporters in the mammary gland respond to marginal zinc and vitamin A intake during lactation in rats. J Nutr 132: 3280-3285, 2002.
18. Kelleher SL, Lonnerdal B. Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells. J Nutr 133: 3378-3385, 2003.
19. Lee EW, Lai Y, Zhang H, Unadkat JD. Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine. J Biol Chem 281: 16700-16706, 2006.
20. Lemire J, Mailloux R, Appanna V. Zinc toxicity alters mitochondrial metabolism and leads to decreased ATP production in hepatocytes. J Appl Toxicol 28: 175-182, 2008.
21. Liang JY, Liu YY, Zou J, Franklin RB, Costello LC, Feng P. Inhibitory effect of zinc on human prostatic carcinoma cell growth. Prostate 40: 200-207, 1999.
22. Lichten LA, Cousins RJ. Mammalian zinc transporters: nutritional and physiologic regulation. Annu Rev Nutr 29: 153-176, 2009.
23. Liu Y, Franklin RB, Costello LC. Prolactin and testosterone regulation of mitochondrial zinc in prostate epithelial cells. Prostate 30: 26-32, 1997.
24. Lopez V, Kelleher SL. Zinc transporter-2 (ZnT2) variants are localized to distinct sub-cellular compartments and functionally transport zinc. Biochem J 29: 43-52, 2009.
25. Lopez V, Kelleher SL. Zip6-attenuation promotes epithelial-to-mesenchymal transition in ductal breast tumor (T47D) cells. Exp Cell Res 316: 366-375.
26. 2+ inhibits mitochondrial movement in neurons by phosphatidylinositol 3-kinase activation. J Neurosci 25: 9507-9514, 2005.
27. 2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia. J Neurosci 29: 1105-1114, 2009.
28. Neve E, Ingelman-Sundberg M. Intracellular transport and localization of microsomal cytochrome P450. Anal Bioanal Chem 392: 1075-1084, 2008.
29. Neville M, Mather I. Introduction: secretory activation: from the past to the future. J Mammary Gland Biol Neoplasia 12: 205-210, 2007.
30. Pizzo P, Pozzan T. Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics. Trends Cell Biol 17: 511-517, 2007.
31. Qian L, Lopez V, Seo Y, Kelleher S. Prolactin regulates ZNT2 expression through the JAK/STAT signaling pathway in mammary cells. Am J Physiol Cell Physiol 297: C369-C377, 2009.
32. Robin MA, Anandatheerthavarada HK, Biswas G, Sepuri NBV, Gordon DM, Pain D, Avadhani NG. Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation. J Biol Chem 277: 40583-40593, 2002.
33. Rudolf E. Depletion of ATP and oxidative stress underlie zinc-induced cell injury. Acta Medica (Hradec Kralove) 50: 43-49, 2007.
34. 2+ pools. Proc Natl Acad Sci USA 100: 6157-6162, 2003.
35. Sensi SL, Ton-That D, Weiss JH, Rothe A, Gee KR. A new mitochondrial fluorescent zinc sensor. Cell Calcium 34: 281-284, 2003.
36. Strub A, Zufall N, Voos W. The putative helical lid of the Hsp70 peptide-binding domain is required for efficient preprotein translocation into mitochondria. J Mol Biol 334: 1087-1099, 2003.
37. Wadhwa R, Takano S, Kaur K, Aida S, Yaguchi T, Kaul Z, Hirano T, Taira K, Kaul SC. Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60. Biochem J 391: 185-190, 2005.