The temporal scaling of Caenorhabditis elegans ageing

Nature

Volumn 530, Issue 7588, 2016, Pages 103-107

  Stroustrup, Nicholas ^a   Anthony, Winston E ^a   Nash, Zachary M ^a,b   Gowda, Vivek ^a   Gomez, Adam ^a,c   López Moyado, Isaac F ^a,d   Apfeld, Javier ^a,e   Fontana, Walter ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^e NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK TRANSCRIPTION FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1; SOMATOMEDIN C; TRANSCRIPTION FACTOR DAF 16; AGE-1 PROTEIN, C ELEGANS; CAENORHABDITIS ELEGANS PROTEIN; DAF-16 PROTEIN, C ELEGANS; DAF-2 PROTEIN, C ELEGANS; FORKHEAD TRANSCRIPTION FACTOR; HEAT SHOCK FACTOR-1, C ELEGANS; HIF-1 PROTEIN, C ELEGANS; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR;

AGING; GENE; HEAT SHOCK; HYPOXIA; MORTALITY; NEMATODE; PHYSIOLOGY; QUANTITATIVE ANALYSIS; TEMPORAL ANALYSIS;

AGING; ARTICLE; CAENORHABDITIS ELEGANS; DIET; GENE; GENE DISRUPTION; LIFESPAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RATE CONSTANT; TEMPERATURE DEPENDENCE; ANIMAL; DEATH; GENETICS; KINETICS; LONGEVITY; PHYSIOLOGY; RISK; TEMPERATURE; TIME;

CAENORHABDITIS ELEGANS;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DEATH; DIET; FORKHEAD TRANSCRIPTION FACTORS; KINETICS; LONGEVITY; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTOR, INSULIN; RISK; TEMPERATURE; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 84956921333     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16550     Document Type: Article

References (35)

1. Pincus, Z., Smith-Vikos, T. & Slack, F. J. MicroRNA predictors of longevity in Caenorhabditis elegans. PLoS Genet. 7, e1002306 (2011).
2. Herndon, L. A. et al. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808-814 (2002).
3. Shaw, R. F. & Bercaw, B. L. Temperature and life-span in poikilothermous animals. Nature 196, 454-457 (1962).
4. Mair, W., Goymer, P., Pletcher, S. D. & Partridge, L. Demography of dietary restriction and death in Drosophila. Science 301, 1731-1733 (2003).
5. Wu, D., Rea, S. L., Cypser, J. R. & Johnson, T. E. Mortality shifts in Caenorhabditis elegans: remembrance of conditions past. Aging Cell 8, 666-675 (2009).
6. Conti, B. et al. Transgenic mice with a reduced core body temperature have an increased life span. Science 314, 825-828 (2006).
7. Lithgow, G. J., White, T. M., Melov, S. & Johnson, T. E. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc. Natl Acad. Sci. USA 92, 7540-7544 (1995).
8. Stroustrup, N. et al. The Caenorhabditis elegans lifespan machine. Nature Methods 10, 665-670 (2013).
9. Johnson, T. E., Wu, D., Tedesco, P., Dames, S. & Vaupel, J. W. Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects. J. Gerontol. A 56, B331-B339 (2001).
10. Swindell, W. R. Accelerated failure time models provide a useful statistical framework for aging research. Exp. Gerontol. 44, 190-200 (2009).
11. Vaupel, J. W., Manton, K. G. & Stallard, E. The impact of heterogeneity in individual frailty on the dynamics of mortality. Demography 16, 439-454 (1979).
12. Martin, G. M., Austad, S. N. & Johnson, T. E. Genetic analysis of ageing: role of oxidative damage and environmental stresses. Nature Genet. 13, 25-34 (1996).
13. Tullet, J. M. et al. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132, 1025-1038 (2008).
14. Landis, J. N. & Murphy, C. T. Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Dev. Dyn. 239, 1405-1412 (2010).
15. Hsu, A. L., Murphy, C. T. & Kenyon, C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300, 1142-1145 (2003).
16. Leiser, S. F., Begun, A. & Kaeberlein, M. HIF-1 modulates longevity and healthspan in a temperature-dependent manner. Aging Cell 10, 318-326 (2011).
17. Kirkwood, T. B. & Shanley, D. P. Food restriction, evolution and ageing. Mech. Ageing Dev. 126, 1011-1016 (2005).
18. Garigan, D. et al. Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101-1112 (2002).
19. Lakowski, B. & Hekimi, S. The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl Acad. Sc. USA 95, 13091-13096 (1998).
20. Suda, H., Sato, K. & Yanase, S. Timing mechanism and effective activation energy concerned with aging and lifespan in the long-lived and thermosensory mutants of Caenorhabditis elegans. Mech. Ageing Dev. 133, 600-610 (2012).
21. Atlan, H., Miquel, J., Helmle, L. C. & Dolkas, C. B. Thermodynamics of aging in Drosophila melanogaster. Mech. Ageing Dev. 5, 371-387 (1976).
22. Libina, N., Berman, J. R. & Kenyon, C. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115, 489-502 (2003).
23. Murphy, C. T. et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-283 (2003).
24. Walker, G., Houthoofd, K., Vanfleteren, J. R. & Gems, D. Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways. Mech. Ageing Dev. 126, 929-937 (2005).
25. McColl, G. et al. Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab. 12, 260-272 (2010).
26. Oliveira, R. P. et al. Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell 8, 524-541 (2009).
27. Aalen, O. O. & Gjessing, H. K. Understanding the shape of the hazard rate: a process point of view. Stat. Sci. 16, 1-14 (2001).
28. Medawar, P. B. An Unsolved Problem of Biology: An Inaugural Lecture Delivered at University College, London (H. K. Lewis, 1951).
29. Gladyshev, V. N. The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan. Trends Genet. 29, 506-512 (2013).
30. Samuelson, A. V., Carr, C. E. & Ruvkun, G. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev. 21, 2976-2994 (2007).
31. Stiernagle, T. in WormBook (ed. The C. elegans Research Community) http://dx.doi.org/10.1895/wormbook.1.101.1 (February 11, 2006).
32. Baeriswyl, S. et al. Modulation of aging profiles in isogenic populations of Caenorhabditis elegans by bacteria causing different extrinsic mortality rates. Biogerontology 11, 53-65 (2010).
33. Wilkinson, D. S., Taylor, R. C. & Dillin, A. Analysis of aging in Caenorhabditis elegans. Methods Cell Biol. 107, 353-381 (2012).
34. R Core Team. R: a language and environment for statistical computing (R Foundation for Statistical Computing, 2013).
35. Rebora, P., Salim, A. & Reilly, M. bshazard: a flexible tool for nonparametric smoothing of the hazard function. R J. 6, 114-122 (2014).