The caenorhabditis elegans lifespan machine

Nature Methods

Volumn 10, Issue 7, 2013, Pages 665-670

  Stroustrup, Nicholas ^a   Ulmschneider, Bryne E ^a   Nash, Zachary M ^a   López Moyado, Isaac F ^a   Apfeld, Javier ^a   Fontana, Walter ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ARTICLE; CAENORHABDITIS ELEGANS; ENVIRONMENTAL STRESS; GENETIC SCREENING; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STATISTICAL ANALYSIS; SURVIVAL RATE; WORM; ANIMAL; COMPUTER ASSISTED DIAGNOSIS; LIFE EXPECTANCY; LONGEVITY; PHYSIOLOGY; PROCEDURES; SURVIVAL; VIDEORECORDING;

CAENORHABDITIS ELEGANS; NEMATODA;

ANIMALS; CAENORHABDITIS ELEGANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LIFE EXPECTANCY; LONGEVITY; SURVIVAL ANALYSIS; SURVIVAL RATE; VIDEO RECORDING;

EID: 84879690627     PISSN: 15487091     EISSN: 15487105     Source Type: Journal    
DOI: 10.1038/nmeth.2475     Document Type: Article

References (35)

1. Kirkwood, T.B. et al. What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment? Mech. Ageing Dev. 126, 439-443 (2005).
2. Friedman, D.B. & Johnson, T.E. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118, 75-86 (1988).
3. Kenyon, C., Chang, J., Gensch, E., Rudner, A. & Tabtiang, R. A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464 (1993).
4. Kimura, K.D., Tissenbaum, H.A., Liu, Y. & Ruvkun, G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-946 (1997).
5. Kenyon, C.J. The genetics of ageing. Nature 464, 504-512 (2010).
6. Sutphin, G.L. & Kaeberlein, M. Measuring Caenorhabditis elegans life span on solid media. J. Vis. Exp. 12, pii: 1152 (2009).
7. Wilkinson, D.S., Taylor, R.C. & Dillin, A. Analysis of aging in Caenorhabditis elegans. Methods Cell Biol. 107, 353-381 (2012).
8. Curtsinger, J.W., Fukui, H.H., Townsend, D.R. & Vaupel, J.W. Demography of genotypes: failure of the limited life-span paradigm in Drosophila melanogaster. Science 258, 461-463 (1992).
9. Carey, J.R., Liedo, P. & Vaupel, J.W. Mortality dynamics of density in the Mediterranean fruit fly. Exp. Gerontol. 30, 605-629 (1995).
10. Vaupel, J.W. et al. Biodemographic trajectories of longevity. Science 280, 855-860 (1998).
11. Vanfleteren, J.R., De Vreese, A. & Braeckman, B.P. Two-parameter logistic and Weibull equations provide better fits to survival data from isogenic populations of Caenorhabditis elegans in axenic culture than does the Gompertz model. J. Gerontol. A Biol. Sci. Med. Sci. 53, B393-B408 (1998).
12. Johnson, T.E., Wu, D., Tedesco, P., Dames, S. & Vaupel, J.W. Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects. J. Gerontol. A Biol. Sci. Med. Sci. 56, B331-B339 (2001).
13. Mair, W., Goymer, P., Pletcher, S.D. & Partridge, L. Demography of dietary restriction and death in Drosophila. Science 301, 1731-1733 (2003).
14. Baeriswyl, S. et al. Modulation of aging profiles in isogenic populations of Caenorhabditis elegans by bacteria causing different extrinsic mortality rates. Biogerontology 11, 53-65 (2010).
15. Wu, D., Rea, S.L., Cypser, J.R. & Johnson, T.E. Mortality shifts in Caenorhabditis elegans: remembrance of conditions past. Aging Cell 8, 666-675 (2009).
16. Lithgow, G.J., White, T.M., Melov, S. & Johnson, T.E. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc. Natl. Acad. Sci. USA 92, 7540-7544 (1995).
17. Klass, M.R. Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech. Ageing Dev. 6, 413-429 (1977).
18. Herndon, L.A. et al. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808-814 (2002).
19. Huang, C., Xiong, C. & Kornfeld, K. Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 101, 8084-8089 (2004).
20. Müller, H.G. & Wang, J.L. Hazard rate estimation under random censoring with varying kernels and bandwidths. Biometrics 50, 61-76 (1994).
21. Vaupel, J.W., Manton, K.G. & Stallard, E. The impact of heterogeneity in individual frailty on the dynamics of mortality. Demography 16, 439-454 (1979).
22. Weitz, J.S. & Fraser, H.B. Explaining mortality rate plateaus. Proc. Natl. Acad. Sci. USA 98, 15383-15386 (2001).
23. Mathew, M.D., Mathew, N.D. & Ebert, P.R. WormScan: a technique for high-throughput phenotypic analysis of Caenorhabditis elegans. PLoS ONE 7, e33483 (2012).
24. Dillin, A., Crawford, D.K. & Kenyon, C. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298, 830-834 (2002).
25. Larsen, P.L., Albert, P.S. & Riddle, D.L. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139, 1567-1583 (1995).
26. Ailion, M., Inoue, T., Weaver, C.I., Holdcraft, R.W. & Thomas, J.H. Neurosecretory control of aging in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 96, 7394-7397 (1999).
27. Haskins, K.A., Russell, J.F., Gaddis, N., Dressman, H.K. & Aballay, A. Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity. Dev. Cell 15, 87-97 (2008).
28. Tullet, J.M. et al. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132, 1025-1038 (2008).
29. Kiontke, K.C. et al. A phylogeny and molecular barcodes for Caenorhabditis, with numerous new species from rotting fruits. BMC Evol. Biol. 11, 339 (2011).
30. Amrit, F.R., Boehnisch, C.M. & May, R.C. Phenotypic covariance of longevity, immunity and stress resistance in the Caenorhabditis nematodes. PLoS ONE 5, e9978 (2010).
31. Stiernagle, T. Maintenance of C. elegans. in WormBook http://dx.doi.org/10.1895/wormbook.1.101.1 (2006).
32. Dong, J.X., Krzyzak, A. & Suen, C.Y. Fast SVM training algorithm with decomposition on very large data sets. IEEE Trans. Pattern Anal. Mach. Intell. 27, 603-618 (2005).
33. Sall, J., Lehman, A., Stephens, M. & Creighton, L. JMP Start Statistics: A Guide to Statistics and Data Analysis using JMP 5th edn. (SAS Institute, Cary, North Carolina, 2012).
34. R Development Core Team. R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, Vienna, 2006).
35. Buckley, J. & James, I. Linear regression with censored data. Biometrika 66, 429-436 (1979).