MGL Receptor and Immunity: When the Ligand Can Make the Difference

Journal of Immunology Research

Volumn 2015, Issue , 2015, Pages

  Zizzari, Ilaria Grazia ^a   Napoletano, Chiara ^a   Battisti, Federico ^a   Rahimi, Hassan ^a   Caponnetto, Salvatore ^a   Pierelli, Luca ^a   Nuti, Marianna ^a   Rughetti, Aurelia ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD209 ANTIGEN; DECTIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; LANGERIN; LECTIN RECEPTOR; LIGAND; MACROPHAGE GALACTOSE TYPE C TYPE LECTIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUCIN 1; N ACETYLGLUCOSAMINE; TN ANTIGEN; TOLL LIKE RECEPTOR 2; TUMOR ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTOANTIGEN; BACTERIAL ANTIGEN; HLA ANTIGEN; IMMUNOLOGIC FACTOR; LECTIN; N ACETYLGALACTOSAMINE; PEPTIDOMIMETIC AGENT; VIRUS ANTIGEN;

BREAST CANCER; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CROHN DISEASE; DENDRITIC CELL; GENE MUTATION; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; INTRACELLULAR SIGNALING; LIGAND BINDING; MACROPHAGE FUNCTION; MULTIPLE SCLEROSIS; NONHUMAN; OLIGOMERIZATION; PROTEIN BINDING; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; STEREOSPECIFICITY; T LYMPHOCYTE ACTIVATION; TUMOR IMMUNITY; ANTIGEN PRESENTATION; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; IMMUNOLOGY; MACROPHAGE; NEOPLASMS; PATHOLOGY;

ACETYLGALACTOSAMINE; ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; ANTIGENS, VIRAL; AUTOANTIGENS; DENDRITIC CELLS; GENE EXPRESSION; HLA ANTIGENS; HUMANS; IMMUNOLOGIC FACTORS; LECTINS, C-TYPE; LIGANDS; MACROPHAGES; NEOPLASMS; PEPTIDOMIMETICS; SIGNAL TRANSDUCTION;

EID: 84956911517     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2015/450695     Document Type: Review

References (59)

1. B. Pulendran, K. Palucka, and J. Banchereau, "Sensing pathogens and tuning immune responses, " Science, vol. 293, no. 5528, pp. 253-256, 2001.
2. C. A. Janeway Jr. and R. Medzhitov, "Innate immune recognition, " Annual Review of Immunology, vol. 20, pp. 197-216, 2002.
3. I. M. Dambuza and G. D. Brown, "C-type lectins in immunity: recent developments, " Current Opinion in Immunology, vol. 32, pp. 21-27, 2015.
4. T. Kawai and S. Akira, "Toll-like receptor and RIG-1-like receptor signaling, " Annals of the New York Academy of Sciences, vol. 1143, pp. 1-20, 2008.
5. A. N. Zelensky and J. E. Gready, "The C-type lectin-like domain superfamily, "The FEBS Journal, vol. 272, no. 24, pp. 6179-6217, 2005.
6. Y. Van Kooyk and T. B. H. Geijtenbeek, "DC-SIGN: escape mechanism for pathogens, " Nature Reviews Immunology, vol. 3, no. 9, pp. 697-709, 2003.
7. A. Engering, T. B. H. Geijtenbeek, S. J. Van Vliet et al., "The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells, " The Journal of Immunology, vol. 168, no. 5, pp. 2118-2126, 2002.
8. T. B. H. Geijtenbeek and S. I. Gringhuis, "Signalling through C-type lectin receptors: shaping immune responses, " Nature Reviews Immunology, vol. 9, no. 7, pp. 465-479, 2009.
9. S. J. vanVliet, J. J. Garća-Vallejo, and Y. van Kooyk, "Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune responses, " Immunology and Cell Biology, vol. 86, no. 7, pp. 580-587, 2008.
10. G. D. Brown, J. Herre, D. L. Williams, J. A. Willment, A. S. J. Marshall, and S. Gordon, "Dectin-1 mediates the biological effects of β-glucans, " Journal of ExperimentalMedicine, vol. 197, no. 9, pp. 1119-1124, 2003.
11. B. N. Gantner, R. M. Simmons, S. J. Canavera, S. Akira, and D. M. Underhill, "Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2, " Journal of Experimental Medicine, vol. 197, no. 9, pp. 1107-1117, 2003.
12. P. Chakraborty, D. Ghosh, and M. K. Basu, "Modulation of macrophage mannose receptor affects the uptake of virulent and avirulent Leishmania donovani promastigotes, " Journal of Parasitology, vol. 87, no. 5, pp. 1023-1027, 2001.
13. S. Oo-puthinan, K. Maenuma, M. Sakakura et al., "The amino acids involved in the distinct carbohydrate specificities between macrophage galactose-type C-type lectins 1 and 2 (CD301a and b) of mice, " Biochimica et Biophysica Acta (BBA): General Subjects, vol. 1780, no. 2, pp. 89-100, 2008.
14. L. A. J. ONeill, "When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction, " Immunity, vol. 29, no. 1, pp. 12-20, 2008.
15. S. J. van Vliet, E. Saeland, and Y. van Kooyk, "Sweet preferences of MGL: carbohydrate specificity and function, " Trends in Immunology, vol. 29, no. 2, pp. 83-90, 2008.
16. C. Napoletano, A. Rughetti, M. P. Agervig Tarp et al., "Tumorassociated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells, " Cancer Research, vol. 67, no. 17, pp. 8358-8367, 2007.
17. P. J. Tacken, I. J. M. de Vries, K. Gijzen et al., "Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DCSIGN antibody, " Blood, vol. 106, no. 4, pp. 1278-1285, 2005.
18. G. Raes, L. Brys, B. K. Dahal et al., "Macrophage galactosetype C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation, " Journal of Leukocyte Biology, vol. 77, no. 3, pp. 321-327, 2005.
19. S. J. Van Vliet, L. C. Paessens, V. C. M. Broks-van Den Berg, T. B. H. Geijtenbeek, and Y. Van Kooyk, "The C-type lectin macrophage galactose-type lectin impedes migration of immature APCs, " The Journal of Immunology, vol. 181, no. 5, pp. 3148-3155, 2008.
20. S. J. Van Vliet, E. Van Liempt, E. Saeland et al., "Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells, " International Immunology, vol. 17, no. 5, pp. 661-669, 2005.
21. N. Mortezai, H. N. Behnken, A.-K. Kurze et al., "Tumorassociated Neu5Ac-Tn and Neu5Gc-Tn antigens bind to C-type lectin CLEC10A (CD301, MGL), " Glycobiology, vol. 23, no. 7, pp. 844-852, 2013.
22. M. Tsuiji, M. Fujimori, Y. Ohashi et al., "Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1, " The Journal of Biological Chemistry, vol. 277, no. 32, pp. 28892-28901, 2002.
23. Y. Kumamoto, K. Denda-Nagai, S. Aida, N. Higashi, and T. Irimura, "MGL2+ dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo, " PLoS ONE, vol. 4, no. 5, Article ID e5619, 2009.
24. S. K. Singh, I. Streng-Ouwehand, M. Litjens et al., "Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties, " Molecular Immunology, vol. 46, no. 6, pp. 1240-1249, 2009.
25. S. J. VanVliet, C. A. Aarnoudse, V. C. M. Broks-vandenBerg, M. Boks, T. B. H. Geijtenbeek, and Y. van Kooyk, "MGL-mediated internalization and antigen presentation by dendritic cells: a role for tyrosine-5, " European Journal of Immunology, vol. 37, no. 8, pp. 2075-2081, 2007.
26. N. M. van Sorge, N. M. C. Bleumink, S. J. van Vliet et al., "N-glycosylated proteins and distinct lipooligosaccharide glycoforms of Campylobacter jejuni target the human C-type lectin receptor MGL, " Cellular Microbiology, vol. 11, no. 12, pp. 1768-1781, 2009.
27. S. J. Van Vliet, L. Steeghs, S. C. M. Bruijns et al., "Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses, " PLoS Pathogens, vol. 5, no. 10, Article ID e1000625, 2009.
28. S. J. Van Vliet, S. I. Gringhuis, T. B. H. Geijtenbeek, and Y. Van Kooyk, "Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45, " Nature Immunology, vol. 7, no. 11, pp. 1200-1208, 2006.
29. E. Saeland, S. J. Van Vliet, M. Bäckström et al., "The Ctype lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma, " Cancer Immunology, Immunotherapy, vol. 56, no. 8, pp. 1225-1236, 2007.
30. I. G. Zizzari, P. Martufi, F. Battisti et al., "The macrophage galactose-type C-type lectin (MGL)modulates regulatory T cell functions, " PLoS ONE, vol. 10, no. 7, Article IDe0132617, 2015.
31. A. Takada, K. Fujioka, M. Tsuiji et al., "Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry, " Journal of Virology, vol. 78, no. 6, pp. 2943-2947, 2004.
32. E. Van Liempt, S. J. Van Vliet, A. Engering et al., "Schistosoma mansoni soluble egg antigens are internalized by human dendritic cells through multiple C-type lectins and suppress TLRinduced dendritic cell activation, " Molecular Immunology, vol. 44, no. 10, pp. 2605-2615, 2007.
33. M. H. J. Meevissen, N. N. Driessen, H. H. Smits et al., "Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors, " International Journal for Parasitology, vol. 42, no. 3, pp. 269-277, 2012.
34. A. S. MacDonald, A. D. Straw, B. Bauman, and E. J. Pearce, "CD8-dendritic cell activation status plays an integral role in influencing Th2 response development, " The Journal of Immunology, vol. 167, no. 4, pp. 1982-1988, 2001.
35. E. C. De Jong, P. L. Vieira, P. Kalinski et al., "Microbial compounds selectively induce Th1 cell-promoting or Th2 cellpromoting dendritic cells in vitro with diverse th cell-polarizing signals, " The Journal of Immunology, vol. 168, no. 4, pp. 1704-1709, 2002.
36. C. M. Kane, L. Cervi, J. Sun et al., "Helminth antigens modulate TLR-initiated dendritic cell activation, "TheJournal of Immunology, vol. 173, no. 12, pp. 7454-7461, 2004.
37. L. Cervi, A. S. MacDonald, C. Kane, F. Dzierszinski, and E. J. Pearce, "Cutting edge: dendritic cells copulsed with microbial and helminth antigens undergomodifiedmaturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific Th1 and helminth-specific Th2 responses, " Journal of Immunology, vol. 172, no. 4, pp. 2016-2020, 2004.
38. D. Jankovic, M. C. Kullberg, P. Caspar, and A. Sher, "Parasiteinduced Th2 polarization is associated with down-regulated dendritic cell responsiveness toTh1 stimuli and a transient delay in T lymphocyte cycling, " The Journal of Immunology, vol. 173, no. 4, pp. 2419-2427, 2004.
39. E. J. Klaver, L. M. Kuijk, L. C. Laan et al., "Trichuris suisinducedmodulation of human dendritic cell function is glycanmediated, " International Journal for Parasitology, vol. 43, no. 3-4, pp. 191-200, 2013.
40. S. J. Jenkins, G. Perona-Wright, A. G. F. Worsley, N. Ishii, and A. S. MacDonald, "Dendritic cell expression ofOX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming andmemory induction in vivo, " Journal of Immunology, vol. 179, no. 6, pp. 3515-3523, 2007.
41. M. Bruckner, D. Dickel, E. Singer, and D. F. Legler, "Converse regulation of CCR7-driven human dendritic cell migration by prostaglandin E2 and liver X receptor activation, " European Journal of Immunology, vol. 42, no. 11, pp. 2949-2958, 2012.
42. I. G. Zizzari, C. Napoletano, A. Rughetti, H. Rahimi, and M. Nuti, "Seasonalmodulation of theC-type lectinMGL on human DCs, " Open Journal of Immunology, vol. 3, no. 4, pp. 218-220, 2013.
43. S. J. Van Vliet, E. Van Liempt, T. B. H. Geijtenbeek, and Y. Van Kooyk, "Differential regulation of C-type lectin expression on tolerogenic dendritic cell subsets, " Immunobiology, vol. 211, no. 6-8, pp. 577-585, 2006.
44. D. Li, G. Romain, A.-L. Flamar et al., "Targeting self-and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells, " Journal of Experimental Medicine, vol. 209, no. 1, pp. 109-121, 2012.
45. J. M. Burchell, A. Mungul, and J. Taylor-Papadimitriou, "Olinked glycosylation in the mammary gland: changes that occur during malignancy, " Journal of Mammary Gland Biology and Neoplasia, vol. 6, no. 3, pp. 355-364, 2001.
46. C. Welinder, B. Baldetorp, C. Borrebaeck, B.-M. Fredlund, and B. Jansson, "A new murine IgG1 anti-Tn monoclonal antibody with in vivo anti-tumor activity, " Glycobiology, vol. 21, no. 8, pp. 1097-1107, 2011.
47. P. Nollau, G. Wolters-Eisfeld, N. Mortezai et al., "Protein domain histochemistry (PDH): binding of the carbohydrate recognition domain (CRD) of recombinant human glycoreceptor CLEC10A (CD301) to formalin-fixed, paraffin embedded breast cancer tissues, " Journal of Histochemistry and Cytochemistry, vol. 61, no. 3, pp. 199-205, 2013.
48. K. Lenos, J. A. Goos, I. M. Vuist et al., "MGL ligand expression is correlated to BRAFmutation and associated with poor survival of stage III colon cancer patients, " Oncotarget, vol. 6, no. 28, pp. 26278-26290, 2015.
49. S. H. Itzkowitz, M. Yuan, C. K. Montgomery et al., "Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer, " Cancer Research, vol. 49, no. 1, pp. 197-204, 1989.
50. D. J. Gill, K. M. Tham, J. Chia et al., "Initiation of GalNActype O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness, " Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 34, pp. E3152-E3161, 2013.
51. T. Freire, R. Lo-Man, S. Bay, and C. Leclerc, "Tn glycosylation of theMUC6proteinmodulates itsimmunogenicity and promotes the induction of Th17-biased T cell responses, " The Journal of Biological Chemistry, vol. 286, no. 10, pp. 7797-7811, 2011.
52. R. Beatson, G. Maurstad, G. Picco et al., "The breast cancerassociated glycoforms of MUC1, MUC1-Tn and sialyl-Tn, are expressed in COSMCwild-type cells and bind theC-type lectin MGL, " PLoS ONE, vol. 10, no. 5, Article IDe0125994, 2015.
53. S. A. Jégouzo, A. Quintero-Martnez, X. Ouyang, A. Dos Santos, M. E. Taylor, and K. Drickamer, "Organization of the extracellular portion of the macrophage galactose receptor: a trimeric cluster of simple binding sites for N-acetylgalactosamine, " Glycobiology, vol. 23, no. 7, pp. 853-864, 2013.
54. D. W. Miles, L. C. Happerfield, P. Smith et al., "Expression of sialyl-Tn predicts the effect of adjuvant chemotherapy in nodepositive breast cancer, " British Journal of Cancer, vol. 70, no. 6, pp. 1272-1275, 1994.
55. C. Napoletano, I. G. Zizzari, A. Rughetti et al., "Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation, " European Journal of Immunology, vol. 42, no. 4, pp. 936-945, 2012.
56. N. Higashi, K. Fujioka, K. Denda-Nagai et al., "Themacrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cells, " Journal of Biological Chemistry, vol. 277, no. 23, pp. 20686-20693, 2002.
57. A. Rughetti, H. Rahimi, F. Belleudi et al., "Microvesicle cargo of tumor-associated MUC1 to dendritic cells allows crosspresentation and specific carbohydrate processing, " Cancer Immunology Research, vol. 2, no. 2, pp. 177-186, 2014.
58. S. Iborra and D. Sancho, "Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors, " Immunobiology, vol. 220, no. 2, pp. 175-184, 2015.
59. S. J. van Vliet, S. Bay, I. M. Vuist et al., "MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-α secretion, " Journal of Leukocyte Biology, vol. 94, no. 2, pp. 315-323, 2013.