Double-stranded microRNA mimics can induce length-and passenger strand-dependent effects in a cell type-specific manner

RNA

Volumn 22, Issue 2, 2016, Pages 193-203

  Goldgraben, Mae A ^a   Russell, Roslin ^b   Rueda, Oscar M ^a   Caldas, Carlos ^a   Git, Anna ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

DsRNA sensing; MicroRNA; MicroRNA mimics; MiR 155; SiRNA

Indexed keywords

BETA INTERFERON; DOUBLE STRANDED RNA; MICRORNA 145; MICRORNA 155; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; MICRORNA; POLYINOSINIC POLYCYTIDYLIC ACID;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; CELL HETEROGENEITY; CONTROLLED STUDY; GENE EXPRESSION; IN VITRO STUDY; MCF 7 CELL LINE; PRIORITY JOURNAL; WESTERN BLOTTING; ANTIBODY SPECIFICITY; BIOSYNTHESIS; CELL PROLIFERATION; EPITHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MAMMARY GLAND; METABOLISM; MICROARRAY ANALYSIS; MOLECULAR MIMICRY; PATHOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERFERON-BETA; MAMMARY GLANDS, HUMAN; MICROARRAY ANALYSIS; MICRORNAS; MOLECULAR MIMICRY; ORGAN SPECIFICITY; POLY I-C; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84956814263     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.054072.115     Document Type: Article

References (37)

1. Ali HR, Rueda OM, Chin SF, Curtis C, Dunning MJ, Aparicio SA, Caldas C. 2014. Genome-driven integrated classification of breast cancer validated in over 7,500 samples. Genome Biol 15: 431.
2. Bartel DP. 2009. MicroRNAs: Target recognition and regulatory functions. Cell 136: 215-233.
3. Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, et al. 2009. The MIQE guidelines: Minimum information for publication of quantitative real-Time PCR experiments. Clin Chem 55: 611-622.
4. Cascione L, Gasparini P, Lovat F, Carasi S, Pulvirenti A, Ferro A, Alder H, He G, Vecchione A, Croce CM, et al. 2013. Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer. PLoS One 8: E55910.
5. Chang C, Hong SW, Dua P, Kim S, Lee DK. 2013. The design, preparation, and evaluation of asymmetric small interfering RNA for specific gene silencing in mammalian cells. Methods Mol Biol 942: 135-152.
6. Chen J, Wang BC, Tang JH. 2012. Clinical significance of microRNA-155 expression in human breast cancer. J Surg Oncol 106: 260-266.
7. Chorn G, Klein-McDowell M, Zhao L, Saunders MA, Flanagan WM, Willingham AT, Lim LP. 2012. Single-stranded microRNA mimics. RNA 18: 1796-1804.
8. Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, et al. 2012. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 486: 346-352.
9. Djuranovic S, Nahvi A, Green R. 2011. A parsimonious model for gene regulation by miRNAs. Science 331: 550-553.
10. Dvinge H, Git A, Gräf S, Salmon-Divon M, Curtis C, Sottoriva A, Zhao Y, Hirst M, Armisen J, Miska EA, et al. 2013. The shaping and functional consequences of the microRNA landscape in breast cancer. Nature 497: 378-382.
11. Git A, Spiteri I, Blenkiron C, Dunning MJ, Pole JC, Chin SF, Wang Y, Smith J, Livesey FJ, Caldas C. 2008. PMC42, a breast progenitor cancer cell line, has normal-like mRNA and microRNA transcriptomes. Breast Cancer Res 10: R54.
12. Ha M, Kim VN. 2014. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol 15: 509-524.
13. Hu HY, Yan Z, Xu Y, Hu H, Menzel C, Zhou YH, ChenW, Khaitovich P. 2009. Sequence features associated with microRNA strand selection in humans and flies. BMC Genomics 10: 413.
14. Ishibashi O, Ali MM, Luo SS, Ohba T, Katabuchi H, Takeshita T, Takizawa T. 2011. Short RNA duplexes elicit RIG-I-mediated apoptosis in a cell type-And length-dependent manner. Sci Signal 4: Ra74.
15. Johansson J, Berg T, Kurzejamska E, Pang MF, Tabor V, Jansson M, Roswall P, Pietras K, Sund M, Religa P, et al. 2013. MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer. Oncogene 32: 5614-5624.
16. Karpala AJ, Doran TJ, Bean AG. 2005. Immune responses to dsRNA: Implications for gene silencing technologies. Immunol Cell Biol 83: 211-216.
17. Kong W, Yang H, He L, Zhao JJ, Coppola D, Dalton WS, Cheng JQ. 2008. MicroRNA-155 is regulated by the transforming growth factor β/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 28: 6773-6784.
18. KongW, He L, Coppola M, Guo J, Esposito NN, Coppola D, Cheng JQ. 2010. MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer. J Biol Chem 285: 17869-17879.
19. Kong W, He L, Richards EJ, Challa S, Xu CX, Permuth-Wey J, Lancaster JM, Coppola D, Sellers TA, Djeu JY, et al. 2014. Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer. Oncogene 33: 679-689.
20. Kozomara A, Griffiths-Jones S. 2014. miRBase: Annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res 42: D68-D73.
21. McInnes N, Sadlon TJ, Brown CY, Pederson S, Beyer M, Schultze JL, McColl S, Goodall GJ, Barry SC. 2012. FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells. Oncogene 31: 1045-1054.
22. Meijer HA, Kong YW, Lu WT, Wilczynska A, Spriggs RV, Robinson SW, Godfrey JD, Willis AE, Bushell M. 2013. Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation. Science 340: 82-85.
23. Neilsen PM, Noll JE, Mattiske S, Bracken CP, Gregory PA, Schulz RB, Lim SP, Kumar R, Suetani RJ, Goodall GJ, et al. 2013. Mutant p53 drives invasion in breast tumors through up-regulation of miR-155. Oncogene 32: 2992-3000.
24. Olive V, Li Q, He L. 2013. mir-17-92: A polycistronic oncomir with pleiotropic functions. Immunol Rev 253: 158-166.
25. Peacock H, Fucini RV, Jayalath P, Ibarra-Soza JM, Haringsma HJ, Flanagan WM, Willingham A, Beal PA. 2011. Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA. J Am Chem Soc 133: 9200-9203.
26. Reynolds A, Anderson EM, Vermeulen A, Fedorov Y, Robinson K, Leake D, Karpilow J, Marshall WS, Khvorova A. 2006. Induction of the interferon response by siRNA is cell type-And duplex length-dependent. RNA 12: 988-993.
27. Seddiki N, Brezar V, Ruffin N, Lévy Y, Swaminathan S. 2014. Role of miR-155 in the regulation of lymphocyte immune function and disease. Immunology 142: 32-38.
28. Søkilde R, Newie I, Persson H, Borg A, Rovira C. 2015. Passenger strand loading in overexpression experiments using microRNA mimics. RNA Biol 12: 787-791.
29. Spizzo R, Nicoloso MS, Lupini L, Lu Y, Fogarty J, Rossi S, Zagatti B, Fabbri M, Veronese A, Liu X, et al. 2010. miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-A in human breast cancer cells. Cell Death Differ 17: 246-254.
30. Sun YM, Lin KY, Chen YQ. 2013. Diverse functions of miR-125 family in different cell contexts. J Hematol Oncol 6: 6.
31. van Rooij E, Kauppinen S. 2014. Development of microRNA therapeutics is coming of age. EMBO Mol Med 6: 851-864.
32. Vigorito E, Kohlhaas S, Lu D, Leyland R. 2013. miR-155: An ancient regulator of the immune system. Immunol Rev 253: 146-157.
33. Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, et al. 2006. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci 103: 2257-2261.
34. Wang PH, Weng SP, He JG. 2015. Nucleic acid-induced antiviral immunity in invertebrates: An evolutionary perspective. Dev Comp Immunol 48: 291-296.
35. Wilson RC, Tambe A, Kidwell MA, Noland CL, Schneider CP, Doudna JA. 2015. Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis. Mol Cell 57: 397-407.
36. WitwerKW, Sisk JM, Gama L, Clements JE. 2010. MicroRNA regulation of IFN-β protein expression: Rapid and sensitive modulation of the innate immune response. J Immunol 184: 2369-2376.
37. Yin Q, McBride J, Fewell C, Lacey M, Wang X, Lin Z, Cameron J, Flemington EK. 2008. MicroRNA-155 is an Epstein-Barr virus-induced gene that modulates Epstein-Barr virus-regulated gene expression pathways. J Virol 82: 5295-5306.