G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension

Journal of Human Hypertension

Volumn 26, Issue 5, 2012, Pages 334-339

  Rayner, B ^a   Ramesar, R ^b   Steyn, K ^b,c   Levitt, N ^b   Lombard, C ^c   Charlton, K ^d  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^d UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

blood pressure response; dietary intervention; GRK 4

Indexed keywords

DOPAMINE; G PROTEIN COUPLED RECEPTOR KINASE 4;

ADULT; AGED; ARTICLE; BLOOD PRESSURE MONITORING; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIET THERAPY; DISEASE SEVERITY; DNA DETERMINATION; ENZYME ACTIVITY; FEMALE; GENETIC POLYMORPHISM; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; NATRIURESIS; NEGRO; PATIENT SELECTION; PREDICTION; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM; SODIUM BALANCE; SODIUM URINE LEVEL; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME; TREATMENT RESPONSE;

AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; FEMALE; G-PROTEIN-COUPLED RECEPTOR KINASE 4; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERTENSION; LINEAR MODELS; MALE; MIDDLE AGED; PATIENT SELECTION; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT; RISK FACTORS; SEQUENCE ANALYSIS, DNA; SOUTH AFRICA; TIME FACTORS; TREATMENT OUTCOME;

EID: 84859803725     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/jhh.2011.33     Document Type: Article

References (19)

1. Steyn K, Gaziano TA, Bradshaw D, Laubscher R, Fourie J. For the South African demographic and health coordinating team. J Hypertens 2001; 19: 1717-1725. (Pubitemid 32924936)
2. Rayner B. Hypertension: detection and management in South Africa. Nephron 2010; 116: c269-c273.
3. Charlton KE, Steyn K, Levitt NS, Zulu JV, Jonathan D, Veldman FJ et al. Ethnic differences in intake andexcretion of sodium, potassium, calcium and magnesium inSouth Africans. Eur J Cardiovasc Prev Rehabil 2005; 12: 355-362. (Pubitemid 41192167)
4. Charlton KE, Steyn K, Levitt NS, Zulu JV, Jonathan D, Veldman FJ et al. Diet and blood pressure in South Africa: the intake of foods containing sodium, potassium, calcium and magnesium in three ethnic groups. Nutrition 2005; 21: 39-50. (Pubitemid 40127564)
5. Matlou SM, Isles CG, Higgs A, Milne FJ, Murray GD, Schultz E et al. Potassium supplementation in blacks with mild to moderate essential hypertension. J Hypertens 1986; 4: 61-64. (Pubitemid 16129685)
6. World Health Organization/Food and Agricultural Organization Expert Consultation on Diet. Nutrition and the Prevention of Chronic Diseases. (Background paper on the Scientific Basis for Diet, Nutrition and the Prevention of Cardiovascular Disease, Annex 4). WHO: Geneva. 28 January-1 February 2002.
7. Sacks FM, Svetky LP, Vollmer WM LJ, Bray GA, Harsha D, Obarzanek E et al. Effects on blood pressure of reduced dietary sodium and the dietary approaches to stop hypertension (DASH) diet. New Engl J Med 2001; 344: 3-10. (Pubitemid 32064838)
8. Charlton KE, Steyn K, Levitt NS, Peer N, Jonathan D, Gogela T et al. A food-based dietary strategy lowers blood pressure in a low socio-economic setting: a randomised study in South Africa. Public Health Nutr 2008; 11: 1397-1406.
9. Shih PA, O'Connor DT. Hereditary determinants of human hypertension: strategies in the setting of genetic complexity. Hypertension 2008; 51: 1456-1464.
10. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 2001; 104: 545-556. (Pubitemid 32201949)
11. Weinberger MH. Salt sensitivity of blood pressure in humans. Hypertension 1996; 27: 481-490. (Pubitemid 26084617)
12. Sullivan JM, Prewitt RL, Ratts TE. Sodium sensitivity in normotensive and borderline hypertensive humans. Am J Med Sci 1988; 295(4): 370-377.
13. Rayner BL, Myers JE, Opie LH, Trinder YA, Davidson JS. Screening for primary aldosteronism-normal ranges for aldosterone and renin in three South African population groups. S Afr Med J 2001; 91: 594-599. (Pubitemid 32707864)
14. Jose PA, Eisner GM, Felder RA. Dopamine and the kidney: a role in hypertension? Curr Opin Nephrol Hypertens 2003; 12: 189-194. (Pubitemid 36288320)
15. Felder R, Sanada H, Xu J, Pei-Ying Y, Watanabe H, Asico L et al. G protein-coupled receptor kinase 4 variants in human essential hypertension. Proc Natl Acad Sci USA 2002; 99: 3872-3877. (Pubitemid 34252198)
16. Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Watanabe T, Moore JH et al. Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clin Chem 2006; 52: 352-360.
17. Zhu H, Lu Y, Wang X, Snieder H, Treiber FA, Harshfield GA et al. The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescents. Pediatr Res 2006; 60: 440-442. (Pubitemid 44427597)
18. Goodwin J, Bilous M, Winship S, Finn P, Jones SC. Validation of the Oscar 2 oscillometric 24-h ambulatory blood pressure monitor according to the British Hypertension Society protocol. Blood Press Monit 2007; 12: 113-117. (Pubitemid 46412118)
19. Androgué HJ, Madias ME. Mechanisms of disease. Sodium and potassium in the pathogenesis of disease. N Engl J Med 2007; 356: 1956-1978.