메뉴 건너뛰기




Volumn 36, Issue 4, 2016, Pages 1373-1385

Age-related phasic patterns of mitochondrial maintenance in adult Caenorhabditis elegans neurons

Author keywords

Age related changes; Caenorhabditis elegans; In vivo microscopy; Mitochondrial trafficking; Neuronal mitochondria

Indexed keywords

CD97 ANTIGEN; CAENORHABDITIS ELEGANS PROTEIN; GREEN FLUORESCENT PROTEIN; HYDROGEN PEROXIDE; MITOCHONDRIAL PROTEIN;

EID: 84956774413     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2799-15.2016     Document Type: Article
Times cited : (70)

References (63)
  • 1
    • 84922385920 scopus 로고    scopus 로고
    • Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants
    • CrossRef Medline
    • Bansal A, Zhu LJ, Yen K, Tissenbaum HA (2015) Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc Natl Acad Sci U S A 112:E277-E286. CrossRef Medline
    • (2015) Proc Natl Acad Sci U S A , vol.112
    • Bansal, A.1    Zhu, L.J.2    Yen, K.3    Tissenbaum, H.A.4
  • 2
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restrictioninduced longevity in C. Elegans
    • CrossRef Medline
    • Bishop NA, Guarente L (2007) Two neurons mediate diet-restrictioninduced longevity in C. elegans. Nature 447:545-549. CrossRef Medline
    • (2007) Nature , vol.447 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 3
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Medline
    • Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94. Medline
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 4
    • 77953924893 scopus 로고    scopus 로고
    • Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans
    • CrossRef Medline
    • Brys K, Castelein N, Matthijssens F, Vanfleteren JR, Braeckman BP (2010) Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans. BMC Biol 8:91. CrossRef Medline
    • (2010) BMC Biol , vol.8 , pp. 91
    • Brys, K.1    Castelein, N.2    Matthijssens, F.3    Vanfleteren, J.R.4    Braeckman, B.P.5
  • 5
    • 77954711627 scopus 로고    scopus 로고
    • Enhanced neuronal RNAi in C. Elegans using SID-1
    • CrossRef Medline
    • Calixto A, Chelur D, Topalidou I, Chen X, Chalfie M (2010) Enhanced neuronal RNAi in C. elegans using SID-1. Nat Methods 7:554-559. CrossRef Medline
    • (2010) Nat Methods , vol.7 , pp. 554-559
    • Calixto, A.1    Chelur, D.2    Topalidou, I.3    Chen, X.4    Chalfie, M.5
  • 6
    • 84869030015 scopus 로고    scopus 로고
    • Fusion and fission: Interlinked processes critical for mitochondrial health
    • CrossRef Medline
    • Chan DC (2012) Fusion and fission: interlinked processes critical for mitochondrial health. Annu Rev Genet 46:265-287. CrossRef Medline
    • (2012) Annu Rev Genet , vol.46 , pp. 265-287
    • Chan, D.C.1
  • 7
    • 34547601410 scopus 로고    scopus 로고
    • Mitochondrial fusion protects against neurodegeneration in the cerebellum
    • CrossRef Medline
    • Chen H, McCaffery JM, Chan DC (2007) Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130:548-562. CrossRef Medline
    • (2007) Cell , vol.130 , pp. 548-562
    • Chen, H.1    McCaffery, J.M.2    Chan, D.C.3
  • 8
    • 84876531457 scopus 로고    scopus 로고
    • PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria
    • CrossRef Medline
    • Chen Y, Dorn GW (2013) PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 340:471-475.CrossRef Medline
    • (2013) Science , vol.340 , pp. 471-475
    • Chen, Y.1    Dorn, G.W.2
  • 9
    • 84880806405 scopus 로고    scopus 로고
    • Kinesin-1-syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport
    • CrossRef Medline
    • Chen Y, Sheng ZH (2013) Kinesin-1-syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport. J Cell Biol 202:351-364. CrossRef Medline
    • (2013) J Cell Biol , vol.202 , pp. 351-364
    • Chen, Y.1    Sheng, Z.H.2
  • 10
    • 68049135457 scopus 로고    scopus 로고
    • Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial docking in axons
    • CrossRef Medline
    • Chen YM, Gerwin C, Sheng ZH (2009) Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial docking in axons. J Neurosci 29: 9429-9438. CrossRef Medline
    • (2009) J Neurosci , vol.29 , pp. 9429-9438
    • Chen, Y.M.1    Gerwin, C.2    Sheng, Z.H.3
  • 11
    • 42049086126 scopus 로고    scopus 로고
    • The measurement and analysis of age-related changes in Caenorhabditis elegans
    • CrossRef
    • Collins JJ, Huang C, Hughes S, Kornfeld K (2008) The measurement and analysis of age-related changes in Caenorhabditis elegans. WormBook Jan 24:1-21. CrossRef
    • (2008) Wormbook Jan , vol.24 , pp. 1-21
    • Collins, J.J.1    Huang, C.2    Hughes, S.3    Kornfeld, K.4
  • 12
    • 84861674629 scopus 로고    scopus 로고
    • Mitochondria as a central sensor for axonal degenerative stimuli
    • CrossRef Medline
    • Court FA, Coleman MP (2012) Mitochondria as a central sensor for axonal degenerative stimuli. Trends Neurosci 35:364-372. CrossRef Medline
    • (2012) Trends Neurosci , vol.35 , pp. 364-372
    • Court, F.A.1    Coleman, M.P.2
  • 13
    • 5344237419 scopus 로고    scopus 로고
    • Incidence of parkinsonism and Parkinson disease in a general population: The Rotterdam Study
    • CrossRef Medline
    • de Lau LM, Giesbergen PC, de Rijk MC, Hofman A, Koudstaal PJ, Breteler MM (2004) Incidence of parkinsonism and Parkinson disease in a general population: the Rotterdam Study. Neurology 63:1240-1244.CrossRef Medline
    • (2004) Neurology , vol.63 , pp. 1240-1244
    • De Lau, L.M.1    Giesbergen, P.C.2    De Rijk, M.C.3    Hofman, A.4    Koudstaal, P.J.5    Breteler, M.M.6
  • 14
    • 55749090654 scopus 로고    scopus 로고
    • The Parkinson’s disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
    • CrossRef Medline
    • Deng H, Dodson MW, Huang H, Guo M (2008) The Parkinson’s disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A 105:14503-14508.CrossRef Medline
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14503-14508
    • Deng, H.1    Dodson, M.W.2    Huang, H.3    Guo, M.4
  • 15
    • 84878586555 scopus 로고    scopus 로고
    • Why size matters - Balancing mitochondrial dynamics in Alzheimer’s disease
    • CrossRef Medline
    • DuBoff B, Feany M, Götz J (2013) Why size matters - balancing mitochondrial dynamics in Alzheimer’s disease. Trends Neurosci 36:325-335.CrossRef Medline
    • (2013) Trends Neurosci , vol.36 , pp. 325-335
    • Duboff, B.1    Feany, M.2    Götz, J.3
  • 16
    • 78650944949 scopus 로고    scopus 로고
    • The cell-non-autonomous nature of electron transport chain-mediated longevity
    • CrossRef Medline
    • Durieux J, Wolff S, Dillin A (2011) The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 144:79-91. CrossRef Medline
    • (2011) Cell , vol.144 , pp. 79-91
    • Durieux, J.1    Wolff, S.2    Dillin, A.3
  • 18
    • 35948978460 scopus 로고    scopus 로고
    • Moving mitochondria: Establishing distribution of an essential organelle
    • CrossRef Medline
    • Frederick RL, Shaw JM (2007) Moving mitochondria: establishing distribution of an essential organelle. Traffic 8:1668-1675. CrossRef Medline
    • (2007) Traffic , vol.8 , pp. 1668-1675
    • Frederick, R.L.1    Shaw, J.M.2
  • 19
    • 0036021375 scopus 로고    scopus 로고
    • Genetic analysis of tissue aging in Caenorhabditis elegans: A role for heatshock factor and bacterial proliferation
    • Medline
    • Garigan D, Hsu AL, Fraser AG, Kamath RS, Ahringer J, Kenyon C (2002) Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heatshock factor and bacterial proliferation. Genetics 161:1101-1112.Medline
    • (2002) Genetics , vol.161 , pp. 1101-1112
    • Garigan, D.1    Hsu, A.L.2    Fraser, A.G.3    Kamath, R.S.4    Ahringer, J.5    Kenyon, C.6
  • 20
    • 23844436700 scopus 로고    scopus 로고
    • In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans
    • CrossRef Medline
    • Gerstbrein B, Stamatas G, Kollias N, Driscoll M (2005) In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans. Aging Cell 4:127-137. CrossRef Medline
    • (2005) Aging Cell , vol.4 , pp. 127-137
    • Gerstbrein, B.1    Stamatas, G.2    Kollias, N.3    Driscoll, M.4
  • 21
    • 84892765743 scopus 로고    scopus 로고
    • Anoxiareoxygenation regulates mitochondrial dynamics through the hypoxia response pathway, SKN-1/Nrf, and stomatin-like protein STL-1/SLP-2
    • CrossRef Medline
    • Ghose P, Park EC, Tabakin A, Salazar-Vasquez N, Rongo C (2013) Anoxiareoxygenation regulates mitochondrial dynamics through the hypoxia response pathway, SKN-1/Nrf, and stomatin-like protein STL-1/SLP-2. PLoS Genet 9:e1004063. CrossRef Medline
    • (2013) Plos Genet , vol.9
    • Ghose, P.1    Park, E.C.2    Tabakin, A.3    Salazar-Vasquez, N.4    Rongo, C.5
  • 22
    • 38449107943 scopus 로고    scopus 로고
    • Mechanosensation
    • GoodmanMB, Jan, CrossRef
    • GoodmanMB (2006) Mechanosensation. WormBook Jan 6:1-14. CrossRef
    • (2006) Wormbook , vol.6 , pp. 1-14
  • 23
    • 0029447441 scopus 로고
    • Electron microscopy and three-dimensional image reconstruction
    • CrossRef Medline
    • Hall DH (1995) Electron microscopy and three-dimensional image reconstruction. Methods Cell Biol 48:395-436. CrossRef Medline
    • (1995) Methods Cell Biol , vol.48 , pp. 395-436
    • Hall, D.H.1
  • 24
    • 0842344106 scopus 로고    scopus 로고
    • Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators
    • CrossRef Medline
    • Hanson GT, Aggeler R, Oglesbee D, Cannon M, Capaldi RA, Tsien RY, Remington SJ (2004) Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators. J Biol Chem 279: 13044-13053. CrossRef Medline
    • (2004) J Biol Chem , vol.279 , pp. 13044-13053
    • Hanson, G.T.1    Aggeler, R.2    Oglesbee, D.3    Cannon, M.4    Capaldi, R.A.5    Tsien, R.Y.6    Remington, S.J.7
  • 27
    • 0032782364 scopus 로고    scopus 로고
    • The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
    • Medline
    • Honda Y, Honda S (1999) The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J 13:1385-1393. Medline
    • (1999) FASEB J , vol.13 , pp. 1385-1393
    • Honda, Y.1    Honda, S.2
  • 28
    • 0036460933 scopus 로고    scopus 로고
    • Life span extensions associated with upregulation of gene expression of antioxidant enzymes in Caenorhabditis elegans; studies of mutation in the age-1, PI3 kinase homologue and short-term exposure to hyperoxia
    • Medline
    • Honda Y, Honda S (2002) Life span extensions associated with upregulation of gene expression of antioxidant enzymes in Caenorhabditis elegans; studies of mutation in the age-1, PI3 kinase homologue and short-term exposure to hyperoxia. J Am Aging Assoc 25:21-28. Medline
    • (2002) J am Aging Assoc , vol.25 , pp. 21-28
    • Honda, Y.1    Honda, S.2
  • 30
    • 2542643174 scopus 로고    scopus 로고
    • Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans
    • CrossRef Medline
    • Huang C, Xiong C, Kornfeld K (2004) Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. Proc Natl Acad Sci U S A 101:8084-8089. CrossRef Medline
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8084-8089
    • Huang, C.1    Xiong, C.2    Kornfeld, K.3
  • 31
    • 84871982184 scopus 로고    scopus 로고
    • Synaptic vesicle exocytosis in hippocampal synaptosomes correlates directly with total mitochondrial volume
    • CrossRef Medline
    • Ivannikov MV, Sugimori M, Llinás RR (2013) Synaptic vesicle exocytosis in hippocampal synaptosomes correlates directly with total mitochondrial volume. J Mol Neurosci 49:223-230. CrossRef Medline
    • (2013) J Mol Neurosci , vol.49 , pp. 223-230
    • Ivannikov, M.V.1    Sugimori, M.2    Llinás, R.R.3
  • 33
    • 37749053855 scopus 로고    scopus 로고
    • Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation
    • CrossRef Medline
    • Kang JS, Tian JH, Pan PY, Zald P, Li C, Deng C, Sheng ZH (2008) Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. Cell 132:137-148. CrossRef Medline
    • (2008) Cell , vol.132 , pp. 137-148
    • Kang, J.S.1    Tian, J.H.2    Pan, P.Y.3    Zald, P.4    Li, C.5    Deng, C.6    Sheng, Z.H.7
  • 34
    • 0035917440 scopus 로고    scopus 로고
    • A conserved regulatory system for aging
    • CrossRef Medline
    • Kenyon C (2001) A conserved regulatory system for aging. Cell 105:165-168. CrossRef Medline
    • (2001) Cell , vol.105 , pp. 165-168
    • Kenyon, C.1
  • 35
    • 0027771804 scopus 로고
    • A C. Elegans mutant that lives twice as long as wild type
    • CrossRef Medline
    • Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366:461-464.CrossRef Medline
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 36
    • 0030813398 scopus 로고    scopus 로고
    • Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • CrossRef Medline
    • Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G (1997) daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277:942-946. CrossRef Medline
    • (1997) Science , vol.277 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 37
    • 0032573178 scopus 로고    scopus 로고
    • The genetics of caloric restriction in Caenorhabditis elegans
    • CrossRef Medline
    • Lakowski B, Hekimi S (1998) The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95:13091-13096. CrossRef Medline
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13091-13096
    • Lakowski, B.1    Hekimi, S.2
  • 38
    • 33846596646 scopus 로고    scopus 로고
    • RLE-1, an E3 ubiquitin ligase, regulates C. Elegans aging by catalyzing DAF-16 polyubiquitination
    • CrossRef Medline
    • Li W, Gao B, Lee SM, Bennett K, Fang D (2007) RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. Dev Cell 12:235-246. CrossRef Medline
    • (2007) Dev Cell , vol.12 , pp. 235-246
    • Li, W.1    Gao, B.2    Lee, S.M.3    Bennett, K.4    Fang, D.5
  • 39
  • 40
    • 79151485570 scopus 로고    scopus 로고
    • Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses
    • CrossRef Medline
    • MacAskill AF, Atkin TA, Kittler JT (2010) Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses. Eur J Neurosci 32:231-240. CrossRef Medline
    • (2010) Eur J Neurosci , vol.32 , pp. 231-240
    • Macaskill, A.F.1    Atkin, T.A.2    Kittler, J.T.3
  • 41
    • 0042631524 scopus 로고    scopus 로고
    • Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
    • CrossRef Medline
    • McElwee J, Bubb K, Thomas JH (2003) Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2:111-121.CrossRef Medline
    • (2003) Aging Cell , vol.2 , pp. 111-121
    • McElwee, J.1    Bubb, K.2    Thomas, J.H.3
  • 43
    • 79952786042 scopus 로고    scopus 로고
    • Imaging in vivo neuronal transport in genetic model organisms using microfluidic devices
    • CrossRef Medline
    • Mondal S, Ahlawat S, Rau K, Venkataraman V, Koushika SP (2011) Imaging in vivo neuronal transport in genetic model organisms using microfluidic devices. Traffic 12:372-385. CrossRef Medline
    • (2011) Traffic , vol.12 , pp. 372-385
    • Mondal, S.1    Ahlawat, S.2    Rau, K.3    Venkataraman, V.4    Koushika, S.P.5
  • 46
    • 84866183226 scopus 로고    scopus 로고
    • Ageing as a risk factor for disease
    • CrossRef Medline
    • Niccoli T, Partridge L (2012) Ageing as a risk factor for disease. Curr Biol 22:R741-R752. CrossRef Medline
    • (2012) Curr Biol , vol.22
    • Niccoli, T.1    Partridge, L.2
  • 47
    • 79959339376 scopus 로고    scopus 로고
    • Genetic analysis of agedependent defects of the Caenorhabditis elegans touch receptor neurons
    • CrossRef Medline
    • Pan CL, Peng CY, Chen CH, McIntire S (2011) Genetic analysis of agedependent defects of the Caenorhabditis elegans touch receptor neurons. Proc Natl Acad Sci U S A 108:9274-9279. CrossRef Medline
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 9274-9279
    • Pan, C.L.1    Peng, C.Y.2    Chen, C.H.3    McIntire, S.4
  • 48
    • 84881393265 scopus 로고    scopus 로고
    • Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion
    • CrossRef Medline
    • Rolland SG, Motori E, Memar N, Hench J, Frank S, Winklhofer KF, Conradt B (2013) Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion. Proc Natl Acad Sci U S A 110:E2967-E2976. CrossRef Medline
    • (2013) Proc Natl Acad Sci U S A , vol.110
    • Rolland, S.G.1    Motori, E.2    Memar, N.3    Hench, J.4    Frank, S.5    Winklhofer, K.F.6    Conradt, B.7
  • 49
    • 84906275924 scopus 로고    scopus 로고
    • Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neurons
    • Medline
    • Scerbak C, Vayndorf EM, Parker JA, Neri C, Driscoll M, Taylor BE (2014) Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neurons. Front Genet 5:212. Medline
    • (2014) Front Genet , vol.5 , pp. 212
    • Scerbak, C.1    Vayndorf, E.M.2    Parker, J.A.3    Neri, C.4    Driscoll, M.5    Taylor, B.E.6
  • 50
    • 79959305691 scopus 로고    scopus 로고
    • Mitochondria: The next (neurode)generation
    • CrossRef Medline
    • Schon EA, Przedborski S (2011) Mitochondria: the next (neurode)generation. Neuron 70:1033-1053. CrossRef Medline
    • (2011) Neuron , vol.70 , pp. 1033-1053
    • Schon, E.A.1    Przedborski, S.2
  • 51
    • 84897567836 scopus 로고    scopus 로고
    • Mitochondrial trafficking and anchoring in neurons: New insight and implications
    • ShengZH, CrossRef Medline
    • ShengZH (2014) Mitochondrial trafficking and anchoring in neurons: New insight and implications. J Cell Biol 204:1087-1098. CrossRef Medline
    • (2014) J Cell Biol , vol.204 , pp. 1087-1098
  • 52
    • 84856056846 scopus 로고    scopus 로고
    • Mitochondrial transport in neurons: Impact on synaptic homeostasis and neurodegeneration
    • CrossRef Medline
    • Sheng ZH, Cai Q (2012) Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat Rev Neurosci 13: 77-93. CrossRef Medline
    • (2012) Nat Rev Neurosci , vol.13 , pp. 77-93
    • Sheng, Z.H.1    Cai, Q.2
  • 53
    • 84871813112 scopus 로고    scopus 로고
    • Staying cool in difficult times: Mitochondrial dynamics, quality control and the stress response
    • CrossRef Medline
    • Shutt TE, McBride HM (2013) Staying cool in difficult times: mitochondrial dynamics, quality control and the stress response. Biochim Biophys Acta 1833:417-424. CrossRef Medline
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 417-424
    • Shutt, T.E.1    McBride, H.M.2
  • 54
    • 79959654038 scopus 로고    scopus 로고
    • Spontaneous age-related neurite branching in Caenorhabditis elegans
    • CrossRef Medline
    • Tank EM, Rodgers KE, Kenyon C (2011) Spontaneous age-related neurite branching in Caenorhabditis elegans. J Neurosci 31:9279-9288. CrossRef Medline
    • (2011) J Neurosci , vol.31 , pp. 9279-9288
    • Tank, E.M.1    Rodgers, K.E.2    Kenyon, C.3
  • 55
    • 0037470501 scopus 로고    scopus 로고
    • The Endocrine Regulation of Aging by Insulin-Like Signals
    • CrossRef Medline
    • Tatar M, Bartke A, Antebi A (2003) The Endocrine Regulation of Aging by Insulin-Like Signals. Science 299:1346-1351. CrossRef Medline
    • (2003) Science , vol.299 , pp. 1346-1351
    • Tatar, M.1    Bartke, A.2    Antebi, A.3
  • 58
    • 0028803718 scopus 로고
    • The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans
    • Medline
    • Vanfleteren JR, De Vreese A (1995) The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans. FASEB J 9:1355-1361. Medline
    • (1995) FASEB J , vol.9 , pp. 1355-1361
    • Vanfleteren, J.R.1    De Vreese, A.2
  • 59
    • 80053134340 scopus 로고    scopus 로고
    • Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
    • CrossRef Medline
    • Viswanathan M, Guarente L (2011) Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature 477:E1-E2. CrossRef Medline
    • (2011) Nature , vol.477
    • Viswanathan, M.1    Guarente, L.2
  • 60
    • 0034613164 scopus 로고    scopus 로고
    • Regulation of C. Elegans life-span by insulinlike signaling in the nervous system
    • CrossRef Medline
    • Wolkow CA, Kimura KD, Lee MS, Ruvkun G (2000) Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290:147-150. CrossRef Medline
    • (2000) Science , vol.290 , pp. 147-150
    • Wolkow, C.A.1    Kimura, K.D.2    Lee, M.S.3    Ruvkun, G.4
  • 61
    • 0036860964 scopus 로고    scopus 로고
    • Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans Age-1, mev-1 and daf-16 that affect life span
    • CrossRef Medline
    • Yanase S, Yasuda K, Ishii N (2002) Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans age-1, mev-1 and daf-16 that affect life span. Mech Ageing Dev 123:1579-1587. CrossRef Medline
    • (2002) Mech Ageing Dev , vol.123 , pp. 1579-1587
    • Yanase, S.1    Yasuda, K.2    Ishii, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.