Brominated flame retardants (BFRs) in breast milk and associated health risks to nursing infants in Northern Tanzania

Environment International

Volumn 89-90, Issue , 2016, Pages 38-47

  Muller M H B ^a   Polder, A ^a   Brynildsrud, O B ^a   Lie, E ^a,b   Loken K B ^a,b   Manyilizu, W B ^c   Mdegela, R H ^c   Mokiti, F ^d   Murtadha, M ^d   Nonga, H E ^c   Skaare, J U ^e   Lyche, J L ^a  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

^b NORWEGIAN INSTITUTE FOR WATER RESEARCH   (Norway)

^c SOKOINE UNIVERSITY OF AGRICULTURE   (Tanzania)

^d Mount Meru Regional Referral Hospital   (Tanzania)

^e NORWEGIAN VETERINARY INSTITUTE   (Norway)

Author keywords

Brominated flame retardants; Estimated daily intake; Human breast milk; Infant growth; Pemba; Tanzania

Indexed keywords

CLAY; DAIRIES; ETHERS; HEALTH RISKS; LINEAR REGRESSION; NURSING; ORGANIC POLLUTANTS; RISK PERCEPTION;

BROMINATED FLAME RETARDANTS; ESTIMATED DAILY INTAKES; HUMAN BREAST MILKS; PEMBA; TANZANIA;

FLAME RETARDANTS;

(2,3 DIBROMOPROPYL)(2,4,6 TRIBROMOPHENYL)ETHER; 1,2 BIS(2,4,6 TRIBROMOPHENOXY)ETHANE; 2,2',4,4' TETRABROMODIPHENYL ETHER; 2,2',4,4',5,5' HEXABROMODIPHENYL ETHER; 2,3,4,5,6 PENTABROMOTOLUENE; BDE 100; BDE 154; BDE 183; BDE 99; BROMINATED FLAME RETARDANT; FLAME RETARDANT; HEXABROMOBENZENE; HEXABROMOCYCLODODECANE; PENTABROMOETHYLBENZENE; POLYBROMINATED DIPHENYL ETHER; UNCLASSIFIED DRUG; DIPHENYL ETHER DERIVATIVE;

HEALTH RISK; INFANT FEEDING; MILK; ORGANIC COMPOUND; PREGNANCY;

ADULT; ARTICLE; BIOLOGICAL MONITORING; BIRTH LENGTH; BIRTH WEIGHT; BREAST MILK; CHEMICAL ANALYSIS; CLAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; GEOGRAPHIC DISTRIBUTION; HEALTH HAZARD; HUMAN; INFANT; LIMIT OF DETECTION; MALE; MOLECULAR WEIGHT; PARAMETERS CONCERNING THE FETUS, NEWBORN AND PREGNANCY; PREGNANCY; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SOIL ANALYSIS; TANZANIA; YOUNG ADULT; ADVERSE EFFECTS; BREAST FEEDING; CHEMISTRY; MATERNAL EXPOSURE; RISK;

ARUSHA [TANZANIA]; TANZANIA;

BREAST FEEDING; FEMALE; FLAME RETARDANTS; HALOGENATED DIPHENYL ETHERS; HUMANS; INFANT; MATERNAL EXPOSURE; MILK, HUMAN; RISK; TANZANIA;

EID: 84956766760     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2015.12.032     Document Type: Article

References (102)

1. Abdallah M.A., Harrad S. Polybrominated diphenyl ethers in UK human milk: implications for infant exposure and relationship to external exposure. Environ. Int. 2014, 63:130-136.
2. Akutsu K., Takatori S., Nozawa S., Yoshiike M., Nakazawa H., Hayakawa K., Makino T., Iwamoto T. Polybrominated diphenyl ethers in human serum and sperm quality. Bull. Environ. Contam. Toxicol. 2008, 80(4):345-350.
3. Asante K.A., Adu-Kumi S., Nakahiro K., Takahashi S., Isobe T., Sudaryanto A., Devanathan G., Clarke E., Ansa-Asare O.D., Dapaah-Siakwan S., Tanabe S. Human exposure to PCBs, PBDEs and HBCDs in Ghana: Temporal variation, sources of exposure and estimation of daily intakes by infants. Environ. Int. 2011, 37(5):921-928.
4. Ballard O., Morrow A.L. Human milk composition: nutrients and bioactive factors. Pediatr. Clin. N. Am. 2013, 60(1):49-74.
5. Birnbaum L.S., Staskal D.F. Brominated flame retardants: cause for concern?. Environ. Health Perspect. 2003, 112(1):9-17.
6. Brevik E.M. Gas chromatograhic method for the determination of organochlorine pesticides in human milk. Bull. Environ. Contam. Toxicol. 1978, 19(3):281-286.
7. Chao H.R., Wang S.L., Lee W.J., Wang Y.F., Papke O. Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects. Environ. Int. 2007, 33(2):239-245.
8. Chao H.A., Chen S.C., Chang C.M., Koh T.W., Chang-Chien G.P., Ouyang E., Lin S.L., Shy C.G., Chen F.A., Chao H.R. Concentrations of polybrominated diphenyl ethers in breast milk correlated to maternal age, education level, and occupational exposure. J. Hazard. Mater. 2010, 175(1-3):492-500.
9. Chevrier J., Dewailly E., Ayotte P., Mauriege P., Despres J.P., Tremblay A. Body weight loss increases plasma and adipose tissue concentrations of potentially toxic pollutants in obese individuals. Int. J. Obes. Relat. Metab. Disord. 2000, 24(10):1272-1278.
10. Chevrier J., Harley K.G., Bradman A., Gharbi M., Sjodin A., Eskenazi B. Polybrominated diphenyl ether (PBDE) flame retardants and thyroid hormone during pregnancy. Environ. Health Perspect. 2010, 118(10):1444-1449.
11. Daniels J.L., Pan I.J., Jones R., Anderson S., Patterson D.G., Needham L.L., Sjodin A. Individual characteristics associated with PBDE levels in U.S. human milk samples. Environ. Health Perspect. 2010, 118(1):155-160.
12. Darnerud P. Toxic effects of brominated flame retardants in man and in wildlife. Environ. Int. 2003, 29(6):841-853.
13. Darnerud P.O., Eriksen G.S., Johannesson T., Larsen P.B., Viluksela M. Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environ. Health Perspect. 2001, 109(Suppl. 1):49-68.
14. Darnerud P.O., Aune M., Larsson L., Lignell S., Mutshatshi T., Okonkwo J., Botha B., Agyei N. Levels of brominated flame retardants and other pesistent organic pollutants in breast milk samples from Limpopo Province, South Africa. Sci. Total Environ. 2011, 409(19):4048-4053.
15. Darnerud P.O., Lignell S., Aune M., Isaksson M., Cantillana T., Redeby J., Glynn A. Time trends of polybrominated diphenylether (PBDE) congeners in serum of Swedish mothers and comparisons to breast milk data. Environ. Res. 2015, 138:352-360.
16. EFSA Panel on contaminants in the food chain (CONTAM). Scientific opinion on polybrominated diphenyl ethers (PBDEs) in Food. EFSA J. 2011, 9(5):2156.
17. Eskenazi B., Chevrier J., Rauch S.A., Kogut K., Harley K.G., Johnson C., Trujillo C., Sjodin A., Bradman A. In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMACOS study. Environ. Health Perspect. 2013, 121(2):257-262.
18. Foster W.G., Gregorovich S., Morrison K.M., Atkinson S.A., Kubwabo C., Stewart B., Teo K. Human maternal and umbilical cord blood concentrations of polybrominated diphenyl ethers. Chemosphere 2011, 84(10):1301-1309.
19. Frederiksen M., Vorkamp K., Thomsen M., Knudsen L.E. Human internal and external exposure to PBDEs-a review of levels and sources. Int. J. Hyg. Environ. Health 2009, 212(2):109-134.
20. Fromme H., Hilger B., Kopp E., Miserok M., Volkel W. Polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane (HBCD) and "novel" brominated flame retardants in house dust in Germany. Environ. Int. 2014, 64:61-68.
21. Gari M., Grimalt J.O. Inverse age-dependent accumulation of decabromodiphenyl ether and other PBDEs in serum from a general adult population. Environ. Int. 2013, 54:119-127.
22. Gascon M., Fort M., Martinez D., Carsin A.E., Forns J., Grimalt J.O., Santa Marina L., Lertxundi N., Sunyer J., Vrijheid M. Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants. Environ. Health Perspect. 2012, 120(12):1760-1765.
23. Geyer H.J., Schramm K.W., Darnerud P.O., Aune M., Feicht E.A., Fried K.W., et al. Terminal elimination half-lives of the brominated flame retardants TBBPA, HBCD, and lower brominated PBDEs in humans. Organohalogen Compd. 2004, 66:3867-3872.
24. Gomara B., Herrero L., Ramos J.J., Mateo J.R., Fernandez M.A., Garcia J.F., Gonzalez M.J. Distribution of polybrominated diphenyl ethers in human umbilical cord serum, paternal serum, maternal serum, placentas, and breast milk from Madrid population, Spain. Environ. Sci. Technol. 2007, 41(20):6961-6968.
25. Haggarty P. Fatty acid supply to the human fetus. Annu. Rev. Nutr. 2010, 30:237-255.
26. Halldorsson T.I., Rytter D., Haug L.S., Bech B.H., Danielsen I., Becher G., Henriksen T.B., Olsen S.F. Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study. Environ. Health Perspect. 2012, 120(5):668-673.
27. Harley K.G., Chevrier J., Aguilar Schall R., Sjodin A., Bradman A., Eskenazi B. Association of prenatal exposure to polybrominated diphenyl ethers and infant birth weight. Am. J. Epidemiol. 2011, 174(8):885-892.
28. Hassine S.B., Ameur W.B., Gandoura N., Driss M.R. Determination of chlorinated pesticides, polychlorinated biphenyls, and polybrominated diphenyl ethers in human milk from Bizerte (Tunisia) in 2010. Chemosphere 2012, 89(4):369-377.
29. Hellar-Kihampa H., De Wael K., Lugwisha E., Malarvannan G., Covaci A., Van Grieken R. Spatial monitoring of organohalogen compounds in surface water and sediments of a rural-urban river basin in Tanzania. Sci. Total Environ. 2013, 447:186-197.
30. Herbstman J.B., Sjodin A., Kurzon M., Lederman S.A., Jones R.S., Rauh V., Needham L.L., Tang D., Niedzwiecki M., Wang R.Y., Perera F. Prenatal exposure to PBDEs and neurodevelopment. Environ. Health Perspect. 2010, 118(5):712-719.
31. Hertz-Picciotto I., Charles M.J., James R.A., Keller J.A., Willman E., Teplin S. In utero polychlorinated biphenyl exposures in relation to fetal and early childhood growth. Epidemiology 2005, 16(5):648-656.
32. Hites R.A. Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Environ. Sci. Technol. 2004, 38(4):945-956.
33. Hoppe A.A., Carey G.B. Polybrominated diphenyl ethers as endocrine disruptors of adipocyte metabolism. Obesity (Silver Spring) 2007, 15(12):2942-2950.
34. Jakobsson K., Fang J., Athanasiadou M., Rignell-Hydbom A., Bergman A. Polybrominated diphenyl ethers in maternal serum, umbilical cord serum, colostrum and mature breast milk. Insights from a pilot study and the literature. Environ. Int. 2012, 47:121-130.
35. Jin J., Wang Y., Yang C., Hu J., Liu W., Cui J., Tang X. Polybrominated diphenyl ethers in the serum and breast milk of the resident population from production area, China. Environ. Int. 2009, 35(7):1048-1052.
36. Johnson P.I., Stapleton H.M., Mukherjee B., Hauser R., Meeker J.D. Associations between brominated flame retardants in house dust and hormone levels in men. Sci. Total Environ. 2013, 445-446:177-184.
37. Johnson-Restrepo B., Kannan K. An assessment of sources and pathways of human exposure to polybrominated diphenyl ethers in the United States. Chemosphere 2009, 76(4):542-548.
38. Johnson-Restrepo B., Addink R., Wong C., Arcaro K., Kannan K. Polybrominated diphenyl ethers and organochlorine pesticides in human breast milk from Massachusetts, USA. J. Environ. Monit. 2007, 9(11):1205-1212.
39. Jones-Otazo H.A., Clarke J.P., Diamond M.L., Archbold J.A., Ferguson G., Harner T., Richardson G.M., Ryan J.J., Wilford B. Is house dust the missing exposure pathway for PBDEs? An analysis of the urban fate and human exposure to PBDEs. Environ. Sci. Technol. 2005, 39(14):5121-5130.
40. Kamstra J.H., Hruba E., Blumberg B., Janesick A., Mandrup S., Hamers T., Legler J. Transcriptional and epigenetic mechanisms underlying enhanced in vitro adipocyte differentiation by the brominated flame retardant BDE-47. Environ. Sci. Technol. 2014, 48(7):4110-4119.
41. Kaseva M.E., Mbuligwe S.E., Kassenga G. Recycling inorganic domestic solid wastes: results from a pilot study in Dar es Salaam City, Tanzania. Resour. Conserv. Recycl. 2002, 35:243-257.
42. La A.G.M.J., Hale R.C., Harvey E. Detailed polybrominated diphenyl ether (PBDE) congener composition of the widely used penta-, octa-, and deca-PBDE technical flame-retardant mixtures. Environ. Sci. Technol. 2006, 40(20):6247-6254.
43. Landrigan P.J., Kimmel C.A., Correa A., Eskenazi B. Children's health and the environment: public health issues and challenges for risk assessment. Environ. Health Perspect. 2004, 112(2):257-265.
44. Law R.J., Covaci A., Harrad S., Herzke D., Abdallah M.A., Fernie K., Toms L.M., Takigami H. Levels and trends of PBDEs and HBCDs in the global environment: status at the end of 2012. Environ. Int. 2014, 65:147-158.
45. Leung A.O., Chan J.K., Xing G.H., Xu Y., Wu S.C., Wong C.K., Leung C.K., Wong M.H. Body burdens of polybrominated diphenyl ethers in childbearing-aged women at an intensive electronic-waste recycling site in China. Environ. Sci. Pollut. Res. Int. 2010, 17(7):1300-1313.
46. Lignell S., Aune M., Darnerud P.O., Hanberg A., Larsson S.C., Glynn A. Prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) may influence birth weight among infants in a Swedish cohort with background exposure: a cross-sectional study. Environ. Heal. 2013, 12:44.
47. Linares V., Belles M., Domingo J.L. Human exposure to PBDE and critical evaluation of health hazards. Arch. Toxicol. 2015, 89(3):335-356.
48. Lopez-Espinosa M.J., Costa O., Vizcaino E., Murcia M., Fernandez-Somoano A., Iniguez C., Llop S., Grimalt J.O., Ballester F., Tardon A. Prenatal exposure to polybrominated flame retardants and fetal growth in the INMA cohort (Spain). Environ. Sci. Technol. 2015.
49. Lorber M. Exposure of Americans to polybrominated diphenyl ethers. J. Expo. Sci. Environ. Epidemiol. 2008, 18(1):2-19.
50. Lyche J.L., Nourizadeh-Lillabadi R., Almaas C., Stavik B., Berg V., Skare J.U., Alestrom P., Ropstad E. Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish. J. Toxicol. Environ. Health A 2010, 73(15):1032-1057.
51. Lyche J.L., Nourizadeh-Lillabadi R., Karlsson C., Stavik B., Berg V., Skare J.U., Alestrom P., Ropstad E. Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling. Aquat. Toxicol. 2011, 102(3-4):197-204.
52. Lyche J.L., Rosseland C., Berge G., Polder A. Human health risk associated with brominated flame-retardants (BFRs). Environ. Int. 2015, 74:170-180.
53. Magashi A., Schluep M. e-Waste Assessment Tanzania, UNIDO e-waste initiative for Tanzania. FINAL Report 20 January 2011. 2011, Available at: https://www.unido.org/fileadmin/user_media/Services/PSD/ICT/110120_Assessment-Tanzania_FINAL_01.PDF.
54. Main K.M., Kiviranta H., Virtanen H.E., Sundqvist E., Tuomisto J.T., Tuomisto J., Vartiainen T., Skakkebaek N.E., Toppari J. Flame retardants in placenta and breast milk and cryptorchidism in newborn boys. Environ. Health Perspect. 2007, 115(10):1519-1526.
55. Map of Tanzania http://www.ruby-sapphire.com/images/tanzania-ruby-sapphire/tanzania_corundum_simple.jpg.
56. Nash J.T., Szabo D.T., Carey G.B. Polybrominated diphenyl ethers alter hepatic phosphoenolpyruvate carboxykinase enzyme kinetics in male Wistar rats: implications for lipid and glucose metabolism. J. Toxicol. Environ. Health A 2013, 76(2):142-156.
57. Noren K., Meironyte D. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30years. Chemosphere 2000, 40(9-11):1111-1123.
58. Norwegian Environment Agency Report Risk of combination effects between decabromodiphenyl ether and other polybrominated diphenyl ethers. 2014, http://www.miljodirektoratet.no/Documents/publikasjoner/M223/M223.pdf.
59. Park J.S., She J., Holden A., Sharp M., Gephart R., Souders-Mason G., Zhang V., Chow J., Leslie B., Hooper K. High postnatal exposures to polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) via breast milk in California: does BDE-209 transfer to breast milk?. Environ. Sci. Technol. 2011, 45(10):4579-4585.
60. Parolini M., Guazzoni N., Comolli R., Binelli A., Tremolada P. Background levels of polybrominated diphenyl ethers (PBDEs) in soils from Mount Meru area, Arusha district (Tanzania). Sci. Total Environ. 2013, 452-453:253-261.
61. Polder A., Gabrielsen G.W., Odland J.Ø., Savinova T.N., Tkachev A., Løken K.B., Skaare J.U. Spatial and temporal changes of chlorinated pesticides, PCBs, dioxins (PCDDs/PCDFs) and brominated flame retardants in human breast milk from Northern Russia. Sci. Total Environ. 2008, 391(1):41-54.
62. Polder A., Muller M.B., Lyche J.L., Mdegela R.H., Nonga H.E., Mabiki F.P., Mbise T.J., Skaare J.U., Sandvik M., Skjerve E., Lie E. Levels and patterns of persistent organic pollutants (POPs) in tilapia (Oreochromis sp.) from four different lakes in Tanzania: geographical differences and implications for human health. Sci. Total Environ. 2014, 488-489:252-260.
63. Rasmussen T., Stene L.C., Samuelsen S.O., Cinek O., Wetlesen T., Torjesen P.A., Ronningen K.S. Maternal BMI before pregnancy, maternal weight gain during pregnancy, and risk of persistent positivity for multiple diabetes-associated autoantibodies in children with the high-risk HLA genotype: the MIDIA study. Diabetes Care 2009, 32(10):1904-1906.
64. Reeuwijk N.M., Talidda A., Malisch R., Kotz A., Tritscher A., Fiedler H., Zeilmaker M.J., Kooijman M., Wienk K.J., Traag W.A., Hoogenboom R.L. Dioxins (polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-furans) in traditional clay products used during pregnancy. Chemosphere 2013, 90(5):1678-1685.
65. Ryan J.J., Rawn D.F. The brominated flame retardants, PBDEs and HBCD, in Canadian human milk samples collected from 1992 to 2005; concentrations and trends. Environ. Int. 2014, 70:1-8.
66. Rylander L., Dyremark E., Stromberg U., Ostman C., Hagmar L. The impact of age, lactation and dietary habits on PCB in plasma in Swedish women. Sci. Total Environ. 1997, 207(1):55-61.
67. Rylander L., Stromberg U., Hagmar L. Decreased birthweight among infants born to women with a high dietary intake of fish contaminated with persistent organochlorine compounds. Scand J. Work Environ. Health 1995, 21(5):368-375.
68. Schecter A., Pavuk M., Papke O., Ryan J.J., Birnbaum L., Rosen R. Polybrominated diphenyl ethers (PBDEs) in U.S. mothers' milk. Environ. Health Perspect. 2003, 111(14):1723-1729.
69. Schecter A., Colacino J., Sjodin A., Needham L., Birnbaum L. Partitioning of polybrominated diphenyl ethers (PBDEs) in serum and milk from the same mothers. Chemosphere 2010, 78(10):1279-1284.
70. She J., Holden A., Sharp M., Tanner M., Williams-Derry C., Hooper K. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in breast milk from the Pacific Northwest. Chemosphere 2007, 67(9):S307-S317.
71. Sjodin A., Wong L.Y., Jones R.S., Park A., Zhang Y., Hodge C., Dipietro E., McClure C., Turner W., Needham L.L., Patterson D.G. Serum concentrations of polybrominated diphenyl ethers (PBDEs) and polybrominated biphenyl (PBB) in the United States population: 2003-2004. Environ. Sci. Technol. 2008, 42(4):1377-1384.
72. Skaare J.U., Polder A. Polychlorinated biphenyls and organochlorine pesticides in milk of Norwegian women during lactation. Arch. Environ. Contam. Toxicol. 1990, 19(5):640-645.
73. Sonneborn D., Park H.Y., Petrik J., Kocan A., Palkovicova L., Trnovec T., Nguyen D., Hertz-Picciotto I. Prenatal polychlorinated biphenyl exposures in eastern Slovakia modify effects of social factors on birthweight. Paediatr. Perinat. Epidemiol. 2008, 22(3):202-213.
74. Stapleton H.M., Eagle S., Anthopolos R., Wolkin A., Miranda M.L. Associations between polybrominated diphenyl ether (PBDE) flame retardants, phenolic metabolites, and thyroid hormones during pregnancy. Environ. Health Perspect. 2011, 119(10):1454-1459.
75. Stockholm Convention UNEP Global Monitoring Report UNEP/POP/COP.4/33 2009, http://chm.pops.int/TheConvention/ConferenceoftheParties/Meetings/COP4/COP4Documents/tabid/531/Default.aspx.
76. Stockholm Convention http://chm.pops.int.com.
77. Sudaryanto A., Kajiwara N., Takahashi S., Muawanah H., Tanabe S. Geographical distribution and accumulation features of PBDEs in human breast milk from Indonesia. Environ. Pollut. 2008, 151(1):130-138.
78. Sudaryanto A., Kajiwara N., Tsydenova O.V., Isobe T., Yu H., Takahashi S., Tanabe S. Levels and congener specific profiles of PBDEs in human breast milk from China: implication on exposure sources and pathways. Chemosphere 2008, 73(10):1661-1668.
79. Suvorov A., Battista M.C., Takser L. Perinatal exposure to low-dose 2,2',4,4'-tetrabromodiphenyl ether affects growth in rat offspring: what is the role of IGF-1?. Toxicology 2009, 260(1-3):126-131.
80. Tang-Péronard J.L., Heitmann B.L., Andersen H.R., Steuerwald U., Grandjean P., Weihe P., Jensen T.K. Association between prenatal polychlorinated biphenyl exposure and obesity development at ages 5 and 7 y: a prospective cohort study of 656 children from the Faroe Islands. Am. J. Clin. Nutr. 2014, 99(1):5-13.
81. Tang-Péronard J.L., Heitmann B.L., Jensen T.K., Vinggaard A.M., Madsbad S., Steuerwald U., Grandjean P., Weihe P., Nielsen F., Andersen H.R. Prenatal exposure to persistent organochlorine pollutants is associated with high insulin levels in 5-year-old girls. Environ. Res. 2015, 142:407-413.
82. Thomsen C., Stigum H., Froshaug M., Broadwell S.L., Becher G., Eggesbo M. Determinants of brominated flame retardants in breast milk from a large scale Norwegian study. Environ. Int. 2010, 36(1):68-74.
83. Toms L.M., Harden F., Paepke O., Hobson P., Ryan J.J., Mueller J.F. Higher accumulation of polybrominated diphenyl ethers in infants than in adults. Environ. Sci. Technol. 2008, 42(19):7510-7515.
84. Toms L.M., Hearn L., Kennedy K., Harden F., Bartkow M., Temme C., Mueller J.F. Concentrations of polybrominated diphenyl ethers (PBDEs) in matched samples of human milk, dust and indoor air. Environ. Int. 2009, 35(6):864-869.
85. Toms L.M., Sjodin A., Harden F., Hobson P., Jones R., Edenfield E., Mueller J.F. Serum polybrominated diphenyl ether (PBDE) levels are higher in children (2-5years of age) than in infants and adults. Environ. Health Perspect. 2009, 117(9):1461-1465.
86. Trading Economics http://www.tradingeconomics.com/tanzania/imports.
87. Turyk M.E., Persky V.W., Imm P., Knobeloch L., Chatterton R., Anderson H.A. Hormone disruption by PBDEs in adult male sport fish consumers. Environ. Health Perspect. 2008, 116(12):1635-1641.
88. United Nations Report Waste Management in Tanzania. 2010, http://www.un.org/esa/dsd/dsd_aofw_ni/ni_pdfs/NationalReports/tanzania/waste.pdf.
89. US EPAa IRIS (Integrated Risk Information System) 2015, http://www.epa.gov/ncea/iris/index.html.
90. US EPAb IRIS (Integrated Risk Information System) 2015, http://www.epa.gov/iris/subst/1009.htm.
91. Van Oostdam J., Gilman A., Dewailly E., Usher P., Wheatley B., Kuhnlein H., Neve S., Walker J., Tracy B., Feeley M., Jerome V., Kwavnick B. Human health implications of environmental contaminants in Arctic Canada: a review. Sci. Total Environ. 1999, 230(1-3):1-82.
92. Vizcaino E., Grimalt J.O., Glomstad B., Fernandez-Somoano A., Tardon A. Gestational weight gain and exposure of newborns to persistent organic pollutants. Environ. Health Perspect. 2014, 122(8):873-879.
93. Wang S.L., Tsai P.C., Yang C.Y., Guo Y.L. See comment in PubMed Commons below Increased risk of diabetes and polychlorinated biphenyls and dioxins: a 24-year follow-up study of the Yucheng cohort. Diabetes Care. 2008, 31(8):1574-1579.
94. Wania F., Dugani C.B. Assessing the long-range transport potential of polybrominated diphenyl ethers: a comparison of four multimedia models. Environ. Toxicol. Chem. 2003, 22(6):1252-1261.
95. WHO Fourth WHO- coordinated survey of human milk for persistent organic pollutants in cooperation with UNEP 2007, http://www.who.int/foodsafety/chem/POPprotocol.pdf.
96. Worldbank Municipal Solid Waste Management in Dar es Salaam, Draft baseline analysis 2012, http://siteresources.worldbank.org/INTUSWM/Resources/463617-1202332338898/MSWM_Dar-es-Salaam.pdf.
97. Wu K., Xu X., Liu J., Guo Y., Li Y., Huo X. Polybrominated diphenyl ethers in umbilical cord blood and relevant factors in neonates from Guiyu, China. Environ. Sci. Technol. 2010, 44(2):813-819.
98. Yanai J., Yanai J., Noguchi J., Yamada H., Sugihara S., Kilasara M., Kosaki T. Function of geophagy as supplementation of micronutrients in Tanzania. Soil Sci. Plant Nutr. 2009, 55(1):215-223.
99. Zhang Y., Guo G.L., Han X., Zhu C., Kilfoy B.A., Zhu Y., Boyle P., Zheng T. Do polybrominated diphenyl ethers (PBDE) increase the risk of thyroid cancer?. Biosci. Hypotheses 2008, 1(4):195-199.
100. Zhang L., Li J., Zhao Y., Li X., Yang X., Wen S., Cai Z., Wu Y. A national survey of polybrominated diphenyl ethers (PBDEs) and indicator polychlorinated biphenyls (PCBs) in Chinese mothers' milk. Chemosphere 2011, 84(5):625-633.
101. Zhou T., Taylor M.M., DeVito M.J., Crofton K.M. Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicol. Sci. 2002, 66(1):105-116.
102. Zota A.R., Linderholm L., Park J.S., Petreas M., Guo T., Privalsky M.L., Zoeller R.T., Woodruff T.J. Temporal comparison of PBDEs, OH-PBDEs, PCBs, and OH-PCBs in the serum of second trimester pregnant women recruited from San Francisco General Hospital, California. Environ. Sci. Technol. 2013, 47(20):11776-11784.