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Volumn 18, Issue 2, 2016, Pages 145-156

Human keratinocytes have two interconvertible modes of proliferation

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CHROMOBOX PROTEIN CBX4; CHROMOBOX PROTEIN CBX5; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; POLYCOMB GROUP PROTEIN; POLYCOMB GROUP PROTEIN SUZ12; PROTEIN S 100; TRANSCRIPTION FACTOR YY1; UNCLASSIFIED DRUG; EPIDERMAL GROWTH FACTOR; RHO KINASE; ROCK2 PROTEIN, HUMAN;

EID: 84956766463     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3282     Document Type: Article
Times cited : (68)

References (70)
  • 1
    • 0016729431 scopus 로고
    • Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells
    • Rheinwald, J. G. & Green, H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 6, 331-343 (1975).
    • (1975) Cell , vol.6 , pp. 331-343
    • Rheinwald, J.G.1    Green, H.2
  • 2
    • 0020080826 scopus 로고
    • Stratification and terminal differentiation of cultured epidermal cells
    • Watt, F. M. & Green, H. Stratification and terminal differentiation of cultured epidermal cells. Nature 295, 434-436 (1982).
    • (1982) Nature , vol.295 , pp. 434-436
    • Watt, F.M.1    Green, H.2
  • 3
    • 84878760040 scopus 로고    scopus 로고
    • Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications
    • Sato, T. & Clevers, H. Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 340, 1190-1194 (2013).
    • (2013) Science , vol.340 , pp. 1190-1194
    • Sato, T.1    Clevers, H.2
  • 4
    • 84885846800 scopus 로고    scopus 로고
    • Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
    • Huch, M. et al. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J. 32, 2708-2721 (2013).
    • (2013) EMBO J , vol.32 , pp. 2708-2721
    • Huch, M.1
  • 5
    • 84873712443 scopus 로고    scopus 로고
    • In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
    • Huch, M. et al. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature 494, 247-250 (2013).
    • (2013) Nature , vol.494 , pp. 247-250
    • Huch, M.1
  • 6
    • 0027195638 scopus 로고
    • Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression
    • Jones, P. H. & Watt, F. M. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 73, 713-724 (1993).
    • (1993) Cell , vol.73 , pp. 713-724
    • Jones, P.H.1    Watt, F.M.2
  • 7
    • 0011478490 scopus 로고
    • Three clonal types of keratinocyte with different capacities for multiplication
    • Barrandon, Y. & Green, H. Three clonal types of keratinocyte with different capacities for multiplication. Proc. Natl Acad. Sci. USA 84, 2302-2306 (1987).
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 2302-2306
    • Barrandon, Y.1    Green, H.2
  • 8
    • 84890125390 scopus 로고    scopus 로고
    • Human epidermal stem cell function is regulated by circadian oscillations
    • Janich, P. et al. Human epidermal stem cell function is regulated by circadian oscillations. Cell Stem Cell 13, 745-753 (2013).
    • (2013) Cell Stem Cell , vol.13 , pp. 745-753
    • Janich, P.1
  • 9
    • 80052300618 scopus 로고    scopus 로고
    • Regulation of human epidermal stem cell proliferation and senescence requires polycomb-dependent and -independent functions of Cbx4
    • Luis, N. M. et al. Regulation of human epidermal stem cell proliferation and senescence requires polycomb-dependent and -independent functions of Cbx4. Cell Stem Cell 9, 233-246 (2011).
    • (2011) Cell Stem Cell , vol.9 , pp. 233-246
    • Luis, N.M.1
  • 10
    • 84863222901 scopus 로고    scopus 로고
    • Diverse epigenetic strategies interact to control epidermal differentiation
    • Mulder, K. W. et al. Diverse epigenetic strategies interact to control epidermal differentiation. Nat. Cell Biol. 14, 753-763 (2012).
    • (2012) Nat. Cell Biol. , vol.14 , pp. 753-763
    • Mulder, K.W.1
  • 11
    • 77954243855 scopus 로고    scopus 로고
    • Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions
    • Connelly, J. T. et al. Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat. Cell Biol. 12, 711-718 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 711-718
    • Connelly, J.T.1
  • 12
    • 84875059973 scopus 로고    scopus 로고
    • Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells
    • Tan, D. W. et al. Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells. Development 140, 1433-1444 (2013).
    • (2013) Development , vol.140 , pp. 1433-1444
    • Tan, D.W.1
  • 13
    • 0032584093 scopus 로고    scopus 로고
    • Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype
    • Li, A., Simmons, P. J. & Kaur, P. Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. Proc. Natl Acad. Sci. USA 95, 3902-3907 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 3902-3907
    • Li, A.1    Simmons, P.J.2    Kaur, P.3
  • 14
    • 0034192461 scopus 로고    scopus 로고
    • Stimulation of human epidermal differentiation by δ-notch signalling at the boundaries of stem-cell clusters
    • Lowell, S., Jones, P., Le Roux, I., Dunne, J. & Watt, F. M. Stimulation of human epidermal differentiation by δ-notch signalling at the boundaries of stem-cell clusters. Curr. Biol. 10, 491-500 (2000).
    • (2000) Curr. Biol. , vol.10 , pp. 491-500
    • Lowell, S.1    Jones, P.2    Le Roux, I.3    Dunne, J.4    Watt, F.M.5
  • 15
    • 0028267236 scopus 로고
    • Location of stem cells of human hair follicles by clonal analysis
    • Rochat, A., Kobayashi, K. & Barrandon, Y. Location of stem cells of human hair follicles by clonal analysis. Cell 76, 1063-1073 (1994).
    • (1994) Cell , vol.76 , pp. 1063-1073
    • Rochat, A.1    Kobayashi, K.2    Barrandon, Y.3
  • 16
    • 0021232701 scopus 로고
    • Permanent coverage of large burn wounds with autologous cultured human epithelium
    • Gallico, G. G. III, O'Connor, N. E., Compton, C. C., Kehinde, O. & Green, H. Permanent coverage of large burn wounds with autologous cultured human epithelium. New Engl. J. Med. 311, 448-451 (1984).
    • (1984) New Engl. J. Med. , vol.311 , pp. 448-451
    • Gallico, G.G.1    O'Connor, N.E.2    Compton, C.C.3    Kehinde, O.4    Green, H.5
  • 17
    • 0024358264 scopus 로고
    • Skin regenerated from cultured epithelial autografts on full-thickness burn wounds from 6 days to 5 years after grafting. A light, electron microscopic and immunohistochemical study
    • Compton, C. C. et al. Skin regenerated from cultured epithelial autografts on full-thickness burn wounds from 6 days to 5 years after grafting. A light, electron microscopic and immunohistochemical study. Lab Invest. 60, 600-612 (1989).
    • (1989) Lab Invest. , vol.60 , pp. 600-612
    • Compton, C.C.1
  • 18
    • 0028888316 scopus 로고
    • Stem cell patterning and fate in human epidermis
    • Jones, P. H., Harper, S. & Watt, F. M. Stem cell patterning and fate in human epidermis. Cell 80, 83-93 (1995).
    • (1995) Cell , vol.80 , pp. 83-93
    • Jones, P.H.1    Harper, S.2    Watt, F.M.3
  • 19
    • 77951719337 scopus 로고    scopus 로고
    • Exploration of the functional hierarchy of the basal layer of human epidermis at the single-cell level using parallel clonal microcultures of keratinocytes
    • Fortunel, N. O. et al. Exploration of the functional hierarchy of the basal layer of human epidermis at the single-cell level using parallel clonal microcultures of keratinocytes. Exp. Dermatol. 19, 387-392 (2010).
    • (2010) Exp. Dermatol. , vol.19 , pp. 387-392
    • Fortunel, N.O.1
  • 20
    • 33947104197 scopus 로고    scopus 로고
    • A single type of progenitor cell maintains normal epidermis
    • Clayton, E. et al. A single type of progenitor cell maintains normal epidermis. Nature 446, 185-189 (2007).
    • (2007) Nature , vol.446 , pp. 185-189
    • Clayton, E.1
  • 21
    • 76249112830 scopus 로고    scopus 로고
    • The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate
    • Doupe, D. P., Klein, A. M., Simons, B. D. & Jones, P. H. The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate. Dev. Cell 18, 317-323 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 317-323
    • Doupe, D.P.1    Klein, A.M.2    Simons, B.D.3    Jones, P.H.4
  • 22
    • 84866147372 scopus 로고    scopus 로고
    • Distinct contribution of stem and progenitor cells to epidermal maintenance
    • Mascre, G. et al. Distinct contribution of stem and progenitor cells to epidermal maintenance. Nature 489, 257-262 (2012).
    • (2012) Nature , vol.489 , pp. 257-262
    • Mascre, G.1
  • 23
    • 84889242647 scopus 로고    scopus 로고
    • Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling
    • Lim, X. et al. Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science 342, 1226-1230 (2013).
    • (2013) Science , vol.342 , pp. 1226-1230
    • Lim, X.1
  • 24
    • 84901852284 scopus 로고    scopus 로고
    • Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change
    • Alcolea, M. P. et al. Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change. Nat. Cell Biol. 16, 615-622 (2014).
    • (2014) Nat. Cell Biol. , vol.16 , pp. 615-622
    • Alcolea, M.P.1
  • 25
    • 84883303584 scopus 로고    scopus 로고
    • Probing cellular processes by long-term live imaging - Historic problems and current solutions
    • Coutu, D. L. & Schroeder, T. Probing cellular processes by long-term live imaging - historic problems and current solutions. J. Cell Sci. 126, 3805-3815 (2013).
    • (2013) J. Cell Sci. , vol.126 , pp. 3805-3815
    • Coutu, D.L.1    Schroeder, T.2
  • 26
    • 84866241140 scopus 로고    scopus 로고
    • High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)-mediated inhibition of platelet production
    • Thon, J. N., Devine, M. T., Jurak Begonja, A., Tibbitts, J. & Italiano, J. E. Jr High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)-mediated inhibition of platelet production. Blood 120, 1975-1984 (2012).
    • (2012) Blood , vol.120 , pp. 1975-1984
    • Thon, J.N.1    Devine, M.T.2    Jurak Begonja, A.3    Tibbitts, J.4    Italiano, J.E.5
  • 27
    • 0034332563 scopus 로고    scopus 로고
    • Epidermal stem cells as targets for gene transfer
    • Watt, F. M. Epidermal stem cells as targets for gene transfer. Hum. Gene Ther. 11, 2261-2266 (2000).
    • (2000) Hum. Gene Ther. , vol.11 , pp. 2261-2266
    • Watt, F.M.1
  • 28
    • 84865975387 scopus 로고    scopus 로고
    • How variable clones build an invariant retina
    • He, J. et al. How variable clones build an invariant retina. Neuron 75, 786-798 (2012).
    • (2012) Neuron , vol.75 , pp. 786-798
    • He, J.1
  • 29
    • 0025346055 scopus 로고
    • Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila
    • Simpson, P. Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila. Development 109, 509-519 (1990).
    • (1990) Development , vol.109 , pp. 509-519
    • Simpson, P.1
  • 30
    • 17844384528 scopus 로고    scopus 로고
    • Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
    • Rangarajan, A. et al. Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 20, 3427-3436 (2001).
    • (2001) EMBO J , vol.20 , pp. 3427-3436
    • Rangarajan, A.1
  • 31
    • 84865539510 scopus 로고    scopus 로고
    • A single progenitor population switches behavior to maintain and repair esophageal epithelium
    • Doupe, D. P. et al. A single progenitor population switches behavior to maintain and repair esophageal epithelium. Science 337, 1091-1093 (2012).
    • (2012) Science , vol.337 , pp. 1091-1093
    • Doupe, D.P.1
  • 32
    • 84875460038 scopus 로고    scopus 로고
    • Tracking cells in their native habitat: Lineage tracing in epithelial neoplasia
    • Alcolea, M. P. & Jones, P. H. Tracking cells in their native habitat: lineage tracing in epithelial neoplasia. Nat. Rev. Cancer 13, 161-171 (2013).
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 161-171
    • Alcolea, M.P.1    Jones, P.H.2
  • 33
    • 70349123829 scopus 로고    scopus 로고
    • The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells
    • Cicalese, A. et al. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 138, 1083-1095 (2009).
    • (2009) Cell , vol.138 , pp. 1083-1095
    • Cicalese, A.1
  • 34
    • 1942436975 scopus 로고    scopus 로고
    • Upside-down transfer of porcine keratinocytes from a porous, synthetic dressing to experimental full-thickness wounds
    • van den Bogaerdt, A. J. et al. Upside-down transfer of porcine keratinocytes from a porous, synthetic dressing to experimental full-thickness wounds. Wound Repair Regen. 12, 225-234 (2004).
    • (2004) Wound Repair Regen , vol.12 , pp. 225-234
    • Van Den Bogaerdt, A.J.1
  • 35
    • 0034624233 scopus 로고    scopus 로고
    • PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation
    • O'Shaughnessy, R. F., Seery, J. P., Celis, J. E., Frischauf, A. & Watt, F. M. PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation. FEBS Lett. 486, 149-154 (2000).
    • (2000) FEBS Lett. , vol.486 , pp. 149-154
    • O'Shaughnessy, R.F.1    Seery, J.P.2    Celis, J.E.3    Frischauf, A.4    Watt, F.M.5
  • 36
    • 3042688916 scopus 로고    scopus 로고
    • S100 proteins in the epidermis
    • Eckert, R. L. et al. S100 proteins in the epidermis. J. Invest. Dermatol. 123, 23-33 (2003).
    • (2003) J. Invest. Dermatol. , vol.123 , pp. 23-33
    • Eckert, R.L.1
  • 37
    • 84898739668 scopus 로고    scopus 로고
    • Haematopoietic stem cells require a highly regulated protein synthesis rate
    • Signer, R. A., Magee, J. A., Salic, A. & Morrison, S. J. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature 509, 49-54 (2014).
    • (2014) Nature , vol.509 , pp. 49-54
    • Signer, R.A.1    Magee, J.A.2    Salic, A.3    Morrison, S.J.4
  • 38
    • 84862908426 scopus 로고    scopus 로고
    • Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin
    • Liu, J., Xu, Y., Stoleru, D. & Salic, A. Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin. Proc. Natl Acad. Sci. USA 109, 413-418 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 413-418
    • Liu, J.1    Xu, Y.2    Stoleru, D.3    Salic, A.4
  • 39
    • 84887984423 scopus 로고    scopus 로고
    • Lin28 enhances tissue repair by reprogramming cellular metabolism
    • Shyh-Chang, N. et al. Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell 155, 778-792 (2013).
    • (2013) Cell , vol.155 , pp. 778-792
    • Shyh-Chang, N.1
  • 40
    • 84892564905 scopus 로고    scopus 로고
    • Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage
    • Zhang, Q., Shalaby, N. A. & Buszczak, M. Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage. Science 343, 298-301 (2014).
    • (2014) Science , vol.343 , pp. 298-301
    • Zhang, Q.1    Shalaby, N.A.2    Buszczak, M.3
  • 41
    • 84916908897 scopus 로고    scopus 로고
    • Cellular differences in protein synthesis regulate tissue homeostasis
    • Buszczak, M., Signer, R. A. J. & Morrison, S. J. Cellular differences in protein synthesis regulate tissue homeostasis. Cell 159, 242-251 (2014).
    • (2014) Cell , vol.159 , pp. 242-251
    • Buszczak, M.1    Signer, R.A.J.2    Morrison, S.J.3
  • 42
    • 78650261903 scopus 로고    scopus 로고
    • Overexpression of the transcription factor Yin-Yang-1 suppresses differentiation of HaCaT cells in three-dimensional cell culture
    • Taguchi, S. et al. Overexpression of the transcription factor Yin-Yang-1 suppresses differentiation of HaCaT cells in three-dimensional cell culture. J. Invest. Dermatol. 131, 37-45 (2011).
    • (2011) J. Invest. Dermatol. , vol.131 , pp. 37-45
    • Taguchi, S.1
  • 43
    • 68249128477 scopus 로고    scopus 로고
    • Epigenetic reprogramming during wound healing: Loss of polycomb-mediated silencing may enable upregulation of repair genes
    • Shaw, T. & Martin, P. Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. EMBO Rep. 10, 881-886 (2009).
    • (2009) EMBO Rep. , vol.10 , pp. 881-886
    • Shaw, T.1    Martin, P.2
  • 44
    • 84901659560 scopus 로고    scopus 로고
    • YY1 is indispensable for Lgr5+ intestinal stem cell renewal
    • Perekatt, A. O. et al. YY1 is indispensable for Lgr5+ intestinal stem cell renewal. Proc. Natl Acad. Sci. USA 111, 7695-7700 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 7695-7700
    • Perekatt, A.O.1
  • 45
    • 9744286986 scopus 로고    scopus 로고
    • Yin-yang 1 negatively regulates the differentiation-specific transcription of mouse loricrin gene in undifferentiated keratinocytes
    • Xu, X. et al. Yin-yang 1 negatively regulates the differentiation-specific transcription of mouse loricrin gene in undifferentiated keratinocytes. J. Invest. Dermatol. 123, 1120-1126 (2004).
    • (2004) J. Invest. Dermatol. , vol.123 , pp. 1120-1126
    • Xu, X.1
  • 46
    • 58949102947 scopus 로고    scopus 로고
    • Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells
    • Somervaille, T. C. et al. Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell 4, 129-140 (2009).
    • (2009) Cell Stem Cell , vol.4 , pp. 129-140
    • Somervaille, T.C.1
  • 47
    • 79958152841 scopus 로고    scopus 로고
    • Histone H4K20me3 and HP1α are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells
    • Wongtawan, T., Taylor, J. E., Lawson, K. A., Wilmut, I. & Pennings, S. Histone H4K20me3 and HP1α are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. J. Cell Sci. 124, 1878-1890 (2011).
    • (2011) J. Cell Sci. , vol.124 , pp. 1878-1890
    • Wongtawan, T.1    Taylor, J.E.2    Lawson, K.A.3    Wilmut, I.4    Pennings, S.5
  • 48
    • 0023624729 scopus 로고
    • Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor
    • Barrandon, Y. & Green, H. Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-α and epidermal growth factor. Cell 50, 1131-1137 (1987).
    • (1987) Cell , vol.50 , pp. 1131-1137
    • Barrandon, Y.1    Green, H.2
  • 49
    • 0017349282 scopus 로고
    • Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes
    • Rheinwald, J. G. & Green, H. Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes. Nature 265, 421-424 (1977).
    • (1977) Nature , vol.265 , pp. 421-424
    • Rheinwald, J.G.1    Green, H.2
  • 50
    • 84907692927 scopus 로고    scopus 로고
    • Forms, forces, and stem cell fate
    • Bellas, E. & Chen, C. S. Forms, forces, and stem cell fate. Curr. Opin. Cell Biol. 31, 92-97 (2014).
    • (2014) Curr. Opin. Cell Biol. , vol.31 , pp. 92-97
    • Bellas, E.1    Chen, C.S.2
  • 51
    • 73049116186 scopus 로고    scopus 로고
    • Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
    • Barker, N. et al. Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 6, 25-36 (2010).
    • (2010) Cell Stem Cell , vol.6 , pp. 25-36
    • Barker, N.1
  • 52
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262-265 (2009).
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1
  • 53
    • 84901436415 scopus 로고    scopus 로고
    • The effect of Rho kinase inhibition on long-term keratinocyte proliferation is rapid and conditional
    • Chapman, S., McDermott, D. H., Shen, K., Jang, M. K. & McBride, A. A. The effect of Rho kinase inhibition on long-term keratinocyte proliferation is rapid and conditional. Stem Cell Res. Ther. 5, 60 (2014).
    • (2014) Stem Cell Res. Ther. , vol.5 , pp. 60
    • Chapman, S.1    McDermott, D.H.2    Shen, K.3    Jang, M.K.4    McBride, A.A.5
  • 54
    • 77954975403 scopus 로고    scopus 로고
    • Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor
    • Chapman, S., Liu, X., Meyers, C., Schlegel, R. & McBride, A. A. Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor. J. Clin. Invest. 120, 2619-2626 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 2619-2626
    • Chapman, S.1    Liu, X.2    Meyers, C.3    Schlegel, R.4    McBride, A.A.5
  • 55
    • 84928938527 scopus 로고    scopus 로고
    • Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity
    • Luxenburg, C. et al. Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity. Nat. Cell Biol. 17, 592-604 (2015).
    • (2015) Nat. Cell Biol. , vol.17 , pp. 592-604
    • Luxenburg, C.1
  • 56
    • 84898469892 scopus 로고    scopus 로고
    • Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells
    • Lee, B. et al. Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev. Cell 29, 47-58 (2014).
    • (2014) Dev. Cell , vol.29 , pp. 47-58
    • Lee, B.1
  • 57
    • 84869112150 scopus 로고    scopus 로고
    • miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration
    • Amelio, I. et al. miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration. J. Cell Biol. 199, 347-363 (2012).
    • (2012) J. Cell Biol. , vol.199 , pp. 347-363
    • Amelio, I.1
  • 58
    • 84979971105 scopus 로고    scopus 로고
    • Cell motion predicts human epidermal stemness
    • Nanba, D. et al. Cell motion predicts human epidermal stemness. J. Cell Biol. 209, 305-315 (2015).
    • (2015) J. Cell Biol. , vol.209 , pp. 305-315
    • Nanba, D.1
  • 59
    • 84929464060 scopus 로고    scopus 로고
    • E-cadherin junctions as active mechanical integrators in tissue dynamics
    • Lecuit, T. & Yap, A. S. E-cadherin junctions as active mechanical integrators in tissue dynamics. Nat. Cell Biol. 17, 533-539 (2015).
    • (2015) Nat. Cell Biol. , vol.17 , pp. 533-539
    • Lecuit, T.1    Yap, A.S.2
  • 60
    • 0033535838 scopus 로고    scopus 로고
    • Signaling via β1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro
    • Zhu, A. J., Haase, I. & Watt, F. M. Signaling via β1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro. Proc. Natl Acad. Sci. USA 96, 6728-6733 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 6728-6733
    • Zhu, A.J.1    Haase, I.2    Watt, F.M.3
  • 61
    • 84875800732 scopus 로고    scopus 로고
    • Actin filament dynamics impacts keratinocyte stem cell maintenance
    • Nanba, D. et al. Actin filament dynamics impacts keratinocyte stem cell maintenance. EMBO Mol. Med. 5, 640-653 (2013).
    • (2013) EMBO Mol. Med. , vol.5 , pp. 640-653
    • Nanba, D.1
  • 62
    • 9144244819 scopus 로고    scopus 로고
    • Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway
    • McMullan, R. et al. Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway. Curr. Biol. 13, 2185-2189 (2003).
    • (2003) Curr. Biol. , vol.13 , pp. 2185-2189
    • McMullan, R.1
  • 63
    • 84866054806 scopus 로고    scopus 로고
    • mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis
    • Iglesias-Bartolome, R. et al. mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell 11, 401-414 (2012).
    • (2012) Cell Stem Cell , vol.11 , pp. 401-414
    • Iglesias-Bartolome, R.1
  • 64
    • 84929657263 scopus 로고    scopus 로고
    • Switching roles: The functional plasticity of adult tissue stem cells
    • Wabik, A. & Jones, P. H. Switching roles: the functional plasticity of adult tissue stem cells. EMBO J. 34, 1164-1179 (2015).
    • (2015) EMBO J , vol.34 , pp. 1164-1179
    • Wabik, A.1    Jones, P.H.2
  • 65
    • 84906861192 scopus 로고    scopus 로고
    • Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina
    • Centanin, L. et al. Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina. Development 141, 3472-3482 (2014).
    • (2014) Development , vol.141 , pp. 3472-3482
    • Centanin, L.1
  • 66
    • 84886950363 scopus 로고    scopus 로고
    • Spatial organization within a niche as a determinant of stem-cell fate
    • Rompolas, P., Mesa, K. R. & Greco, V. Spatial organization within a niche as a determinant of stem-cell fate. Nature 502, 513-518 (2013).
    • (2013) Nature , vol.502 , pp. 513-518
    • Rompolas, P.1    Mesa, K.R.2    Greco, V.3
  • 67
    • 84874730918 scopus 로고    scopus 로고
    • Intestinal label-retaining cells are secretory precursors expressing Lgr5
    • Buczacki, S. J. et al. Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature 495, 65-69 (2013).
    • (2013) Nature , vol.495 , pp. 65-69
    • Buczacki, S.J.1
  • 68
    • 84925959802 scopus 로고    scopus 로고
    • Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines
    • Aspinall-O'Dea, M. et al. Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines. Nat. Protoc. 10, 149-168 (2015).
    • (2015) Nat. Protoc , vol.10 , pp. 149-168
    • Aspinall-O'Dea, M.1
  • 69
    • 77955489664 scopus 로고    scopus 로고
    • Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis
    • Jensen, K. B., Driskell, R. R. & Watt, F. M. Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis. Nat. Protoc. 5, 898-911 (2010).
    • (2010) Nat. Protoc , vol.5 , pp. 898-911
    • Jensen, K.B.1    Driskell, R.R.2    Watt, F.M.3
  • 70
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1


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