Whole Genome Gene Expression Analysis Reveals Casiopeína-Induced Apoptosis Pathways

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Valencia Cruz, Alejandra Idan ^a   Uribe Figueroa, Laura I ^a   Galindo Murillo, Rodrigo ^b,c   Baca López, Karol ^a,d   Gutiérrez, Anllely G ^b   Vázquez Aguirre, Adriana ^b   Ruiz Azuara, Lena ^b   Hernández Lemus, Enrique ^a,b   Mejía, Carmen ^b  

^a INSTITUTO NACIONAL DE MEDICINA GENÓMICA   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MÉXICO   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASIOPEINA II GLYCINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; CANCER CELL; CONTROLLED STUDY; DRUG STRUCTURE; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENOME; HUMAN; HUMAN CELL; MATHEMATICAL ANALYSIS; MITOCHONDRION; NEUROBLASTOMA CELL; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; UTERINE CERVIX CANCER; VALIDATION STUDY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CLUSTER ANALYSIS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; GLUTATHIONE; HELA CELLS; HUMANS; MITOCHONDRIA; MOLECULAR SEQUENCE ANNOTATION; ORGANOMETALLIC COMPOUNDS; REACTIVE OXYGEN SPECIES; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION;

EID: 84873196536     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054664     Document Type: Article

References (53)

1. Lowe SW, Lin AW, (2000) Apoptosis in cancer. Carcinogenesis 21(3): 485-95.
2. Shailaja K, Ben T, (2003) Why Target Apoptosis in Cancer Treatment? Mol Cancer Ther 2: 573.
3. Hanahan D, Weinberg RA, (2011) Hallmarks of Cancer: The Next Generation, Cell. 144(5): 646-674.
4. Kim JW, Song SH, Jin CH, Lee JK, Lee NW, et al. (2012) Factors affecting the clearance of high-risk human papillomavirus infection and the progression of cervical intraepithelial neoplasia. J Int Med Res 40(2): 486-96.
5. Lim YB, Park TJ, Lim IK, (2008) B cell translocation gene 2 enhances susceptibility of HeLa cells to doxorubicin-induced oxidative damage. J Biol Chem 283(48): 33110-8.
6. Trejo-Solís C, Palencia G, Zúñiga S, Rodrguez-Ropon A, Osorio-Rico L, et al. (2005) Cas IIgly induces apoptosis in glioma C6 cells in vitro and in vivo through caspase-dependent and caspase-independent mechanisms. Neoplasia 7(6): 563-74.
7. Leal-García M, García-Ortuño L, Ruiz-Azuara L, Gracia-Mora I, Luna-Delvillar J, et al. (2007) Assessment of acute respiratory and cardiovascular toxicity of casiopeinas in anaesthetized dogs Basic Clin Pharmacol Toxicol. 101(3): 151-8.
8. Carvallo-Chaigneau F, Trejo-Solís C, Gómez-Ruiz C, Rodríguez-Aguilera E, Macías-Rosales L, et al. (2008) Casiopeina III-ia induces apoptosis in HCT-15 cells in vitro through caspase-dependent mechanisms and has antitumor effect in vivo. Biometals 21(1): 17-28.
9. Mejia C, Ruiz-Azuara L, (2008) Casiopeinas IIgly and IIIia induce apoptosis in medulloblastoma cells. Pathol Oncol Res 14(4): 467-72.
10. Chikira M, Tomizawa Y, Fukita D, Sugizaki T, Sugawara N, (2002) DNA-fiber EPR study of the orientation of Cu(II) complexes of 1,10-phenanthroline and its derivatives bound to DNA: mono(phenanthroline)-Copper(II) and its ternary complexes with amino acids. J Inorg Biochem 89(3-4): 163-73.
11. Hernández-Esquivel L, Marín-Hernández A, Pavón N, Carvajal K, Moreno-Sánchez R, (2006) Cardiotoxicity of Copper-based antineoplastic drugs casiopeinas is related to inhibition of energy metabolism. Toxicol Appl Pharmacol 212(1): 79-88.
12. Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S, Encalada R, Moreno-Sánchez R, et al. (2011) Modeling cancer glycolysis, Biochim Biophys Acta 1807. 6: 755-67.
13. Marín-Hernández A, Gallardo-Pérez JC, López-Ramírez SY, García-García JD, Rodríguez-Zavala JS, et al. (2012) Casiopeina II-gly and bromo-pyruvate inhibition of tumor hexokinase, glycolysis, and oxidative phosphorylation. Arch Toxicol 86(5): 753-66.
14. Alemón-Medina R, Breña-Valle M, Muñoz-Sánchez JL, Gracia-Mora MI, Ruiz-Azuara L, (2007) Induction of oxidative damage by Copper-based antineoplastic drugs (Casiopeínas). Cancer Chemother Pharmacol 60(2): 219-28.
15. Alemón-Medina R, Muñoz-Sánchez JL, Ruiz-Azuara L, Gracia-Mora I, (2008) Casiopena IIgly induced cytotoxicity to HeLa cells depletes the levels of reduced glutathione and is prevented by dimethyl sulfoxide. Toxicol In Vitro 22(3): 710-5.
16. De Vizcaya-Ruiz A, Rivero-Muller A, Ruiz-Ramirez L, Kass GE, Kelland LR, et al. (2000) Induction of apoptosis by a novel Copper-based anticancer compound, casiopeina II, in L1210 murine leukaemia and CH1 human ovarian carcinoma cells. Toxicol In Vitro 14(1): 1-5.
17. Rivero-Müller A, De Vizcaya-Ruiz A, Plant N, Ruiz L, Dobrota M, (2007) Mixed chelate Copper complex, Casiopeina IIgly, binds and degrades nucleic acids: a mechanism of cytotoxicity. Chem Biol Interact 165(3): 189-99.
18. Gutiérrez AG, Vázquez-Aguirre A, Ruiz-Azuara L, Hernández-Lemus E, Mejía MC (2013) Mitochondrial apoptosis by reactive species in neuroblastoma is an effect of Casiopeínas. In press.
19. Bravo-Gómez ME, García-Ramos JC, Gracia-Mora I, Ruiz-Azuara L, (2009) Antiproliferative activity and QSAR study of Copper(II) mixed chelate Cu(N-N)(acetylacetonato)]NO3 and Cu(N-N)(glycinato)]NO3 complexes, (Casiopeínas). J Inorg Biochem 103(2): 299-309.
20. Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, et al. (1990) New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 82Z(13): 1107-12.
21. Expression Analysis Technical Manual, with Specific Protocols for Use with the Hybridization, Wash, and Stain Kit, Affymetrix technical note. Available: http://www.affymetrix.com/support/downloads/manuals/expression_analysis_technical_manual.pdf. Accessed 2013 Jan 8.
22. Baca-López K, Hernández-Lemus E, Mayorga M, (2009) Information-theoretical analysis of gene expression to infer transcriptional interactions, Revista Mexicana de Fsica. 55(6): 456-466.
23. Bolstad BM, Irizarry RA, Astrand M, Speed TP, (2003) A Comparison of Normalization Methods for High Density Oligonucleotide Array Data Based on Bias and Variance. Bioinformatics 19(2): 185-193.
24. Smyth G, (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments, Statistical Applications in Genetics and Molecular Biology. 3: 3.
25. The Gene Ontology Consortium (2000), Gene Ontology: tool for the unification of biology., Nature Genet. 25: 25-29; see also the webpage http://www.geneontology.org.
26. Benjamini Y, Hochberg Y, (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society Series B (Methodological) 57(1): 289-300.
27. Croft D, O'Kelly G, Wu G, Haw R, Gillespie M, et al. (2011) Reactome: a database of reactions, pathways and biological processes. Nucleic Acids Res 39(Database issue), D691-7. (See also the webpage http://www.reactome.org.).
28. Ingenuity systems webpage. Available: http://www.ingenuity.com/products/pathways_analysis.html. Accessed 2013 Jan 8.
29. Subramanian A, Tamayo P, Mootha KV, Mukherjee S, Ebert BL, et al. (2005) Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. PNAS 102(43): 15545-15550.
30. Broad Institute Gene Set Enrichment Analysis web page. Available: http://www.broadinstitute.org/gsea/downloads.jsp. Accessed 2013 Jan 8.
31. Edgar R, Domrachev M, Lash AE, (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30(1): 207-10 (See also the webpage http://www.ncbi.nlm.nih.gov/geo/.).
32. NCBI Gene Expression Omnibus webpage. Available: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE41827. Accessed 2013 Jan 8.
33. D'haeseleer P, (2005) How does gene expression clustering work? Nature Biotechnology 23: 12.
34. Ohana E, Segal D, Palty R, Ton-That D, Moran A, et al. (2004) A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells. J Biol Chem. 279(6): 4278-84.
35. Toyoshima M, Howie HL, Imakura M, Walsh RM, Annis JE, et al. (2012) Functional genomics identifies therapeutic targets for MYC-driven cancer. Proc Natl Acad Sci U S A 109(24): 9545-50.
36. Deighton RF, Kerr LE, Short DM, Allerhand M, Whittle IR, et al. (2010) Network generation enhances interpretation of proteomic data from induced apoptosis. Proteomics 10(6): 1307-15.
37. Valmiki MG, Ramos JW, (2009) Death effector domain-containing proteins. Cell Mol Life Sci 66(5): 814-30.
38. Moshe Y, Bar-On O, Ganoth D, Hershko A, (2011) Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases. J Biol Chem 286(19): 16647-57.
39. Diers AR, Higdon AN, Ricart KC, Johnson MS, Agarwal A, et al. (2010) Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. Biochem J 426(1): 31-41.
40. Segal E, Friedman N, Koller D, Regev A, (2004) A module map showing conditional activity of expression modules in cancer. Nat Genet 36(10): 1090-1098.
41. Kachadourian R, Brechbuhl HM, Ruiz-Azuara L, Gracia-Mora I, Day BJ, (2010) Casiopena IIgly-induced oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cells. Toxicology 268(3): 176-83.
42. Shtyrlin VG, Zyavkina YI, Gilyazetdinov EM, Bukharov MS, Krutikov AA, et al. (2012) Complex formation, chemical exchange, species structure, and stereoselective effects in the Copper(II)-L/DL-histidine systems. Dalton Trans 41(4): 1216-28.
43. Speisky H, Gmez M, Carrasco-Pozo C, Pastene E, Lopez-Alarcn C, et al. (2008) Cu(I)-glutathione complex: a potential source of superoxide radicals generation. Bioorg Med Chem 16(13): 6568-74.
44. Jouini M, Lapluye G, Huet J, Julien R, Ferradini C, (1986) Catalytic activity of a Copper(II)-oxidized glutathione complex on aqueous superoxide ion dismutation. J Inorg Biochem 26(4): 269-80.
45. Garcia-Ramos JC, Toledano-Magaña Y, Talavera-Contreras LG, Flores-Alamo M, Ramirez-Delgado V, et al. (2012) Potential cytotoxic and amoebicide activity of first row transition metal compounds with 2,9-bis-(2',5'-diazahexanyl)-1,1-phenanthroline (L1). Dalton Trans. doi:10.1039/C2DT30224A.
46. Rodriguez-Enriquez S, Gallardo-Perez JC, Aviles-Salas A, Marin-Hernandez A, Carreño-Fuentes L, et al. (2008) Energy metabolism transition in multi-cellular human tumor spheroids. J Cell Physiol 216(1): 189-97.
47. France-Lanord V, Brugg B, Michel PP, Agid Y, Ruberg M, (1997) Mitochondrial free radical signal in ceramide-dependent apoptosis: a putative mechanism for neuronal death in Parkinson's disease. J Neurochem 69(4): 1612-21.
48. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, et al. (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262(5137): 1274-7.
49. Greenlund LJ, Korsmeyer SJ, Johnson EM Jr, (1995) Role of BCL-2 in the survival and function of developing and mature sympathetic neurons. Neuron 15(3): 649-61.
50. Majima HJ, Oberley TD, Furukawa K, Mattson MP, Yen HC, et al. (1998) Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkaline-induced cell death. J Biol Chem 273(14): 8217-24.
51. Kiningham KK, Oberley TD, Lin S, Mattingly CA, St Clair DK, (1999) Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death. FASEB J 13(12): 1601-10.
52. Hernández-Lemus E, Mejía C (2012) Inference and analysis of apoptotic pathways in Papillary Thyroid Cancer. In: Thyroid Cancer: Diagnosis, Treatment and Prognosis. Hauppauge, NY: Nova Science Publishing.
53. Lazebnik Y, (2002) Can a biologist fix a radio?Or, what I learned while studying apoptosis. Cancer Cell 2(3): 179-82.