메뉴 건너뛰기




Volumn 20, Issue 1, 2016, Pages 65-74

KRAS Exon 2 Mutations as Prognostic Indicators in Advanced Colorectal Cancer in Clinical Practice: A Mono-Institutional Study

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; IRINOTECAN; K RAS PROTEIN; OXALIPLATIN; CODON; KRAS PROTEIN, HUMAN; PROTEIN P21;

EID: 84956668594     PISSN: 11771062     EISSN: 11792000     Source Type: Journal    
DOI: 10.1007/s40291-015-0178-8     Document Type: Article
Times cited : (6)

References (28)
  • 1
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: a review
    • Bos JL. Ras oncogenes in human cancer: a review. Cancer Res. 1989;1989(49):4682–9.
    • (1989) Cancer Res , vol.1989 , Issue.49 , pp. 4682-4689
    • Bos, J.L.1
  • 2
    • 33947594129 scopus 로고    scopus 로고
    • Hyperactive ras in developmental disorders and cancer
    • Schubbert S, Shannon K, Bollag G. Hyperactive ras in developmental disorders and cancer. Nat Rev Cancer. 2007;2007(7):295–308.
    • (2007) Nat Rev Cancer , vol.2007 , Issue.7 , pp. 295-308
    • Schubbert, S.1    Shannon, K.2    Bollag, G.3
  • 4
    • 0032490124 scopus 로고    scopus 로고
    • Kirsten Ras mutations in patients with colorectal cancer: the multicenter ‘RASCAL’ study
    • PID: 9586664, COI: 1:CAS:528:DyaK1cXjtlSiu7s%3D
    • Andreyev HJN, Norman AR, Cunningham D, Oates JR, Clarke PA. Kirsten Ras mutations in patients with colorectal cancer: the multicenter ‘RASCAL’ study. J Natl Cancer Inst. 1998;90(9):675–84.
    • (1998) J Natl Cancer Inst. , vol.90 , Issue.9 , pp. 675-684
    • Andreyev, H.J.N.1    Norman, A.R.2    Cunningham, D.3    Oates, J.R.4    Clarke, P.A.5
  • 5
    • 79957523828 scopus 로고    scopus 로고
    • KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer
    • Roock WD, Vriendt VD, Normanno N, Ciardiello F, Tejpar S. KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol. 2011;2011(12):594–603.
    • (2011) Lancet Oncol , vol.2011 , Issue.12 , pp. 594-603
    • Roock, W.D.1    Vriendt, V.D.2    Normanno, N.3    Ciardiello, F.4    Tejpar, S.5
  • 6
    • 84883680951 scopus 로고    scopus 로고
    • Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
    • PID: 24024839, COI: 1:CAS:528:DC%2BC3sXhsFGktr3L
    • Douillard JY, Oliner KS, Siena S, Tabernero J. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med. 2013;369(11):1023–34. doi:10.1056/NEJMoa1305275.
    • (2013) N Engl J Med. , vol.369 , Issue.11 , pp. 1023-1034
    • Douillard, J.Y.1    Oliner, K.S.2    Siena, S.3    Tabernero, J.4
  • 8
    • 84875742535 scopus 로고    scopus 로고
    • Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer, assessment as prognostic and predictive biomarkers of response to Panitumumab
    • Peeters M, Douillard JY, Van Cutsem E, Siena S. Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer, assessment as prognostic and predictive biomarkers of response to Panitumumab. J Clin Oncol. 2012;2012(31):759–65.
    • (2012) J Clin Oncol , vol.2012 , Issue.31 , pp. 759-765
    • Peeters, M.1    Douillard, J.Y.2    Van Cutsem, E.3    Siena, S.4
  • 9
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E, Kohne CH, Lang I, Folprecht G. Cetuximab plus irinotecan, fluorouracil and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol. 2011;2011(29):2011–9.
    • (2011) J Clin Oncol , vol.2011 , Issue.29 , pp. 2011-2019
    • Van Cutsem, E.1    Kohne, C.H.2    Lang, I.3    Folprecht, G.4
  • 11
    • 0033052966 scopus 로고    scopus 로고
    • Structural differences between valin-12 and aspartate-12 Ras proteins may modify carcinoma aggression
    • Al-Mulla F, Milner-White EJ, Going JJ, Birnie GD. Structural differences between valin-12 and aspartate-12 Ras proteins may modify carcinoma aggression. J Pathol. 1999;1999(187):433–8.
    • (1999) J Pathol , vol.1999 , Issue.187 , pp. 433-438
    • Al-Mulla, F.1    Milner-White, E.J.2    Going, J.J.3    Birnie, G.D.4
  • 12
    • 0034548712 scopus 로고    scopus 로고
    • K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression
    • Guerrero S, Casanova I, Farrè L, Mazo A, Capellà G, Mangues R. K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression. Cancer Res. 2000;2000(60):6750–6.
    • (2000) Cancer Res , vol.2000 , Issue.60 , pp. 6750-6756
    • Guerrero, S.1    Casanova, I.2    Farrè, L.3    Mazo, A.4    Capellà, G.5    Mangues, R.6
  • 13
    • 0035444798 scopus 로고    scopus 로고
    • Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study
    • PID: 11531254, COI: 1:CAS:528:DC%2BD3MXns1yktr8%3D
    • Andreyev HJN, Norman AR, Cunningham D, Oates J, Dix BR. Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study. Br J Cancer. 2001;85(5):692–6.
    • (2001) Br J Cancer. , vol.85 , Issue.5 , pp. 692-696
    • Andreyev, H.J.N.1    Norman, A.R.2    Cunningham, D.3    Oates, J.4    Dix, B.R.5
  • 15
    • 0033739215 scopus 로고    scopus 로고
    • Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study
    • PID: 11097226, COI: 1:CAS:528:DC%2BD3cXos12isb4%3D
    • Samowitz WS, Curtin K, Schaffer D, Robertson M, Leppert M, Slattery ML. Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study. Cancer Epidemiol Biomarkers Prev. 2000;9(11):1193–7.
    • (2000) Cancer Epidemiol Biomarkers Prev. , vol.9 , Issue.11 , pp. 1193-1197
    • Samowitz, W.S.1    Curtin, K.2    Schaffer, D.3    Robertson, M.4    Leppert, M.5    Slattery, M.L.6
  • 16
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial
    • PID: 21641636, COI: 1:CAS:528:DC%2BC3MXnslShtLk%3D
    • Maughan TS, Adams RA, Smith CG, Meade AM, Seymour MT. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet. 2011;377(9783):2103–14. doi:10.1016/S0140-6736(11)60613-2.
    • (2011) Lancet , vol.377 , Issue.9783 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3    Meade, A.M.4    Seymour, M.T.5
  • 17
    • 84879590699 scopus 로고    scopus 로고
    • KRAS as prognostic biomarker in metastatic colorectal cancer patients treated with bevacizumab: a pooled analysis of 12 published trials
    • Petrelli F, Coinu A, Cabiddu M, Ghilardi M, Barni S. KRAS as prognostic biomarker in metastatic colorectal cancer patients treated with bevacizumab: a pooled analysis of 12 published trials. Med Oncol. 2013;2013(30):650.
    • (2013) Med Oncol , vol.2013 , Issue.30 , pp. 650
    • Petrelli, F.1    Coinu, A.2    Cabiddu, M.3    Ghilardi, M.4    Barni, S.5
  • 18
    • 79956310674 scopus 로고    scopus 로고
    • Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study
    • PID: 21228335, COI: 1:STN:280:DC%2BC3Mnjt1aqug%3D%3D
    • Bokemeyer C, Bondarenko I, Hartmann JT, de Braud F, Schuch G, Zubel A, Celik I, Schlichting M, Koralewski P. Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol. 2011;22(7):1535–46. doi:10.1093/annonc/mdq632.
    • (2011) Ann Oncol. , vol.22 , Issue.7 , pp. 1535-1546
    • Bokemeyer, C.1    Bondarenko, I.2    Hartmann, J.T.3    de Braud, F.4    Schuch, G.5    Zubel, A.6    Celik, I.7    Schlichting, M.8    Koralewski, P.9
  • 19
    • 84925324704 scopus 로고    scopus 로고
    • Fluorouracil, Leucovorin, and Irinotecan plus Cetuximab treatment and RAS mutations in colorectal cancer
    • PID: 25605843
    • Van Cutsem E, Lenz HJ, Kohne CH, Heinemann V. Fluorouracil, Leucovorin, and Irinotecan plus Cetuximab treatment and RAS mutations in colorectal cancer. J Clin Oncol. 2015;33(7):692–700. doi:10.1200/JCO.2014.59.4812.
    • (2015) J Clin Oncol. , vol.33 , Issue.7 , pp. 692-700
    • Van Cutsem, E.1    Lenz, H.J.2    Kohne, C.H.3    Heinemann, V.4
  • 21
    • 84905870196 scopus 로고    scopus 로고
    • PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer
    • PID: 24687833, COI: 1:CAS:528:DC%2BC2cXhsFKntLnJ
    • Schwartzberg LS, Rivera F, Karthaus M, Fasola G, Canon JL, Hecht JR, Yu H, Oliner KS, Go WY. PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer. J Clin Oncol. 2014;32(21):2240–7. doi:10.1200/JCO.2013.53.2473.
    • (2014) J Clin Oncol. , vol.32 , Issue.21 , pp. 2240-2247
    • Schwartzberg, L.S.1    Rivera, F.2    Karthaus, M.3    Fasola, G.4    Canon, J.L.5    Hecht, J.R.6    Yu, H.7    Oliner, K.S.8    Go, W.Y.9
  • 22
    • 84937204003 scopus 로고    scopus 로고
    • PHASE III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with expanded ras analyses untreated metastatic adenocarcinoma of the colon or rectum (mCRC)—ESMO 2014 Congress
    • Lenz H, Niedzwiecki D, Innocenti F, Blanke C, Mahony MR, O’Neil BH, Shaw JE, Polite B, Hochster H, Atkins J, Goldberg R, Mayer R, Schilsky R, Bertagnolli M, Venook A. CALGB/SWOG 80405: PHASE III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with expanded ras analyses untreated metastatic adenocarcinoma of the colon or rectum (mCRC)—ESMO 2014 Congress, Proffered Paper Session—ref. 501O; 2014.
    • (2014) Proffered Paper Session—ref , pp. 501O
    • Lenz, H.1    Niedzwiecki, D.2    Innocenti, F.3    Blanke, C.4    Mahony, M.R.5    O’Neil, B.H.6    Shaw, J.E.7    Polite, B.8    Hochster, H.9    Atkins, J.10    Goldberg, R.11    Mayer, R.12    Schilsky, R.13    Bertagnolli, M.14    Venook, A.15
  • 24
    • 84922453787 scopus 로고    scopus 로고
    • The prevalent KRAS exon 2 c.35G>A mutation in metastatic colorectal cancer patients: A biomarker of worse prognosis and potential benefit of bevacizumab-containing intensive regimens?
    • PID: 25459669
    • Bruera G, Cannita K, Tessitore A, Russo A, Alesse E, Ficorella C, Ricevuto E. The prevalent KRAS exon 2 c.35G>A mutation in metastatic colorectal cancer patients: A biomarker of worse prognosis and potential benefit of bevacizumab-containing intensive regimens? Crit Rev Oncol Hematol. 2015;93(3):190–202. doi:10.1016/j.critrevonc.2014.10.004.
    • (2015) Crit Rev Oncol Hematol. , vol.93 , Issue.3 , pp. 190-202
    • Bruera, G.1    Cannita, K.2    Tessitore, A.3    Russo, A.4    Alesse, E.5    Ficorella, C.6    Ricevuto, E.7
  • 25
    • 33644825856 scopus 로고    scopus 로고
    • Overall survival of patients with advanced colorectal cancer correlates with availability of fluorouracil, irinotecan, and oxaliplatin regardless of whether doublet or single-agent therapy is used first line
    • PID: 16361649
    • Grothey A, Sargent D. Overall survival of patients with advanced colorectal cancer correlates with availability of fluorouracil, irinotecan, and oxaliplatin regardless of whether doublet or single-agent therapy is used first line. J Clin Oncol. 2005;23(36):9441–2.
    • (2005) J Clin Oncol. , vol.23 , Issue.36 , pp. 9441-9442
    • Grothey, A.1    Sargent, D.2
  • 26
    • 0028822834 scopus 로고
    • Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis
    • Rak J, Mitsuhashi Y, Sheehan C, Tamir A, Viloria-Petit A, Filmus J, Shirasawa S, Sasazuki T. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res. 1995;1995(55):4575–80.
    • (1995) Cancer Res , vol.1995 , Issue.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, Y.2    Sheehan, C.3    Tamir, A.4    Viloria-Petit, A.5    Filmus, J.6    Shirasawa, S.7    Sasazuki, T.8
  • 28
    • 84923462929 scopus 로고    scopus 로고
    • KRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colorectal cancer
    • PID: 25688918, COI: 1:CAS:528:DC%2BC2MXivFajsbc%3D
    • Renaud S, Romain B, Falcoz PE, Olland A, Santelmo N, Brigand C, Rohr S, Guenot D, Massard G. KRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colorectal cancer. Br J Cancer. 2015;112(4):720–8. doi:10.1038/bjc.2014.499.
    • (2015) Br J Cancer. , vol.112 , Issue.4 , pp. 720-728
    • Renaud, S.1    Romain, B.2    Falcoz, P.E.3    Olland, A.4    Santelmo, N.5    Brigand, C.6    Rohr, S.7    Guenot, D.8    Massard, G.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.