Formononetin promotes proliferation that involves a feedback loop of microRNA-375 and estrogen receptor alpha in estrogen receptor-positive cells

Molecular Carcinogenesis

Volumn 55, Issue 3, 2016, Pages 312-319

  Chen, Jian ^a   Zhang, Xing ^a   Wang, Yong ^a   Ye, Yu ^b   Huang, Zhaoquan ^a  

^a GUILIN MEDICAL UNIVERSITY   (China)

^b FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Akt; ER ; Formononetin; HUVEC; MiR 375

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FORMONONETIN; MESSENGER RNA; MICRORNA 375; PROTEIN BCL 2; PROTEIN KINASE B; RALOXIFENE; ANTINEOPLASTIC AGENT; ESTROGEN RECEPTOR ALPHA, HUMAN; ISOFLAVONE DERIVATIVE; MICRORNA; MIRN375 MICRORNA, HUMAN; PHYTOESTROGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CELL PROLIFERATION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MCF 7 CELL LINE; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN DETERMINATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; UTERINE TISSUE; UTERUS WEIGHT; WESTERN BLOTTING; ANIMAL; ASTRAGALUS MEMBRANACEUS; BREAST NEOPLASMS; CHEMISTRY; DRUG EFFECTS; METABOLISM;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ASTRAGALUS MEMBRANACEUS; BREAST NEOPLASMS; CELL PROLIFERATION; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; ISOFLAVONES; MCF-7 CELLS; MICE; MICRORNAS; PHYTOESTROGENS; SIGNAL TRANSDUCTION;

EID: 84956658261     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22282     Document Type: Article

References (23)

1. Durando M, Kass L, Perdomo V, Bosquiazzo VL, Luque EH, Muñoz-de-Toro M. Prenatal exposure to bisphenol A promotes angiogenesis and alters steroid-mediated responses in the mammary glands of cycling rats. J Steroid Biochem Mol Biol 2011; 127:35-43.
2. Liu XJ, Li YQ, Chen QY, Xiao SJ, Zeng SE. Up-regulating of RASD1 and apoptosis of DU-145 human prostate cancer cells induced by formononetin in vitro. Asian Pacif J Cancer Prevent 2014; 15:2835-2839.
3. Chen J, Zeng J, Xin M, Huang W, Chen X. Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo. Horm Metab Res 2011; 43:681-686.
4. Chen J, Sun L. Formononetin-induced apoptosis by activation of Ras/p38 mitogen-activated protein kinase in estrogen receptor-positive human breast cancer cells. Horm Metab Res 2012; 44:943-948.
5. Chen J, Zhao XG, Ye Y, Wang Y, Tian J. Estrogen receptor beta-mediated proliferative inhibition and apoptosis in human breast cancer by calycosin and formononetin. Cell Physiol Biochem 2013; 32:1790-1797.
6. Schwartz N, Chaudhri RA, Hadadi A, Schwartz Z, Boyan BD. 17Beta-estradiol promotes aggressive laryngeal cancer through membrane-associated estrogen receptor-alpha 36. Horm Cancer 2014; 5:22-32.
7. Doshida M, Ohmichi M, Tsutsumi S, Kawagoe J, Takahashi T. Raloxifene increases proliferation and up-regulates telomerase activity in human umbilical vein endothelial cells. J Biol Chem 2006; 281:24270-24278.
8. Hall JM, Couse JF, Korach KS. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 2001; 276:36869-36872.
9. De Souza Rocha Simonini P, Breiling A, Gupta N, et al. Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells. Cancer Res 2010; 70:9175-9184.
10. Pillai RS, Bhattacharyya SN, Artus CG. Inhibition of translational initiation by Let-7 microRNA in human cells. Science 2005; 309:1573-1576.
11. Pulito C, Donzelli S, Muti P, Puzzo L, Strano S, Blandino G. microRNAs and cancer metabolism reprogramming: The paradigm of metformin. Ann Transl Med 2014; 2:58.
12. He L, Hannon GJ. MicroRNAs small RNAs with a big role in gene regulation. Nat Rev Genet 2004; 5:522-531.
13. Zhu Z, Zhang X, Wang G, Zheng H. Role of microRNAs in hepatocellular carcinoma. Hepat Mon 2014; 14:e18672.
14. Chen J, Xiong WB, Xiong Y, et al. Calycosin stimulates proliferation of estrogen receptor-positive human breast cancer cells through down regulation of Bax gene expression and up regulation of Bcl-2 gene expression at low concentrations. J Parenter Enteral Nutr 2011; 35:763-769.
15. Chen J, Zeng J, Xin M, Huang W, Chen X. Formononetin induced cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo. Horm Metab Res 2011; 43:681-686.
16. Chen J, Tao LT, Hou RL, et al. Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo. Cancer Lett 2011; 308:144-151.
17. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9:653-660.
18. Tang JY, Li S, Li ZH, et al. Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC. PLoS ONE 2010; 5:e11822.
19. Berthois Y, Katzenellenbogen JA, Katzenellenbogen BS. Phenol red in tissue culture media is a weak estrogen: Implications concerning the study of estrogen-responsive cells in culture. Proc Nat Acad Sci USA 1986; 83:2496-2500.
20. Harquail J, Benzina S, Robichaud GA. MicroRNAs and breast cancer malignancy: An overview of miRNA-regulated cancer processes leading to metastasis. Cancer Biomark 2012; 11:269-280.
21. Rivas MA, Venturutti L, Huang YW, Schillaci R, Huang TH, Elizalde PV. Downregulation of the tumor suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development. Breast Cancer Res 2012; 14:R77.
22. Moldoveanu T, Follis AV, Kriwacki RW, Green DR. Many players in BCL-2 family affairs. Trends Biochem Sci 2014; 39:101-111.
23. Chi SW. Structural insights into the transcription-independent apoptotic pathway of p53. BMB Rep. 2014; 47:167-172.