메뉴 건너뛰기




Volumn 5, Issue 4, 2014, Pages 280-295

Current and future systemic treatment options in metastatic pancreatic cancer

Author keywords

FOLFINOX; Immunotherapy; Nabpaclitaxel; Pancreatic cancer treatment; Targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENT; AXITINIB; AZACITIDINE; BUPARLISIB; CAPECITABINE; CETUXIMAB; CISPLATIN; CISPLATIN DERIVATIVE; DACTOLISIB; DENDRITIC CELL VACCINE; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; GALUNISERTIB; GEMCITABINE; IRINOTECAN; MASITINIB; MK 0752; N (6,7 DIHYDRO 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL) 2,2 DIMETHYL N' (2,2,3,3,3 PENTAFLUOROPROPYL)PROPANEDIAMIDE; OXALIPLATIN; PACLITAXEL; PLATINUM DERIVATIVE; SORAFENIB; TIPIFARNIB; TRAMETINIB; UNINDEXED DRUG; VELIPARIB; VISMODEGIB; VORINOSTAT;

EID: 84995752686     PISSN: 20786891     EISSN: 2219679X     Source Type: Journal    
DOI: 10.3978/j.issn.2078-6891.2014.030     Document Type: Review
Times cited : (41)

References (157)
  • 2
    • 79960275005 scopus 로고    scopus 로고
    • Pancreatic neoplasm in 2011: an update
    • Saif MW. Pancreatic neoplasm in 2011: an update. JOP 2011;12:316-21.
    • (2011) JOP , vol.12 , pp. 316-321
    • Saif, M.W.1
  • 3
    • 34547568957 scopus 로고    scopus 로고
    • National failure to operate on early stage pancreatic cancer
    • Bilimoria KY, Bentrem DJ, Ko CY, et al. National failure to operate on early stage pancreatic cancer. Ann Surg 2007;246:173-80.
    • (2007) Ann Surg , vol.246 , pp. 173-180
    • Bilimoria, K.Y.1    Bentrem, D.J.2    Ko, C.Y.3
  • 4
    • 84860671112 scopus 로고    scopus 로고
    • Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intent
    • Mayo SC, Nathan H, Cameron JL, et al. Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intent. Cancer 2012;118:2674-81.
    • (2012) Cancer , vol.118 , pp. 2674-2681
    • Mayo, S.C.1    Nathan, H.2    Cameron, J.L.3
  • 5
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011;364:1817-25.
    • (2011) N Engl J Med , vol.364 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 6
    • 84886741654 scopus 로고    scopus 로고
    • Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
    • Von Hoff DD, Ervin T, Arena FP, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 2013;369:1691-703.
    • (2013) N Engl J Med , vol.369 , pp. 1691-1703
    • Von Hoff, D.D.1    Ervin, T.2    Arena, F.P.3
  • 7
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
    • Burris HA 3rd, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997;15:2403-13.
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris 3rd., H.A.1    Moore, M.J.2    Andersen, J.3
  • 8
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo M. Pancreatic cancer. N Engl J Med 2010;362:1605-17.
    • (2010) N Engl J Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 9
    • 84860267502 scopus 로고    scopus 로고
    • Systemic treatment of advanced pancreatic cancer
    • Heinemann V, Haas M, Boeck S. Systemic treatment of advanced pancreatic cancer. Cancer Treat Rev 2012;38:843-53.
    • (2012) Cancer Treat Rev , vol.38 , pp. 843-853
    • Heinemann, V.1    Haas, M.2    Boeck, S.3
  • 10
    • 84877087883 scopus 로고    scopus 로고
    • Treatment options for advanced pancreatic cancer: a review
    • Warsame R, Grothey A. Treatment options for advanced pancreatic cancer: a review. Expert Rev Anticancer Ther 2012;12:1327-36.
    • (2012) Expert Rev Anticancer Ther , vol.12 , pp. 1327-1336
    • Warsame, R.1    Grothey, A.2
  • 11
    • 84876395812 scopus 로고    scopus 로고
    • Chemotherapeutic Strategies in Advanced or Metastatic Pancreatic Adenocarcinoma
    • [Epub ahead of print].
    • Zafar SF, El-Rayes BF. Chemotherapeutic Strategies in Advanced or Metastatic Pancreatic Adenocarcinoma. Am J Clin Oncol 2012. [Epub ahead of print].
    • (2012) Am J Clin Oncol
    • Zafar, S.F.1    El-Rayes, B.F.2
  • 12
    • 84995812023 scopus 로고    scopus 로고
    • A phase IB/randomized phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): Interim analysis of a University of Chicago phase II consortium study
    • 4022
    • Catenacci DVT, Bahary N, Edelman MJ, et al. A phase IB/randomized phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): Interim analysis of a University of Chicago phase II consortium study. 2012 ASCO Annual Meeting Abstract No: 4022.
    • 2012 ASCO Annual Meeting
    • Catenacci, D.V.T.1    Bahary, N.2    Edelman, M.J.3
  • 13
    • 84929321103 scopus 로고    scopus 로고
    • Masitinib in nonresectable pancreatic cancer: Results of a phase III randomized placebo-controlled trial
    • 158
    • Deplanque D, Demarchi D, Hebbar M, et al. Masitinib in nonresectable pancreatic cancer: Results of a phase III randomized placebo-controlled trial. J Clin Oncol 2013;31:abstr 158.
    • (2013) J Clin Oncol , vol.31
    • Deplanque, D.1    Demarchi, D.2    Hebbar, M.3
  • 14
    • 84868107516 scopus 로고    scopus 로고
    • BAYPAN study: a double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer
    • Gonc¸alves A, Gilabert M, Franc¸ois E, et al. BAYPAN study: a double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer. Ann Oncol 2012;23:2799-805.
    • (2012) Ann Oncol , vol.23 , pp. 2799-2805
    • Gonc¸alves, A.1    Gilabert, M.2    Franc¸ois, E.3
  • 16
    • 84995734152 scopus 로고    scopus 로고
    • Combination With Gemcitabine in Patients With Metastatic Pancreatic Cancer
    • NCT01130142.
    • A Study Evaluating IPI-926 in Combination With Gemcitabine in Patients With Metastatic Pancreatic Cancer. NCT01130142.
  • 17
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007;25:1960-6.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 18
    • 73949135518 scopus 로고    scopus 로고
    • Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
    • Cunningham D, Chau I, Stocken DD, et al. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J Clin Oncol 2009;27:5513-8.
    • (2009) J Clin Oncol , vol.27 , pp. 5513-5518
    • Cunningham, D.1    Chau, I.2    Stocken, D.D.3
  • 19
    • 42349093032 scopus 로고    scopus 로고
    • Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer
    • Heinemann V, Boeck S, Hinke A, et al. Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer. BMC Cancer 2008;8:82.
    • (2008) BMC Cancer , vol.8 , pp. 82
    • Heinemann, V.1    Boeck, S.2    Hinke, A.3
  • 20
    • 84865080615 scopus 로고    scopus 로고
    • The pancreas cancer microenvironment
    • Feig C, Gopinathan A, Neesse A, et al. The pancreas cancer microenvironment. Clin Cancer Res 2012;18:4266-76.
    • (2012) Clin Cancer Res , vol.18 , pp. 4266-4276
    • Feig, C.1    Gopinathan, A.2    Neesse, A.3
  • 21
    • 79955828776 scopus 로고    scopus 로고
    • Stromal biology and therapy in pancreatic cancer
    • Neesse A, Michl P, Frese KK, et al. Stromal biology and therapy in pancreatic cancer. Gut 2011;60:861-8.
    • (2011) Gut , vol.60 , pp. 861-868
    • Neesse, A.1    Michl, P.2    Frese, K.K.3
  • 22
    • 83355169753 scopus 로고    scopus 로고
    • Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial
    • Von Hoff DD, Ramanathan RK, Borad MJ, et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol 2011;29:4548-54.
    • (2011) J Clin Oncol , vol.29 , pp. 4548-4554
    • Von Hoff, D.D.1    Ramanathan, R.K.2    Borad, M.J.3
  • 23
    • 80052470635 scopus 로고    scopus 로고
    • Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer
    • Garrido-Laguna I, Uson M, Rajeshkumar NV, et al. Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer. Clin Cancer Res 2011;17:5793-800.
    • (2011) Clin Cancer Res , vol.17 , pp. 5793-5800
    • Garrido-Laguna, I.1    Uson, M.2    Rajeshkumar, N.V.3
  • 24
    • 84995782936 scopus 로고    scopus 로고
    • Feasibility to obtain a chemogram in circulating tumorigenic cells to guide further treatments in refractory solid tumors
    • 3066
    • Cubillo A, Calles A, Lo´pez-Casas PP, et al. Feasibility to obtain a chemogram in circulating tumorigenic cells to guide further treatments in refractory solid tumors. J Clin Oncol 2012;30:abstr 3066.
    • (2012) J Clin Oncol , vol.30
    • Cubillo, A.1    Calles, A.2    Lo´pez-Casas, P.P.3
  • 25
    • 79951906119 scopus 로고    scopus 로고
    • Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers
    • Von Hoff DD, Stephenson JJ Jr, Rosen P, et al. Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers. J Clin Oncol 2010;28:4877-83.
    • (2010) J Clin Oncol , vol.28 , pp. 4877-4883
    • Von Hoff, D.D.1    Stephenson Jr., J.J.2    Rosen, P.3
  • 26
    • 84995734169 scopus 로고    scopus 로고
    • Metabolic Profiling in Patients With Previously Treated Metastatic Pancreatic Cancer
    • NCT01196247.
    • A Study of Therapy Selected by Molecular/Metabolic Profiling in Patients With Previously Treated Metastatic Pancreatic Cancer. NCT01196247.
  • 27
    • 84875044556 scopus 로고    scopus 로고
    • Use of pharmacogenomic modeling in pancreatic cancer for prediction of chemotherapy response and resistance
    • 142
    • Sangar V, Ricigliano M, O'Reilly EM et al. Use of pharmacogenomic modeling in pancreatic cancer for prediction of chemotherapy response and resistance. J Clin Oncol 2013;31:abstr 142.
    • (2013) J Clin Oncol , vol.31
    • Sangar, V.1    Ricigliano, M.2    O'Reilly, E.M.3
  • 28
    • 84995734168 scopus 로고    scopus 로고
    • Na in Previously Untreated Metastatic Pancreatic Cancer
    • NCT01360853.
    • Gemcitabine and ON 01910.Na in Previously Untreated Metastatic Pancreatic Cancer. NCT01360853.
  • 29
    • 84995782945 scopus 로고    scopus 로고
    • Combination With Gemcitabine in Previously Untreated Subjects With Metastatic or Locally Advanced Unresectable Pancreatic Adenocarcinoma
    • NCT01746979.
    • Clinical Trial Testing TH-302 in Combination With Gemcitabine in Previously Untreated Subjects With Metastatic or Locally Advanced Unresectable Pancreatic Adenocarcinoma. NCT01746979.
  • 31
    • 84995761735 scopus 로고    scopus 로고
    • NCT01839487.
    • PEGPH20 Plus Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Subjects With Stage IV Untreated Pancreatic Cancer. NCT01839487.
  • 32
    • 84995812036 scopus 로고    scopus 로고
    • NCT01621243.
    • M402 in Combination With Nab-Paclitaxel and Gemcitabine in Pancreatic Cancer. NCT01621243.
  • 34
    • 84995742809 scopus 로고    scopus 로고
    • NCT01088815.
    • Hedgehog Inhibitors for Metastatic Adenocarcinoma of the Pancreas. NCT01088815.
  • 35
    • 84995812035 scopus 로고    scopus 로고
    • NCT01064622.
    • Gemcitabine Hydrochloride With or Without Vismodegib in Treating Patients With Recurrent or Metastatic Pancreatic Cancer. NCT01064622.
  • 36
    • 84995782935 scopus 로고    scopus 로고
    • Vismodegib and Gemcitabine Hydrochloride in Treating Patients With Advanced Pancreatic Cancer. NCT01195415.
    • Vismodegib and Gemcitabine Hydrochloride in Treating Patients With Advanced Pancreatic Cancer. NCT01195415.
  • 37
    • 84995764797 scopus 로고    scopus 로고
    • LDE225 With Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan for Untreated Advanced Pancreatic Cancer. NCT01485744.
    • LDE225 With Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan for Untreated Advanced Pancreatic Cancer. NCT01485744.
  • 38
    • 84995807351 scopus 로고    scopus 로고
    • Combination With Nab-Paclitaxel and Gemcitabine in Subjects With Previously Untreated Stage IV Pancreatic Cancer
    • NCT01647828.
    • A Phase 1b/2 Study of OMP-59R5 in Combination With Nab-Paclitaxel and Gemcitabine in Subjects With Previously Untreated Stage IV Pancreatic Cancer. NCT01647828.
  • 39
    • 84995807357 scopus 로고    scopus 로고
    • MK0752 and Gemcitabine Hydrochloride in Treating Patients With Stage III and IV Pancreatic Cancer That Cannot Be Removed by Surgery. NCT01098344.
    • MK0752 and Gemcitabine Hydrochloride in Treating Patients With Stage III and IV Pancreatic Cancer That Cannot Be Removed by Surgery. NCT01098344.
  • 40
    • 84995766152 scopus 로고    scopus 로고
    • Patients With Metastatic Pancreatic Cancer
    • NCT01844817.
    • Phase II Trial Of Gemcitabine Plus Nab-Paclitaxel +/- OGX-427 In Patients With Metastatic Pancreatic Cancer. NCT01844817.
  • 41
    • 84995761722 scopus 로고    scopus 로고
    • Trial of Gemcitabine With or Without MSC1936369B in Pancreatic Cancer. NCT01016483.
    • Trial of Gemcitabine With or Without MSC1936369B in Pancreatic Cancer. NCT01016483.
  • 42
    • 84995812030 scopus 로고    scopus 로고
    • Metastatic Pancreatic Cancer
    • NCT01028495.
    • A Safety and Efficacy Study of RX-0201 Plus Gemcitabine in Metastatic Pancreatic Cancer. NCT01028495.
  • 43
    • 84995812032 scopus 로고    scopus 로고
    • Afatinib as Cancer Therapy for Exocrine Pancreatic Tumours. NCT01728818.
    • Afatinib as Cancer Therapy for Exocrine Pancreatic Tumours. NCT01728818.
  • 44
    • 84995812052 scopus 로고    scopus 로고
    • A Clinical Trial of Anti-Angiogenic Drug Combination Tl-118 for Pancreatic Cancer Patients Who Are Starting Gemcitabine Treatment. NCT01509911.
    • A Clinical Trial of Anti-Angiogenic Drug Combination Tl-118 for Pancreatic Cancer Patients Who Are Starting Gemcitabine Treatment. NCT01509911.
  • 45
    • 84995764663 scopus 로고    scopus 로고
    • NCT01505530.
    • A Phase 2 Study of LY2495655 in Participants With Pancreatic Cancer. NCT01505530.
  • 46
    • 84995800891 scopus 로고    scopus 로고
    • Carboplatin and Paclitaxel With or Without Viral Therapy in Treating Patients With Recurrent or Metastatic Pancreatic Cancer. NCT01280058.
    • Carboplatin and Paclitaxel With or Without Viral Therapy in Treating Patients With Recurrent or Metastatic Pancreatic Cancer. NCT01280058.
  • 47
    • 84995804968 scopus 로고    scopus 로고
    • Without Veliparib or Veliparib Alone in Patients With Locally Advanced or Metastatic Pancreatic Cancer.
    • NCT01585805.
    • Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Patients With Locally Advanced or Metastatic Pancreatic Cancer. NCT01585805.
  • 48
    • 84995774927 scopus 로고    scopus 로고
    • Metformin Combined With Chemotherapy for Pancreatic Cancer. NCT01210911.
    • Metformin Combined With Chemotherapy for Pancreatic Cancer. NCT01210911.
  • 49
    • 84995734188 scopus 로고    scopus 로고
    • Treatment of Patients Suffering From a Progressive Pancreas Carcinoma With Everolimus (RAD001) and Gemcitabine. NCT00560963.
    • Treatment of Patients Suffering From a Progressive Pancreas Carcinoma With Everolimus (RAD001) and Gemcitabine. NCT00560963.
  • 51
    • 84995800897 scopus 로고    scopus 로고
    • Vorinostat in Combination With Radiation Therapy and Infusional Fluorouracil (5-FU) in Patients With Locally Advanced Adenocarcinoma of the Pancreas. NCT00948688.
    • Vorinostat in Combination With Radiation Therapy and Infusional Fluorouracil (5-FU) in Patients With Locally Advanced Adenocarcinoma of the Pancreas. NCT00948688.
  • 52
    • 84995766170 scopus 로고    scopus 로고
    • NCT01167816.
    • Phase I Trial of 5-Azacitidine Plus Gemcitabine in Patients With Advanced Pancreatic Cancer. NCT01167816.
  • 53
    • 79960019683 scopus 로고    scopus 로고
    • Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: a phase III-study from the German CONKO-study group
    • Pelzer U, Schwaner I, Stieler J, et al. Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: a phase III-study from the German CONKO-study group. Eur J Cancer 2011;47:1676-81.
    • (2011) Eur J Cancer , vol.47 , pp. 1676-1681
    • Pelzer, U.1    Schwaner, I.2    Stieler, J.3
  • 54
    • 84995782940 scopus 로고    scopus 로고
    • Versus 5-Fluorouracil and Leucovorin in Patients With Metastatic Pancreatic Cancer
    • NCT01494506.
    • Study of MM-398 With or Without 5-Fluorouracil and Leucovorin, Versus 5-Fluorouracil and Leucovorin in Patients With Metastatic Pancreatic Cancer. NCT01494506.
  • 55
    • 84995734173 scopus 로고    scopus 로고
    • NCT01423604.
    • Study of Ruxolitinib in Pancreatic Cancer Patients. NCT01423604.
  • 56
    • 84995766155 scopus 로고    scopus 로고
    • NCT01954992.
    • Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic Cancer. NCT01954992.
  • 57
    • 84995804960 scopus 로고    scopus 로고
    • Selumetinib and Akt Inhibitor MK2206 or mFOLFOX Therapy Comprising Oxaliplatin and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer Previously Treated With Chemotherapy. NCT01658943.
    • Selumetinib and Akt Inhibitor MK2206 or mFOLFOX Therapy Comprising Oxaliplatin and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer Previously Treated With Chemotherapy. NCT01658943.
  • 58
    • 84995766156 scopus 로고    scopus 로고
    • NCT01222689.
    • Selumetinib and Erlotinib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer. NCT01222689.
  • 59
    • 84995782955 scopus 로고    scopus 로고
    • Sorafenib Tosylate and Everolimus in Treating Patients With Advanced Solid Tumors and Metastatic Pancreatic Cancer That Does Not Respond to Gemcitabine Hydrochloride. NCT00981162.
    • Sorafenib Tosylate and Everolimus in Treating Patients With Advanced Solid Tumors and Metastatic Pancreatic Cancer That Does Not Respond to Gemcitabine Hydrochloride. NCT00981162.
  • 60
    • 84872063359 scopus 로고    scopus 로고
    • The association of rash severity with overall survival: findings from patients receiving erlotinib for pancreatic cancer in the community setting
    • Stepanski EJ, Reyes C, Walker MS, et al. The association of rash severity with overall survival: findings from patients receiving erlotinib for pancreatic cancer in the community setting. Pancreas 2013;42:32-6.
    • (2013) Pancreas , vol.42 , pp. 32-36
    • Stepanski, E.J.1    Reyes, C.2    Walker, M.S.3
  • 61
    • 77955914277 scopus 로고    scopus 로고
    • Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205
    • Philip PA, Benedetti J, Corless CL, et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205. J Clin Oncol 2010;28:3605-10.
    • (2010) J Clin Oncol , vol.28 , pp. 3605-3610
    • Philip, P.A.1    Benedetti, J.2    Corless, C.L.3
  • 62
    • 65549150854 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
    • Van Cutsem E, Vervenne WL, Bennouna J, et al. Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol 2009;27:2231-7.
    • (2009) J Clin Oncol , vol.27 , pp. 2231-2237
    • Van Cutsem, E.1    Vervenne, W.L.2    Bennouna, J.3
  • 63
    • 84880071078 scopus 로고    scopus 로고
    • Phase II, randomized, double-blind placebo-controlled trial of nimotuzumab plus gemcitabine compared with gemcitabine alone in patients (pts) with advanced pancreatic cancer (PC)
    • 4009
    • Strumberg D, Schultheis B, Ebert MP, et al. Phase II, randomized, double-blind placebo-controlled trial of nimotuzumab plus gemcitabine compared with gemcitabine alone in patients (pts) with advanced pancreatic cancer (PC). J Clin Oncol 2013;31:abstr 4009.
    • (2013) J Clin Oncol , vol.31
    • Strumberg, D.1    Schultheis, B.2    Ebert, M.P.3
  • 64
    • 79952036599 scopus 로고    scopus 로고
    • Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study
    • Kindler HL, Ioka T, Richel DJ, et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Lancet Oncol 2011;12:256-62.
    • (2011) Lancet Oncol , vol.12 , pp. 256-262
    • Kindler, H.L.1    Ioka, T.2    Richel, D.J.3
  • 65
    • 84856547073 scopus 로고    scopus 로고
    • Gemcitabine plus sorafenib in patients with advanced pancreatic cancer: a phase II trial of the University of Chicago Phase II Consortium
    • Kindler HL, Wroblewski K, Wallace JA, et al. Gemcitabine plus sorafenib in patients with advanced pancreatic cancer: a phase II trial of the University of Chicago Phase II Consortium. Invest New Drugs 2012;30:382-6.
    • (2012) Invest New Drugs , vol.30 , pp. 382-386
    • Kindler, H.L.1    Wroblewski, K.2    Wallace, J.A.3
  • 66
    • 2342645506 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
    • Van Cutsem E, van de Velde H, Karasek P, et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol 2004;22:1430-8.
    • (2004) J Clin Oncol , vol.22 , pp. 1430-1438
    • Van Cutsem, E.1    van de Velde, H.2    Karasek, P.3
  • 67
    • 84929321103 scopus 로고    scopus 로고
    • masitinib in nonresectable pancreatic cancer: Results of a phase III randomized placebo-controlled trial
    • 158
    • Deplanque G, Hebbar M, Flynn PJ, et al. masitinib in nonresectable pancreatic cancer: Results of a phase III randomized placebo-controlled trial. J Clin Oncol 2013; 31:abstr 158.
    • (2013) J Clin Oncol , vol.31
    • Deplanque, G.1    Hebbar, M.2    Flynn, P.J.3
  • 68
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall SR, Schulz J, Nemunaitis J, et al. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 2002;87:161-7.
    • (2002) Br J Cancer , vol.87 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3
  • 69
    • 84858671578 scopus 로고    scopus 로고
    • Phase I randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib as first-line treatment in patients with metastatic pancreatic cancer (SWOG-0727)
    • 198
    • Philip PA, Goldman BH, Ramanathan RK, et al. Phase I randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib as first-line treatment in patients with metastatic pancreatic cancer (SWOG-0727). J Clin Oncol 2012;30:abstr 198.
    • (2012) J Clin Oncol , vol.30
    • Philip, P.A.1    Goldman, B.H.2    Ramanathan, R.K.3
  • 70
    • 84875046931 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of trametinib, a MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas
    • 291
    • Infante JR, Somer BG, Park JO, et al. A randomized, double-blind, placebo-controlled trial of trametinib, a MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas. J Clin Oncol 2013;31:abstr 291.
    • (2013) J Clin Oncol , vol.31
    • Infante, J.R.1    Somer, B.G.2    Park, J.O.3
  • 72
    • 84995769939 scopus 로고    scopus 로고
    • Safety, Pharmacokinetics and Pharmacodynamics of BEZ235 Plus MEK162 in Selected Advanced Solid Tumor Patients. NCT01337765.
    • Safety, Pharmacokinetics and Pharmacodynamics of BEZ235 Plus MEK162 in Selected Advanced Solid Tumor Patients. NCT01337765.
  • 73
    • 58249085318 scopus 로고    scopus 로고
    • Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer
    • Wolpin BM, Hezel AF, Abrams T, et al. Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer. J Clin Oncol 2009;27:193-8.
    • (2009) J Clin Oncol , vol.27 , pp. 193-198
    • Wolpin, B.M.1    Hezel, A.F.2    Abrams, T.3
  • 74
    • 84995743558 scopus 로고    scopus 로고
    • Erlotinib and RAD001 (Everolimus) in Patients With Previously Treated Advanced Pancreatic Cancer. NCT00640978.
    • Erlotinib and RAD001 (Everolimus) in Patients With Previously Treated Advanced Pancreatic Cancer. NCT00640978.
  • 75
    • 84995769932 scopus 로고    scopus 로고
    • CCI-779 in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer. NCT00075647.
    • CCI-779 in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer. NCT00075647.
  • 77
    • 84899116653 scopus 로고    scopus 로고
    • SWOG S1115: Randomized phase II clinical trial of selumetinib (AZD6244; ARRY 142886) hydrogen sulfate (NSC-748727) and MK-2206 (NSC-749607) versus mFOLFOX in patients withmetastatic pancreatic cancer after prior chemotherapy
    • Chung VM, McDonough S, Philip PA, et al. SWOG S1115: Randomized phase II clinical trial of selumetinib (AZD6244; ARRY 142886) hydrogen sulfate (NSC-748727) and MK-2206 (NSC-749607) versus mFOLFOX in patients withmetastatic pancreatic cancer after prior chemotherapy. J Clin Oncol 2013;31:TPS4145.
    • (2013) J Clin Oncol , vol.31
    • Chung, V.M.1    McDonough, S.2    Philip, P.A.3
  • 78
    • 84995764669 scopus 로고    scopus 로고
    • NCT00777699.
    • Safety Study of XL765 (SAR245409) in Combination With Erlotinib in Adults With Solid Tumors. NCT00777699.
  • 79
    • 84995734187 scopus 로고    scopus 로고
    • Gamma-Secretase Inhibitor RO4929097 and Gemcitabine Hydrochloride in Treating Patients With Advanced Solid Tumors. NCT01145456.
    • Gamma-Secretase Inhibitor RO4929097 and Gemcitabine Hydrochloride in Treating Patients With Advanced Solid Tumors. NCT01145456.
  • 80
    • 84995758948 scopus 로고    scopus 로고
    • NCT00902291.
    • A Study of AGS-1C4D4 Given in Combination With Gemcitabine in Subjects With Metastatic Pancreatic Cancer. NCT00902291.
  • 81
    • 84886059624 scopus 로고    scopus 로고
    • Phase II study of dasatinib (BMS-354825) in patients with metastatic adenocarcinoma of the pancreas
    • Chee CE, Krishnamurthi S, Nock CJ, et al. Phase II study of dasatinib (BMS-354825) in patients with metastatic adenocarcinoma of the pancreas. Oncologist 2013;18:1091-2.
    • (2013) Oncologist , vol.18 , pp. 1091-1092
    • Chee, C.E.1    Krishnamurthi, S.2    Nock, C.J.3
  • 82
    • 84862018553 scopus 로고    scopus 로고
    • A phase I/II study of the Src inhibitor saracatinib (AZD0530) in combination with gemcitabine in advanced pancreatic cancer
    • Renouf DJ, Moore MJ, Hedley D, et al. A phase I/II study of the Src inhibitor saracatinib (AZD0530) in combination with gemcitabine in advanced pancreatic cancer. Invest New Drugs 2012;30:779-86.
    • (2012) Invest New Drugs , vol.30 , pp. 779-786
    • Renouf, D.J.1    Moore, M.J.2    Hedley, D.3
  • 84
    • 84883207410 scopus 로고    scopus 로고
    • Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer
    • Le DT, Lutz E, Uram JN, et al. Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J Immunother 2013;36:382-9.
    • (2013) J Immunother , vol.36 , pp. 382-389
    • Le, D.T.1    Lutz, E.2    Uram, J.N.3
  • 85
    • 84995799912 scopus 로고    scopus 로고
    • Subjects With Advanced or Metastatic Solid Tumors
    • NCT01928394.
    • A Phase 1/2, Open-label Study of Nivolumab Monotherapy or Nivolumab Combined With Ipilimumab in Subjects With Advanced or Metastatic Solid Tumors. NCT01928394.
  • 86
    • 84861152001 scopus 로고    scopus 로고
    • Metformin and pancreatic cancer: a clue requiring investigation
    • Pollak M. Metformin and pancreatic cancer: a clue requiring investigation. Clin Cancer Res 2012;18:2723-5.
    • (2012) Clin Cancer Res , vol.18 , pp. 2723-2725
    • Pollak, M.1
  • 87
    • 79955828776 scopus 로고    scopus 로고
    • Stromal biology and therapy in pancreatic cancer
    • Neesse A, Michl P, Frese KK, et al. Stromal biology and therapy in pancreatic cancer. Gut 2011;60:861-8.
    • (2011) Gut , vol.60 , pp. 861-868
    • Neesse, A.1    Michl, P.2    Frese, K.K.3
  • 88
    • 70349238733 scopus 로고    scopus 로고
    • Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
    • Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009;361:1164-72.
    • (2009) N Engl J Med , vol.361 , pp. 1164-1172
    • Von Hoff, D.D.1    LoRusso, P.M.2    Rudin, C.M.3
  • 89
  • 90
    • 27744476725 scopus 로고    scopus 로고
    • The Notch pathway in cancer: differentiation gone awry
    • Sjo¨lund J, Manetopoulos C, Stockhausen MT, et al. The Notch pathway in cancer: differentiation gone awry. Eur J Cancer 2005;41:2620-9.
    • (2005) Eur J Cancer , vol.41 , pp. 2620-2629
    • Sjo¨lund, J.1    Manetopoulos, C.2    Stockhausen, M.T.3
  • 91
    • 84938081971 scopus 로고    scopus 로고
    • Phase Ib of anticancer stem cell antibody OMP-59R5 (anti-Notch2/3) in combination with nab-paclitaxel and gemcitabine (Nab-P+Gem) in patients (pts) with untreated metastatic pancreatic cancer (mPC)
    • 220
    • O'Reilly EM, Smith LS, Bendell JC, et al. Phase Ib of anticancer stem cell antibody OMP-59R5 (anti-Notch2/3) in combination with nab-paclitaxel and gemcitabine (Nab-P+Gem) in patients (pts) with untreated metastatic pancreatic cancer (mPC). J Clin Oncol 2014;32:abstr 220.
    • (2014) J Clin Oncol , vol.32
    • O'Reilly, E.M.1    Smith, L.S.2    Bendell, J.C.3
  • 93
    • 84866334922 scopus 로고    scopus 로고
    • TGF-β-induced epithelial-mesenchymal transition: a link between cancer and inflammation
    • Fuxe J, Karlsson MC. TGF-β-induced epithelial-mesenchymal transition: a link between cancer and inflammation. Semin Cancer Biol 2012;22:455-61.
    • (2012) Semin Cancer Biol , vol.22 , pp. 455-461
    • Fuxe, J.1    Karlsson, M.C.2
  • 94
    • 84864528071 scopus 로고    scopus 로고
    • Final results of a phase I/II study in patients with pancreatic cancer, malignant melanoma, and colorectal carcinoma with trabedersen
    • 4034
    • Oettle H, Seufferlein T, Luger T, et al. Final results of a phase I/II study in patients with pancreatic cancer, malignant melanoma, and colorectal carcinoma with trabedersen. J Clin Oncol 2012;30:abstr 4034.
    • (2012) J Clin Oncol , vol.30
    • Oettle, H.1    Seufferlein, T.2    Luger, T.3
  • 95
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • Provenzano PP, Cuevas C, Chang AE, et al. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 2012;21:418-29.
    • (2012) Cancer Cell , vol.21 , pp. 418-429
    • Provenzano, P.P.1    Cuevas, C.2    Chang, A.E.3
  • 96
    • 78649638780 scopus 로고    scopus 로고
    • Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models
    • Thompson CB, Shepard HM, O'Connor PM, et al. Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models. Mol Cancer Ther 2010;9:3052-64.
    • (2010) Mol Cancer Ther , vol.9 , pp. 3052-3064
    • Thompson, C.B.1    Shepard, H.M.2    O'Connor, P.M.3
  • 97
    • 84890936723 scopus 로고    scopus 로고
    • A phase Ib study of gemcitabine plus PEGPH20 (pegylated recombinant human hyaluronidase) in patients with stage IV previously untreated pancreatic cancer
    • 4010
    • Hingorani SR, Harris WP, Beck JT, et al. A phase Ib study of gemcitabine plus PEGPH20 (pegylated recombinant human hyaluronidase) in patients with stage IV previously untreated pancreatic cancer. J Clin Oncol 2013;31:abstr 4010.
    • (2013) J Clin Oncol , vol.31
    • Hingorani, S.R.1    Harris, W.P.2    Beck, J.T.3
  • 98
    • 84995733158 scopus 로고    scopus 로고
    • NCT01959139.
    • S1313, Phase IB/II Randomized Study of MFOLFIRINOX + PEGPH20 Vs MFOLFIRINOX Alone in Patients With Good Performance Status Metastatic Pancreatic Adenocarcinoma. NCT01959139.
  • 99
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of 'BRCAness' in sporadic cancers
    • Turner N, Tutt A, Ashworth A. Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer 2004;4:814-9.
    • (2004) Nat Rev Cancer , vol.4 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 100
    • 25444471892 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy
    • Helleday T, Bryant HE, Schultz N. Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy. Cell Cycle 2005;4:1176-8.
    • (2005) Cell Cycle , vol.4 , pp. 1176-1178
    • Helleday, T.1    Bryant, H.E.2    Schultz, N.3
  • 101
    • 25144445294 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 pathways and the risk of cancers other than breast or ovarian
    • Friedenson B. BRCA1 and BRCA2 pathways and the risk of cancers other than breast or ovarian. MedGenMed 2005;7:60.
    • (2005) MedGenMed , vol.7 , pp. 60
    • Friedenson, B.1
  • 102
    • 37649022748 scopus 로고    scopus 로고
    • Determining prognosis in patients with pancreatic endocrine neoplasms: can the WHO classification system be simplified?
    • Ferrone CR, Tang LH, Tomlinson J, et al. Determining prognosis in patients with pancreatic endocrine neoplasms: can the WHO classification system be simplified? J Clin Oncol 2007;25:5609-15.
    • (2007) J Clin Oncol , vol.25 , pp. 5609-5615
    • Ferrone, C.R.1    Tang, L.H.2    Tomlinson, J.3
  • 104
    • 27744568392 scopus 로고    scopus 로고
    • BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency
    • McCabe N, Lord CJ, Tutt AN, et al. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency. Cancer Biol Ther 2005;4:934-6.
    • (2005) Cancer Biol Ther , vol.4 , pp. 934-936
    • McCabe, N.1    Lord, C.J.2    Tutt, A.N.3
  • 105
    • 12644253827 scopus 로고    scopus 로고
    • Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
    • Goggins M, Schutte M, Lu J, et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 1996;56:5360-4.
    • (1996) Cancer Res , vol.56 , pp. 5360-5364
    • Goggins, M.1    Schutte, M.2    Lu, J.3
  • 106
    • 84862907868 scopus 로고    scopus 로고
    • Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor
    • Liu X, Shi Y, Maag DX, et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res 2012;18:510-23.
    • (2012) Clin Cancer Res , vol.18 , pp. 510-523
    • Liu, X.1    Shi, Y.2    Maag, D.X.3
  • 107
  • 108
    • 34547100275 scopus 로고    scopus 로고
    • The resurgence of platinum-based cancer chemotherapy
    • Kelland L. The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer 2007;7:573-84.
    • (2007) Nat Rev Cancer , vol.7 , pp. 573-584
    • Kelland, L.1
  • 109
    • 75749143502 scopus 로고    scopus 로고
    • Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy
    • Byrski T, Gronwald J, Huzarski T, et al. Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. J Clin Oncol 2010;28:375-9.
    • (2010) J Clin Oncol , vol.28 , pp. 375-379
    • Byrski, T.1    Gronwald, J.2    Huzarski, T.3
  • 110
    • 77949908546 scopus 로고    scopus 로고
    • Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer
    • Silver DP, Richardson AL, Eklund AC, et al. Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer. J Clin Oncol 2010;28:1145-53.
    • (2010) J Clin Oncol , vol.28 , pp. 1145-1153
    • Silver, D.P.1    Richardson, A.L.2    Eklund, A.C.3
  • 111
    • 84857911626 scopus 로고    scopus 로고
    • Clinical and immunologic evaluation of dendritic cell-based immunotherapy in combination with gemcitabine and/or S-1 in patients with advanced pancreatic carcinoma
    • Kimura Y, Tsukada J, Tomoda T, et al. Clinical and immunologic evaluation of dendritic cell-based immunotherapy in combination with gemcitabine and/or S-1 in patients with advanced pancreatic carcinoma. Pancreas 2012;41:195-205.
    • (2012) Pancreas , vol.41 , pp. 195-205
    • Kimura, Y.1    Tsukada, J.2    Tomoda, T.3
  • 112
    • 0344837817 scopus 로고    scopus 로고
    • The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer
    • Morse MA, Nair SK, Boczkowski D, et al. The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer. Int J Gastrointest Cancer 2002;32:1-6.
    • (2002) Int J Gastrointest Cancer , vol.32 , pp. 1-6
    • Morse, M.A.1    Nair, S.K.2    Boczkowski, D.3
  • 113
    • 0028235908 scopus 로고
    • Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients
    • Kotera Y, Fontenot JD, Pecher G, et al. Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res 1994;54:2856-60.
    • (1994) Cancer Res , vol.54 , pp. 2856-2860
    • Kotera, Y.1    Fontenot, J.D.2    Pecher, G.3
  • 114
    • 19944433959 scopus 로고    scopus 로고
    • Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with SB-AS2 adjuvant in resected and locally advanced pancreatic cancer
    • Ramanathan RK, Lee KM, McKolanis J, et al. Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with SB-AS2 adjuvant in resected and locally advanced pancreatic cancer. Cancer Immunol Immunother 2005;54:254-64.
    • (2005) Cancer Immunol Immunother , vol.54 , pp. 254-264
    • Ramanathan, R.K.1    Lee, K.M.2    McKolanis, J.3
  • 115
    • 84865476248 scopus 로고    scopus 로고
    • A phase I pilot trial of MUC1-peptide-pulsed dendritic cells in the treatment of advanced pancreatic cancer
    • Rong Y, Qin X, Jin D, et al. A phase I pilot trial of MUC1-peptide-pulsed dendritic cells in the treatment of advanced pancreatic cancer. Clin Exp Med 2012;12:173-80.
    • (2012) Clin Exp Med , vol.12 , pp. 173-180
    • Rong, Y.1    Qin, X.2    Jin, D.3
  • 116
    • 38849160991 scopus 로고    scopus 로고
    • Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer
    • Kaufman HL, Kim-Schulze S, Manson K, et al. Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer. J Transl Med 2007;5:60.
    • (2007) J Transl Med , vol.5 , pp. 60
    • Kaufman, H.L.1    Kim-Schulze, S.2    Manson, K.3
  • 118
    • 34347380750 scopus 로고    scopus 로고
    • A phase I pilot study of autologous heat shock protein vaccine HSPPC-96 in patients with resected pancreatic adenocarcinoma
    • Maki RG, Livingston PO, Lewis JJ, et al. A phase I pilot study of autologous heat shock protein vaccine HSPPC-96 in patients with resected pancreatic adenocarcinoma. Dig Dis Sci 2007;52:1964-72.
    • (2007) Dig Dis Sci , vol.52 , pp. 1964-1972
    • Maki, R.G.1    Livingston, P.O.2    Lewis, J.J.3
  • 119
    • 0024297335 scopus 로고
    • Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells
    • Galili U, Shohet SB, Kobrin E, et al. Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. J Biol Chem 1988;263:17755-62.
    • (1988) J Biol Chem , vol.263 , pp. 17755-17762
    • Galili, U.1    Shohet, S.B.2    Kobrin, E.3
  • 120
    • 28544437092 scopus 로고    scopus 로고
    • Effective treatment of preexisting melanoma with whole cell vaccines expressing alpha(1,3)-galactosyl epitopes
    • Rossi GR, Mautino MR, Unfer RC, et al. Effective treatment of preexisting melanoma with whole cell vaccines expressing alpha(1,3)-galactosyl epitopes. Cancer Res 2005;65:10555-61.
    • (2005) Cancer Res , vol.65 , pp. 10555-10561
    • Rossi, G.R.1    Mautino, M.R.2    Unfer, R.C.3
  • 121
    • 84890238900 scopus 로고    scopus 로고
    • Effect of algenpantucel-L immunotherapy for pancreatic cancer on anti-mesothelin antibody titers and correlation with improved overall survival
    • 3007
    • Rossi GR, Hardcare JM, Mulcahy MF, et al. Effect of algenpantucel-L immunotherapy for pancreatic cancer on anti-mesothelin antibody titers and correlation with improved overall survival. J Clin Oncol 2013;31:abstr 3007.
    • (2013) J Clin Oncol , vol.31
    • Rossi, G.R.1    Hardcare, J.M.2    Mulcahy, M.F.3
  • 122
    • 79151486551 scopus 로고    scopus 로고
    • A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A Phase II trial of safety, efficacy, and immune activation
    • Lutz E, Yeo CJ, Lillemoe KD, et al. A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A Phase II trial of safety, efficacy, and immune activation. Ann Surg 2011;253:328-35.
    • (2011) Ann Surg , vol.253 , pp. 328-335
    • Lutz, E.1    Yeo, C.J.2    Lillemoe, K.D.3
  • 123
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • Almoguera C, Shibata D, Forrester K, et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988;53:549-54.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3
  • 124
    • 0035342594 scopus 로고    scopus 로고
    • Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma
    • Gjertsen MK, Buanes T, Rosseland AR, et al. Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma. Int J Cancer 2001;92:441-50.
    • (2001) Int J Cancer , vol.92 , pp. 441-450
    • Gjertsen, M.K.1    Buanes, T.2    Rosseland, A.R.3
  • 125
    • 0033493173 scopus 로고    scopus 로고
    • Telomerase activity in human solid tumors. Diagnostic utility and clinical applications
    • Vasef MA, Ross JS, Cohen MB. Telomerase activity in human solid tumors. Diagnostic utility and clinical applications. Am J Clin Pathol 1999;112:S68-75.
    • (1999) Am J Clin Pathol , vol.112 , pp. S68-75
    • Vasef, M.A.1    Ross, J.S.2    Cohen, M.B.3
  • 126
    • 0032431630 scopus 로고    scopus 로고
    • Telomerase activity detected in pancreatic juice 19 months before a tumor is detected in a patient with pancreatic cancer
    • Suehara N, Mizumoto K, Kusumoto M, et al. Telomerase activity detected in pancreatic juice 19 months before a tumor is detected in a patient with pancreatic cancer. Am J Gastroenterol 1998;93:1967-71.
    • (1998) Am J Gastroenterol , vol.93 , pp. 1967-1971
    • Suehara, N.1    Mizumoto, K.2    Kusumoto, M.3
  • 127
    • 33845247353 scopus 로고    scopus 로고
    • Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study
    • Bernhardt SL, Gjertsen MK, Trachsel S, et al. Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study. Br J Cancer 2006;95:1474-82.
    • (2006) Br J Cancer , vol.95 , pp. 1474-1482
    • Bernhardt, S.L.1    Gjertsen, M.K.2    Trachsel, S.3
  • 128
    • 84930836060 scopus 로고    scopus 로고
    • A randomized phase II study of gemcitabine(G) versus GV1001 in sequential combination witg G in patients with unresectable and metastatic panreas cancer
    • 4601
    • Buanes T, Maurel J, Liauw W, et al. A randomized phase II study of gemcitabine(G) versus GV1001 in sequential combination witg G in patients with unresectable and metastatic panreas cancer. J Clin Oncol 2009;27:abstr 4601.
    • (2009) J Clin Oncol , vol.27
    • Buanes, T.1    Maurel, J.2    Liauw, W.3
  • 131
    • 84995794850 scopus 로고    scopus 로고
    • ™-VF Vaccine for the Treatment of Metastatic Pancreatic Cancer After Failing a Gemcitabine-Containing Regimen. NCT00088660.
    • ™-VF Vaccine for the Treatment of Metastatic Pancreatic Cancer After Failing a Gemcitabine-Containing Regimen. NCT00088660.
  • 132
    • 84995764621 scopus 로고    scopus 로고
    • NCT01836432.
    • Immunotherapy Study in Borderline Resectable or Locally Advanced Unresectable Pancreatic Cancer. NCT01836432.
  • 133
    • 84995794855 scopus 로고    scopus 로고
    • NCT01896869.
    • A Phase 2, Multicenter Study of FOLFIRINOX Followed by Ipilimumab With Allogenic GM-CSF Transfected Pancreatic Tumor Vaccine in the Treatment of Metastatic Pancreatic Cancer. NCT01896869.
  • 134
    • 84995764619 scopus 로고    scopus 로고
    • NCT01417000.
    • Safety and Efficacy of Combination Listeria/GVAX Immunotherapy in Pancreatic Cancer. NCT01417000.
  • 135
    • 84995769522 scopus 로고    scopus 로고
    • NCT02004262.
    • Safety and Efficacy of Combination Listeria/GVAX Pancreas Vaccine in the Pancreatic Cancer Setting. NCT02004262.
  • 136
    • 84995807348 scopus 로고    scopus 로고
    • NCT00529984.
    • A Phase I/II Study With CEA(6D) VRP Vaccine in Patients With Advanced or Metastatic CEA-Expressing Malignancies (CEA(6D)VRP). NCT00529984.
  • 137
    • 84995744779 scopus 로고    scopus 로고
    • NCT00002475.
    • Cyclophosphamide Plus Vaccine Therapy in Treating Patients With Advanced Cancer. NCT00002475.
  • 138
    • 84995774867 scopus 로고    scopus 로고
    • GM-CSF in Treating Patients With Advanced Pancreatic Cancer
    • NCT00002773
    • Vaccine Therapy, Chemotherapy, and GM-CSF in Treating Patients With Advanced Pancreatic Cancer. NCT00002773.
  • 139
    • 84995774872 scopus 로고    scopus 로고
    • Vaccine Therapy, Interleukin-2, and Sargramostim in Treating Patients With Advanced Tumors. NCT00003125
    • Vaccine Therapy, Interleukin-2, and Sargramostim in Treating Patients With Advanced Tumors. NCT00003125.
  • 140
    • 84995734106 scopus 로고    scopus 로고
    • Vaccine Therapy Plus Biological Therapy in Treating Adults With Metastatic Solid Tumors. NCT00019331
    • Vaccine Therapy Plus Biological Therapy in Treating Adults With Metastatic Solid Tumors. NCT00019331.
  • 141
    • 84995774883 scopus 로고    scopus 로고
    • Vaccine Therapy in Treating Patients With Cancer of the Gastrointestinal Tract. NCT00012246
    • Vaccine Therapy in Treating Patients With Cancer of the Gastrointestinal Tract. NCT00012246.
  • 142
    • 84995791607 scopus 로고    scopus 로고
    • Vaccine Therapy, Cyclophosphamide, and Cetuximab in Treating Patients With Metastatic or Locally Advanced Pancreatic Cancer. NCT00305760
    • Vaccine Therapy, Cyclophosphamide, and Cetuximab in Treating Patients With Metastatic or Locally Advanced Pancreatic Cancer. NCT00305760.
  • 143
    • 84995794844 scopus 로고    scopus 로고
    • Vaccine Therapy in Treating Patients With Resected or Locally Advanced Unresectable Pancreatic Cancer. NCT00008099
    • Vaccine Therapy in Treating Patients With Resected or Locally Advanced Unresectable Pancreatic Cancer. NCT00008099.
  • 144
    • 84995764611 scopus 로고    scopus 로고
    • Study of CAP1-6D in Patients With Locally Advanced or Surgically Resected Pancreatic Adenocarcinoma. NCT00203892
    • Study of CAP1-6D in Patients With Locally Advanced or Surgically Resected Pancreatic Adenocarcinoma. NCT00203892.
  • 145
    • 84995744776 scopus 로고    scopus 로고
    • Antiangiogenic Peptide Vaccine Therapy With Gemcitabine in Treating Patient With Pancreatic Cancer (Phase1/2). NCT00655785
    • Antiangiogenic Peptide Vaccine Therapy With Gemcitabine in Treating Patient With Pancreatic Cancer (Phase1/2). NCT00655785.
  • 149
    • 84995769532 scopus 로고    scopus 로고
    • Efficacy and Safety of BC-819 and Gemcitabine in Patients With Locally Advanced Pancreatic Adenocarcinoma. NCT01413087
    • Efficacy and Safety of BC-819 and Gemcitabine in Patients With Locally Advanced Pancreatic Adenocarcinoma. NCT01413087.
  • 150
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty GL, Chiorean EG, Fishman MP, et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 2011;331:1612-6.
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1    Chiorean, E.G.2    Fishman, M.P.3
  • 151
    • 84995774905 scopus 로고    scopus 로고
    • NCT01088789
    • A Trial of Boost Vaccinations of Pancreatic Tumor Cell Vaccine. NCT01088789.
  • 152
    • 84995774906 scopus 로고    scopus 로고
    • Novel tertiary lymphoid aggregates induced in pancreatic adenocarcinoma by an allogeneic GM-CSF secreting pancreatic tumor vaccine as a neoadjuvant treatment
    • 157
    • Zheng L, Edil B, Nguyen T, et al. Novel tertiary lymphoid aggregates induced in pancreatic adenocarcinoma by an allogeneic GM-CSF secreting pancreatic tumor vaccine as a neoadjuvant treatment. 2010 Gastrointestinal Cancers Symposium Abstract No,157.
    • 2010 Gastrointestinal Cancers Symposium
    • Zheng, L.1    Edil, B.2    Nguyen, T.3
  • 153
    • 84871185239 scopus 로고    scopus 로고
    • Vaccines for pancreatic cancer
    • Soares KC, Zheng L, Edil B, et al. Vaccines for pancreatic cancer. Cancer J 2012;18:642-52.
    • (2012) Cancer J , vol.18 , pp. 642-652
    • Soares, K.C.1    Zheng, L.2    Edil, B.3
  • 154
    • 84903187931 scopus 로고    scopus 로고
    • A phase 2, randomized trial of GVAX pancreas and CRS-207 immunotherapy versus GVAX alone in patients with metastatic pancreatic adenocarcinoma: Updated results
    • 177
    • Le DT, Wang-Gillam A, Picozzi V, et al. A phase 2, randomized trial of GVAX pancreas and CRS-207 immunotherapy versus GVAX alone in patients with metastatic pancreatic adenocarcinoma: Updated results. J Clin Oncol 2014;32:abstr 177.
    • (2014) J Clin Oncol , vol.32
    • Le, D.T.1    Wang-Gillam, A.2    Picozzi, V.3
  • 155
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013;369:122-33.
    • (2013) N Engl J Med , vol.369 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 156
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-54.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 157
    • 84883811812 scopus 로고    scopus 로고
    • Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus AGS-1C4D4 in patients with previously untreated, metastatic pancreatic cancer
    • Wolpin BM, O'Reilly EM, Ko YJ, et al. Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus AGS-1C4D4 in patients with previously untreated, metastatic pancreatic cancer. Ann Oncol 2013;24:1792-801.
    • (2013) Ann Oncol , vol.24 , pp. 1792-1801
    • Wolpin, B.M.1    O'Reilly, E.M.2    Ko, Y.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.