A novel host-proteome signature for distinguishing between acute bacterial and viral infections

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Oved, Kfir ^a   Cohen, Asi ^a   Boico, Olga ^a   Navon, Roy ^a   Friedman, Tom ^a,b   Etshtein, Liat ^a,c   Kriger, Or ^a,g   Bamberger, Ellen ^a,c,d   Fonar, Yura ^a   Yacobov, Renata ^a   Wolchinsky, Ron ^e   Denkberg, Galit ^c   Dotan, Yaniv ^c,f   Hochberg, Amit ^a   Reiter, Yoram ^e   Grupper, Moti ^c,e   Srugo, Isaac ^c,d   Feigin, Paul ^e   Gorfine, Malka ^e   Chistyakov, Irina ^c,d   Dagan, Ron ^c   Klein, Adi ^a   Potasman, Israel ^c,e   Eden, Eran ^a   more..

^a MeMed Diagnostics ^*  (Israel)

^b RAMBAM MEDICAL CENTER   (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^d HILLEL YAFFE MEDICAL CENTER   (Israel)

^e BNAI ZION MEDICAL CENTER   (Israel)

^f Applied Immune Technologies Ltd   (Israel)

^g BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; BIOLOGICAL MARKER;

ADOLESCENT; ADULT; AREA UNDER THE CURVE; ARTICLE; BACTERIAL INFECTION; BIOINFORMATICS; CELLULITIS; CENTRAL NERVOUS SYSTEM INFECTION; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC ODDS RATIO; DIAGNOSTIC TEST ACCURACY STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; GASTROENTERITIS; HAEMOPHILUS INFLUENZAE; HUMAN; LOGISTIC REGRESSION ANALYSIS; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MALE; MULTIPLEX POLYMERASE CHAIN REACTION; NEGATIVE LIKELIHOOD RATIO; POSITIVE LIKELIHOOD RATIO; PREDICTIVE VALUE; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; STATISTICAL ANALYSIS; STREPTOCOCCUS PNEUMONIAE; UPPER RESPIRATORY TRACT INFECTION; UPREGULATION; URINARY TRACT INFECTION; VIRUS INFECTION; BACTERIAL INFECTIONS; METABOLISM; MIDDLE AGED; PRESCHOOL CHILD; PROTEOMICS; RANDOMIZED CONTROLLED TRIAL; REPRODUCIBILITY; VIRUS DISEASES; YOUNG ADULT;

BACTERIA (MICROORGANISMS);

ADOLESCENT; ADULT; BACTERIAL INFECTIONS; BIOMARKERS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; PROTEOMICS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; VIRUS DISEASES; YOUNG ADULT;

EID: 84956638767     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120012     Document Type: Article

References (51)

1. Laxminarayan R, Duse A, Wattal C, Zaidi AKM, Wertheim HFL, Sumpradit N, et al. Antibiotic resistance - the need for global solutions. Lancet Infect Dis. 2013; 13: 1057-1098. doi: 10.1016/S1473-3099(13)70318-9 PMID: 24252483
2. Threat Report 2013 | Antimicrobial Resistance | CDC [Internet]. [cited 10 Nov 2013]. Available: http://www.cdc.gov/drugresistance/threat-report-2013/
3. Craig JC, Williams GJ, Jones M, Codarini M, Macaskill P, Hayen A, et al. The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses. BMJ. 2010; 340: c1594. doi: 10.1136/bmj.c1594 PMID: 20406860
4. Dedier J, Singer DE, Chang Y, Moore M, Atlas SJ. Processes of care, illness severity, and outcomes in the management of community-acquired pneumonia at academic hospitals. Arch Intern Med. 2001; 161: 2099-2104. PMID: 11570938
5. Caterino JM, Hiestand BC, Martin DR. Quality of care in elder emergency department patients with pneumonia: a prospective cohort study. BMC Emerg Med. 2008; 8: 6. doi: 10.1186/1471-227X-8-6 PMID: 18447936
6. Houck PM. Timing of antibiotic administration and outcomes for medicare patients hospitalized with community-acquired pneumonia. Arch Intern Med. 2004; 164: 637-644. doi: 10.1001/archinte.164.6.637 PMID: 15037492
7. Van Zuijlen DA, Schilder AG, Van Balen FA, Hoes AW. National differences in incidence of acute mastoiditis: relationship to prescribing patterns of antibiotics for acute otitis media? Pediatr Infect Dis J. 2001; 20: 140-144. PMID: 11224830
8. Proulx N, Fréchette D, Toye B, Chan J, Kravcik S. Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM. 2005; 98: 291-298. doi: 10.1093/qjmed/hci047 PMID: 15760921
9. Lodise TP, McKinnon PS, Swiderski L, Rybak MJ. Outcomes Analysis of Delayed Antibiotic Treatment for Hospital-Acquired Staphylococcus aureus Bacteremia. Clin Infect Dis. 2003; 36: 1418-1423. doi: 10.1086/375057 PMID: 12766837
10. Meehan TP, Fine MJ, Krumholz HM, Scinto JD, Galusha DH, Mockalis JT, et al. Quality of care, process, and outcomes in elderly patients with pneumonia. JAMA J Am Med Assoc. 1997; 278: 2080-2084.
11. Van den Bruel A, Thompson MJ, Haj-Hassan T, Stevens R, Moll H, Lakhanpaul M, et al. Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review. BMJ. 2011; 342: d3082. doi: 10.1136/bmj.d3082 PMID: 21653621
12. Bogaert D, De Groot R, Hermans PWM. Streptococcus pneumoniae colonisation: the key to pneumococcal disease. Lancet Infect Dis. 2004; 4: 144-154. doi: 10.1016/S1473-3099(04)00938-7 PMID: 14998500
13. Rhedin S, Lindstrand A, Rotzén-Östlund M, Tolfvenstam T, Öhrmalm L, Rinder MR, et al. Clinical Utility of PCR for Common Viruses in Acute Respiratory Illness. Pediatrics. 2014; peds.2013-3042. doi:10.1542/peds.2013-3042
14. Shaikh N, Leonard E, Martin JM. Prevalence of streptococcal pharyngitis and streptococcal carriage in children: a meta-analysis. Pediatrics. 2010; 126: e557-564. doi: 10.1542/peds.2009-2648 PMID: 20696723
15. Falsey AR, Becker KL, Swinburne AJ, Nylen ES, Formica MA, Hennessey PA, et al. Bacterial Complications of Respiratory Viral Illness: A Comprehensive Evaluation. J Infect Dis. 2013; 208: 432-441. doi: 10.1093/infdis/jit190 PMID: 23661797
16. Thorburn K, Harigopal S, Reddy V, Taylor N, van Saene HKF. High incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitis. Thorax. 2006; 61: 611-615. doi: 10.1136/thx.2005.048397 PMID: 16537670
17. Ramilo O, Mejías A. Shifting the paradigm: host gene signatures for diagnosis of infectious diseases. Cell Host Microbe. 2009; 6: 199-200. doi: 10.1016/j.chom.2009.08.007 PMID: 19748461
18. Ramilo O, Allman W, Chung W, Mejias A, Ardura M, Glaser C, et al. Gene expression patterns in blood leukocytes discriminate patients with acute infections. Blood. 2007; 109: 2066-2077. doi: 10.1182/blood-2006-02-002477 PMID: 17105821
19. Woods CW, McClain MT, Chen M, Zaas AK, Nicholson BP, Varkey J, et al. A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2. PloS One. 2013; 8: e52198. doi: 10.1371/journal.pone.0052198 PMID: 23326326
20. Zaas AK, Burke T, Chen M, McClain M, Nicholson B, Veldman T, et al. A host-based RT-PCR gene expression signature to identify acute respiratory viral infection. Sci Transl Med. 2013; 5: 203ra126. doi: 10.1126/scitranslmed.3006280
21. Zaas AK, Chen M, Varkey J, Veldman T, Hero AO 3rd, Lucas J, et al. Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans. Cell Host Microbe. 2009; 6: 207-217. doi: 10.1016/j.chom.2009.07.006 PMID: 19664979
22. Limper M, de Kruif MD, Duits AJ, Brandjes DPM, van Gorp ECM. The diagnostic role of Procalcitonin and other biomarkers in discriminating infectious from non-infectious fever. J Infect. 2010; 60: 409-416. doi: 10.1016/j.jinf.2010.03.016 PMID: 20347867
23. Tang BM, Eslick GD, Craig JC, McLean AS. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. Lancet Infect Dis. 2007; 7: 210-217. doi: 10.1016/S1473-3099(07)70052-X PMID: 17317602
24. Engel MF, Paling FP, Hoepelman AIM, van der Meer V, Oosterheert JJ. Evaluating the evidence for the implementation of C-reactive protein measurement in adult patients with suspected lower respiratory tract infection in primary care: a systematic review. Fam Pract. 2012; 29: 383-393. doi: 10.1093/fampra/cmr119 PMID: 22159030
25. Quenot J-P, Luyt C-E, Roche N, Chalumeau M, Charles P-E, Claessens Y-E, et al. Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy. Ann Intensive Care. 2013; 3: 21. doi: 10.1186/2110-5820-3-21 PMID: 23830525
26. Van der Meer V, Neven AK, van den Broek PJ, Assendelft WJJ. Diagnostic value of C reactive protein in infections of the lower respiratory tract: systematic review. BMJ. 2005; 331: 26. doi: 10.1136/bmj.38483.478183.EB PMID: 15979984
27. Falk G, Fahey T. C-reactive protein and community-acquired pneumonia in ambulatory care: systematic review of diagnostic accuracy studies. Fam Pract. 2009; 26: 10-21. doi: 10.1093/fampra/cmn095 PMID: 19074757
28. Henriquez-Camacho C, Losa J. Biomarkers for sepsis. BioMed Res Int. 2014;2014: 547818. doi:10.1155/2014/547818
29. Schuetz P, Müller B, Christ-Crain M, Stolz D, Tamm M, Bouadma L, et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database Syst Rev. 2012; 9: CD007498. doi: 10.1002/14651858.CD007498.pub2
30. Reinhart K, Meisner M. Biomarkers in the critically ill patient: procalcitonin. Crit Care Clin. 2011; 27: 253-263. doi: 10.1016/j.ccc.2011.01.002 PMID: 21440200
31. Pierrakos C, Vincent J-L. Sepsis biomarkers: a review. Crit Care Lond Engl. 2010; 14: R15. doi: 10.1186/cc8872 PMID: 20144219
32. Musher DM, Roig IL, Cazares G, Stager CE, Logan N, Safar H. Can an etiologic agent be identified in adults who are hospitalized for community-acquired pneumonia: results of a one-year study. J Infect. 2013; 67: 11-18. doi: 10.1016/j.jinf.2013.03.003 PMID: 23523447
33. Musher DM, Bebko SP, Roig IL. Serum procalcitonin level, viral polymerase chain reaction analysis, and lower respiratory tract infection. J Infect Dis. 2014; 209: 631-633. doi: 10.1093/infdis/jit579 PMID: 24218499
34. Polzin A, Pletz M, Erbes R, Raffenberg M, Mauch H, Wagner S, et al. Procalcitonin as a diagnostic tool in lower respiratory tract infections and tuberculosis. Eur Respir J. 2003; 21: 939-943. PMID: 12797485
35. Woodhead M, Blasi F, Ewig S, Garau J, Huchon G, Ieven M, et al. Guidelines for the management of adult lower respiratory tract infections - Full version. Clin Microbiol Infect. 2011; 17: E1-E59. doi: 10.1111/j.1469-0691.2011.03672.x PMID: 21951385
36. Kunze W, Beier D, Groeger K. Adenovirus Respiratory Infections In Children. Do They Mimic Bacterial Infections? 2010; Available: http://www.webmedcentral.com/article-view/1098
37. Waage A, Brandtzaeg P, Halstensen A, Kierulf P, Espevik T. The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome. J Exp Med. 1989; 169: 333-338. PMID: 2783334
38. Bafadhel M, Clark TW, Reid C, Medina M, Batham S, Barer MR, et al. Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD. Chest. 2011; 139: 1410-1418. doi: 10.1378/chest.10-1747 PMID: 21030489
39. Gibot S, Béné MC, Noel R, Massin F, Guy J, Cravoisy A, et al. Combination biomarkers to diagnose sepsis in the critically ill patient. Am J Respir Crit Care Med. 2012; 186: 65-71. doi: 10.1164/rccm.201201-0037OC PMID: 22538802
40. Thayyil S, Shenoy M, Hamaluba M, Gupta A, Frater J, Verber IG. Is procalcitonin useful in early diagnosis of serious bacterial infections in children? Acta Paediatr Oslo Nor 1992. 2005; 94: 155-158. PMID: 15981747
41. Galetto-Lacour A, Zamora SA, Gervaix A. Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referral center. Pediatrics. 2003; 112: 1054-1060. PMID: 14595045
42. Lacour AG, Gervaix A, Zamora SA, Vadas L, Lombard PR, Dayer JM, et al. Procalcitonin, IL-6, IL-8, IL-1 receptor antagonist and C-reactive protein as identificators of serious bacterial infections in children with fever without localising signs. Eur J Pediatr. 2001; 160: 95-100. PMID: 11271398
43. Robriquet L, Séjourné C, Kipnis E, D Herbomez M, Fourrier F. A composite score combining procalcitonin, C-reactive protein and temperature has a high positive predictive value for the diagnosis of intensive care-acquired infections. BMC Infect Dis. 2013; 13: 159. doi: 10.1186/1471-2334-13-159 PMID: 23547830
44. Bertens LCM, Broekhuizen BDL, Naaktgeboren CA, Rutten FH, Hoes AW, van Mourik Y, et al. Use of expert panels to define the reference standard in diagnostic research: a systematic review of published methods and reporting. PLoS Med. 2013; 10: e1001531. doi: 10.1371/journal.pmed.1001531 PMID: 24143138
45. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, et al. The STARD Statement for Reporting Studies of Diagnostic Accuracy: Explanation and Elaboration. Ann Intern Med. 2003; 138: W1-W12. PMID: 12513067
46. Rutjes AWS, Reitsma JB, Coomarasamy A, Khan KS, Bossuyt PMM. Evaluation of diagnostic tests when there is no gold standard. A review of methods. Health Technol Assess Winch Engl. 2007; 11: iii, ix-51.
47. Falschlehner C, Schaefer U, Walczak H. Following TRAIL's path in the immune system. Immunology. 2009; 127: 145-154. doi: 10.1111/j.1365-2567.2009.03058.x PMID: 19476510
48. Liu M, Guo S, Hibbert JM, Jain V, Singh N, Wilson NO, et al. CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications. Cytokine Growth Factor Rev. 2011; 22: 121-130. doi: 10.1016/j.cytogfr.2011.06.001 PMID: 21802343
49. Gabay C, Kushner I. Acute-Phase Proteins and Other Systemic Responses to Inflammation. N Engl J Med. 1999; 340: 448-454. doi: 10.1056/NEJM199902113400607 PMID: 9971870
50. Hall KK, Lyman JA. Updated review of blood culture contamination. Clin Microbiol Rev. 2006; 19: 788-802. doi: 10.1128/CMR.00062-05 PMID: 17041144
51. Richter SS, Beekmann SE, Croco JL, Diekema DJ, Koontz FP, Pfaller MA, et al. Minimizing the workup of blood culture contaminants: implementation and evaluation of a laboratory-based algorithm. J Clin Microbiol. 2002; 40: 2437-2444. PMID: 12089259