A composite score combining procalcitonin, C-reactive protein and temperature has a high positive predictive value for the diagnosis of intensive care-acquired infections

BMC Infectious Diseases

Volumn 13, Issue 1, 2013, Pages

  Robriquet, Laurent ^a   Séjourné, Caroline ^a   Kipnis, Eric ^a   D'herbomez, Michele ^a   Fourrier, François ^a  

^a LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

C reactive protein; Intensive care unit; Nosocomial infection; Procalcitonin

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; PROCALCITONIN;

ADULT; AGED; ARTICLE; BODY TEMPERATURE MEASUREMENT; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HOSPITAL INFECTION; HUMAN; INTENSIVE CARE; INTERMETHOD COMPARISON; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PATIENT IDENTIFICATION; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY;

AGED; BIOLOGICAL MARKERS; BODY TEMPERATURE; C-REACTIVE PROTEIN; CALCITONIN; CROSS INFECTION; FEMALE; HUMANS; INTENSIVE CARE UNITS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PROTEIN PRECURSORS; SENSITIVITY AND SPECIFICITY;

EID: 84875508261     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-13-159     Document Type: Article

References (29)

1. Kumar A, Zarychanski R, Light B, Parrillo J, Maki D, Simon D, Laporta D, Lapinsky S, Ellis P, Mirzanejad Y, Martinka G, Keenan S, Wood G, Arabi Y, Feinstein D, Kumar A, Dodek P, Kravetsky L, Doucette S, . Cooperative Antimicrobial Therapy of Septic Shock CATSS Database Research Group Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis. Crit Care Med 2010, 38:1773-1785. 10.1097/CCM.0b013e3181eb3ccd, 20639750, Cooperative Antimicrobial Therapy of Septic Shock CATSS Database Research Group.
2. Calandra T, Cohen J, . International Sepsis Forum Definition of Infection in the ICU Consensus Conference The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med 2005, 33:1538-1548. 10.1097/01.CCM.0000168253.91200.83, 16003060, International Sepsis Forum Definition of Infection in the ICU Consensus Conference.
3. Luna CM, Vujacich P, Niederman MS, Vay C, Gherardi C, Matera J, Jolly EC. Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia. Chest 1997, 111:676-685. 10.1378/chest.111.3.676, 9118708.
4. American Thoracic Society Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005, 171:388-416. American Thoracic Society.
5. Martin MA, Pfaller MA, Wenzel RP. Coagulase-negative staphylococcal bacteremia. Mortality and hospital stay. Ann Intern Med 1989, 110:9-16. 10.7326/0003-4819-110-1-9, 2908834.
6. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988, 16:128-140. 10.1016/0196-6553(88)90053-3, 2841893.
7. Povoa P, Coelho L, Almeida E, Fernandes A, Mealha R, Moreira P, Sabino H. Early identification of intensive care unit-acquired infections with daily monitoring of C-reactive protein: a prospective observational study. Crit Care 2006, 10:R63. 10.1186/cc4892, 1550913, 16635270.
8. Cohen J, Guyatt G, Bernard GR, Calandra T, Cook D, Elbourne D, Marshall J, Nunn A, Opal S, . UK Medical Research Council International Working Party New strategies for clinical trials in patients with sepsis and septic shock. Crit Care Med 2001, 29:880-886. 10.1097/00003246-200104000-00039, 11373487, UK Medical Research Council International Working Party.
9. Circiumaru B, Baldock G, Cohen J. A prospective study of fever in the intensive care unit. Intensive Care Med 1999, 25:668-673. 10.1007/s001340050928, 10470569.
10. Marik PE. Fever in the ICU. Chest 2000, 117:855-869. 10.1378/chest.117.3.855, 10713016.
11. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993, 341:515-518. 10.1016/0140-6736(93)90277-N, 8094770.
12. Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis 2004, 39:206-217. 10.1086/421997, 15307030.
13. Brunkhorst FM, Wegscheider K, Forycki ZF, Brunkhorst R. Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis, and septic shock. Intensive Care Med 2000, 26:S148-S152.
14. Aouifi A, Piriou V, Bastien O, Blanc P, Bouvier H, Evans R, Célard M, Vandenesch F, Rousson R, Lehot JJ. Usefulness of procalcitonin for diagnosis of infection in cardiac surgical patients. Crit Care Med 2000, 28:3171-3176. 10.1097/00003246-200009000-00008, 11008977.
15. Duflo F, Debon R, Monneret G, Bienvenu J, Chassard D, Allaouchiche B. Alveolar and serum procalcitonin: diagnostic and prognostic value in ventilator-associated pneumonia. Anesthesiology 2002, 96:74-79. 10.1097/00000542-200201000-00018, 11753005.
16. Charles PE, Kus E, Aho S, Prin S, Doise JM, Olsson NO, Blettery B, Quenot JP. Serum procalcitonin for the early recognition of nosocomial infection in the critically ill patients: a preliminary report. BMC Infect Dis 2009, 9:49. 10.1186/1471-2334-9-49, 2679028, 19386110.
17. Luzzani A, Polati E, Dorizzi R, Rungatscher A, Pavan R, Merlini A. Comparison of procalcitonin and C-reactive protein as markers of sepsis. Crit Care Med 2003, 31:1737-1741. 10.1097/01.CCM.0000063440.19188.ED, 12794413.
18. Oberhoffer M, Karzai W, Meier-Hellmann A, Bögel D, Fassbinder J, Reinhart K. Sensitivity and specificity of various markers of inflammation for the prediction of tumor necrosis factor-alpha and interleukin-6 in patients with sepsis. Crit Care Med 1999, 27:1814-1818. 10.1097/00003246-199909000-00018, 10507603.
19. Chirouze C, Schuhmacher H, Rabaud C, Gil H, Khayat N, Estavoyer JM, May T, Hoen B. Low serum procalcitonin level accurately predicts the absence of bacteremia in adult patients with acute fever. Clin Infect Dis 2002, 35:156-161. 10.1086/341023, 12087521.
20. Ugarte H, Silva E, Mercan D, De Mendonça A, Vincent JL. Procalcitonin used as a marker of infection in the intensive care unit. Crit Care Med 1999, 27:498-504. 10.1097/00003246-199903000-00024, 10199528.
21. Suprin E, Camus C, Gacouin A, Le Tulzo Y, Lavoue S, Feuillu A, Thomas R. Procalcitonin: a valuable indicator of infection in a medical ICU?. Intensive Care Med 2000, 26:1232-1238. 10.1007/s001340000580, 11089747.
22. Hambach L, Eder M, Dammann E, Schrauder A, Sykora KW, Dieterich C, Kirschner P, Novotny J, Ganser A, Hertenstein B. Diagnostic value of procalcitonin serum levels in comparison with C-reactive protein in allogeneic stem cell transplantation. Haematologica 2002, 87:643-651.
23. Tang BM, Eslick GD, Craig JC, McLean AS. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. Lancet Infect Dis 2007, 7:210-217. 10.1016/S1473-3099(07)70052-X, 17317602.
24. Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, Tamm M, Müller B. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial. Lancet 2004, 363:600-607. 10.1016/S0140-6736(04)15591-8, 14987884.
25. Söderquist B, Jones I, Fredlund H, Vikerfors T. Bacterial or crystal-associated arthritis? Discriminating ability of serum inflammatory markers. Scand J Infect Dis 1998, 30:591-596. 10.1080/00365549850161151, 10225388.
26. Debard AL, Vautrin C, Pariset C, Bienvenu J, Monneret G. High serum procalcitonin levels do not predict bacteremia in adult patients with acute fever. Clin Infect Dis 2003, 36:825-826. 10.1086/368095, 12627373.
27. Cheval C, Timsit JF, Garrouste-Orgeas M, Assicot M, De Jonghe B, Misset B, Bohuon C, Carlet J. Procalcitonin (PCT) is useful in predicting the bacterial origin of an acute circulatory failure in critically ill patients. Intensive Care Med 2000, 26:S153-S158.
28. Povoa P, Coelho L, Almeida E, Fernandes A, Mealha R, Moreira P, Sabino H. C-reactive protein as a marker of infection in critically ill patients. Clin Microbiol Infect 2005, 11:101-108. 10.1111/j.1469-0691.2004.01044.x, 15679483.
29. Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay MA, . NHLBI ARDS Clinical Trials Network Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest 2010, 137:288-296. 10.1378/chest.09-1484, 2816641, 19858233, NHLBI ARDS Clinical Trials Network.