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Volumn 30, Issue 2, 2016, Pages 327-341

The Present and Future Global Burden of the Inherited Disorders of Hemoglobin

Author keywords

Consanguinity; Genetic disease; Human migrations; Malaria selection; Newborn screening; Public health; Sickle cell disease; Thalassemias

Indexed keywords

HEMOGLOBIN C; HEMOGLOBIN E; HEMOGLOBIN S;

EID: 84956626169     PISSN: 08898588     EISSN: 15581977     Source Type: Journal    
DOI: 10.1016/j.hoc.2015.11.004     Document Type: Review
Times cited : (71)

References (61)
  • 1
    • 34247143171 scopus 로고    scopus 로고
    • Inherited disorders of hemoglobin
    • World Bank, Washington, DC, D.T. Jamison, J.G. Breman, A.R. Measham (Eds.)
    • Weatherall D., Akinyanju O., Fucharoen S., et al. Inherited disorders of hemoglobin. Disease control priorities in developing countries 2006, 663-680. World Bank, Washington, DC. 2nd edition. D.T. Jamison, J.G. Breman, A.R. Measham (Eds.).
    • (2006) Disease control priorities in developing countries , pp. 663-680
    • Weatherall, D.1    Akinyanju, O.2    Fucharoen, S.3
  • 2
    • 80052265880 scopus 로고    scopus 로고
    • The challenge of haemoglobinopathies in resource-poor countries
    • Weatherall D.J. The challenge of haemoglobinopathies in resource-poor countries. Br J Haematol 2011, 154(6):736-744.
    • (2011) Br J Haematol , vol.154 , Issue.6 , pp. 736-744
    • Weatherall, D.J.1
  • 3
    • 77953952024 scopus 로고    scopus 로고
    • The inherited diseases of hemoglobin are an emerging global health burden
    • Weatherall D.J. The inherited diseases of hemoglobin are an emerging global health burden. Blood 2010, 115(22):4331-4336.
    • (2010) Blood , vol.115 , Issue.22 , pp. 4331-4336
    • Weatherall, D.J.1
  • 4
    • 84891800625 scopus 로고    scopus 로고
    • Updates of the HbVar database of human hemoglobin variants and thalassemia mutations
    • Giardine B., Borg J., Viennas E., et al. Updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucleic Acids Res 2014, 42(Database issue):D1063-D1069.
    • (2014) Nucleic Acids Res , vol.42 , Issue.DATABASE ISSUE , pp. D1063-D1069
    • Giardine, B.1    Borg, J.2    Viennas, E.3
  • 5
  • 6
    • 78650101852 scopus 로고    scopus 로고
    • Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis
    • Piel F.B., Patil A.P., Howes R.E., et al. Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis. Nat Commun 2010, 1:104.
    • (2010) Nat Commun , vol.1 , pp. 104
    • Piel, F.B.1    Patil, A.P.2    Howes, R.E.3
  • 7
    • 84872062977 scopus 로고    scopus 로고
    • Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates
    • Piel F.B., Patil A.P., Howes R.E., et al. Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates. Lancet 2013, 381(9861):142-151.
    • (2013) Lancet , vol.381 , Issue.9861 , pp. 142-151
    • Piel, F.B.1    Patil, A.P.2    Howes, R.E.3
  • 8
    • 84876545537 scopus 로고    scopus 로고
    • The distribution of haemoglobin C and its prevalence in newborns in Africa
    • Piel F.B., Howes R.E., Patil A.P., et al. The distribution of haemoglobin C and its prevalence in newborns in Africa. Sci Rep 2013, 3:1671.
    • (2013) Sci Rep , vol.3 , pp. 1671
    • Piel, F.B.1    Howes, R.E.2    Patil, A.P.3
  • 10
    • 84910138945 scopus 로고    scopus 로고
    • The α-thalassemias
    • Piel F.B., Weatherall D.J. The α-thalassemias. N Engl J Med 2014, 371(20):1908-1916.
    • (2014) N Engl J Med , vol.371 , Issue.20 , pp. 1908-1916
    • Piel, F.B.1    Weatherall, D.J.2
  • 11
    • 77952592557 scopus 로고    scopus 로고
    • The importance of micromapping the gene frequencies for the common inherited disorders of haemoglobin
    • Weatherall D.J. The importance of micromapping the gene frequencies for the common inherited disorders of haemoglobin. Br J Haematol 2010, 149(5):635-637.
    • (2010) Br J Haematol , vol.149 , Issue.5 , pp. 635-637
    • Weatherall, D.J.1
  • 12
    • 84871940456 scopus 로고    scopus 로고
    • Alpha thalassaemia and extended alpha globin genes in Sri Lanka
    • Suresh S., Fisher C., Ayyub H., et al. Alpha thalassaemia and extended alpha globin genes in Sri Lanka. Blood Cells Mol Dis 2013, 50(2):93-98.
    • (2013) Blood Cells Mol Dis , vol.50 , Issue.2 , pp. 93-98
    • Suresh, S.1    Fisher, C.2    Ayyub, H.3
  • 13
    • 80455132488 scopus 로고    scopus 로고
    • The inherited disorders of haemoglobin: an increasingly neglected global health burden
    • Weatherall D. The inherited disorders of haemoglobin: an increasingly neglected global health burden. Indian J Med Res 2011, 134:493-497.
    • (2011) Indian J Med Res , vol.134 , pp. 493-497
    • Weatherall, D.1
  • 14
    • 58349102500 scopus 로고    scopus 로고
    • Implementation of universal newborn bloodspot screening for sickle cell disease and other clinically significant haemoglobinopathies in England: screening results for 2005-7
    • Streetly A., Latinovic R., Hall K., et al. Implementation of universal newborn bloodspot screening for sickle cell disease and other clinically significant haemoglobinopathies in England: screening results for 2005-7. J Clin Pathol 2009, 62(1):26-30.
    • (2009) J Clin Pathol , vol.62 , Issue.1 , pp. 26-30
    • Streetly, A.1    Latinovic, R.2    Hall, K.3
  • 17
    • 84962955294 scopus 로고    scopus 로고
    • Accessed June 30
    • Global Burden of Diseases IaRF. Available at: . Accessed June 30, 2015. http://www.healthdata.org/gbd.
    • (2015)
  • 18
    • 84962955291 scopus 로고    scopus 로고
    • Accessed June 30
    • Thalassemia International Federation. Available at: . Accessed June 30, 2015. http://www.thalassaemia.org.cy/.
    • (2015)
  • 19
    • 84962935696 scopus 로고    scopus 로고
    • Accessed June 30
    • Global Sickle Cell Disease Network. Available at: . Accessed June 30, 2015. http://globalsicklecelldisease.org/.
    • (2015)
  • 20
    • 22544441601 scopus 로고    scopus 로고
    • How malaria has affected the human genome and what human genetics can teach us about malaria
    • Kwiatkowski D.P. How malaria has affected the human genome and what human genetics can teach us about malaria. Am J Hum Genet 2005, 77(2):171-192.
    • (2005) Am J Hum Genet , vol.77 , Issue.2 , pp. 171-192
    • Kwiatkowski, D.P.1
  • 21
    • 80053050662 scopus 로고    scopus 로고
    • Population genetics of malaria resistance in humans
    • Hedrick P.W. Population genetics of malaria resistance in humans. Heredity (Edinb) 2011, 107(4):283-304.
    • (2011) Heredity (Edinb) , vol.107 , Issue.4 , pp. 283-304
    • Hedrick, P.W.1
  • 22
    • 84981839006 scopus 로고
    • The rate of mutation of human genes
    • Haldane J.B.S. The rate of mutation of human genes. Hereditas 1949, 35(S1):267-273.
    • (1949) Hereditas , vol.35 , pp. 267-273
    • Haldane, J.B.S.1
  • 23
    • 77049164783 scopus 로고
    • Protection afforded by sickle-cell trait against subtertian malareal infection
    • Allison A.C. Protection afforded by sickle-cell trait against subtertian malareal infection. Br Med J 1954, 1(4857):290-294.
    • (1954) Br Med J , vol.1 , Issue.4857 , pp. 290-294
    • Allison, A.C.1
  • 24
    • 84879287709 scopus 로고    scopus 로고
    • World distribution, population genetics, and health burden of the hemoglobinopathies
    • Williams T.N., Weatherall D.J. World distribution, population genetics, and health burden of the hemoglobinopathies. Cold Spring Harb Perspect Med 2012, 2(9):a011692.
    • (2012) Cold Spring Harb Perspect Med , vol.2 , Issue.9 , pp. a011692
    • Williams, T.N.1    Weatherall, D.J.2
  • 25
    • 27644566200 scopus 로고    scopus 로고
    • Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait
    • Williams T.N., Mwangi T.W., Wambua S., et al. Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait. Nat Genet 2005, 37(11):1253-1257.
    • (2005) Nat Genet , vol.37 , Issue.11 , pp. 1253-1257
    • Williams, T.N.1    Mwangi, T.W.2    Wambua, S.3
  • 26
    • 75849133408 scopus 로고    scopus 로고
    • Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean
    • Penman B.S., Pybus O.G., Weatherall D.J., et al. Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean. Proc Natl Acad Sci U S A 2009, 106(50):21242-21246.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.50 , pp. 21242-21246
    • Penman, B.S.1    Pybus, O.G.2    Weatherall, D.J.3
  • 27
    • 84930656432 scopus 로고    scopus 로고
    • Malaria continues to select for sickle cell trait in central Africa
    • Elguero E., Delicat-Loembet L.M., Rougeron V., et al. Malaria continues to select for sickle cell trait in central Africa. Proc Natl Acad Sci U S A 2015, 112(22):7051-7054.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.22 , pp. 7051-7054
    • Elguero, E.1    Delicat-Loembet, L.M.2    Rougeron, V.3
  • 28
    • 0030821670 scopus 로고    scopus 로고
    • Environment change, geographic migration and sickle cell anaemia
    • Veytsman B. Environment change, geographic migration and sickle cell anaemia. Evol Ecol 1997, 11(5):519-529.
    • (1997) Evol Ecol , vol.11 , Issue.5 , pp. 519-529
    • Veytsman, B.1
  • 29
    • 27244454155 scopus 로고    scopus 로고
    • The frequency of the sickle allele in Jamaica has not declined over the last 22 years
    • Hanchard N.A., Hambleton I., Harding R.M., et al. The frequency of the sickle allele in Jamaica has not declined over the last 22 years. Br J Haematol 2005, 130(6):939-942.
    • (2005) Br J Haematol , vol.130 , Issue.6 , pp. 939-942
    • Hanchard, N.A.1    Hambleton, I.2    Harding, R.M.3
  • 30
    • 33750600751 scopus 로고    scopus 로고
    • Predicted declines in sickle allele frequency in Jamaica using empirical data
    • Hanchard N.A., Hambleton I., Harding R.M., et al. Predicted declines in sickle allele frequency in Jamaica using empirical data. Am J Hematol 2006, 81(11):817-823.
    • (2006) Am J Hematol , vol.81 , Issue.11 , pp. 817-823
    • Hanchard, N.A.1    Hambleton, I.2    Harding, R.M.3
  • 31
    • 84869106745 scopus 로고    scopus 로고
    • Consanguineous marriages: preconception consultation in primary health care settings
    • Hamamy H. Consanguineous marriages: preconception consultation in primary health care settings. J Community Genet 2012, 3(3):185-192.
    • (2012) J Community Genet , vol.3 , Issue.3 , pp. 185-192
    • Hamamy, H.1
  • 32
    • 76549106642 scopus 로고    scopus 로고
    • Consanguinity, human evolution, and complex diseases
    • Bittles A.H., Black M.L. Consanguinity, human evolution, and complex diseases. Proc Natl Acad Sci U S A 2010, 107(Suppl 1):1779-1786.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1779-1786
    • Bittles, A.H.1    Black, M.L.2
  • 33
    • 44949128064 scopus 로고    scopus 로고
    • Global epidemiology of haemoglobin disorders and derived service indicators
    • Modell B., Darlison M. Global epidemiology of haemoglobin disorders and derived service indicators. Bull World Health Organ 2008, 86:480-487.
    • (2008) Bull World Health Organ , vol.86 , pp. 480-487
    • Modell, B.1    Darlison, M.2
  • 34
    • 84881220584 scopus 로고    scopus 로고
    • Global burden of sickle cell anaemia in children under five, 2010-2050: modelling based on demographics, excess mortality, and interventions
    • Piel F.B., Hay S.I., Gupta S., et al. Global burden of sickle cell anaemia in children under five, 2010-2050: modelling based on demographics, excess mortality, and interventions. PLoS Med 2013, 10(7):e1001484.
    • (2013) PLoS Med , vol.10 , Issue.7 , pp. e1001484
    • Piel, F.B.1    Hay, S.I.2    Gupta, S.3
  • 35
    • 31144452300 scopus 로고    scopus 로고
    • The epidemiologic transition: a theory of the epidemiology of population change. 1971
    • Omran A.R. The epidemiologic transition: a theory of the epidemiology of population change. 1971. Milbank Q 2005, 83(4):731-757.
    • (2005) Milbank Q , vol.83 , Issue.4 , pp. 731-757
    • Omran, A.R.1
  • 36
    • 77952987403 scopus 로고    scopus 로고
    • Neonatal, postneonatal, childhood, and under-5 mortality for 187 countries, 1970-2010: a systematic analysis of progress towards millennium development goal 4
    • Rajaratnam J.K., Marcus J.R., Flaxman A.D., et al. Neonatal, postneonatal, childhood, and under-5 mortality for 187 countries, 1970-2010: a systematic analysis of progress towards millennium development goal 4. Lancet 2010, 375(9730):1988-2008.
    • (2010) Lancet , vol.375 , Issue.9730 , pp. 1988-2008
    • Rajaratnam, J.K.1    Marcus, J.R.2    Flaxman, A.D.3
  • 37
    • 84920703518 scopus 로고    scopus 로고
    • Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
    • Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015, 385(9963):117-171. GBD 2013 Mortality and Causes of Death Collaborators.
    • (2015) Lancet , vol.385 , Issue.9963 , pp. 117-171
  • 38
    • 0022628893 scopus 로고
    • Prophylaxis with oral penicillin in children with sickle cell anemia
    • Gaston M.H., Verter J.I., Woods G., et al. Prophylaxis with oral penicillin in children with sickle cell anemia. N Engl J Med 1986, 314(25):1593-1599.
    • (1986) N Engl J Med , vol.314 , Issue.25 , pp. 1593-1599
    • Gaston, M.H.1    Verter, J.I.2    Woods, G.3
  • 39
    • 0032474692 scopus 로고    scopus 로고
    • Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography
    • Adams R.J., McKie V.C., Hsu L., et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med 1998, 339(1):5-11.
    • (1998) N Engl J Med , vol.339 , Issue.1 , pp. 5-11
    • Adams, R.J.1    McKie, V.C.2    Hsu, L.3
  • 40
    • 84892951517 scopus 로고    scopus 로고
    • Global migration and the changing distribution of sickle haemoglobin: a quantitative study of temporal trends between 1960 and 2000
    • Piel F.B., Tatem A.J., Huang Z., et al. Global migration and the changing distribution of sickle haemoglobin: a quantitative study of temporal trends between 1960 and 2000. Lancet Glob Health 2014, 2(2):e80-e89.
    • (2014) Lancet Glob Health , vol.2 , Issue.2 , pp. e80-e89
    • Piel, F.B.1    Tatem, A.J.2    Huang, Z.3
  • 41
    • 84976109994 scopus 로고
    • Sickle cell anaemia, genetic variations, and the slave trade to the United States
    • Schroeder W.A., Munger E.S., Powars D.R. Sickle cell anaemia, genetic variations, and the slave trade to the United States. J Afr Hist 1990, 31(2):163-180.
    • (1990) J Afr Hist , vol.31 , Issue.2 , pp. 163-180
    • Schroeder, W.A.1    Munger, E.S.2    Powars, D.R.3
  • 42
    • 0032442537 scopus 로고    scopus 로고
    • Origin of the hemoglobin S gene in a Northern Brazilian population: the combined effects of slave trade and internal migrations
    • Pante-de-Sousa G., Mousinho-Ribeiro R.D.C., Santos E.J.M.D., et al. Origin of the hemoglobin S gene in a Northern Brazilian population: the combined effects of slave trade and internal migrations. Genet Mol Biol 1998, 21:427-430.
    • (1998) Genet Mol Biol , vol.21 , pp. 427-430
    • Pante-de-Sousa, G.1    Mousinho-Ribeiro, R.D.C.2    Santos, E.J.M.D.3
  • 43
    • 33644701423 scopus 로고    scopus 로고
    • Changes in the epidemiology of thalassemia in North America: a new minority disease
    • Vichinsky E.P., MacKlin E.A., Waye J.S., et al. Changes in the epidemiology of thalassemia in North America: a new minority disease. Pediatrics 2005, 116(6):e818-e825.
    • (2005) Pediatrics , vol.116 , Issue.6 , pp. e818-e825
    • Vichinsky, E.P.1    MacKlin, E.A.2    Waye, J.S.3
  • 45
    • 33645716357 scopus 로고    scopus 로고
    • Relationship of the sickle cell gene to the ethnic and geographic groups populating the Sudan
    • Mohammed A.O., Attalla B., Bashir F.M.K., et al. Relationship of the sickle cell gene to the ethnic and geographic groups populating the Sudan. Community Genet 2006, 9(2):113-120.
    • (2006) Community Genet , vol.9 , Issue.2 , pp. 113-120
    • Mohammed, A.O.1    Attalla, B.2    Bashir, F.M.K.3
  • 46
    • 0035543925 scopus 로고    scopus 로고
    • Hb Dartmouth [α66(E15)Leu → Pro (α2) (CTG → CCG)]: a novel α2-globin gene mutation associated with severe neonatal anemia when inherited in trans with Southeast Asian α-thalassemia-1
    • McBride K.L., Snow K., Kubik K.S., et al. Hb Dartmouth [α66(E15)Leu → Pro (α2) (CTG → CCG)]: a novel α2-globin gene mutation associated with severe neonatal anemia when inherited in trans with Southeast Asian α-thalassemia-1. Hemoglobin 2001, 25(4):375-382.
    • (2001) Hemoglobin , vol.25 , Issue.4 , pp. 375-382
    • McBride, K.L.1    Snow, K.2    Kubik, K.S.3
  • 48
    • 0346882608 scopus 로고    scopus 로고
    • An analysis of consanguinity and social structure within the UK Asian population using microsatellite data
    • Overall A.D., Ahmad M., Thomas M.G., et al. An analysis of consanguinity and social structure within the UK Asian population using microsatellite data. Ann Hum Genet 2003, 67(Pt 6):525-537.
    • (2003) Ann Hum Genet , vol.67 , pp. 525-537
    • Overall, A.D.1    Ahmad, M.2    Thomas, M.G.3
  • 50
    • 84962922394 scopus 로고    scopus 로고
    • Observed and expected frequencies of structural haemoglobin variants in newborn screening programmes in Africa and the Middle East
    • [Epub ahead of print]
    • Piel F.B., Adamkiewitzc T.V., Amendah D.D., et al. Observed and expected frequencies of structural haemoglobin variants in newborn screening programmes in Africa and the Middle East. Genetics in Medicine 2015, [Epub ahead of print].
    • (2015) Genetics in Medicine
    • Piel, F.B.1    Adamkiewitzc, T.V.2    Amendah, D.D.3
  • 51
    • 79953794193 scopus 로고    scopus 로고
    • The global distribution of the Duffy blood group
    • Howes R.E., Patil A.P., Piel F.B., et al. The global distribution of the Duffy blood group. Nat Commun 2011, 2:266.
    • (2011) Nat Commun , vol.2 , pp. 266
    • Howes, R.E.1    Patil, A.P.2    Piel, F.B.3
  • 52
    • 84870267029 scopus 로고    scopus 로고
    • G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map
    • Howes R.E., Piel F.B., Patil A.P., et al. G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map. PLoS Med 2012, 9(11):e1001339.
    • (2012) PLoS Med , vol.9 , Issue.11 , pp. e1001339
    • Howes, R.E.1    Piel, F.B.2    Patil, A.P.3
  • 53
    • 81355163446 scopus 로고    scopus 로고
    • Sickle cell disease in Africa: a neglected cause of early childhood mortality
    • Grosse S.D., Odame I., Atrash H.K., et al. Sickle cell disease in Africa: a neglected cause of early childhood mortality. Am J Prev Med 2011, 41(6 Suppl 4):S398-S405.
    • (2011) Am J Prev Med , vol.41 , Issue.6 , pp. S398-S405
    • Grosse, S.D.1    Odame, I.2    Atrash, H.K.3
  • 54
    • 77949482609 scopus 로고    scopus 로고
    • Population estimates of sickle cell disease in the U.S
    • Hassell K.L. Population estimates of sickle cell disease in the U.S. Am J Prev Med 2010, 38(4 Suppl):S512-S521.
    • (2010) Am J Prev Med , vol.38 , Issue.4 , pp. S512-S521
    • Hassell, K.L.1
  • 55
    • 0019363539 scopus 로고
    • Prevention of thalassaemia in Cyprus
    • Angastiniotis M.A., Hadjiminas M.G. Prevention of thalassaemia in Cyprus. Lancet 1981, 1(8216):369-371.
    • (1981) Lancet , vol.1 , Issue.8216 , pp. 369-371
    • Angastiniotis, M.A.1    Hadjiminas, M.G.2
  • 57
    • 84861084030 scopus 로고    scopus 로고
    • Newborn screening services in Bahrain between 1985 and 2010
    • Al Arrayed S., Al Hajeri A. Newborn screening services in Bahrain between 1985 and 2010. Adv Hematol 2012, 2012:4.
    • (2012) Adv Hematol , vol.2012 , pp. 4
    • Al Arrayed, S.1    Al Hajeri, A.2
  • 58
    • 20044367676 scopus 로고    scopus 로고
    • Predicting clinical severity in sickle cell anaemia
    • Steinberg M.H. Predicting clinical severity in sickle cell anaemia. Br J Haematol 2005, 129(4):465-481.
    • (2005) Br J Haematol , vol.129 , Issue.4 , pp. 465-481
    • Steinberg, M.H.1
  • 59
    • 66849138584 scopus 로고    scopus 로고
    • The cost of health care for children and adults with sickle cell disease
    • Kauf T.L., Coates T.D., Huazhi L., et al. The cost of health care for children and adults with sickle cell disease. Am J Hematol 2009, 84(6):323-327.
    • (2009) Am J Hematol , vol.84 , Issue.6 , pp. 323-327
    • Kauf, T.L.1    Coates, T.D.2    Huazhi, L.3
  • 60
    • 77953406829 scopus 로고    scopus 로고
    • Global burden, distribution and prevention of β-thalassemias and hemoglobin E disorders
    • Colah R., Gorakshakar A., Nadkarni A. Global burden, distribution and prevention of β-thalassemias and hemoglobin E disorders. Expert Rev Hematol 2010, 3(1):103-117.
    • (2010) Expert Rev Hematol , vol.3 , Issue.1 , pp. 103-117
    • Colah, R.1    Gorakshakar, A.2    Nadkarni, A.3
  • 61
    • 0035320886 scopus 로고    scopus 로고
    • Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias
    • Weatherall D.J. Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias. Nat Rev Genet 2001, 2(4):245-255.
    • (2001) Nat Rev Genet , vol.2 , Issue.4 , pp. 245-255
    • Weatherall, D.J.1


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