Malaria continues to select for sickle cell trait in Central Africa

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 22, 2015, Pages 7051-7054

  Elguero, Eric ^a   Délicat Loembet, Lucrèce M ^a,b   Rougeron, Virginie ^a,b   Arnathau, Céline ^a   Roche, Benjamin ^c   Becquart, Pierre ^a   Gonzalez, Jean Paul ^d   Nkoghe, Dieudonné ^b   Sica, Lucas ^b   Leroy, Eric M ^a,b   Durand, Patrick ^a   Ayala, Francisco J ^e   Ollomo, Benjamin ^b   Renaud, François ^a   Prugnolle, Franck ^a,b  

^a UNIV MONTPELLIER   (France)

^b CENTRE INTERNATIONAL DE RECHERCHES MÉDICALES DE FRANCEVILLE   (Gabon)

^c SORBONNE UNIVERSITÉ   (France)

^d METABIOTA INC   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Gabon; Human evolution; Natural selection; Plasmodium falciparum; Sickle cell disease

Indexed keywords

HEMOGLOBIN VARIANT;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CENTRAL AFRICA; CHILDHOOD MORTALITY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GABONESE; GENETIC COUNSELING; GENOTYPE; HUMAN; MALARIA; MALARIA FALCIPARUM; MALE; NONHUMAN; NORMAL HUMAN; PLASMODIUM MALARIAE INFECTION; PREVALENCE; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; SICKLE CELL ANEMIA; SICKLE CELL TRAIT; SPECIES IDENTIFICATION; TROPICS; AGE; ANEMIA, SICKLE CELL; COHORT ANALYSIS; DNA SEQUENCE; EVOLUTION; GABON; GENETIC SELECTION; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALARIA, FALCIPARUM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PLASMODIUM; POLYMERASE CHAIN REACTION; SPECIES DIFFERENCE;

PLASMODIUM FALCIPARUM;

AGE FACTORS; ANEMIA, SICKLE CELL; BASE SEQUENCE; BIOLOGICAL EVOLUTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COHORT STUDIES; GABON; HUMANS; MALARIA, FALCIPARUM; MOLECULAR SEQUENCE DATA; PLASMODIUM; POLYMERASE CHAIN REACTION; SELECTION, GENETIC; SEQUENCE ANALYSIS, DNA; SPECIES SPECIFICITY;

EID: 84930656432     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1505665112     Document Type: Article

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