메뉴 건너뛰기




Volumn 24, Issue 2, 2016, Pages 368-378

DEHP induces obesity and hypothyroidism through both central and peripheral pathways in C3H/He mice

Author keywords

[No Author keywords available]

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; LEPTIN; NEUROPEPTIDE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PROTIRELIN; UNCOUPLING PROTEIN 1; PLASTICIZER;

EID: 84956588686     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.21359     Document Type: Article
Times cited : (57)

References (40)
  • 1
    • 84869180863 scopus 로고    scopus 로고
    • National, regional, and global trends in adult overweight and obesity prevalences
    • Stevens GA, Singh GM, Lu Y, et al.; National, regional, and global trends in adult overweight and obesity prevalences. Popul Health Metr 2012; 10: 22.
    • (2012) Popul Health Metr , vol.10 , pp. 22
    • Stevens, G.A.1    Singh, G.M.2    Lu, Y.3
  • 2
    • 67349154088 scopus 로고    scopus 로고
    • Endocrine disrupters as obesogens
    • Grun F, Blumberg B.; Endocrine disrupters as obesogens. Mol Cell Endocrinol 2009; 304: 19-29.
    • (2009) Mol Cell Endocrinol , vol.304 , pp. 19-29
    • Grun, F.1    Blumberg, B.2
  • 4
    • 61349084350 scopus 로고    scopus 로고
    • Phthalate risks, phthalate regulation, and public health: A review
    • Kamrin MA.; Phthalate risks, phthalate regulation, and public health: a review. J Toxicol Environ Health B Crit Rev 2009; 12: 157-174.
    • (2009) J Toxicol Environ Health B Crit Rev , vol.12 , pp. 157-174
    • Kamrin, M.A.1
  • 5
    • 2442661389 scopus 로고    scopus 로고
    • Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP
    • Koch HM, Bolt HM, Angerer J.; Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP. Arch Toxicol 2004; 78: 123-130.
    • (2004) Arch Toxicol , vol.78 , pp. 123-130
    • Koch, H.M.1    Bolt, H.M.2    Angerer, J.3
  • 6
    • 0041697034 scopus 로고    scopus 로고
    • Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers
    • Barr DB, Silva MJ, Kato K, et al.; Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers. Environ Health Perspect 2003; 111: 1148-1151.
    • (2003) Environ Health Perspect , vol.111 , pp. 1148-1151
    • Barr, D.B.1    Silva, M.J.2    Kato, K.3
  • 7
    • 84921720579 scopus 로고    scopus 로고
    • Urinary excretion of phthalate metabolites in school children of China: Implication for cumulative risk assessment of phthalate exposure
    • 2015
    • Wang B, Wang H, Zhou W, Chen Y, Zhou Y, Jiang Q.; Urinary excretion of phthalate metabolites in school children of China: implication for cumulative risk assessment of phthalate exposure. Environ Sci Technol 2015; 49: 1120-1129.
    • Environ Sci Technol , vol.49 , pp. 1120-1129
    • Wang, B.1    Wang, H.2    Zhou, W.3    Chen, Y.4    Zhou, Y.5    Jiang, Q.6
  • 8
    • 67349261714 scopus 로고    scopus 로고
    • PPAR-mediated activity of phthalates: A link to the obesity epidemic?
    • Desvergne B, Feige JN, Casals-Casas C.; PPAR-mediated activity of phthalates: a link to the obesity epidemic? Mol Cell Endocrinol 2009; 304: 43-48.
    • (2009) Mol Cell Endocrinol , vol.304 , pp. 43-48
    • Desvergne, B.1    Feige, J.N.2    Casals-Casas, C.3
  • 9
    • 34250184495 scopus 로고    scopus 로고
    • Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. Males
    • Stahlhut RW, van Wijngaarden E, Dye TD, Cook S, Swan SH.; Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect 2007; 115: 876-882.
    • (2007) Environ Health Perspect , vol.115 , pp. 876-882
    • Stahlhut, R.W.1    Van Wijngaarden, E.2    Dye, T.D.3    Cook, S.4    Swan, S.H.5
  • 10
    • 84875911959 scopus 로고    scopus 로고
    • Race/ethnicity-specific associations of urinary phthalates with childhood body mass in a nationally representative sample
    • Trasande L, Attina TM, Sathyanarayana S, Spanier AJ, Blustein J.; Race/ethnicity-specific associations of urinary phthalates with childhood body mass in a nationally representative sample. Environ Health Perspect 2013; 121: 501-506.
    • (2013) Environ Health Perspect , vol.121 , pp. 501-506
    • Trasande, L.1    Attina, T.M.2    Sathyanarayana, S.3    Spanier, A.J.4    Blustein, J.5
  • 11
    • 84864740299 scopus 로고    scopus 로고
    • Effects of di(2-ethylhexyl) phthalate (DEHP) on female fertility and adipogenesis in C3H/N mice
    • Schmidt JS, Schaedlich K, Fiandanese N, Pocar P, Fischer B.; Effects of di(2-ethylhexyl) phthalate (DEHP) on female fertility and adipogenesis in C3H/N mice. Environ Health Perspect 2012; 120: 1123-1129.
    • (2012) Environ Health Perspect , vol.120 , pp. 1123-1129
    • Schmidt, J.S.1    Schaedlich, K.2    Fiandanese, N.3    Pocar, P.4    Fischer, B.5
  • 12
    • 0041352906 scopus 로고    scopus 로고
    • Activation of PPARalpha and PPARgamma by environmental phthalate monoesters
    • Hurst CH, Waxman DJ.; Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci 2003; 74: 297-308.
    • (2003) Toxicol Sci , vol.74 , pp. 297-308
    • Hurst, C.H.1    Waxman, D.J.2
  • 13
    • 34548258857 scopus 로고    scopus 로고
    • Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men
    • Meeker JD, Calafat AM, Hauser R.; Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men. Environ Health Perspect 2007; 115: 1029-1034.
    • (2007) Environ Health Perspect , vol.115 , pp. 1029-1034
    • Meeker, J.D.1    Calafat, A.M.2    Hauser, R.3
  • 14
    • 80053452007 scopus 로고    scopus 로고
    • Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. Adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008
    • Meeker JD, Ferguson KK.; Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008. Environ Health Perspect 2011; 119: 1396-1402.
    • (2011) Environ Health Perspect , vol.119 , pp. 1396-1402
    • Meeker, J.D.1    Ferguson, K.K.2
  • 15
    • 84871277397 scopus 로고    scopus 로고
    • Thyroidal effects of di-(2-ethylhexyl) phthalate in rats of different selenium status
    • Erkekoglu P, Giray BK, Kizilgun M, et al.; Thyroidal effects of di-(2-ethylhexyl) phthalate in rats of different selenium status. J Environ Pathol Toxicol Oncol 2012; 31: 143-153.
    • (2012) J Environ Pathol Toxicol Oncol , vol.31 , pp. 143-153
    • Erkekoglu, P.1    Giray, B.K.2    Kizilgun, M.3
  • 16
    • 0022924248 scopus 로고
    • Effects of phthalic acid esters on the liver and thyroid
    • Hinton RH, Mitchell FE, Mann A, et al.; Effects of phthalic acid esters on the liver and thyroid. Environ Health Perspect 1986; 70: 195-210.
    • (1986) Environ Health Perspect , vol.70 , pp. 195-210
    • Hinton, R.H.1    Mitchell, F.E.2    Mann, A.3
  • 17
    • 84900404900 scopus 로고    scopus 로고
    • Thyroid hormone regulation of metabolism
    • Mullur R, Liu YY, Brent GA.; Thyroid hormone regulation of metabolism. Physiol Rev 2014; 94: 355-382.
    • (2014) Physiol Rev , vol.94 , pp. 355-382
    • Mullur, R.1    Liu, Y.Y.2    Brent, G.A.3
  • 18
    • 77953083467 scopus 로고    scopus 로고
    • Hypothyroidism and thyroiditis
    • Mark E. Molitch MD. Humana Press, New York City, USA
    • Brent G, Larsen P, Davies T.; Hypothyroidism and thyroiditis. In Williams Textbook of Endocrinology, Mark E. Molitch MD. Humana Press, New York City, USA. Vol. 11; 2008. pp 377-409.
    • (2008) Williams Textbook of Endocrinology , vol.11 , pp. 377-409
    • Brent, G.1    Larsen, P.2    Davies, T.3
  • 19
    • 79953107915 scopus 로고    scopus 로고
    • Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor
    • DeKeyser JG, Laurenzana EM, Peterson EC, Chen T, Omiecinski CJ.; Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor. Toxicol Sci 2011; 120: 381-391.
    • (2011) Toxicol Sci , vol.120 , pp. 381-391
    • DeKeyser, J.G.1    Laurenzana, E.M.2    Peterson, E.C.3    Chen, T.4    Omiecinski, C.J.5
  • 20
    • 75249083175 scopus 로고    scopus 로고
    • Characterization of peroxisome proliferator-activated receptor alpha-independent effects of PPARalpha activators in the rodent liver: Di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor
    • Ren H, Aleksunes LM, Wood C, et al.; Characterization of peroxisome proliferator-activated receptor alpha-independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. Toxicol Sci 2010; 113: 45-59.
    • (2010) Toxicol Sci , vol.113 , pp. 45-59
    • Ren, H.1    Aleksunes, L.M.2    Wood, C.3
  • 21
    • 2442485772 scopus 로고    scopus 로고
    • The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction
    • Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT.; The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction. J Biol Chem 2004; 279: 19832-19838.
    • (2004) J Biol Chem , vol.279 , pp. 19832-19838
    • Maglich, J.M.1    Watson, J.2    McMillen, P.J.3    Goodwin, B.4    Willson, T.M.5    Moore, J.T.6
  • 22
    • 84455193602 scopus 로고    scopus 로고
    • Different effects by sex on hypothalamic-pituitary axis of prepubertal offspring rats produced by in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP)
    • Carbone S, Samaniego YA, Cutrera R, et al.; Different effects by sex on hypothalamic-pituitary axis of prepubertal offspring rats produced by in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP). Neurotoxicology 2012; 33: 78-84.
    • (2012) Neurotoxicology , vol.33 , pp. 78-84
    • Carbone, S.1    Samaniego, Y.A.2    Cutrera, R.3
  • 23
    • 84880955958 scopus 로고    scopus 로고
    • Expression levels of neuroimmune biomarkers in hypothalamus of allergic mice after phthalate exposure
    • 2013;:. Epub 2012 Nov 13
    • Win-Shwe TT, Yanagisawa R, Koike E, Nitta H, Takano H.; Expression levels of neuroimmune biomarkers in hypothalamus of allergic mice after phthalate exposure. J Appl Toxicol 2013; 33: 1070-1078. doi: 10.1002/jat.2835. Epub 2012 Nov 13.
    • J Appl Toxicol , vol.33 , pp. 1070-1078
    • Win-Shwe, T.T.1    Yanagisawa, R.2    Koike, E.3    Nitta, H.4    Takano, H.5
  • 24
    • 0036755741 scopus 로고    scopus 로고
    • NTP Center for the Evaluation of Risks to Human Reproduction: Phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate
    • Kavlock R, Boekelheide K, Chapin R, et al.; NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate. Reprod Toxicol 2002; 16: 529-653.
    • (2002) Reprod Toxicol , vol.16 , pp. 529-653
    • Kavlock, R.1    Boekelheide, K.2    Chapin, R.3
  • 25
    • 84906508112 scopus 로고    scopus 로고
    • Compensatory effects of hOGG1 for hMTH1 in oxidative DNA damage caused by hydrogen peroxide
    • Ke Y, Lv Z, Yang X, et al.; Compensatory effects of hOGG1 for hMTH1 in oxidative DNA damage caused by hydrogen peroxide. Toxicol Lett 2014; 230: 62-68.
    • (2014) Toxicol Lett , vol.230 , pp. 62-68
    • Ke, Y.1    Lv, Z.2    Yang, X.3
  • 26
    • 84926633393 scopus 로고    scopus 로고
    • Central prolactin receptors (PRLRs) regulate hepatic insulin sensitivity in mice via signal transducer and activator of transcription 5 (STAT5) and the vagus nerve
    • Xiao F, Xia T, Lv Z, et al.; Central prolactin receptors (PRLRs) regulate hepatic insulin sensitivity in mice via signal transducer and activator of transcription 5 (STAT5) and the vagus nerve. Diabetologia 2014; 57: 2136-2144.
    • (2014) Diabetologia , vol.57 , pp. 2136-2144
    • Xiao, F.1    Xia, T.2    Lv, Z.3
  • 27
    • 84255199265 scopus 로고    scopus 로고
    • Central nervous control of energy and glucose balance: Focus on the central melanocortin system
    • Xu Y, Elmquist JK, Fukuda M.; Central nervous control of energy and glucose balance: focus on the central melanocortin system. Ann N Y Acad Sci 2011; 1243: 1-14.
    • (2011) Ann N y Acad Sci , vol.1243 , pp. 1-14
    • Xu, Y.1    Elmquist, J.K.2    Fukuda, M.3
  • 29
    • 9444264702 scopus 로고    scopus 로고
    • LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin
    • Bates SH, Dundon TA, Seifert M, Carlson M, Maratos-Flier E, Myers MG Jr.; LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes 2004; 53: 3067-3073.
    • (2004) Diabetes , vol.53 , pp. 3067-3073
    • Bates, S.H.1    Dundon, T.A.2    Seifert, M.3    Carlson, M.4    Maratos-Flier, E.5    Myers, M.G.6
  • 30
    • 84907870320 scopus 로고    scopus 로고
    • 20 years of leptin: Role of leptin in human reproductive disorders
    • Chou SH, Mantzoros C.; 20 years of leptin: role of leptin in human reproductive disorders. J Endocrinol 2014; 223: T49-T62.
    • (2014) J Endocrinol , vol.223 , pp. T49-T62
    • Chou, S.H.1    Mantzoros, C.2
  • 31
    • 33750153292 scopus 로고    scopus 로고
    • Attenuation of leptin and insulin signaling by SOCS proteins
    • Howard JK, Flier JS.; Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab 2006; 17: 365-371.
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 365-371
    • Howard, J.K.1    Flier, J.S.2
  • 32
    • 84923501805 scopus 로고    scopus 로고
    • Leptin resistance in diet-induced obesity: The role of hypothalamic inflammation
    • de Git KC, Adan RA.; Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation. Obes Rev 2015; 16: 207-224.
    • (2015) Obes Rev , vol.16 , pp. 207-224
    • De Git, K.C.1    Adan, R.A.2
  • 33
    • 84911933989 scopus 로고    scopus 로고
    • Adipose tissues and thyroid hormones
    • Obregon MJ.; Adipose tissues and thyroid hormones. Front Physiol 2014; 5: 479.
    • (2014) Front Physiol , vol.5 , pp. 479
    • Obregon, M.J.1
  • 34
    • 0025970029 scopus 로고
    • Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat
    • Oppenheimer JH, Schwartz HL, Lane JT, Thompson MP.; Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat. J Clin Invest 1991; 87: 125-132.
    • (1991) J Clin Invest , vol.87 , pp. 125-132
    • Oppenheimer, J.H.1    Schwartz, H.L.2    Lane, J.T.3    Thompson, M.P.4
  • 35
    • 77249166060 scopus 로고    scopus 로고
    • The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms
    • Feige JN, Gerber A, Casals-Casas C, et al.; The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms. Environ Health Perspect 2010; 118: 234-241.
    • (2010) Environ Health Perspect , vol.118 , pp. 234-241
    • Feige, J.N.1    Gerber, A.2    Casals-Casas, C.3
  • 36
    • 84939613075 scopus 로고    scopus 로고
    • The environmental pollutants perfluorooctane sulfonate and perfluorooctanoic acid upregulate uncoupling protein 1 (UCP1) in brown-fat mitochondria through a UCP1-dependent reduction in food intake
    • 2015;:. Epub 2015 May 21
    • Shabalina IG, Kramarova TV, Mattsson CL, et al.; The environmental pollutants perfluorooctane sulfonate and perfluorooctanoic acid upregulate uncoupling protein 1 (UCP1) in brown-fat mitochondria through a UCP1-dependent reduction in food intake. Toxicol Sci 2015; 146: 334-343. doi: 10.1093/toxsci/kfv098. Epub 2015 May 21.
    • Toxicol Sci , vol.146 , pp. 334-343
    • Shabalina, I.G.1    Kramarova, T.V.2    Mattsson, C.L.3
  • 37
    • 84863661947 scopus 로고    scopus 로고
    • Plasticizers may activate human hepatic peroxisome proliferator-activated receptor alpha less than that of a mouse but may activate constitutive androstane receptor in liver
    • Ito Y, Nakamura T, Yanagiba Y, et al.; Plasticizers may activate human hepatic peroxisome proliferator-activated receptor alpha less than that of a mouse but may activate constitutive androstane receptor in liver. PPAR Res 2012; 2012: 201284.
    • (2012) PPAR Res , vol.2012 , pp. 201284
    • Ito, Y.1    Nakamura, T.2    Yanagiba, Y.3
  • 38
    • 77956932463 scopus 로고    scopus 로고
    • The increased CAR-dependent metabolism of thyroid hormones in mice with high cancer susceptibility
    • Pakharukova M, Smetanina M, Kaledin V, Obut T, Merkulova T.; The increased CAR-dependent metabolism of thyroid hormones in mice with high cancer susceptibility. Life Sci 2010; 87: 439-444.
    • (2010) Life Sci , vol.87 , pp. 439-444
    • Pakharukova, M.1    Smetanina, M.2    Kaledin, V.3    Obut, T.4    Merkulova, T.5
  • 40
    • 0035172040 scopus 로고    scopus 로고
    • Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling
    • Harris M, Aschkenasi C, Elias CF, et al.; Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest 2001; 107: 111-120.
    • (2001) J Clin Invest , vol.107 , pp. 111-120
    • Harris, M.1    Aschkenasi, C.2    Elias, C.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.