Neuroprotective effect of sulfated polysaccharide isolated from sea cucumber Stichopus japonicus on 6-OHDA-induced death in SH-SY5Y through inhibition of MAPK and NF-κB and activation of PI3K/Akt signaling pathways

Biochemical and Biophysical Research Communications

Volumn 470, Issue 2, 2016, Pages 375-383

  Cui, Chao ^a,b   Cui, Ningshan ^a   Wang, Peng ^b   Song, Shuliang ^a   Liang, Hao ^a   Ji, Aiguo ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

6 OHDA; MAPK; NF B; PD; PI3K Akt; SH SY5Y

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; CASPASE 3; CASPASE 9; CYCLIN D3; CYTOCHROME C; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPROTECTIVE AGENT; NITROGEN OXIDE; OXIDOPAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; POLYSACCHARIDE SULFATE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; POLYSACCHARIDE; SULFATE;

APOSTICHOPUS JAPONICUS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; ENZYME ACTIVATION; ENZYME INHIBITION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; NEUROPROTECTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; APOPTOSIS; CELL LINE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; NERVE CELL; PHYSIOLOGY; SEA CUCUMBER;

ANIMALS; APOPTOSIS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MAP KINASE SIGNALING SYSTEM; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; OXIDOPAMINE; PHOSPHATIDYLINOSITOL 3-KINASES; POLYSACCHARIDES; PROTO-ONCOGENE PROTEINS C-AKT; SEA CUCUMBERS; SIGNAL TRANSDUCTION; SULFATES;

EID: 84956579623     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.01.035     Document Type: Article

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