-
1
-
-
84924402296
-
The physical basis of protein misfolding disorders
-
Knowles, T.P.J., Vendruscolo, M. & Dobson, C.M. The physical basis of protein misfolding disorders. Phys. Today 68, 36 (2015).
-
(2015)
Phys. Today
, vol.68
, pp. 36
-
-
Knowles, T.P.J.1
Vendruscolo, M.2
Dobson, C.M.3
-
2
-
-
33746377894
-
Protein misfolding, functional amyloid, and human disease
-
Chiti, F. & Dobson, C.M. Protein misfolding, functional amyloid, and human disease. Annu. Rev. Biochem. 75, 333-366 (2006).
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 333-366
-
-
Chiti, F.1
Dobson, C.M.2
-
3
-
-
0347357617
-
Protein folding and misfolding
-
Dobson, C.M. Protein folding and misfolding. Nature 426, 884-890 (2003).
-
(2003)
Nature
, vol.426
, pp. 884-890
-
-
Dobson, C.M.1
-
4
-
-
0242300624
-
Games played by rogue proteins in prion disorders and Alzheimer's disease
-
Aguzzi, A. & Haass, C. Games played by rogue proteins in prion disorders and Alzheimer's disease. Science 302, 814-818 (2003).
-
(2003)
Science
, vol.302
, pp. 814-818
-
-
Aguzzi, A.1
Haass, C.2
-
5
-
-
77649202326
-
Protein aggregation diseases: Pathogenicity and therapeutic perspectives
-
Aguzzi, A. & O'Connor, T. Protein aggregation diseases: pathogenicity and therapeutic perspectives. Nat. Rev. Drug Discov. 9, 237-248 (2010).
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 237-248
-
-
Aguzzi, A.1
O'Connor, T.2
-
6
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy, J. & Selkoe, D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356 (2002).
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
7
-
-
73949089674
-
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide
-
Hu, X. et al. Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc. Natl. Acad. Sci. USA 106, 20324-20329 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 20324-20329
-
-
Hu, X.1
-
9
-
-
0021837479
-
Kinetics of sickle hemoglobin polymerization. II. A double nucleation mechanism
-
Ferrone, F.A., Hofrichter, J. & Eaton, W.A. Kinetics of sickle hemoglobin polymerization. II. A double nucleation mechanism. J. Mol. Biol. 183, 611-631 (1985).
-
(1985)
J. Mol. Biol.
, vol.183
, pp. 611-631
-
-
Ferrone, F.A.1
Hofrichter, J.2
Eaton, W.A.3
-
11
-
-
72149118250
-
An analytical solution to the kinetics of breakable filament assembly
-
Knowles, T.P.J. et al. An analytical solution to the kinetics of breakable filament assembly. Science 326, 1533-1537 (2009).
-
(2009)
Science
, vol.326
, pp. 1533-1537
-
-
Knowles, T.P.J.1
-
12
-
-
84924196173
-
The molecular chaperone brichos breaks the catalytic cycle that generates toxic Aβ oligomers
-
Cohen, S.I.A. et al. The molecular chaperone brichos breaks the catalytic cycle that generates toxic Aβ oligomers. Nat. Struct. Mol. Biol. 22, 207-213 (2015).
-
(2015)
Nat. Struct. Mol. Biol.
, vol.22
, pp. 207-213
-
-
Cohen, S.I.A.1
-
13
-
-
84896695581
-
Chemical kinetics for drug discovery to combat protein aggregation diseases
-
Arosio, P., Vendruscolo, M., Dobson, C.M. & Knowles, T.P.J. Chemical kinetics for drug discovery to combat protein aggregation diseases. Trends Pharmacol. Sci. 35, 127-135 (2014).
-
(2014)
Trends Pharmacol. Sci.
, vol.35
, pp. 127-135
-
-
Arosio, P.1
Vendruscolo, M.2
Dobson, C.M.3
Knowles, T.P.J.4
-
14
-
-
84928546414
-
Preventing peptide and protein misbehavior
-
Arosio, P., Meisl, G., Andreasen, M. & Knowles, T.P.J. Preventing peptide and protein misbehavior. Proc. Natl. Acad. Sci. USA 112, 5267-5268 (2015).
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 5267-5268
-
-
Arosio, P.1
Meisl, G.2
Andreasen, M.3
Knowles, T.P.J.4
-
15
-
-
34547638452
-
Fiber-dependent amyloid formation as catalysis of an existing reaction pathway
-
Ruschak, A.M. & Miranker, A.D. Fiber-dependent amyloid formation as catalysis of an existing reaction pathway. Proc. Natl. Acad. Sci. USA 104, 12341-12346 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 12341-12346
-
-
Ruschak, A.M.1
Miranker, A.D.2
-
16
-
-
80051866825
-
Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments
-
Cohen, S.I.A. et al. Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments. J. Chem. Phys. 135, 065105 (2011).
-
(2011)
J. Chem. Phys.
, vol.135
-
-
Cohen, S.I.A.1
-
17
-
-
80051899060
-
Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations
-
Cohen, S.I.A., Vendruscolo, M., Dobson, C.M. & Knowles, T.P.J. Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations. J. Chem. Phys. 135, 065106 (2011).
-
(2011)
J. Chem. Phys.
, vol.135
-
-
Cohen, S.I.A.1
Vendruscolo, M.2
Dobson, C.M.3
Knowles, T.P.J.4
-
18
-
-
84903696629
-
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the aβ40 and aβ42 peptides
-
Meisl, G. et al. Differences in nucleation behavior underlie the contrasting aggregation kinetics of the aβ40 and aβ42 peptides. Proc. Natl. Acad. Sci. USA 111, 9384-9389 (2014).
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 9384-9389
-
-
Meisl, G.1
-
19
-
-
84928580256
-
Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation
-
Abelein, A., Graslund, A. & Danielsson, J. Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation. Proc. Natl. Acad. Sci. USA 112, 5407-5412 (2015).
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 5407-5412
-
-
Abelein, A.1
Graslund, A.2
Danielsson, J.3
-
20
-
-
84863981137
-
From macroscopic measurements to microscopic mechanisms of protein aggregation
-
Cohen, S.I.A., Vendruscolo, M., Dobson, C.M. & Knowles, T.P.J. From macroscopic measurements to microscopic mechanisms of protein aggregation. J. Mol. Biol. 421, 160-171 (2012).
-
(2012)
J. Mol. Biol.
, vol.421
, pp. 160-171
-
-
Cohen, S.I.A.1
Vendruscolo, M.2
Dobson, C.M.3
Knowles, T.P.J.4
-
21
-
-
34247899121
-
Functional amyloid - From bacteria to humans
-
Fowler, D.M., Koulov, A.V., Balch, W.E. & Kelly, J.W. Functional amyloid - from bacteria to humans. Trends Biochem. Sci. 32, 217-224 (2007).
-
(2007)
Trends Biochem. Sci.
, vol.32
, pp. 217-224
-
-
Fowler, D.M.1
Koulov, A.V.2
Balch, W.E.3
Kelly, J.W.4
-
22
-
-
84861563520
-
Direct observation of the interconversion of normal and toxic forms of α-synuclein
-
Cremades, N. Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell 149, 1048-1059 (2012).
-
(2012)
Cell
, vol.149
, pp. 1048-1059
-
-
Cremades, N.1
-
23
-
-
84902440293
-
Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization
-
Michaels, T.C.T. & Knowles, T.P.J. Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization. J. Chem. Phys. 140, 214904 (2014).
-
(2014)
J. Chem. Phys.
, vol.140
-
-
Michaels, T.C.T.1
Knowles, T.P.J.2
-
24
-
-
1442330505
-
The elongation of yeast prion fibers involves separable steps of association and conversion
-
Scheibel, T., Bloom, J. & Lindquist, S.L. The elongation of yeast prion fibers involves separable steps of association and conversion. Proc. Natl. Acad. Sci. USA 101, 2287-2292 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 2287-2292
-
-
Scheibel, T.1
Bloom, J.2
Lindquist, S.L.3
-
25
-
-
0034733023
-
Alzheimer's disease amyloid propagation by a template-dependent dock-lock mechanism
-
Esler, W.P. et al. Alzheimer's disease amyloid propagation by a template-dependent dock-lock mechanism. Biochemistry 39, 6288-6295 (2000).
-
(2000)
Biochemistry
, vol.39
, pp. 6288-6295
-
-
Esler, W.P.1
-
26
-
-
33947613349
-
A theory of linear and helical aggregations of macromolecules
-
Oosawa, F. & Kasai, M. A theory of linear and helical aggregations of macromolecules. J. Mol. Biol. 4, 10-21 (1962).
-
(1962)
J. Mol. Biol.
, vol.4
, pp. 10-21
-
-
Oosawa, F.1
Kasai, M.2
-
27
-
-
0000560869
-
Global optimization by basin-hopping and the lowest energy structures of Lennard-Jones clusters containing up to 110 atoms
-
Wales, D.J. & Doye, J.P.K. Global optimization by basin-hopping and the lowest energy structures of Lennard-Jones clusters containing up to 110 atoms. J. Phys. Chem. A 101, 5111-5116 (1997).
-
(1997)
J. Phys. Chem. A
, vol.101
, pp. 5111-5116
-
-
Wales, D.J.1
Doye, J.P.K.2
-
28
-
-
84878994873
-
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
-
Cohen, S.I.A. et al. Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism. Proc. Natl. Acad. Sci. USA 110, 9758-9763 (2013).
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 9758-9763
-
-
Cohen, S.I.A.1
-
29
-
-
84892178364
-
Quantification of the concentration of aβ42 propagons during the lag phase by an amyloid chain reaction assay
-
Paolo Arosio, P., Cukalevski, R., Frohm, B., Knowles, T.P.J. & Linse, S. Quantification of the concentration of aβ42 propagons during the lag phase by an amyloid chain reaction assay. J. Am. Chem. Soc. 136, 219-225 (2014).
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 219-225
-
-
Paolo Arosio, P.1
Cukalevski, R.2
Frohm, B.3
Knowles, T.P.J.4
Linse, S.5
-
30
-
-
60349100306
-
A facile method for expression and purification of the Alzheimer's disease-associated amyloid β-peptide
-
Walsh, D.M. et al. A facile method for expression and purification of the Alzheimer's disease-associated amyloid β-peptide. FEBS J. 276, 1266-1281 (2009).
-
(2009)
FEBS J
, vol.276
, pp. 1266-1281
-
-
Walsh, D.M.1
-
31
-
-
74649086711
-
The recombinant amyloid-beta peptide Aβ1-42 aggregates faster and is more neurotoxic than synthetic Aβ1-42
-
Finder, V.H., Vodopivec, I., Nitsch, R.M. & Glockshuber, R. The recombinant amyloid-beta peptide Aβ1-42 aggregates faster and is more neurotoxic than synthetic Aβ1-42. J. Mol. Biol. 396, 9-18 (2010).
-
(2010)
J. Mol. Biol.
, vol.396
, pp. 9-18
-
-
Finder, V.H.1
Vodopivec, I.2
Nitsch, R.M.3
Glockshuber, R.4
-
32
-
-
84871285635
-
Role of aromatic side chains in amyloid β-protein aggregation
-
Cukalevski, R. et al. Role of aromatic side chains in amyloid β-protein aggregation. ACS Chem. Neurosci. 3, 1008-1016 (2012).
-
(2012)
ACS Chem. Neurosci
, vol.3
, pp. 1008-1016
-
-
Cukalevski, R.1
-
33
-
-
77951676986
-
Amyloid β-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process
-
Hellstrand, E., Boland, B., Walsh, D.M. & Linse, S. Amyloid β-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process. ACS Chem. Neurosci. 1, 13-18 (2010).
-
(2010)
ACS Chem. Neurosci.
, vol.1
, pp. 13-18
-
-
Hellstrand, E.1
Boland, B.2
Walsh, D.M.3
Linse, S.4
|