True and apparent optogenetic BOLD fMRI signals

Magnetic Resonance in Medicine

Volumn 77, Issue 1, 2017, Pages 126-136

  Schmid, Florian ^a   Wachsmuth, Lydia ^a   Albers, Franziska ^a   Schwalm, Miriam ^b   Stroh, Albrecht ^b   Faber, Cornelius ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

apparent stimulation; BOLD fMRI; ofMRI; optogenetics; small animal fMRI

Indexed keywords

NEUROIMAGING; OPTICAL FIBERS; SIGNAL SYSTEMS; VISION;

APPARENT STIMULATION; BOLD FMRI; OFMRI; OPTOGENETICS; SMALL ANIMAL;

CHEMICAL ACTIVATION;

OPSIN; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BOLD SIGNAL; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; ILLUMINATION; LIGHT; NONHUMAN; OPTOGENETICS; RAT; SOMATOSENSORY CORTEX; THALAMUS; VISUAL STIMULATION; VISUAL SYSTEM; ANIMAL; BLOOD; BRAIN; DIAGNOSTIC IMAGING; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOTOSTIMULATION; PROCEDURES; SIGNAL PROCESSING; VASCULARIZATION;

ANIMALS; BRAIN; FEMALE; MAGNETIC RESONANCE IMAGING; OPTOGENETICS; OXYGEN; PHOTIC STIMULATION; RATS; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 84956486961     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.26095     Document Type: Article

References (25)

1. Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity. Nature Neurosci 2005;8:1263–1268.
2. Gradinaru V, Mogri M, Thompson KR, Henderson JM, Deisseroth K. Optical deconstruction of parkinsonian neural circuitry. Science 2009;324:354–359.
3. Lee JH, Durand R, Gradinaru V, Zhang F, Goshen I, Kim DS, Fenno LE, Ramakrishnan C, Deisseroth K. Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature 2010;465:788–792.
4. Desai M, Kahn I, Knoblich U, et al. Mapping brain networks in awake mice using combined optical neural control and fMRI. J Neurophys 2011;105:1393–1405.
5. Logothetis NK. Bold claims for optogenetics. Nature 2010;468:E3–E4.
6. Vazquez AL, Fukuda M, Crowley JC, Kim SG. Neural and hemodynamic responses elicited by forelimb- and photo-stimulation in channelrhodopsin-2 mice: insights into the hemodynamic point spread function. Cerebral Cortex 2014;24:2908–2919.
7. Iordanova B, Vazquez AL, Poplawsky AJ, Fukuda M, Kim SG. Neural and hemodynamic responses to optogenetic and sensory stimulation in the rat somatosensory cortex. J Cereb Blood Flow Metab 2015;35:922–932.
8. Christie IN, Wells JA, Southern P, Marina N, Kasparov S, Gourine AV, Lythgoe MF. fMRI response to blue light delivery in the naive brain: implications for combined optogenetic fMRI studies. NeuroImage 2013;66:634–641.
9. Kahn I, Desai M, Knoblich U, Bernstein J, Henninger M, Graybiel AM, Boyden ES, Buckner RL, Moore CI. Characterization of the functional MRI response temporal linearity via optical control of neocortical pyramidal neurons. J Neurosci 2011;31:15086–15091.
10. Honjoh T, Ji ZG, Yokoyama Y, Sumiyoshi A, Shibuya Y, Matsuzaka Y, Kawashima R, Mushiake H, Ishizuka T, Yawo H. Optogenetic patterning of whisker-barrel cortical system in transgenic rat expressing channelrhodopsin-2. PloS One 2014;9:e93706.
11. Gerits A, Farivar R, Rosen BR, Wald LL, Boyden ES, Vanduffel W. Optogenetically induced behavioral and functional network changes in primates. Current Biology 2012;22:1722–1726.
12. Kahn I, Knoblich U, Desai M, Bernstein J, Graybiel AM, Boyden ES, Buckner RL, Moore CI. Optogenetic drive of neocortical pyramidal neurons generates fMRI signals that are correlated with spiking activity. Brain Research 2013;1511:33–45.
13. Weitz AJ, Fang Z, Lee HJ, Fisher RS, Smith WC, Choy M, Liu J, Lin P, Rosenberg M, Lee JH. Optogenetic fMRI reveals distinct, frequency-dependent networks recruited by dorsal and intermediate hippocampus stimulations. NeuroImage 2015;107:229–241.
14. Liang Z, Watson GD, Alloway KD, Lee G, Neuberger T, Zhang N. Mapping the functional network of medial prefrontal cortex by combining optogenetics and fMRI in awake rats. NeuroImage 2015;117:114-123.
15. Takata N, Yoshida K, Komaki Y, Xu M, Sakai Y, Hikishima K, Mimura M, Okano H, Tanaka KF. Optogenetic activation of CA1 pyramidal neurons at the dorsal and ventral hippocampus evokes distinct brain-wide responses revealed by mouse fMRI. PloS One 2015;10:e0121417.
16. Domingos AI, Vaynshteyn J, Voss HU, Ren X, Gradinaru V, Zang F, Deisseroth K, de Araujo IE, Friedman J. Leptin regulates the reward value of nutrient. Nature Neurosci 2011;14:1562–1568.
17. Yizhar O, Fenno LE, Prigge M. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 2011;477:171–178.
18. Mattis J, Tye KM, Ferenczi EA. Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nat Meth 2012;9:159–172.
19. Fois C, Prouvot P-H, Stroh A. A roadmap to applying optogenetics in neuroscience. In: Cambridge S, editor. Photoswitching proteins. Vol. 1148, Methods in Molecular Biology. New York: Springer; 2014, 129–147.
20. Yizhar O, Fenno LE, Davidson TJ, Mogri M, Deisseroth K. Optogenetics in neural systems. Neuron 2011;71:9–34.
21. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Amsterdam: Academic Press; 2013.
22. Weber R, Ramos-Cabrer P, Wiedermann D, van Camp N, Hoehn M. A fully noninvasive and robust experimental protocol for longitudinal fMRI studies in the rat. NeuroImage 2006;29:1303–1310.
23. Schmid F, Wachsmuth L, Schwalm M, Prouvot P-H, Rosales Jubal E, Fois C, Pramanik G, Zimmer C, Faber C, Stroh A. Assessing sensory versus optogenetic network activation by combining (o)fMRI with optical Ca2 + recordings. J Cerebral Blood Flow Metab; DOI: 10.1177/0271678X15619428.
24. Stroh A, Tsai H-C, Wang L-P, Zhang F, Kressel J, Aravanis A, Santhanam N, Deisseroth K, Konnerth A, Schneider MB. Tracking stem cell differentiation in the setting of automated optogenetic stimulation. Stem Cells 2011;29:78–88.
25. Van Camp N, Verhoye M, De Zeeuw CI, Van der Linden A. Light stimulus frequency dependence of activity in the rat visual system as studied with high-resolution BOLD fMRI. J Neurophys 2006;95:3164–3170.