메뉴 건너뛰기




Volumn 16, Issue 1, 2016, Pages 119-128

Secukinumab for treating plaque psoriasis

Author keywords

interleukin (IL) 17; plaque psoriasis; psoriatic arthritis; secukinumab; Th17

Indexed keywords

BIOLOGICAL PRODUCT; IL17A PROTEIN, HUMAN; INTERLEUKIN 17; MONOCLONAL ANTIBODY; SECUKINUMAB; TUMOR NECROSIS FACTOR;

EID: 84955729361     PISSN: 14712598     EISSN: 17447682     Source Type: Journal    
DOI: 10.1517/14712598.2016.1121986     Document Type: Review
Times cited : (20)

References (72)
  • 1
    • 1842555395 scopus 로고    scopus 로고
    • Psoriasis is common, carries a substantial burden even when not extensive, and is associated with widespread treatment dissatisfaction
    • Stern RS, Nijsten T, Feldman SR., et al. Psoriasis is common, carries a substantial burden even when not extensive, and is associated with widespread treatment dissatisfaction. J Investig Dermatol Symp Proc. 2004; 9 (2): 136-139
    • (2004) J Investig Dermatol Symp Proc , vol.9 , Issue.2 , pp. 136-139
    • Stern, R.S.1    Nijsten, T.2    Feldman, S.R.3
  • 2
    • 29144466801 scopus 로고    scopus 로고
    • Prevalence and treatment of psoriasis in the United Kingdom: A population-based study
    • Gelfand JM, Weinstein R, Porter SB., et al. Prevalence and treatment of psoriasis in the United Kingdom: a population-based study. Arch Dermatol. 2005; 141 (12): 1537-1541
    • (2005) Arch Dermatol , vol.141 , Issue.12 , pp. 1537-1541
    • Gelfand, J.M.1    Weinstein, R.2    Porter, S.B.3
  • 3
    • 58149336900 scopus 로고    scopus 로고
    • The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: Results from NHANES 2003-2004
    • Kurd SK, Gelfand JM. The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: results from NHANES 2003-2004. J Am Acad Dermatol. 2009; 60 (2): 218-224
    • (2009) J Am Acad Dermatol , vol.60 , Issue.2 , pp. 218-224
    • Kurd, S.K.1    Gelfand, J.M.2
  • 4
    • 41949094481 scopus 로고    scopus 로고
    • Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics
    • Menter A, Gottlieb A, Feldman SR., et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J Am Acad Dermatol. 2008; 58: 826-850
    • (2008) J Am Acad Dermatol , vol.58 , pp. 826-850
    • Menter, A.1    Gottlieb, A.2    Feldman, S.R.3
  • 5
    • 34447539622 scopus 로고    scopus 로고
    • Pathogenesis and clinical features of psoriasis
    • Griffiths CEM, Barker JNWN. Pathogenesis and clinical features of psoriasis. The Lancet. 2007; 370 (9583): 263-271
    • (2007) The Lancet , vol.370 , Issue.9583 , pp. 263-271
    • Griffiths, C.E.M.1    Barker, J.2
  • 6
    • 84875956855 scopus 로고    scopus 로고
    • High prevalence of psoriatic arthritis in patients with severe psoriasis with suboptimal performance of screening questionnaires
    • Haroon M, Kirby B, FitzGerald O. High prevalence of psoriatic arthritis in patients with severe psoriasis with suboptimal performance of screening questionnaires. Ann Rheum Dis. 2013; 72 (5): 736-740
    • (2013) Ann Rheum Dis , vol.72 , Issue.5 , pp. 736-740
    • Haroon, M.1    Kirby, B.2    FitzGerald, O.3
  • 8
    • 8744240727 scopus 로고    scopus 로고
    • Determinants of quality of life in patients with psoriasis: A study from the US population
    • Gelfand JM, Feldman SR, Stern RS., et al. Determinants of quality of life in patients with psoriasis: a study from the US population. J Am Acad Dermatol. 2004; 51 (5): 704-708
    • (2004) J Am Acad Dermatol , vol.51 , Issue.5 , pp. 704-708
    • Gelfand, J.M.1    Feldman, S.R.2    Stern, R.S.3
  • 9
    • 79958800583 scopus 로고    scopus 로고
    • Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: Case-based presentations and evidence-based conclusions
    • Menter A, Korman NJ, Elmets CA., et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: section 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: case-based presentations and evidence-based conclusions. J Am Acad Dermatol. 2011; 65 (1): 137-174
    • (2011) J Am Acad Dermatol , vol.65 , Issue.1 , pp. 137-174
    • Menter, A.1    Korman, N.J.2    Elmets, C.A.3
  • 10
    • 84955720045 scopus 로고    scopus 로고
    • Biologic Drugs: Fact Sheets. [cited 2015 Jul 20 ]. Available from: https://www.psoriasis.org/.
    • Biologic Drugs: Fact Sheets. [cited 2015 Jul 20 ]. Available from: https://www.psoriasis.org/.
  • 11
    • 84893072201 scopus 로고    scopus 로고
    • Treating moderate to severe psoriasis - Best use of biologics
    • Lynch M, Kirby B, Warren RB. Treating moderate to severe psoriasis-best use of biologics. Expert Rev Clin Immunol. 2014; 10 (2): 269-279
    • (2014) Expert Rev Clin Immunol , vol.10 , Issue.2 , pp. 269-279
    • Lynch, M.1    Kirby, B.2    Warren, R.B.3
  • 12
    • 84881564770 scopus 로고    scopus 로고
    • Satisfaction with treatment among patients with psoriasis: A web-based survey study
    • van Cranenburgh OD, de Korte J, Sprangers MA., et al. Satisfaction with treatment among patients with psoriasis: a web-based survey study. Br J Dermatol. 2013; 169 (2): 398-405
    • (2013) Br J Dermatol , vol.169 , Issue.2 , pp. 398-405
    • Van Cranenburgh, O.D.1    De Korte, J.2    Sprangers, M.A.3
  • 14
    • 70249137988 scopus 로고    scopus 로고
    • European S3-guidelines on the systemic treatment of psoriasis vulgaris
    • Pathirana D, Ormerod AD, Saiag P., et al. European S3-guidelines on the systemic treatment of psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2009; 23 (Suppl 2): 1-70
    • (2009) J Eur Acad Dermatol Venereol , vol.23 , Issue.2 , pp. 1-70
    • Pathirana, D.1    Ormerod, A.D.2    Saiag, P.3
  • 15
    • 37349003068 scopus 로고    scopus 로고
    • Adalimumab therapy for moderate to severe psoriasis: A randomized, controlled phase III trial
    • Menter A, Tyring SK, Gordon K., et al. Adalimumab therapy for moderate to severe psoriasis: a randomized, controlled phase III trial. J Am Acad Dermatol. 2008; 58 (1): 106-115
    • (2008) J Am Acad Dermatol , vol.58 , Issue.1 , pp. 106-115
    • Menter, A.1    Tyring, S.K.2    Gordon, K.3
  • 16
    • 39049143819 scopus 로고    scopus 로고
    • Efficacy and safety results from the randomized controlled comparative study of adalimumab vs. Methotrexate vs. Placebo in patients with psoriasis (CHAMPION)
    • Saurat JH, Stingl G, Dubertret L., et al. Efficacy and safety results from the randomized controlled comparative study of adalimumab vs. methotrexate vs. placebo in patients with psoriasis (CHAMPION). Br J Dermatol. 2008; 158 (3): 558-566
    • (2008) Br J Dermatol , vol.158 , Issue.3 , pp. 558-566
    • Saurat, J.H.1    Stingl, G.2    Dubertret, L.3
  • 17
    • 26644433889 scopus 로고    scopus 로고
    • Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: A phase III, multicentre, double-blind trial
    • Reich K, Nestle FO, Papp K., et al. Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, double-blind trial. Lancet. 2005; 366 (9494): 1367-1374
    • (2005) Lancet , vol.366 , Issue.9494 , pp. 1367-1374
    • Reich, K.1    Nestle, F.O.2    Papp, K.3
  • 18
    • 33845692734 scopus 로고    scopus 로고
    • A randomized comparison of continuous vs. Intermittent infliximab maintenance regimens over 1 year in the treatment of moderate-to-severe plaque psoriasis
    • Menter A, Feldman SR, Weinstein GD., et al. A randomized comparison of continuous vs. intermittent infliximab maintenance regimens over 1 year in the treatment of moderate-to-severe plaque psoriasis. J Am Acad Dermatol. 2007; 56 (1): 31.e1-15
    • (2007) J Am Acad Dermatol , vol.56 , Issue.1 , pp. 31e1-31e15
    • Menter, A.1    Feldman, S.R.2    Weinstein, G.D.3
  • 19
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    • Leonardi CL, Kimball AB, Papp KA., et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet. 2008; 371 (9625): 1665-1674
    • (2008) Lancet , vol.371 , Issue.9625 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3
  • 20
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
    • Papp KA, Langley RG, Lebwohl M., et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet. 2008; 371 (9625): 1675-1684
    • (2008) Lancet , vol.371 , Issue.9625 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3
  • 21
    • 0344926414 scopus 로고    scopus 로고
    • Etanercept as monotherapy in patients with psoriasis
    • Leonardi CL, Powers JL, Matheson RT., et al. Etanercept as monotherapy in patients with psoriasis. N Engl J Med. 2003; 349 (21): 2014-2022
    • (2003) N Engl J Med , vol.349 , Issue.21 , pp. 2014-2022
    • Leonardi, C.L.1    Powers, J.L.2    Matheson, R.T.3
  • 22
    • 84938992082 scopus 로고    scopus 로고
    • Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): Results from two phase 3 randomised trials
    • Griffiths CE, Reich K, Lebwohl M., et al. Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials. Lancet. 2015; 386 (9993): 541-551
    • (2015) Lancet , vol.386 , Issue.9993 , pp. 541-551
    • Griffiths, C.E.1    Reich, K.2    Lebwohl, M.3
  • 23
    • 84859017988 scopus 로고    scopus 로고
    • Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
    • Papp KA, Leonardi C, Menter A., et al. Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N Engl J Med. 2012; 366 (13): 1181-1189
    • (2012) N Engl J Med , vol.366 , Issue.13 , pp. 1181-1189
    • Papp, K.A.1    Leonardi, C.2    Menter, A.3
  • 24
    • 84925226246 scopus 로고    scopus 로고
    • Safety and efficacy of brodalumab for psoriasis after 120 weeks of treatment
    • Papp K, Leonardi C, Menter A., et al. Safety and efficacy of brodalumab for psoriasis after 120 weeks of treatment. J Am Acad Dermatol. 2014; 71 (6): 1183-90.e3
    • (2014) J Am Acad Dermatol , vol.71 , Issue.6 , pp. 1183-1183e3
    • Papp, K.1    Leonardi, C.2    Menter, A.3
  • 25
    • 84942876148 scopus 로고    scopus 로고
    • Phase 3 studies comparing brodalumab with ustekinumab in psoriasis
    • Lebwohl M, Strober B, Menter A., et al. Phase 3 studies comparing brodalumab with ustekinumab in psoriasis. N Engl J Med. 2015; 373 (14): 1318-1328
    • (2015) N Engl J Med , vol.373 , Issue.14 , pp. 1318-1328
    • Lebwohl, M.1    Strober, B.2    Menter, A.3
  • 26
    • 84954258528 scopus 로고    scopus 로고
    • Press Release]; [cited 2015 Aug 1 ]. Available from
    • Amgen to terminate participation in co-development and commercialization of brodalumab. [Press Release] 2015; [cited 2015 Aug 1 ]. Available from: http://www.prnewswire.com/news-releases/amgen-to-terminate-participation-in-co-development-and-commercialization-of-brodalumab-300088098.html
    • (2015) Amgen to Terminate Participation in Co-development and Commercialization of Brodalumab
  • 27
    • 84955646356 scopus 로고    scopus 로고
    • AstraZeneca and Valeant Pharmaceuticals to Partner on Brodalumab. [Press Release]. [cited 2015 Oct 29 ]. Available from: https://www.astrazeneca.com
    • AstraZeneca and Valeant Pharmaceuticals to Partner on Brodalumab. 2015; [Press Release]. [cited 2015 Oct 29 ]. Available from: https://www.astrazeneca.com
    • (2015)
  • 28
    • 84873124241 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled phase II dose-ranging study
    • Papp KA, Langley RG, Sigurgeirsson B., et al. Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study. Br J Dermatol. 2013; 168 (2): 412-421
    • (2013) Br J Dermatol , vol.168 , Issue.2 , pp. 412-421
    • Papp, K.A.1    Langley, R.G.2    Sigurgeirsson, B.3
  • 29
    • 84873168729 scopus 로고    scopus 로고
    • Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled, phase II regimen-finding study
    • Rich P, Sigurgeirsson B, Thaci D., et al. Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study. Br J Dermatol. 2013; 168 (2): 402-411
    • (2013) Br J Dermatol , vol.168 , Issue.2 , pp. 402-411
    • Rich, P.1    Sigurgeirsson, B.2    Thaci, D.3
  • 31
    • 84974735676 scopus 로고    scopus 로고
    • Interleukin-17 (IL-17) inhibitors in the treatment of plaque psoriasis: A review
    • Gooderham M, Posso-De Los Rios CJ, Rubio-Gomez GA., et al. Interleukin-17 (IL-17) inhibitors in the treatment of plaque psoriasis: a review. Skin Therapy Lett. 2015; 20 (1): 1-5
    • (2015) Skin Therapy Lett , vol.20 , Issue.1 , pp. 1-5
    • Gooderham, M.1    Posso-De Los Rios, C.J.2    Rubio-Gomez, G.A.3
  • 33
    • 69349093225 scopus 로고    scopus 로고
    • Interleukin-17 and type 17 helper T cells
    • Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. New England J Med. 2009; 361 (9): 888-898
    • (2009) New England J Med , vol.361 , Issue.9 , pp. 888-898
    • Miossec, P.1    Korn, T.2    Kuchroo, V.K.3
  • 34
    • 0347285359 scopus 로고    scopus 로고
    • Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
    • Lee E, Trepicchio WL, Oestreicher JL., et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med. 2004; 199 (1): 125-130
    • (2004) J Exp Med , vol.199 , Issue.1 , pp. 125-130
    • Lee, E.1    Trepicchio, W.L.2    Oestreicher, J.L.3
  • 35
    • 84872275425 scopus 로고    scopus 로고
    • The emerging role of IL-17 in the pathogenesis of psoriasis: Preclinical and clinical findings
    • Martin DA, Towne JE, Kricorian G., et al. The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings. J Invest Dermatol. 2013; 133 (1): 17-26
    • (2013) J Invest Dermatol , vol.133 , Issue.1 , pp. 17-26
    • Martin, D.A.1    Towne, J.E.2    Kricorian, G.3
  • 36
    • 84866992632 scopus 로고    scopus 로고
    • Psoriasis: Rationale for targeting interleukin-17
    • Girolomoni G, Mrowietz U, Paul C. Psoriasis: rationale for targeting interleukin-17. Br J Dermatol. 2012; 167 (4): 717-724
    • (2012) Br J Dermatol , vol.167 , Issue.4 , pp. 717-724
    • Girolomoni, G.1    Mrowietz, U.2    Paul, C.3
  • 37
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signalling in the IL-17 receptor family
    • Gaffen SL. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 2009; 9 (8): 556-567
    • (2009) Nat Rev Immunol , vol.9 , Issue.8 , pp. 556-567
    • Gaffen, S.L.1
  • 38
    • 77953541639 scopus 로고    scopus 로고
    • The IL-17 family cytokines in immunity and disease
    • Pappu R, Ramirez-Carrozzi V, Ota N., et al. The IL-17 family cytokines in immunity and disease. J Clin Immunol. 2010; 30 (2): 185-195
    • (2010) J Clin Immunol , vol.30 , Issue.2 , pp. 185-195
    • Pappu, R.1    Ramirez-Carrozzi, V.2    Ota, N.3
  • 40
    • 47249125726 scopus 로고    scopus 로고
    • Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes
    • Pène J, Chevalier S, Preisser L., et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol. 2008; 180 (11): 7423-7430
    • (2008) J Immunol , vol.180 , Issue.11 , pp. 7423-7430
    • Pène, J.1    Chevalier, S.2    Preisser, L.3
  • 41
    • 77958072084 scopus 로고    scopus 로고
    • Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
    • Hueber W, Patel DD, Dryja T., et al. Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med. 2010; 2 (52): 52ra72
    • (2010) Sci Transl Med , vol.2 , Issue.52 , pp. 52ra72
    • Hueber, W.1    Patel, D.D.2    Dryja, T.3
  • 42
    • 67349230808 scopus 로고    scopus 로고
    • The IL-23/Th17 axis in the immunopathogenesis of psoriasis
    • Di Cesare A, Di Meglio P, Nestle FO. The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol. 2009; 129 (6): 1339-1350
    • (2009) J Invest Dermatol , vol.129 , Issue.6 , pp. 1339-1350
    • Di Cesare, A.1    Di Meglio, P.2    Nestle, F.O.3
  • 43
    • 58549114666 scopus 로고    scopus 로고
    • Resident and "inflammatory" dendritic cells in human skin
    • Zaba LC, Krueger JG, Lowes MA. Resident and "inflammatory" dendritic cells in human skin. J Invest Dermatol. 2009; 129 (2): 302-308
    • (2009) J Invest Dermatol , vol.129 , Issue.2 , pp. 302-308
    • Zaba, L.C.1    Krueger, J.G.2    Lowes, M.A.3
  • 44
    • 84955636267 scopus 로고    scopus 로고
    • CosentyxTM (secukinumab subcutaneous injection): US prescribing information. Novartis Pharmaceuticals Corporation. [cited 2015 Sep 10 ]. Available from: http://www.pharma.us.novartis.com
    • CosentyxTM (secukinumab subcutaneous injection): US prescribing information. Novartis Pharmaceuticals Corporation. 2015; [cited 2015 Sep 10 ]. Available from: http://www.pharma.us.novartis.com
    • (2015)
  • 45
    • 70349753261 scopus 로고    scopus 로고
    • Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: Implications for psoriasis pathogenesis
    • Harper EG, Guo C, Rizzo H., et al. Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol. 2009; 129 (9): 2175-2183
    • (2009) J Invest Dermatol , vol.129 , Issue.9 , pp. 2175-2183
    • Harper, E.G.1    Guo, C.2    Rizzo, H.3
  • 46
    • 58349105187 scopus 로고    scopus 로고
    • Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin
    • Johansen C, Usher PA, Kjellerup RB., et al. Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 2009; 160 (2): 319-324
    • (2009) Br J Dermatol , vol.160 , Issue.2 , pp. 319-324
    • Johansen, C.1    Usher, P.A.2    Kjellerup, R.B.3
  • 47
    • 77951091571 scopus 로고    scopus 로고
    • Circulating Th17, Th22, and Th1 cells are increased in psoriasis
    • Kagami S, Rizzo HL, Lee JJ., et al. Circulating Th17, Th22, and Th1 cells are increased in psoriasis. J Invest Dermatol. 2010; 130 (5): 1373-1383
    • (2010) J Invest Dermatol , vol.130 , Issue.5 , pp. 1373-1383
    • Kagami, S.1    Rizzo, H.L.2    Lee, J.J.3
  • 48
    • 84923091605 scopus 로고    scopus 로고
    • cited 2015 Sep 10 ]. Available from
    • Advisory committee briefing material: Secukinumab (AIN457). 2014; [cited 2015 Sep 10 ]. Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/DermatologicandOphthalmicDrugsAdvisoryCommittee/UCM419023.pdf
    • (2014) Advisory Committee Briefing Material: Secukinumab (AIN457)
  • 50
    • 54249138516 scopus 로고    scopus 로고
    • Monoclonal antibody pharmacokinetics and pharmacodynamics
    • Wang W, Wang EQ, Balthasar JP. Monoclonal antibody pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 2008; 84 (5): 548-558
    • (2008) Clin Pharmacol Ther , vol.84 , Issue.5 , pp. 548-558
    • Wang, W.1    Wang, E.Q.2    Balthasar, J.P.3
  • 51
    • 84904545875 scopus 로고    scopus 로고
    • Secukinumab in plaque psoriasis-results of two phase 3 trials
    • Langley RG, Elewski BE, Lebwohl M., et al. Secukinumab in plaque psoriasis-results of two phase 3 trials. N Engl J Med. 2014; 371 (4): 326-338
    • (2014) N Engl J Med , vol.371 , Issue.4 , pp. 326-338
    • Langley, R.G.1    Elewski, B.E.2    Lebwohl, M.3
  • 52
    • 84929629144 scopus 로고    scopus 로고
    • Efficacy, safety and usability of secukinumab administration by autoinjector/pen in psoriasis: A randomized, controlled trial (JUNCTURE)
    • Paul C, Lacour JP, Tedremets L., et al. Efficacy, safety and usability of secukinumab administration by autoinjector/pen in psoriasis: a randomized, controlled trial (JUNCTURE). J Eur Acad Dermatol Venereol. 2015; 29 (6): 1082-1090
    • (2015) J Eur Acad Dermatol Venereol , vol.29 , Issue.6 , pp. 1082-1090
    • Paul, C.1    Lacour, J.P.2    Tedremets, L.3
  • 53
    • 84922933349 scopus 로고    scopus 로고
    • Secukinumab administration by pre-filled syringe: Efficacy, safety and usability results from a randomized controlled trial in psoriasis (FEATURE)
    • Blauvelt A, Prinz JC, Gottlieb AB., et al. Secukinumab administration by pre-filled syringe: efficacy, safety and usability results from a randomized controlled trial in psoriasis (FEATURE). Br J Dermatol. 2015; 172 (2): 484-493
    • (2015) Br J Dermatol , vol.172 , Issue.2 , pp. 484-493
    • Blauvelt, A.1    Prinz, J.C.2    Gottlieb, A.B.3
  • 54
    • 84924340693 scopus 로고    scopus 로고
    • The 5-point Investigators Global Assessment (IGA) Scale: A modified tool for evaluating plaque psoriasis severity in clinical trials
    • Langley RG, Feldman SR, Nyirady J., et al. The 5-point Investigators Global Assessment (IGA) Scale: a modified tool for evaluating plaque psoriasis severity in clinical trials. J Dermatolog Treat. 2015; 26 (1): 23-31
    • (2015) J Dermatolog Treat , vol.26 , Issue.1 , pp. 23-31
    • Langley, R.G.1    Feldman, S.R.2    Nyirady, J.3
  • 55
    • 84939463415 scopus 로고    scopus 로고
    • Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial
    • Thaci D, Blauvelt A, Reich K., et al. Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial. J Am Acad Dermatol. 2015; 73 (3): 400-409
    • (2015) J Am Acad Dermatol , vol.73 , Issue.3 , pp. 400-409
    • Thaci, D.1    Blauvelt, A.2    Reich, K.3
  • 56
    • 84942198180 scopus 로고    scopus 로고
    • Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): A randomised, double-blind, placebo-controlled, phase 3 trial
    • McInnes IB, Mease PJ, Kirkham B., et al. Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2015;386(9999): 1137-1146
    • (2015) Lancet , vol.386 , Issue.9999 , pp. 1137-1146
    • McInnes, I.B.1    Mease, P.J.2    Kirkham, B.3
  • 57
    • 84922411329 scopus 로고    scopus 로고
    • Secukinumab, a human anti-interluekin-17A monoclonal antibody improves active psoriatic arthritis and inhibits radiograph progression: Efficacy and safety data from a phase 3 randomized, multicenter, double-blind, placebo-controlled study
    • Abstract 953
    • Mease PJ, McInnes IB, Kirkham B., et al. Secukinumab, a human anti-interluekin-17A monoclonal antibody improves active psoriatic arthritis and inhibits radiograph progression: efficacy and safety data from a phase 3 randomized, multicenter, double-blind, placebo-controlled study. Am Coll Rheumatol. [Abstract 953] 2014; 66: S423-S4
    • (2014) Am Coll Rheumatol , vol.66 , pp. S423-S424
    • Mease, P.J.1    McInnes, I.B.2    Kirkham, B.3
  • 58
    • 84929158936 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in the treatment of moderate to severe plaque psoriasis: A meta-analysis of randomized controlled trials
    • Xiong HZ, Gu JY, He ZG., et al. Efficacy and safety of secukinumab in the treatment of moderate to severe plaque psoriasis: a meta-analysis of randomized controlled trials. Int J Clin Exp Med. 2015; 8 (3): 3156-3172
    • (2015) Int J Clin Exp Med , vol.8 , Issue.3 , pp. 3156-3172
    • Xiong, H.Z.1    Gu, J.Y.2    He, Z.G.3
  • 59
    • 53949090557 scopus 로고    scopus 로고
    • Patients with chronic mucocutaneous candidiasis exhibit reduced production of Th17-associated cytokines IL-17 and IL-22
    • Eyerich K, Foerster S, Rombold S., et al. Patients with chronic mucocutaneous candidiasis exhibit reduced production of Th17-associated cytokines IL-17 and IL-22. J Invest Dermatol. 2008; 128 (11): 2640-2645
    • (2008) J Invest Dermatol , vol.128 , Issue.11 , pp. 2640-2645
    • Eyerich, K.1    Foerster, S.2    Rombold, S.3
  • 60
    • 0034807936 scopus 로고    scopus 로고
    • Interleukin-17 and lung host defense against Klebsiella pneumoniae infection
    • Ye P, Garvey PB, Zhang P., et al. Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol. 2001; 25 (3): 335-340
    • (2001) Am J Respir Cell Mol Biol , vol.25 , Issue.3 , pp. 335-340
    • Ye, P.1    Garvey, P.B.2    Zhang, P.3
  • 61
    • 3242814586 scopus 로고    scopus 로고
    • Requirement of interleukin-17A for systemic anti- Candida albicans host defense in mice
    • Huang W, Na L, Fidel PL., et al. Requirement of interleukin-17A for systemic anti- Candida albicans host defense in mice. J Infect Dis. 2004; 190 (3): 624-631
    • (2004) J Infect Dis , vol.190 , Issue.3 , pp. 624-631
    • Huang, W.1    Na, L.2    Fidel, P.L.3
  • 62
    • 78149491862 scopus 로고    scopus 로고
    • IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans
    • Kagami S, Rizzo HL, Kurtz SE., et al. IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans. J Immunol. 2010; 185 (9): 5453-5462
    • (2010) J Immunol , vol.185 , Issue.9 , pp. 5453-5462
    • Kagami, S.1    Rizzo, H.L.2    Kurtz, S.E.3
  • 63
    • 0035761425 scopus 로고    scopus 로고
    • Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice
    • Forlow SB, Schurr JR, Kolls JK., et al. Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice. Blood. 2001; 98 (12): 3309-3314
    • (2001) Blood , vol.98 , Issue.12 , pp. 3309-3314
    • Forlow, S.B.1    Schurr, J.R.2    Kolls, J.K.3
  • 64
    • 84892827750 scopus 로고    scopus 로고
    • Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, ROR[gamma]t and dectin-2
    • Taylor PR, Roy S, Leal SM Jr., et al. Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, ROR[gamma]t and dectin-2. Nat Immunol. 2014; 15 (2): 143-151
    • (2014) Nat Immunol , vol.15 , Issue.2 , pp. 143-151
    • Taylor, P.R.1    Roy, S.2    Leal, S.M.3
  • 65
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of interleukin 17 in inflammatory bowel disease
    • Fujino S, Andoh A, Bamba S., et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 2003; 52 (1): 65-70
    • (2003) Gut , vol.52 , Issue.1 , pp. 65-70
    • Fujino, S.1    Andoh, A.2    Bamba, S.3
  • 66
    • 79955563439 scopus 로고    scopus 로고
    • Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
    • Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011; 140 (6): 1756-1767
    • (2011) Gastroenterology , vol.140 , Issue.6 , pp. 1756-1767
    • Strober, W.1    Fuss, I.J.2
  • 67
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohns disease: Unexpected results of a randomised, double-blind placebo-controlled trial
    • Hueber W, Sands BE, Lewitzky S., et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohns disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut. 2012; 61 (12): 1693-1700
    • (2012) Gut , vol.61 , Issue.12 , pp. 1693-1700
    • Hueber, W.1    Sands, B.E.2    Lewitzky, S.3
  • 68
    • 77149124612 scopus 로고    scopus 로고
    • Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type i
    • Puel A, Doffinger R, Natividad A., et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J Exp Med. 2010; 207 (2): 291-297
    • (2010) J Exp Med , vol.207 , Issue.2 , pp. 291-297
    • Puel, A.1    Doffinger, R.2    Natividad, A.3
  • 69
    • 84863722197 scopus 로고    scopus 로고
    • Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: Molecular, cellular, and clinical features from a French national survey
    • Chandesris MO, Melki I, Natividad A., et al. Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey. Medicine (Baltimore). 2012; 91 (4): e1-19
    • (2012) Medicine (Baltimore) , vol.91 , Issue.4 , pp. e1-19
    • Chandesris, M.O.1    Melki, I.2    Natividad, A.3
  • 72
    • 84925430776 scopus 로고    scopus 로고
    • PASI90 response: The new standard in therapeutic efficacy for psoriasis
    • Puig L. PASI90 response: the new standard in therapeutic efficacy for psoriasis. J Eur Acad Dermatol Venereol. 2015; 29 (4): 645-648
    • (2015) J Eur Acad Dermatol Venereol , vol.29 , Issue.4 , pp. 645-648
    • Puig, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.