Genetic Control over mtDNA and Its Relationship to Major Depressive Disorder

Current Biology

Volumn 25, Issue 24, 2015, Pages 3170-3177

  Cai, Na ^a   Li, Yihan ^a   Chang, Simon ^b   Liang, Jieqin ^c   Lin, Chongyun ^c   Zhang, Xiufei ^c   Liang, Lu ^c   Hu, Jingchu ^c   Chan, Wharton ^a   Kendler, Kenneth S ^d   Malinauskas, Tomas ^e   Huang, Guo Jen ^b   Li, Qibin ^c   Mott, Richard ^a   Flint, Jonathan ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c BGI SHENZHEN   (China)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^e Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ANIMAL; ASIAN CONTINENTAL ANCESTRY GROUP; CASE CONTROL STUDY; CHINA; COPY NUMBER VARIATION; FEMALE; GENETICS; HUMAN; MAJOR DEPRESSION; METABOLISM; MOUSE;

ANIMALS; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHINA; DEPRESSIVE DISORDER, MAJOR; DNA COPY NUMBER VARIATIONS; DNA, MITOCHONDRIAL; FEMALE; HUMANS; MICE;

EID: 84955636634     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2015.10.065     Document Type: Article

References (30)

1. E.D. Robin, and R. Wong Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells J. Cell. Physiol. 136 1988 507 513
2. L.L. Clay Montier, J.J. Deng, and Y. Bai Number matters: control of mammalian mitochondrial DNA copy number J. Genet. Genomics 36 2009 125 131
3. Y. Tang, E.A. Schon, E. Wilichowski, M.E. Vazquez-Memije, E. Davidson, and M.P. King Rearrangements of human mitochondrial DNA (mtDNA): new insights into the regulation of mtDNA copy number and gene expression Mol. Biol. Cell 11 2000 1471 1485
4. C.T. Campbell, J.E. Kolesar, and B.A. Kaufman Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number Biochim. Biophys. Acta 1819 2012 921 929
5. I.G. Johnston, B. Gaal, R.P. Neves, T. Enver, F.J. Iborra, and N.S. Jones Mitochondrial variability as a source of extrinsic cellular noise PLoS Comput. Biol. 8 2012 e1002416
6. N. Cai, S. Chang, Y. Li, Q. Li, J. Hu, J. Liang, L. Song, W. Kretzschmar, X. Gan, J. Nicod, and et al. Molecular signatures of major depression Curr. Biol. 25 2015 1146 1156
7. CONVERGE Consortium Sparse whole-genome sequencing identifies two loci for major depressive disorder Nature 523 2015 588 591
8. D. Speed, G. Hemani, M.R. Johnson, and D.J. Balding Improved heritability estimation from genome-wide SNPs Am. J. Hum. Genet. 91 2012 1011 1021
9. R.J. Pruim, R.P. Welch, S. Sanna, T.M. Teslovich, P.S. Chines, T.P. Gliedt, M. Boehnke, G.R. Abecasis, and C.J. Willer LocusZoom: regional visualization of genome-wide association scan results Bioinformatics 26 2010 2336 2337
10. A. Boyd, J. Golding, J. Macleod, D.A. Lawlor, A. Fraser, J. Henderson, L. Molloy, A. Ness, S. Ring, and G. Davey Smith Cohort Profile: the 'children of the 90s' - the index offspring of the Avon Longitudinal Study of Parents and Children Int. J. Epidemiol. 42 2013 111 127
11. K. Walter, J.L. Min, J. Huang, L. Crooks, Y. Memari, S. McCarthy, J.R. Perry, C. Xu, M. Futema, D. Lawson, et al. UK10K Consortium The UK10K project identifies rare variants in health and disease Nature 526 2015 82 90
12. J. Ding, C. Sidore, T.J. Butler, M.K. Wing, Y. Qian, O. Meirelles, F. Busonero, L.C. Tsoi, A. Maschio, A. Angius, and et al. Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ∼2,000 Sardinians Using Tailored Sequencing Analysis Tools PLoS Genet. 11 2015 e1005306
13. E. Hazkani-Covo, R.M. Zeller, and W. Martin Molecular poltergeists: mitochondrial DNA copies (numts) in sequenced nuclear genomes PLoS Genet. 6 2010 e1000834
14. G.K. Marinov, Y.E. Wang, D. Chan, and B.J. Wold Evidence for site-specific occupancy of the mitochondrial genome by nuclear transcription factors PLoS ONE 9 2014 e84713
15. G.R. Abecasis, A. Auton, L.D. Brooks, M.A. DePristo, R.M. Durbin, R.E. Handsaker, H.M. Kang, G.T. Marth, G.A. McVean 1000 Genomes Project Consortium An integrated map of genetic variation from 1,092 human genomes Nature 491 2012 56 65
16. T.R. Mercer, S. Neph, M.E. Dinger, J. Crawford, M.A. Smith, A.M. Shearwood, E. Haugen, C.P. Bracken, O. Rackham, J.A. Stamatoyannopoulos, and et al. The human mitochondrial transcriptome Cell 146 2011 645 658
17. S.H. Lee, J. Yang, M.E. Goddard, P.M. Visscher, and N.R. Wray Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood Bioinformatics 28 2012 2540 2542
18. M.I. Ekstrand, M. Falkenberg, A. Rantanen, C.B. Park, M. Gaspari, K. Hultenby, P. Rustin, C.M. Gustafsson, and N.G. Larsson Mitochondrial transcription factor A regulates mtDNA copy number in mammals Hum. Mol. Genet. 13 2004 935 944
19. K. Meuer, I.E. Suppanz, P. Lingor, V. Planchamp, B. Göricke, L. Fichtner, G.H. Braus, G.P. Dietz, S. Jakobs, M. Bähr, and J.H. Weishaupt Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis Cell Death Differ. 14 2007 651 661
20. S.M. Rosenberg Evolving responsively: adaptive mutation Nat. Rev. Genet. 2 2001 504 515
21. P.J. Hastings, H.J. Bull, J.R. Klump, and S.M. Rosenberg Adaptive amplification: an inducible chromosomal instability mechanism Cell 103 2000 723 731
22. S.S. Lee, R.Y. Lee, A.G. Fraser, R.S. Kamath, J. Ahringer, and G. Ruvkun A systematic RNAi screen identifies a critical role for mitochondria in C. Elegans longevity Nat. Genet. 33 2003 40 48
23. M. Ikeuchi, H. Matsusaka, D. Kang, S. Matsushima, T. Ide, T. Kubota, T. Fujiwara, N. Hamasaki, A. Takeshita, K. Sunagawa, and H. Tsutsui Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction Circulation 112 2005 683 690
24. B.R. Gauthier, A. Wiederkehr, M. Baquié, C. Dai, A.C. Powers, J. Kerr-Conte, F. Pattou, R.J. MacDonald, J. Ferrer, and C.B. Wollheim PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression Cell Metab. 10 2009 110 118
25. Y. Hayashi, M. Yoshida, M. Yamato, T. Ide, Z. Wu, M. Ochi-Shindou, T. Kanki, D. Kang, K. Sunagawa, H. Tsutsui, and H. Nakanishi Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice J. Neurosci. 28 2008 8624 8634
26. Y. Piao, H.G. Kim, M.S. Oh, and Y.K. Pak Overexpression of TFAM, NRF-1 and myr-AKT protects the MPP(+)-induced mitochondrial dysfunctions in neuronal cells Biochim. Biophys. Acta 1820 2012 577 585
27. J. Suarez, Y. Hu, A. Makino, E. Fricovsky, H. Wang, and W.H. Dillmann Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardiomyocytes Am. J. Physiol. Cell Physiol. 295 2008 C1561 C1568
28. H. Li, B. Handsaker, A. Wysoker, T. Fennell, J. Ruan, N. Homer, G. Marth, G. Abecasis, R. Durbin 1000 Genome Project Data Processing Subgroup The Sequence Alignment/Map format and SAMtools Bioinformatics 25 2009 2078 2079
29. H. Li, and R. Durbin Fast and accurate short read alignment with Burrows-Wheeler transform Bioinformatics 25 2009 1754 1760
30. J. Listgarten, C. Lippert, C.M. Kadie, R.I. Davidson, E. Eskin, and D. Heckerman Improved linear mixed models for genome-wide association studies Nat. Methods 9 2012 525 526