Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

Science

Volumn 351, Issue 6271, 2016, Pages 397-400

  Chen, Qi ^a,c   Yan, Menghong ^b   Cao, Zhonghong ^a,e   Li, Xin ^a   Zhang, Yunfang ^a,e   Shi, Junchao ^a,e   Feng, Gui Hai ^a   Peng, Hongying ^a,d   Zhang, Xudong ^a,e   Zhang, Ying ^a   Qian, Jingjing ^a,e   Duan, Enkui ^a   Zhai, Qiwei ^b   Zhou, Qi ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^d BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUCOSE; INSULIN; MICRORNA; TRANSCRIPTOME; TRANSFER RNA; TRANSFER RNA DERIVED SMALL RNA; UNCLASSIFIED DRUG;

DIET; EMBRYO; GENE EXPRESSION; METABOLISM; PATERNAL EFFECT; RNA; RODENT; SPERM;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOHYDRATE METABOLISM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIET INDUCED OBESITY; DNA METHYLATION; EMBRYO; EMBRYO DEVELOPMENT; ENVIRONMENTAL EXPOSURE; EPIGENETICS; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; GLUCOSE BLOOD LEVEL; IMPAIRED GLUCOSE TOLERANCE; INHERITANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; METABOLIC REGULATION; METABOLISM; MOLECULAR SIZE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; RNA SEQUENCE; RNA STABILITY; SPERM; SPERMATOZOON HEAD; UPREGULATION; WEIGHT GAIN; ZYGOTE; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; FATHER; GC RICH SEQUENCE; GENETIC EPIGENESIS; GENETICS; METABOLIC DISORDER; SPERMATOZOON;

ANIMALS; DIET, HIGH-FAT; DNA METHYLATION; EPIGENESIS, GENETIC; FATHERS; GC RICH SEQUENCE; MALE; METABOLIC DISEASES; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; RNA, TRANSFER; SPERMATOZOA;

EID: 84955486679     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad7977     Document Type: Article

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