Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain

ACS Medicinal Chemistry Letters

Volumn 7, Issue 1, 2016, Pages 77-82

  Jones, Brian D ^a   Tochowicz, Anna ^b   Tang, Yinyan ^c   Cameron, Michael D ^a   McCall, Laura Isobel ^d   Hirata, Ken ^e   Siqueira Neto, Jair L ^d   Reed, Sharon L ^f   McKerrow, James H ^b,d   Roush, William R ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chagas' disease; cysteine protease inhibitor; kinetics; noncovalent inhibitor; vinyl sulfone; X ray crystallography

Indexed keywords

CRUZIPAIN; CYSTEINE PROTEINASE INHIBITOR; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; UNCLASSIFIED DRUG; WRR 483; WRR 666; WRR 669; WRR 675;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; TRYPANOSOMA CRUZI;

EID: 84955465701     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00336     Document Type: Article

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