Controlling molecular transport in minimal emulsions

Nature Communications

Volumn 7, Issue , 2016, Pages

  Gruner, Philipp ^a   Riechers, Birte ^a,b   Semin, Benoît ^a,c   Lim, Jiseok ^a,d   Johnston, Abigail ^a   Short, Kathleen ^a   Baret, Jean Christophe ^a,b  

^a MAX PLANCK INSTITUTE FOR DYNAMICS AND SELF ORGANIZATION   (Germany)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d Yeungnam University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FAT DROPLET; FLUORINATED OIL; OIL; UNCLASSIFIED DRUG; WATER; WATER OIL CREAM;

BIOTECHNOLOGY; COMPLEXITY; DESIGN METHOD; DISPERSION; DROPLET; EMULSION; MOLECULAR ANALYSIS; OIL; ORGANIC COMPOUND;

ARTICLE; BIOTECHNOLOGICAL PROCEDURES; CHEMICAL COMPOSITION; DISPERSION; MICROFLUIDICS; MOLECULAR DYNAMICS; THERMODYNAMICS; TRANSPORT KINETICS;

EID: 84955442601     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10392     Document Type: Article

References (60)

1. Bibette, J., Leal-Calderon, F. & Poulin, P. Emulsions: basic principles. Rep. Prog. Phys. 62, 696-1033 (1999).
2. McClements, D. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter 8, 1719-1729 (2012).
3. Rosen, M. J. Surfactants and Interfacial Phenomena, i-xiii (John Wiley & Sons, Inc., 2004).
4. Tawfik, D. S. & Griffiths, A. D. Man-made cell-like compartments for molecular evolution. Nat. Biotechnol. 16, 652-656 (1998).
5. Taly, V., Kelly, B. T. & Griffiths, A. D. Droplets as microreactors for highthroughput biology. ChemBioChem 8, 263-272 (2007).
6. Teh, S.-Y., Lin, R., Hung, L.-H. & Lee, A. P. Droplet microfluidics. Lab Chip 8, 198-220 (2008).
7. Seemann, R., Brinkmann, M., Pfohl, T. & Herminghaus, S. Droplet-based microfluidics. Reports on Progress in Physics 75, 016601 (2012).
8. Guo, M. T., Rotem, A., Heyman, J. A. & Weitz, D. A. Droplet microfluidics for high-throughput biological assays. Lab Chip 12, 2146-2155 (2012).
9. Theberge, A. B. et al. Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology. Angew. Chem. Int. Ed. 49, 5846-5868 (2010).
10. Baret, J.-C., Beck, Y., Billas-Massobrio, I., Moras, D. & Griffiths, A. D. Quantitative cell-based reporter gene assays using droplet-based microfluidics. Chem. Biol. 17, 528-536 (2010).
11. Miller, O. J. et al. High-resolution dose-response screening using droplet-based microfluidics. Proc. Natl Acad. Sci. USA 109, 378-383 (2012).
12. Pekin, D. et al. Quantitative and sensitive detection of rare mutations using droplet-based microfluidics. Lab Chip 11, 2156-2166 (2011).
13. Taly, V. et al. Multiplex picodroplet digital PCR to detect KRAS mutations in circulating DNA from the plasma of colorectal cancer patients. Clin. Chem. 59, 1722-1731 (2013).
14. Didelot, A. et al. Multiplex picoliter-droplet digital PCR for quantitative assessment of DNA integrity in clinical samples. Clin. Chem. 59, 815-823 (2013).
15. Baret, J.-C. et al. Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity. Lab Chip 9, 1850-1858 (2009).
16. Debs, B. E., Utharala, R., Balyasnikova, I. V., Griffiths, A. D. & Merten, C. A. Functional single-cell hybridoma screening using droplet-based microfluidics. Proc. Natl Acad. Sci. USA 109, 11570-11575 (2012).
17. Sjostrom, S. L. et al. High-throughput screening for industrial enzyme production hosts by droplet microfluidics. Lab Chip 14, 806-813 (2014).
18. Agresti, J. J. et al. Ultrahigh-throughput screening in drop-based microfluidics for directed evolution. Proc. Natl Acad. Sci. USA 107, 4004-4009 (2010).
19. Wang, B. L. et al. Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption. Nat. Biotechnol. 32, 473-478 (2014).
20. Krafft, M. P. Fluorocarbons and fluorinated amphiphiles in drug delivery and biomedical research. Adv. Drug Deliv. Rev. 47, 209-228 (2001).
21. Baret, J.-C. Surfactants in droplet-based microfluidics. Lab Chip 12, 422-433 (2012).
22. Scott, R. The solubility of fluorocarbons. J. Am. Chem. Soc. 70, 4090-4093 (1948).
23. Simons, J. H. & Linevsky, M. J. The solubility of organic solids in fluorocarbon derivatives. J. Am. Chem. Soc. 74, 4750-4751 (1952).
24. Kabalnov, A. Can micelles mediate a mass transfer between oil droplets? Langmuir 10, 680-684 (1994).
25. Mazutis, L. et al. Multi-step microfluidic droplet processing: kinetic analysis of an in vitro translated enzyme. Lab Chip 9, 2902-2908 (2009).
26. Courtois, F. et al. Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays. Anal. Chem. 81, 3008-3016 (2009).
27. Bai, Y. et al. A double droplet trap system for studying mass transport across a droplet-droplet interface. Lab Chip 10, 1281-1285 (2010).
28. Wu, N. et al. Management of the diffusion of 4-methylumbelliferone across phases in microdroplet-based systems for in vitro protein evolution. Electrophoresis 31, 3121-3128 (2010).
29. Sandoz, P. A., Chung, A. J., Weaver, W. M. & Carlo, D. D. Sugar additives improve signal fidelity for implementing two-phase resorufin-based enzyme immunoassays. Langmuir 30, 6637-6643 (2014).
30. Thiam, A., Bremond, N. & Bibette, J. From stability to permeability of adhesive emulsion bilayers. Langmuir 28, 6291-6298 (2012).
31. Bremond, N. & Bibette, J. Exploring emulsion science with microfluidics. Soft Matter 8, 10549-10559 (2012).
32. Brosseau, Q., Vrignon, J. & Baret, J.-C. Microfluidic dynamic interfacial tensiometry (mDIT). Soft Matter 10, 3066-3076 (2014).
33. Skhiri, Y. et al. Dynamics of molecular transport by surfactants in emulsions. Soft Matter 8, 10618-10627 (2012).
34. Fradet, E. et al. Combining rails and anchors with laser forcing for selective manipulation within 2d droplet arrays. Lab Chip 11, 4228-4234 (2011).
35. Abate, A. R., Hung, T., Mary, P., Agresti, J. J. & Weitz, D. A. High-throughput injection with microfluidics using picoinjectors. Proc. Natl Acad. Sci. USA 107, 19163-19166 (2010).
36. Thorsen, T., Roberts, R. W., Arnold, F. H. & Quake, S. R. Dynamic pattern formation in a vesicle-generating microfluidic device. Phys. Rev. Lett. 86, 4163-4166 (2001).
37. Woronoff, G. et al. New generation of amino coumarin methyl sulfonate-based fluorogenic substrates for amidase assays in droplet-based microfluidic applications. Anal. Chem. 83, 2852-2857 (2011).
38. Zheng, B., Tice, J. D. & Ismagilov, R. F. Formation of droplets of in microfluidic channels alternating composition and applications to indexing of concentrations in droplet-based assays. Anal. Chem. 76, 4977-4982 (2004).
39. Hung, L. H. et al. Alternating droplet generation and controlled dynamic droplet fusion in microfluidic device for Cds nanoparticle synthesis. Lab Chip 6, 174-178 (2006).
40. Frenz, L., Blouwolff, J., Griffiths, A. D. & Baret, J.-C. Microfluidic production of droplet pairs. Langmuir 24, 12073-12076 (2008).
41. Tang, S. K. Y. et al. A multi-color fast-switching microfluidic droplet dye laser. Lab Chip 9, 2767-2771 (2009).
42. Abbyad, P., Dangla, R., Alexandrou, A. & Baroud, C. N. Rails and anchors: guiding and trapping droplet microreactors in two dimensions. Lab Chip 11, 813-821 (2011).
43. Dangla, R., Lee, S. & Baroud, C. N. Trapping microfluidic drops in wells of surface energy. Phys. Rev. Lett. 107, 124501 (2011).
44. Zwolinski, B. J., Eyring, H. & Reese, C. E. Diffusion and membrane permeability. J. Phys. Chem. 53, 1426-1453 (1949).
45. Chen, Y., Gani, A. & Tang, S. Characterization of sensitivity and specifity in leaky droplet-based assays. Soft Matter 12, 5093-5103 (2012).
46. Poulsen, S., Harrington, R. & Drever, J. The solubility of toluene in aqueous salt solutions. Talanta 48, 633-641 (1999).
47. Boitard, L. et al. Monitoring single-cell bioenergetics via the coarsening of emulsion droplets. Proc. Natl Acad. Sci. USA 109, 7181-7186 (2012).
48. Hofmann, T. W., Hänselmann, S., Janiesch, J.-W., Rademacher, A. & Böhm, C. H. J. Applying microdroplets as sensors for label-free detection of chemical reactions. Lab Chip 12, 916-922 (2012).
49. Mai, Y. & Eisenberg, A. Self assembly of block copolymers. Chem. Soc. Rev. 41, 5969-5985 (2012).
50. Vincent, J. M. Non-covalent associations in fluorous fluids. J. Fluorine Chem. 129, 903-909 (2008).
51. O'Neal, K. L. & Weber, S. G. Extraction of pyridines into fluorous solvents based on hydrogen bond complex formation with carboyxlic acid receptors. Anal. Chem. 79, 3117-3215 (2007).
52. O'Neal, K. L. & Weber, S. G. Molecular and ionic hydrogen bond formation in fluorous solvents. J. Phys. Chem. B 113, 113-149 (2009).
53. Palomo, C., Aizpurua, J. M., Loinaz, M. J., Fernandez-Berridi, M. J. & Irusta, L. Scavenging of fluorinated N,N′-dialkylureas by hydrogen binding: a novel separation method for fluorous synthesis. Org. Lett. 3, 2361-2364 (2001).
54. Hyman, A. A. & Simons, K. Cell biology. beyond oil and water-phase transitions in cells. Science 337, 1047-1049 (2012).
55. Oparin, A. I. The origin of life and the origin of enzymes. Adv. Enzymol. Relat. Areas Mol. Biol. 27, 347-380 (1965).
56. Fallah-Araghi, A. et al. Enhanced chemical synthesis at soft interfaces: A universal reaction-adsorption mechanism in microcompartments. Phys. Rev. Lett. 112, 028301 (2014).
57. Sokolova, E. et al. Enhanced transcription rates in membrane-free protocells formed by coacervation of cell lysate. Proc. Natl Acad. Sci. USA 110, 11692-11697 (2013).
58. Spruijt, E., Sokolova, E. & Huck, W. T. S. Complexity of molecular crowding in cell-free enzymatic reaction networks. Nat. Nanotechnol. 9, 406-407 (2014).
59. Holtze, C. et al. Biocompatible surfactants for water-in-fluorocarbon emulsions. Lab Chip 8, 1632-1639 (2008).
60. Scanga, R. et al. Fluorinated amphiphilic block copolymers to stabilize water-in-fluorocarbon emulsions. Polymer Preprints 50, 148-149 (2009).