Development of epilepsy after ischaemic stroke

The Lancet Neurology

Volumn 15, Issue 2, 2016, Pages 185-197

  Pitkänen, Asla ^a   Roivainen, Reina ^b   Lukasiuk, Katarzyna ^c  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b HYVINKÄÄ HOSPITAL   (Finland)

^c NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

BRAIN BLOOD VESSEL; BRAIN ISCHEMIA; CEREBROVASCULAR DISEASE; DISEASE COURSE; DISEASE SEVERITY; ENDOPHENOTYPE; EPILEPSY; EPILEPTOGENESIS; EXPOSURE; HEREDITY; HUMAN; INJURY SEVERITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK FACTOR; STROKE PATIENT; WHITE MATTER; ANIMAL; CEREBROVASCULAR ACCIDENT; COMPLICATION;

ANIMALS; BRAIN ISCHEMIA; EPILEPSY; HUMANS; STROKE;

EID: 84955384366     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(15)00248-3     Document Type: Review

References (133)

1. Pitkanen A, Nehlig A, Brooks-Kayal AR, et al. Issues related to development of antiepileptogenic therapies. Epilepsia 2013, 54(suppl 4):35-43.
2. Pitkänen A ST Is epilepsy a progressive disease? Prospects for new therapeutic approaches in temporal lobe epilepsy. Lancet Neurol 2002, 1:73-81.
3. Kanner AM, Mazarati A, Koepp M Biomarkers of epileptogenesis: psychiatric comorbidities (?). Neurotherapeutics 2014, 11:358-372.
4. Pitkanen A, Lukasiuk K Mechanisms of epileptogenesis and potential treatment targets. Lancet Neurol 2011, 10:173-186.
5. Hauser WA, Annegers JF, Kurland LT Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 1993, 34:453-468.
6. Bladin CF, Alexandrov AV, Bellavance A, et al. Seizures after stroke: a prospective multicenter study. Arch Neurol 2000, 57:1617-1622.
7. Menon B, Shorvon SD Ischaemic stroke in adults and epilepsy. Epilepsy Res 2009, 87:1-11.
8. Jungehulsing GJ, Heuschmann PU, Holtkamp M, Schwab S, Kolominsky-Rabas PL Incidence and predictors of post-stroke epilepsy. Acta Neurol Scand 2013, 127:427-430.
9. Graham NSN, Crichton S, Koutroumanidis M, Wolfe CD, Rudd AG Incidence and associations of poststroke epilepsy the prospective South London stroke register. Stroke 2013, 44:605-611.
10. Zhang C, Wang X, Wang Y, et al. Risk factors for post-stroke seizures: a systematic review and meta-analysis. Epilepsy Res 2014, 108:1806-1816.
11. Adelow C, Andersson T, Ahlbom A, Tomson T Prior hospitalization for stroke, diabetes, myocardial infarction, and subsequent risk of unprovoked seizures. Epilepsia 2011, 52:301-307.
12. Adams HP, Biller J Classification of subtypes of ischemic stroke: history of the trial of org 10 172 in acute stroke treatment classification. Stroke 2015, 114-118.
13. Nelson KB Is it HIE? And why that matters. Acta Paediatr 2007, 96:1113-1114.
14. Jacobs BS, Boden-Albala B, Lin I-F, Sacco RL Stroke in the young in the northern Manhattan stroke study. Stroke 2002, 33:2789-2793.
15. Putaala J, Curtze S, Hiltunen S, Tolppanen H, Kaste M, Tatlisumak T Causes of death and predictors of 5-year mortality in young adults after first-ever ischemic stroke: the Helsinki Young Stroke Registry. Stroke 2009, 40:2698-2703.
16. Teasdale G, Jennett B Assessment of coma and impaired consciousness. A practical scale. Lancet 1974, 2:81-84.
17. Beghi E, Carpio A, Forsgren L, et al. Recommendation for a definition of acute symptomatic seizure. Epilepsia 2010, 51:671-675.
18. Feigin VL, Lawes CMM, Bennett DA, Barker-Collo SL, Parag V Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol 2009, 8:355-369.
19. So EL, Annegers JF, Hauser W, O'Brien PC, Whisnant JP Population-based study of seizure disorders after cerebral infarction. Neurology 1996, 46:350-355.
20. Burn J, Dennis M, Bamford J, Sandercock P, Wade D, Warlow C Epileptic seizures after a first stroke: the Oxfordshire Community Stroke Project. BMJ 1997, 315:1582-1587.
21. Lamy C, Domigo V, Semah F, et al. Early and late seizures after cryptogenic ischemic stroke in young adults. Neurology 2003, 60:400-404.
22. Lossius MI, Ronning OM, Slapo GD, Mowinckel P, Gjerstad L Poststroke epilepsy: occurrence and predictors-a long-term prospective controlled study (Akershus Stroke Study). Epilepsia 2005, 46:1246-1251.
23. Roivainen R, Haapaniemi E, Putaala J, Kaste M, Tatlisumak T Young adult ischaemic stroke related acute symptomatic and late seizures: risk factors. Eur J Neurol 2013, 20:1247-1255.
24. Lee J-C, Lin K-L, Wang H-S, et al. Seizures in childhood ischemic stroke in Taiwan. Brain Dev 2009, 31:294-299.
25. Hsu C-J, Weng W-C, Peng SS-F, Lee W-T Early-onset seizures are correlated with late-onset seizures in children with arterial ischemic stroke. Stroke 2014, 45:1161-1163.
26. Cloyd J, Hauser W, Towne A, et al. Epidemiological and medical aspects of epilepsy in the elderly. Epilepsy Res 2006, 68(suppl 1):S39-S48.
27. Holmes GL, Milh MDM, Dulac O Maturation of the human brain and epilepsy. Handb Clin Neurol 2012, 107:135-143.
28. De Reuck J, Goethals M, Claeys I, Van Maele G, De Clerck M EEG findings after a cerebral territorial infarct in patients who develop early- and late-onset seizures. Eur Neurol 2006, 55:209-213.
29. Horner S, Ni XS, Duft M, Niederkorn K, Lechner H EEG, CT and neurosonographic findings in patients with postischemic seizures. J Neurol Sci 1995, 132:57-60.
30. McBride AE, Shih TT, Hirsch LJ Video-EEG monitoring in the elderly: a review of 94 patients. Epilepsia 2002, 43:165-169.
31. Jungehulsing GJ, Heuschmann PU, Holtkamp M, Schwab S, Kolominsky-Rabas PL Incidence and predictors of post-stroke epilepsy. Acta Neurol Scand 2013, 127:427-430.
32. Arntz R, Rutten-Jacobs L, Maaijwee N, et al. Post-stroke epilepsy in young adults: a long-term follow-up study. PLoS One 2013, 8:e55498.
33. Hsu C-J, Weng W-C, Peng SS-F, Lee W-T Early-onset seizures are correlated with late-onset seizures in children with arterial ischemic stroke. Stroke 2014, 45:1161-1163.
34. Heuts-van Raak L, Lodder J, Kessels F Late seizures following a first symptomatic brain infarct are related to large infarcts involving the posterior area around the lateral sulcus. Seizure 1996, 5:185-194.
35. Leone MA, Tonini MC, Bogliun G, et al. Risk factors for a first epileptic seizure after stroke: A case control study. J Neurol Sci 2009, 277:138-142.
36. Benbir G, Ince B, Bozluolcay M The epidemiology of post-stroke epilepsy according to stroke subtypes. Acta Neurol Scand 2006, 114:8-12.
37. Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 2013, 12:822-838.
38. Gasparini S, Ferlazzo E, Beghi E, et al. Epilepsy associated with Leukoaraiosis mainly affects temporal lobe: a casual or causal relationship?. Epilepsy Res 2015, 109:1-8.
39. De Reuck JL Evidence for chronic ischaemia in the pathogenesis of vascular dementia: from neuroPATH to neuroPET. Acta Neurol Belg 1996, 96:228-231.
40. De Reuck J, De Clerck M, Van Maele G Vascular cognitive impairment in patients with late-onset seizures after an ischemic stroke. Clin Neurol Neurosurg 2006, 108:632-637.
41. Maxwell H, Hanby M, Parkes LM, Gibson LM, Coutinho C, Emsley HC Prevalence and subtypes of radiological cerebrovascular disease in late-onset isolated seizures and epilepsy. Clin Neurol Neurosurg 2013, 115:591-596.
42. Giroud M, Gras P, Fayolle H, Andre N, Soichot P, Dumas R Early seizures after acute stroke: a study of 1,640 cases. Epilepsia 1994, 35:959-964.
43. Chadehumbe MA, Khatri P, Khoury JC, et al. Seizures are common in the acute setting of childhood stroke: a population-based study. J Child Neurol 2009, 24:9-12.
44. Brigo F, Tezzon F, Nardone R Late-onset seizures and risk of subsequent stroke: a systematic review. Epilepsy Behav 2014, 31:9-12.
45. Cocito L, Favale E, Reni L The frequency, characteristics and prognosis of epileptic seizures at the onset of stroke. J Neurol Neurosurg Psychiatry 1989, 52:292.
46. Cleary P, Shorvon S, Tallis R Late-onset seizures as a predictor of subsequent stroke. Lancet 2004, 363:1184-1186.
47. De Reuck JL Stroke-related seizures and epilepsy. Neurol Neurochir Pol 2007, 41:144-149.
48. Noebels J Pathway-driven discovery of epilepsy genes. Nat Neurosci 2015, 18:344-350.
49. Zhang B, Chen M, Yang H, Wu T, Song C, Guo R Evidence for involvement of the CD40/CD40L system in post-stroke epilepsy. Neurosci Lett 2014, 567:6-10.
50. Yang H, Song Z, Yang G-P, et al. The ALDH2 rs671 polymorphism affects post-stroke epilepsy susceptibility and plasma 4-HNE levels. PLoS One 2014, 9:e109634.
51. McCarron MO, Muir KW, Nicoll JA, et al. Prospective study of apolipoprotein E genotype and functional outcome following ischemic stroke. Arch Neurol 2000, 57:1480-1484.
52. Sarzynska-Dlugosz I, Gromadzka G, Baranska-Gieruszczak M, Ciesielska A, Czlonkowska A APOE does not predict poor outcome 1 year after ischemic stroke. Neurol Res 2007, 29:64-69.
53. Gromadzka G, Baranska-Gieruszczak M, Sarzynska-Dlugosz I, Ciesielska A, Czlonkowska A The APOE polymorphism and 1-year outcome in ischemic stroke: genotype-gender interaction. Acta Neurol Scand 2007, 116:392-398.
54. Marousi S, Ellul J, Antonacopoulou A, Gogos C, Papathanasopoulos P, Karakantza M Functional polymorphisms of interleukin 4 and interleukin 10 may predict evolution and functional outcome of an ischaemic stroke. Eur J Neurol 2011, 18:637-643.
55. Marousi S, Antonacopoulou A, Kalofonos H, Papathanasopoulos P, Karakantza M, Ellul J Functional inflammatory genotypes in ischemic stroke: could we use them to predict age of onset and long-term outcome?. Stroke Res Treat 2011, 2011:792923.
56. Chakraborty B, Chowdhury D, Vishnoi G, Goswami B, Kishore J, Agarwal S Interleukin-6 gene -174 G/C promoter polymorphism predicts severity and outcome in acute ischemic stroke patients from north India. J Stroke Cerebrovasc Dis 2013, 22:683-689.
57. Gromadzka G, Sarzynska-Dlugosz I, Czlonkowska A IL1RN intron 2 polymorphism caused by variable number tandem repeats is associated with 1-year outcome in patients with ischaemic stroke. J Neurol Neurosurg Psychiatry 2007, 78:183-186.
58. Giannakopoulou E, Ragia G, Marousi S, Ellul J, Manolopoulos VG, Tavridou A Association of monocyte chemoattractant protein-1 -2518A>G polymorphism with occurrence, severity, and outcome in ischemic stroke. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol 2013, 34:1315-1320.
59. Aberg ND, Olsson S, Aberg D, et al. Genetic variation at the IGF1 locus shows association with post-stroke outcome and to circulating IGF1. Eur J Endocrinol 2013, 169:759-765.
60. Cervera A, Planas AM, Justicia C, et al. Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke. PLoS One 2010, 5:e8433.
61. Mirowska-Guzel D, Gromadzka G, Czlonkowski A, Czlonkowska A BDNF -270 C>T polymorphisms might be associated with stroke type and BDNF -196 G>A corresponds to early neurological deficit in hemorrhagic stroke. J Neuroimmunol 2012, 249:71-75.
62. Liepert J, Heller A, Behnisch G, Schoenfeld A Catechol-O-methyltransferase polymorphism influences outcome after ischemic stroke: a prospective double-blind study. Neurorehabil Neural Repair 2013, 27:491-496.
63. Antoniades C, Bakogiannis C, Tousoulis D, Antonopoulos AS, Stefanadis C The CD40/CD40 ligand system: linking inflammation with atherothrombosis. J Am Coll Cardiol 2009, 54:669-677.
64. Goldstein LB, Adams R, Alberts MJ, et al. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: the American Academy of Neurology affirms the value of this guideline. Stroke 2006, 37:1583-1633.
65. Wild CP The exposome: from concept to utility. Int J Epidemiol 2012, 41:24-32.
66. Wang G, Jia H, Chen C, et al. Analysis of risk factors for first seizure after stroke in Chinese patients. Biomed Res Int 2013, 2013:702871.
67. Ng SK, Hauser WA, Brust JC, Susser M Hypertension and the risk of new-onset unprovoked seizures. Neurology 1993, 43:425-428.
68. Forsgren L, Bucht G, Eriksson S, Bergmark L Incidence and clinical characterization of unprovoked seizures in adults: a prospective population-based study. Epilepsia 1996, 37:224-229.
69. Fox CK, Glass HC, Sidney S, Lowenstein DH, Fullerton HJ Acute seizures predict epilepsy after childhood stroke. Ann Neurol 2013, 74:249-256.
70. Rumbach L, Sablot D, Berger E, Tatu L, Vuillier F, Moulin T Status epilepticus in stroke: report on a hospital-based stroke cohort. Neurology 2000, 54:350-354.
71. Cordonnier C, Hénon H, Derambure P, Pasquier F, Leys D Influence of pre-existing dementia on the risk of post-stroke epileptic seizures. J Neurol Neurosurg Psychiatry 2005, 76:1649-1653.
72. Nadeau SE, Lu X, Dobkin B, Wu SS, Dai YE, Duncan PW A prospective test of the late effects of potentially antineuroplastic drugs in a stroke rehabilitation study. Int J Stroke 2014, 9:449-456.
73. Guo J, Guo J, Li J, et al. Statin treatment reduces the risk of poststroke seizures. Neurology 2015, 85:701-707.
74. Szaflarski JP, Rackley AY, Kleindorfer DO, et al. Incidence of seizures in the acute phase of stroke: a population-based study. Epilepsia 2008, 49:974-981.
75. Temkin NR Preventing and treating posttraumatic seizures: the human experience. Epilepsia 2009, 50(suppl 2):10-13.
76. Trinka E, Brigo F Antiepileptogenesis in humans: disappointing clinical evidence and ways to move forward. Curr Opin Neurol 2014, 27:227-235.
77. Labovitz DL, Hauser WA, Sacco RL Prevalence and predictors of early seizure and status epilepticus after first stroke. Neurology 2001, 57:200-206.
78. Bateman BT, Claassen J, Willey JZ, et al. Convulsive status epilepticus after ischemic stroke and intracerebral hemorrhage: frequency, predictors, and impact on outcome in a large administrative dataset. Neurocrit Care 2007, 7:187-193.
79. Belcastro V, Vidale S, Gorgone G, et al. Non-convulsive status epilepticus after ischemic stroke: a hospital-based stroke cohort study. J Neurol 2014, 261:2136-2142.
80. Hesdorffer DC, Logroscino G, Cascino G, Annegers JF, Hauser WA Risk of unprovoked seizure after acute symptomatic seizure: effect of status epilepticus. Ann Neurol 1998, 44:908-912.
81. Pitkanen A, Kharatishvili I, Karhunen H, et al. Epileptogenesis in experimental models. Epilepsia 2007, 48(suppl 2):13-20.
82. Conrad J, Pawlowski M, Dogan M, Kovac S, Ritter MA, Evers S Seizures after cerebrovascular events: risk factors and clinical features. Seizure 2013, 22:275-282.
83. Goldstein LB Common drugs may influence motor recovery after stroke. The Sygen In Acute Stroke Study Investigators. Neurology 1995, 45:865-871.
84. De Reuck J, Van Maele G Acute ischemic stroke treatment and the occurrence of seizures. Clin Neurol Neurosurg 2010, 112:328-331.
85. Alvarez V, Rossetti AO, Papavasileiou V, Michel P Acute seizures in acute ischemic stroke: does thrombolysis have a role to play?. J Neurol 2013, 260:55-61.
86. Schmitz ML, Simonsen CZ, Hundborg H, et al. Acute ischemic stroke and long-term outcome after thrombolysis: nationwide propensity score-matched follow-up study. Stroke 2014, 45:3070-3072.
87. Machado C, Pinho J, Alves JN, et al. Five-Year Outcome in Stroke Patients Submitted to Thrombolysis. Stroke 2015, 46:2312-2314.
88. Couillard P, Almekhlafi MA, Irvine A, et al. Subacute seizure incidence in thrombolysis-treated ischemic stroke patients. Neurocrit Care 2012, 16:241-245.
89. Gensicke H, Seiffge DJ, Polasek AE, et al. Long-term outcome in stroke patients treated with IV thrombolysis. Neurology 2013, 80:919-925.
90. Tsirka SE, Gualandris A, Amaral DG, Strickland S Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator. Nature 1995, 377:340-344.
91. Kelly KM, Kharlamov A, Hentosz TM, et al. Photothrombotic brain infarction results in seizure activity in aging Fischer 344 and Sprague Dawley rats. Epilepsy Res 2001, 47:189-203.
92. Liu J, Schmitt KL, Kharlamov EA, Stolarski CJ, Grayson DR, Kelly KM Quantitative reverse transcription-polymerase chain reaction of GABA(A) alpha1, beta1 and gamma2S subunits in epileptic rats following photothrombotic infarction of neocortex. Epilepsy Res 2002, 52:85-95.
93. Kharlamov EA, Jukkola PI, Schmitt KL, Kelly KM Electrobehavioral characteristics of epileptic rats following photothrombotic brain infarction. Epilepsy Res 2003, 56:185-203.
94. Karhunen H, Bezvenyuk Z, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A Epileptogenesis after cortical photothrombotic brain lesion in rats. Neuroscience 2007, 148:314-324.
95. Paz JT, Davidson TJ, Frechette ES, et al. Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci 2013, 16:64-70.
96. Brima T, Otáhal J, Mareš P Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7. Brain Res 2013, 1507:146-153.
97. Karhunen H, Pitkänen A, Virtanen T, et al. Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits. Epilepsy Res 2003, 54:1-10.
98. Kelly KM, Jukkola PI, Kharlamov E a, et al. Long-term video-EEG recordings following transient unilateral middle cerebral and common carotid artery occlusion in Long-Evans rats. Exp Neurol 2006, 201:495-506.
99. Kelly KM Stroke. Models of seizures and epilepsy 2006, 501-519. Elsevier, Amsterdam. A. Pitkänen, P.A. Schwarzkroin, S.L. Moshe (Eds.).
100. Karhunen H, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats. Epilepsy Res 2006, 72:25-38.
101. Mátéffyová A, Otáhal J, Tsenov G, Mareš P, Kubová H Intrahippocampal injection of endothelin-1 in immature rats results in neuronal death, development of epilepsy and behavioral abnormalities later in life. Eur J Neurosci 2006, 24:351-360.
102. Kadam SD, White AM, Staley KJ, Dudek FE Continuous electroencephalographic monitoring with radio-telemetry in a rat model of perinatal hypoxia-ischemia reveals progressive post-stroke epilepsy. J Neurosci 2010, 30:404-415.
103. Rakhade SN, Klein PM, Huynh T, et al. Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures. Epilepsia 2011, 52:753-765.
104. Carmichael ST Cellular and molecular mechanisms of neural repair after stroke: making waves. Ann Neurol 2006, 59:735-742.
105. Li S, Overman JJ, Katsman D, et al. An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke. Nat Neurosci 2010, 13:1496-1504.
106. Kharlamov EA, Kharlamov A, Kelly KM Changes in neuropeptide Y protein expression following photothrombotic brain infarction and epileptogenesis. Brain Res 2007, 1127:151-162.
107. Awada A, Omojola MF, Obeid T Late epileptic seizures after cerebral infarction. Acta Neurol Scand 1999, 99:265-268.
108. Dachet F, Bagla S, Keren-Aviram G, et al. Predicting novel histopathological microlesions in human epileptic brain through transcriptional clustering. Brain 2015, 138:356-370.
109. Alberti A, Paciaroni M, Caso V, Venti M, Palmerini F, Agnelli G Early seizures in patients with acute stroke: frequency, predictive factors, and effect on clinical outcome. Vasc Health Risk Manag 2008, 4:715-720.
110. Renu A, Amaro S, Laredo C, et al. Relevance of blood-brain barrier disruption after endovascular treatment of ischemic stroke: dual-energy computed tomographic study. Stroke 2015, 46:673-679.
111. Raabe A, Schmitz AK, Pernhorst K, et al. Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions. Epilepsia 2012, 53:539-548.
112. Marchi N, Granata T, Ghosh C, Janigro D Blood-brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches. Epilepsia 2012, 53:1877-1886.
113. Van Vliet EA, Aronica E, Gorter JA Blood-brain barrier dysfunction, seizures and epilepsy. Semin Cell Dev Biol 2015, 38:26-34.
114. Gilad R, Lampl Y, Eilam A, Boaz M, Loyberboim M SPECT-DTPA as a tool for evaluating the blood-brain barrier in post-stroke seizures. J Neurol 2012, 259:2041-2044.
115. Blumcke I, Coras R, Miyata H, Ozkara C Defining clinico-neuropathological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis. Brain Pathol 2012, 22:402-411.
116. Rauramaa T, Pikkarainen M, Englund E, et al. Cardiovascular diseases and hippocampal infarcts. Hippocampus 2011, 21:281-287.
117. Squier W, Salisbury H, Sisodiya S Stroke in the developing brain and intractable epilepsy: effect of timing on hippocampal sclerosis. Dev Med Child Neurol 2003, 45:580-585.
118. Salanova V, Markand O, Worth R Temporal lobe epilepsy: analysis of patients with dual pathology. Acta Neurol Scand 2004, 109:126-131.
119. Lu X-CM, Williams AJ, Yao C, et al. Microarray analysis of acute and delayed gene expression profile in rats after focal ischemic brain injury and reperfusion. J Neurosci Res 2004, 77:843-857.
120. Ramos-Cejudo J, Gutierrez-Fernandez M, Rodriguez-Frutos B, et al. Spatial and temporal gene expression differences in core and periinfarct areas in experimental stroke: a microarray analysis. PLoS One 2012, 7:e52121.
121. Gubern C, Camos S, Ballesteros I, et al. miRNA expression is modulated over time after focal ischaemia: up-regulation of miR-347 promotes neuronal apoptosis. FEBS J 2013, 280:6233-6246.
122. Lukasiuk K, Dabrowski M, Adach A, Pitkanen A Epileptogenesis-related genes revisited. Prog Brain Res 2006, 158:223-241.
123. Olsen TS Post-stroke epilepsy. Curr Atheroscler Rep 2001, 3:340-344.
124. Reith J, Jorgensen HS, Nakayama H, Raaschou HO, Olsen TS Seizures in acute stroke: predictors and prognostic significance. The Copenhagen Stroke Study. Stroke 1997, 28:1585-1589.
125. Vargas M, Horcajada JP, Obach V, et al. Clinical consequences of infection in patients with acute stroke: is it prime time for further antibiotic trials?. Stroke 2006, 37:461-465.
126. Stables JP, Bertram E, Dudek FE, et al. Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop. Epilepsia 2003, 44:1472-1478.
127. Galanopoulou AS, Kokaia M, Loeb JA, et al. Epilepsy therapy development: technical and methodologic issues in studies with animal models. Epilepsia 2013, 54(suppl 4):13-23.
128. Afsar N, Kaya D, Aktan S, Sykut-Bingol C Stroke and status epilepticus: stroke type, type of status epilepticus, and prognosis. Seizure 2003, 12:23-27.
129. Pitkanen A, Engel JJ Past and present definitions of epileptogenesis and its biomarkers. Neurotherapeutics 2014, 11:231-241.
130. Green AR Pharmacological approaches to acute ischaemic stroke: reperfusion certainly, neuroprotection possibly. Br J Pharmacol 2008, 153(suppl):S325-S338.
131. Engel JJ, Pitkanen A, Loeb JA, et al. Epilepsy biomarkers. Epilepsia 2013, 54(suppl 4):61-69.
132. Strzelczyk A, Haag A, Raupach H, Herrendorf G, Hamer HM, Rosenow F Prospective evaluation of a post-stroke epilepsy risk scale. J Neurol 2010, 257:1322-1326.
133. Haapaniemi E, Strbian D, Rossi C, et al. The CAVE score for predicting late seizures after intracerebral hemorrhage. Stroke 2014, 45:1971-1976.