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Volumn 27, Issue 2, 2014, Pages 227-235

Antiepileptogenesis in humans: Disappointing clinical evidence and ways to move forward

Author keywords

antiseizure drugs; biomarker; drug trial; epileptogenesis; seizure prevention

Indexed keywords

EVEROLIMUS; RAPAMYCIN; VALPROIC ACID;

EID: 84896399969     PISSN: 13507540     EISSN: 14736551     Source Type: Journal    
DOI: 10.1097/WCO.0000000000000067     Document Type: Review
Times cited : (57)

References (72)
  • 1
    • 84891701056 scopus 로고    scopus 로고
    • Joint AES/ILAE translational workshop to optimize preclinical epilepsy research
    • Galanopoulou AS, Simonato M, French JA, O'Brien TJ. Joint AES/ILAE translational workshop to optimize preclinical epilepsy research. Epilepsia 2013; 54 (Suppl 4):1-2.
    • (2013) Epilepsia , vol.54 , Issue.SUPPL. 4 , pp. 1-2
    • Galanopoulou, A.S.1    Simonato, M.2    French, J.A.3    O'Brien, T.J.4
  • 2
    • 84857648355 scopus 로고    scopus 로고
    • Identification of new epilepsy treatments: Issues in preclinical methodology
    • Galanopoulou AS, Buckmaster PS, Staley KJ, et al. Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia 2012; 53: 571-582.
    • (2012) Epilepsia , vol.53 , pp. 571-582
    • Galanopoulou, A.S.1    Buckmaster, P.S.2    Staley, K.J.3
  • 3
    • 84891673132 scopus 로고    scopus 로고
    • Development of new treatment approaches for epilepsy: Unmet needs and opportunities
    • French JA, White HS, Klitgaard H, et al. Development of new treatment approaches for epilepsy: unmet needs and opportunities. Epilepsia 2013; 54 (Suppl 4):3-12.
    • (2013) Epilepsia , vol.54 , Issue.SUPPL. 4 , pp. 3-12
    • French, J.A.1    White, H.S.2    Klitgaard, H.3
  • 4
    • 84891679696 scopus 로고    scopus 로고
    • Epilepsy therapy development: Technical and methodologic issues in studies with animal models
    • Galanopoulou AS, Kokaia M, Loeb JA, et al. Epilepsy therapy development: technical and methodologic issues in studies with animal models. Epilepsia 2013; 54 (Suppl 4):13-23.
    • (2013) Epilepsia , vol.54 , Issue.SUPPL. 4 , pp. 13-23
    • Galanopoulou, A.S.1    Kokaia, M.2    Loeb, J.A.3
  • 5
    • 84891676185 scopus 로고    scopus 로고
    • Issues related to development of new antiseizure treatments
    • Wilcox KS, Dixon-Salazar T, Sills GJ, et al. Issues related to development of new antiseizure treatments. Epilepsia 2013; 54 (Suppl 4):24-34.
    • (2013) Epilepsia , vol.54 , Issue.SUPPL. 4 , pp. 24-34
    • Wilcox, K.S.1    Dixon-Salazar, T.2    Sills, G.J.3
  • 6
    • 84891698175 scopus 로고    scopus 로고
    • Issues related to development of antiepileptogenic therapies
    • Pitkänen A, Nehlig A, Brooks-Kayal AR, et al. Issues related to development of antiepileptogenic therapies. Epilepsia 2013; 54 (Suppl 4):35-43.
    • (2013) Epilepsia , vol.54 , Issue.SUPPL. 4 , pp. 35-43
    • Pitkänen, A.1    Nehlig, A.2    Brooks-Kayal, A.R.3
  • 7
    • 84888201969 scopus 로고    scopus 로고
    • Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy
    • Brooks-Kayal AR, Bath KG, Berg AT, et al. Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia 2013; 54 (Suppl 4):44-60.
    • (2013) Epilepsia , vol.54 , Issue.SUPPL. 4 , pp. 44-60
    • Brooks-Kayal, A.R.1    Bath, K.G.2    Berg, A.T.3
  • 9
    • 84891714244 scopus 로고    scopus 로고
    • Proposal for a 'phase II' multicenter trial model for preclinical new antiepilepsy therapy development
    • O'Brien TJ, Ben-Menachem E, Bertram EH 3rd, et al. Proposal for a 'phase II' multicenter trial model for preclinical new antiepilepsy therapy development. Epilepsia 2013; 54 (Suppl 4):70-74.
    • (2013) Epilepsia , vol.54 , Issue.SUPPL. 4 , pp. 70-74
    • O'Brien, T.J.1    Ben-Menachem, E.2    Bertram III, E.H.3
  • 11
    • 77954498319 scopus 로고    scopus 로고
    • Therapeutic approaches to epileptogenesis: Hope on the horizon
    • Pitkänen A. Therapeutic approaches to epileptogenesis: hope on the horizon. Epilepsia 2010; 51 (Suppl 3):2-17.
    • (2010) Epilepsia , vol.51 , Issue.SUPPL. 3 , pp. 2-17
    • Pitkänen, A.1
  • 12
    • 78751488401 scopus 로고    scopus 로고
    • Mechanisms of epileptogenesis and potential treatment targets
    • Pitkänen A, Lukasiuk K. Mechanisms of epileptogenesis and potential treatment targets. Lancet Neurol 2011; 10:173-186.
    • (2011) Lancet Neurol , vol.10 , pp. 173-186
    • Pitkänen, A.1    Lukasiuk, K.2
  • 13
    • 0035048478 scopus 로고    scopus 로고
    • Antiepileptogenesis and seizure prevention trials with antiepilep-tic drugs: Meta-analysis of controlled trials
    • Temkin NR. Antiepileptogenesis and seizure prevention trials with antiepilep-tic drugs: meta-analysis of controlled trials. Epilepsia 2001; 42:515-524.
    • (2001) Epilepsia , vol.42 , pp. 515-524
    • Temkin, N.R.1
  • 14
    • 65549100191 scopus 로고    scopus 로고
    • Sweden: First report from the Stockholm Incidence Registry of Epilepsy (SIRE)
    • Newly diagnosed single unprovoked seizures and epilepsy in Stockholm
    • Adelöw C, Andell E, Amark P, et al. Newly diagnosed single unprovoked seizures and epilepsy in Stockholm, Sweden: first report from the Stockholm Incidence Registry of Epilepsy (SIRE). Epilepsia 2009; 50:1094-1101.
    • (2009) Epilepsia , vol.50 , pp. 1094-1101
    • Adelöw, C.1    Andell, E.2    Amark, P.3
  • 15
    • 65249131854 scopus 로고    scopus 로고
    • Emerging concepts in the pathogenesis of epilepsy and pilepto-genesis
    • Dichter MA. Emerging concepts in the pathogenesis of epilepsy and pilepto-genesis. Arch Neurol 2009; 66:443-447.
    • (2009) Arch Neurol , vol.66 , pp. 443-447
    • Dichter, M.A.1
  • 16
    • 84864563651 scopus 로고    scopus 로고
    • Is antiepileptogenesis a realistic goal in clinical trials? Concerns and new horizons
    • Schmidt D. Is antiepileptogenesis a realistic goal in clinical trials? Concerns and new horizons. Epileptic Disord 2012; 14:105-113.
    • (2012) Epileptic Disord , vol.14 , pp. 105-113
    • Schmidt, D.1
  • 17
    • 57249094423 scopus 로고    scopus 로고
    • Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: The importance of the 'latent period' and other concepts
    • Sloviter RS. Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: the importance of the 'latent period' and other concepts. Epilepsia 2008; 49 (Suppl 9):85-92.
    • (2008) Epilepsia , vol.49 , Issue.SUPPL. 9 , pp. 85-92
    • Sloviter, R.S.1
  • 18
    • 84875249960 scopus 로고    scopus 로고
    • Defining 'epileptogenesis' and identifying 'anti-epileptogenic targets' in animal models of acquired temporal lobe epilepsy is not as simple as it might seem
    • Sloviter RS, Bumanglag AV. Defining 'epileptogenesis' and identifying 'anti-epileptogenic targets' in animal models of acquired temporal lobe epilepsy is not as simple as it might seem. Neuropharmacology 2013; 69:3-15.
    • (2013) Neuropharmacology , vol.69 , pp. 3-15
    • Sloviter, R.S.1    Bumanglag, A.V.2
  • 19
    • 58849130137 scopus 로고    scopus 로고
    • Preventing and treating posttraumatic seizures: The human experience
    • Temkin NR. Preventing and treating posttraumatic seizures: the human experience. Epilepsia 2009; 50 (Suppl 2):10-13.
    • (2009) Epilepsia , vol.50 , Issue.SUPPL. 2 , pp. 10-13
    • Temkin, N.R.1
  • 20
    • 77649319457 scopus 로고    scopus 로고
    • Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy
    • Glauser TA, Cnaan A, Shinnar S, et al. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med 2010; 362:790-799.
    • (2010) N Engl J Med , vol.362 , pp. 790-799
    • Glauser, T.A.1    Cnaan, A.2    Shinnar, S.3
  • 21
    • 39749159858 scopus 로고    scopus 로고
    • Early treatment suppresses the development of spike-wave epilepsy in a rat model
    • Blumenfeld H, Klein JP, Schridde U, et al. Early treatment suppresses the development of spike-wave epilepsy in a rat model. Epilepsia 2008; 49:400-409.
    • (2008) Epilepsia , vol.49 , pp. 400-409
    • Blumenfeld, H.1    Klein, J.P.2    Schridde, U.3
  • 22
    • 77955340670 scopus 로고    scopus 로고
    • Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy
    • Russo E, Citraro R, Scicchitano F, et al. Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy. Epilepsia 2010; 51:1560-1569.
    • (2010) Epilepsia , vol.51 , pp. 1560-1569
    • Russo, E.1    Citraro, R.2    Scicchitano, F.3
  • 23
    • 79960010846 scopus 로고    scopus 로고
    • Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model
    • Russo E, Citraro R, Scicchitano F, et al. Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model. Epilepsia 2011; 52: 1341-1350.
    • (2011) Epilepsia , vol.52 , pp. 1341-1350
    • Russo, E.1    Citraro, R.2    Scicchitano, F.3
  • 24
    • 84884713199 scopus 로고    scopus 로고
    • Antiepileptogenesis: Electro-physiology, diffusion tensor imaging and behavior in a genetic absence model
    • van Luijtelaar G, Mishra AM, Edelbroek P, et al. Antiepileptogenesis: electro-physiology, diffusion tensor imaging and behavior in a genetic absence model. Neurobiol Dis 2013; 60:126-138.
    • (2013) Neurobiol Dis , vol.60 , pp. 126-138
    • Van Luijtelaar, G.1    Mishra, A.M.2    Edelbroek, P.3
  • 25
    • 84875859244 scopus 로고    scopus 로고
    • Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy
    • Dezsi G, Ozturk E, Stanic D, et al. Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy. Epilepsia 2013; 54:635-643.
    • (2013) Epilepsia , vol.54 , pp. 635-643
    • Dezsi, G.1    Ozturk, E.2    Stanic, D.3
  • 26
    • 84876911029 scopus 로고    scopus 로고
    • A survey of adult and pediatric epilepsy surgery in the United Kingdom
    • Neligan A, Haliasos N, Pettorini B, et al. A survey of adult and pediatric epilepsy surgery in the United Kingdom. Epilepsia 2013; 54:e62-e65.
    • (2013) Epilepsia , vol.54
    • Neligan, A.1    Haliasos, N.2    Pettorini, B.3
  • 27
    • 84868514506 scopus 로고    scopus 로고
    • Use of anterior temporal lobectomy for epilepsy in a community-based population
    • Van Gompel JJ, Ottman R, Worrell GA, et al. Use of anterior temporal lobectomy for epilepsy in a community-based population. Arch Neurol 2012; 69:1476-1481.
    • (2012) Arch Neurol , vol.69 , pp. 1476-1481
    • Van Gompel, J.J.1    Ottman, R.2    Worrell, G.A.3
  • 28
    • 84860720241 scopus 로고    scopus 로고
    • Epilepsy surgery trends in the United States 1990-2008
    • Englot DJ, Ouyang D, Garcia PA, et al. Epilepsy surgery trends in the United States, 1990-2008. Neurology 2012; 78:1200-1206.
    • (2012) Neurology , vol.78 , pp. 1200-1206
    • Englot, D.J.1    Ouyang, D.2    Garcia, P.A.3
  • 29
    • 84899947403 scopus 로고    scopus 로고
    • Temporal lobe surgery in Germany from 1988 to 2008: Diverse trends in etiological subgroups
    • [Epub ahead of print]
    • Helmstaedter C, May TW, von Lehe M, et al. Temporal lobe surgery in Germany from 1988 to 2008: diverse trends in etiological subgroups. Eur J Neurol 2013. [Epub ahead of print]
    • (2013) Eur J Neurol
    • Helmstaedter, C.1    May, T.W.2    Von Lehe, M.3
  • 30
    • 0142136042 scopus 로고    scopus 로고
    • Overview of studies to prevent posttraumatic epilepsy
    • Beghi E. Overview of studies to prevent posttraumatic epilepsy. Epilepsia 2003; 44 (Suppl 10):21-26.
    • (2003) Epilepsia , vol.44 , Issue.SUPPL. 10 , pp. 21-26
    • Beghi, E.1
  • 31
    • 84921430243 scopus 로고    scopus 로고
    • Antiepileptic drugs for preventing seizures following acute traumatic brain injury
    • Schierhout G, Roberts I. Antiepileptic drugs for preventing seizures following acute traumatic brain injury. Cochrane Database Syst Rev 2001; 4:CD000173.
    • (2001) Cochrane Database Syst Rev , vol.4
    • Schierhout, G.1    Roberts, I.2
  • 33
    • 0014689271 scopus 로고
    • Early traumatic epilepsy, Definition and identity
    • Jennett WB. Early traumatic epilepsy. Definition and identity. Lancet 1969; 1:1023-1025.
    • (1969) Lancet , vol.1 , pp. 1023-1025
    • Jennett, W.B.1
  • 34
    • 0037435505 scopus 로고    scopus 로고
    • Practice parameter: Antiepileptic drug prophylaxis in severe traumatic brain injury: Report of the Quality Standards Subcommittee of the American Academy of Neurology
    • Quality Standards Subcommittee of the American Academy of Neurology
    • Chang BS, Lowenstein DH. Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter: antiepileptic drug prophylaxis in severe traumatic brain injury: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2003; 60:10-16.
    • (2003) Neurology , vol.60 , pp. 10-16
    • Chang, B.S.1    Lowenstein, D.H.2
  • 35
    • 84874878371 scopus 로고    scopus 로고
    • A prospective multicenter comparison of levetiracetam versus phenytoin for early posttraumatic seizure prophylaxis
    • Inaba K, Menaker J, Branco BC, et al. A prospective multicenter comparison of levetiracetam versus phenytoin for early posttraumatic seizure prophylaxis. J Trauma Acute Care Surg 2013; 74:766-771.
    • (2013) J Trauma Acute Care Surg , vol.74 , pp. 766-771
    • Inaba, K.1    Menaker, J.2    Branco, B.C.3
  • 36
    • 80051770295 scopus 로고    scopus 로고
    • Cost-utility analysis of levetirace-tam and phenytoin for posttraumatic seizure prophylaxis
    • Cotton BA, Kao LS, Kozar R, Holcomb JB. Cost-utility analysis of levetirace-tam and phenytoin for posttraumatic seizure prophylaxis. J Trauma 2011; 71:375-379.
    • (2011) J Trauma , vol.71 , pp. 375-379
    • Cotton, B.A.1    Kao, L.S.2    Kozar, R.3    Holcomb, J.B.4
  • 37
    • 0020580409 scopus 로고
    • Seizure prevention using carbamaze-pine following severe brain injuries
    • Glötzner FL, Haubitz I, Miltner F, et al. Seizure prevention using carbamaze-pine following severe brain injuries. Neurochirurgia (Stuttg) 1983; 26:66-79.
    • (1983) Neurochirurgia (Stuttg) , vol.26 , pp. 66-79
    • Glötzner, F.L.1    Haubitz, I.2    Miltner, F.3
  • 38
    • 0020529105 scopus 로고
    • Low risk of late posttraumatic seizures following severe head injury: Implications for clinical trials of prophylaxis
    • McQueen JK, Blackwood DH, Harris P, et al. Low risk of late posttraumatic seizures following severe head injury: implications for clinical trials of prophylaxis. J Neurol Neurosurg Psychiatry 1983; 46:899-904.
    • (1983) J Neurol Neurosurg Psychiatry , vol.46 , pp. 899-904
    • McQueen, J.K.1    Blackwood, D.H.2    Harris, P.3
  • 39
    • 0020656167 scopus 로고
    • Failure of prophylactically administered phenytoin to prevent late posttraumatic seizures
    • Young B, Rapp RP, Norton JA, et al. Failure of prophylactically administered phenytoin to prevent late posttraumatic seizures. J Neurosurg 1983; 58:236-241.
    • (1983) J Neurosurg , vol.58 , pp. 236-241
    • Young, B.1    Rapp, R.P.2    Norton, J.A.3
  • 40
    • 0020672024 scopus 로고
    • Failure of prophylactically administered phenytoin to prevent early posttraumatic seizures
    • Young B, Rapp RP, Norton JA, et al. Failure of prophylactically administered phenytoin to prevent early posttraumatic seizures. J Neurosurg 1983; 58:231-235.
    • (1983) J Neurosurg , vol.58 , pp. 231-235
    • Young, B.1    Rapp, R.P.2    Norton, J.A.3
  • 41
    • 0020964853 scopus 로고
    • Failure of prophylactically administered phenytoin to prevent posttraumatic seizures in children
    • Young B, Rapp RP, Norton JA, et al. Failure of prophylactically administered phenytoin to prevent posttraumatic seizures in children. Childs Brain 1983; 10:185-192.
    • (1983) Childs Brain , vol.10 , pp. 185-192
    • Young, B.1    Rapp, R.P.2    Norton, J.A.3
  • 42
    • 0026422321 scopus 로고
    • Prevention of late posttraumatic epilepsy by phenytoin in severe brain injuries 2 years' follow-up
    • Pechadre JC, Lauxerois M, Colnet G, et al. Prevention of late posttraumatic epilepsy by phenytoin in severe brain injuries. 2 years' follow-up. Presse Med 1991; 20:841-845.
    • (1991) Presse Med , vol.20 , pp. 841-845
    • Pechadre, J.C.1    Lauxerois, M.2    Colnet, G.3
  • 43
    • 0024991892 scopus 로고
    • A randomized, double-blind study of phenytoin for the prevention of posttraumatic seizures
    • Temkin NR, Dikmen SS, Wilensky AJ, et al. A randomized, double-blind study of phenytoin for the prevention of posttraumatic seizures. N Engl J Med 1990; 323:497-502.
    • (1990) N Engl J Med , vol.323 , pp. 497-502
    • Temkin, N.R.1    Dikmen, S.S.2    Wilensky, A.J.3
  • 44
    • 0026062248 scopus 로고
    • Neurobehavioral effects of phenytoin prophylaxis of posttraumatic seizures
    • Dikmen SS, Temkin NR, Miller B, et al. Neurobehavioral effects of phenytoin prophylaxis of posttraumatic seizures. JAMA 1991; 265:1271-1277.
    • (1991) JAMA , vol.265 , pp. 1271-1277
    • Dikmen, S.S.1    Temkin, N.R.2    Miller, B.3
  • 45
    • 0026793130 scopus 로고
    • Cooperative prospective study on posttraumatic epilepsy: Risk factors and the effect of prophylactic anticonvulsant
    • Manaka S. Cooperative prospective study on posttraumatic epilepsy: risk factors and the effect of prophylactic anticonvulsant. Jpn J Psychiatry Neurol 1992; 46:311-315.
    • (1992) Jpn J Psychiatry Neurol , vol.46 , pp. 311-315
    • Manaka, S.1
  • 46
    • 84866648385 scopus 로고    scopus 로고
    • Clinical features of late-onset poststroke seizures
    • Okuda S, Takano S, Ueno M, et al. Clinical features of late-onset poststroke seizures. J Stroke Cerebrovasc Dis 2012; 21:583-586.
    • (2012) J Stroke Cerebrovasc Dis , vol.21 , pp. 583-586
    • Okuda, S.1    Takano, S.2    Ueno, M.3
  • 47
    • 77950895318 scopus 로고    scopus 로고
    • Antiepileptic drugs for the primary and secondary prevention of seizures after stroke
    • Kwan J, Wood E. Antiepileptic drugs for the primary and secondary prevention of seizures after stroke. Cochrane Database Syst Rev 2010; 6:CD005398.
    • (2010) Cochrane Database Syst Rev , vol.6
    • Kwan, J.1    Wood, E.2
  • 48
    • 84890205829 scopus 로고    scopus 로고
    • Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage
    • Marigold R, Günther A, Tiwari D, Kwan J. Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage. Cochrane Database Syst Rev 2013; 6:CD008710.
    • (2013) Cochrane Database Syst Rev , vol.6
    • Marigold, R.1    Günther, A.2    Tiwari, D.3    Kwan, J.4
  • 49
    • 79954424273 scopus 로고    scopus 로고
    • Early treatment after stroke for the prevention of late epileptic seizures: A report on the problems performing a randomised placebo-controlled double-blind trial aimed at antiepileptogen-esis
    • van Tuijl JH, van Raak EP, de Krom MC, et al. Early treatment after stroke for the prevention of late epileptic seizures: a report on the problems performing a randomised placebo-controlled double-blind trial aimed at antiepileptogen-esis. Seizure 2011; 20:285-291.
    • (2011) Seizure , vol.20 , pp. 285-291
    • Van Tuijl, J.H.1    Van Raak, E.P.2    De Krom, M.C.3
  • 50
    • 33845685476 scopus 로고    scopus 로고
    • Optimizing therapy of seizures in patients with brain tumors
    • Vecht CJ, van Breemen M. Optimizing therapy of seizures in patients with brain tumors. Neurology 2006; 67 (Suppl 4):10-13.
    • (2006) Neurology , vol.67 , Issue.SUPPL. 4 , pp. 10-13
    • Vecht, C.J.1    Van Breemen, M.2
  • 51
    • 0023864056 scopus 로고
    • Erythema multiforme and Stevens-Johnson syndrome in patients receiving cranial irradiation and phenytoin
    • Delattre J, Safai B, Posner JB. Erythema multiforme and Stevens-Johnson syndrome in patients receiving cranial irradiation and phenytoin. Neurology 1988; 38:194-198.
    • (1988) Neurology , vol.38 , pp. 194-198
    • Delattre, J.1    Safai, B.2    Posner, J.B.3
  • 52
    • 1042278085 scopus 로고    scopus 로고
    • Treating seizures in patients with brain tumors: Drug interactions between antiepileptic and chemotherapeutic agents
    • Vecht CJ, Wagner GL, Wilms EB. Treating seizures in patients with brain tumors: drug interactions between antiepileptic and chemotherapeutic agents. Semin Oncol 2003; 30 (Suppl 19):49-52.
    • (2003) Semin Oncol , vol.30 , Issue.SUPPL. 19 , pp. 49-52
    • Vecht, C.J.1    Wagner, G.L.2    Wilms, E.B.3
  • 54
    • 0020535425 scopus 로고
    • Phenytoin and postoperative epilepsy. A double-blind study
    • North JB, Penhall RK, Hanieh A, et al. Phenytoin and postoperative epilepsy. A double-blind study. J Neurosurg 1983; 58:672-677.
    • (1983) J Neurosurg , vol.58 , pp. 672-677
    • North, J.B.1    Penhall, R.K.2    Hanieh, A.3
  • 55
    • 0024542054 scopus 로고
    • Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures
    • Lee ST, Lui TN, Chang CN, et al. Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures. Surg Neurol 1989; 31:361-364.
    • (1989) Surg Neurol , vol.31 , pp. 361-364
    • Lee, S.T.1    Lui, T.N.2    Chang, C.N.3
  • 56
    • 0025210536 scopus 로고
    • Influence of surgery and anti-epileptic drugs on seizures symptomatic of cerebral tumours
    • Franceschetti S, Binelli S, Casazza M, et al. Influence of surgery and anti-epileptic drugs on seizures symptomatic of cerebral tumours. Acta Neurochir (Wien) 1990; 103:47-51.
    • (1990) Acta Neurochir (Wien) , vol.103 , pp. 47-51
    • Franceschetti, S.1    Binelli, S.2    Casazza, M.3
  • 57
    • 9244234322 scopus 로고    scopus 로고
    • A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors
    • Glantz MJ, Cole BF, Friedberg MH, et al. A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors. Neurology 1996; 46:985-991.
    • (1996) Neurology , vol.46 , pp. 985-991
    • Glantz, M.J.1    Cole, B.F.2    Friedberg, M.H.3
  • 58
    • 0038797923 scopus 로고    scopus 로고
    • Prophylactic anticonvulsants in patients with brain tumour
    • Forsyth PA, Weaver S, Fulton D, et al. Prophylactic anticonvulsants in patients with brain tumour. Can J Neurol Sci 2003; 30:106-112.
    • (2003) Can J Neurol Sci , vol.30 , pp. 106-112
    • Forsyth, P.A.1    Weaver, S.2    Fulton, D.3
  • 59
    • 80054705372 scopus 로고    scopus 로고
    • Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma
    • Weller M, Gorlia T, Cairncross JG, et al. Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma. Neurology 2011; 77:1156-1164.
    • (2011) Neurology , vol.77 , pp. 1156-1164
    • Weller, M.1    Gorlia, T.2    Cairncross, J.G.3
  • 60
    • 84880598419 scopus 로고    scopus 로고
    • Valproic acid use during radiation therapy for glioblastoma associated with improved survival
    • Barker CA, Bishop AJ, Chang M, et al. Valproic acid use during radiation therapy for glioblastoma associated with improved survival. Int J Radiat Oncol Biol Phys 2013; 86:504-509.
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , pp. 504-509
    • Barker, C.A.1    Bishop, A.J.2    Chang, M.3
  • 61
    • 84879343978 scopus 로고    scopus 로고
    • Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme
    • Kerkhof M, Dielemans JC, van Breemen MS, et al. Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme. Neuro Oncol 2013; 15:961-967.
    • (2013) Neuro Oncol , vol.15 , pp. 961-967
    • Kerkhof, M.1    Dielemans, J.C.2    Van Breemen, M.S.3
  • 62
    • 84861620928 scopus 로고    scopus 로고
    • Effect of valproic acid on the outcome of glioblastoma multiforme
    • Tsai HC, Wei KC, Tsai CN, et al. Effect of valproic acid on the outcome of glioblastoma multiforme. Br J Neurosurg 2012; 26:347-354.
    • (2012) Br J Neurosurg , vol.26 , pp. 347-354
    • Tsai, H.C.1    Wei, K.C.2    Tsai, C.N.3
  • 63
    • 78650118698 scopus 로고    scopus 로고
    • Prevention or modification of epileptogenesis after brain insults: Experimental approaches and translational research
    • Löscher W, Brandt C. Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research. Pharmacol Rev 2010; 62:668-700.
    • (2010) Pharmacol Rev , vol.62 , pp. 668-700
    • Löscher, W.1    Brandt, C.2
  • 64
    • 84865630995 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition: Potential for antiseizure, antiepileptogenic, and epileptostatic therapy
    • Ryther RC, Wong M. Mammalian target of rapamycin (mTOR) inhibition: potential for antiseizure, antiepileptogenic, and epileptostatic therapy. Curr Neurol Neurosci Rep 2012; 12:410-418.
    • (2012) Curr Neurol Neurosci Rep , vol.12 , pp. 410-418
    • Ryther, R.C.1    Wong, M.2
  • 65
    • 0037111851 scopus 로고    scopus 로고
    • On the origin of interictal activity in human temporal lobe epilepsy in vitro
    • Cohen I, Navarro V, Clemenceau S, et al. On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science 2002; 298:1418-1421.
    • (2002) Science , vol.298 , pp. 1418-1421
    • Cohen, I.1    Navarro, V.2    Clemenceau, S.3
  • 66
    • 30744467689 scopus 로고    scopus 로고
    • NKCC1 transporter facilitates seizures in the developing brain
    • Dzhala VI, Talos DM, Sdrulla DA, et al. NKCC1 transporter facilitates seizures in the developing brain. Nat Med 2005; 11:1205-1213.
    • (2005) Nat Med , vol.11 , pp. 1205-1213
    • Dzhala, V.I.1    Talos, D.M.2    Sdrulla, D.A.3
  • 67
    • 84864681736 scopus 로고    scopus 로고
    • GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy
    • Koyama R, Tao K, Sasaki T, et al. GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy. Nat Med 2012; 18:1271-1278.
    • (2012) Nat Med , vol.18 , pp. 1271-1278
    • Koyama, R.1    Tao, K.2    Sasaki, T.3
  • 69
    • 80053580204 scopus 로고    scopus 로고
    • Therapeutic potential of new antiin-flammatory drugs
    • Vezzani A, Bartfai T, Bianchi M, et al. Therapeutic potential of new antiin-flammatory drugs. Epilepsia 2011; 52 (Suppl 8):67-69.
    • (2011) Epilepsia , vol.52 , Issue.SUPPL. 8 , pp. 67-69
    • Vezzani, A.1    Bartfai, T.2    Bianchi, M.3
  • 70
    • 84872163082 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)
    • Bialer M, Johannessen SI, Levy RH, et al. Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI). Epilepsy Res 2013; 103:2-30.
    • (2013) Epilepsy Res , vol.103 , pp. 2-30
    • Bialer, M.1    Johannessen, S.I.2    Levy, R.H.3
  • 71
    • 79957866317 scopus 로고    scopus 로고
    • Human clinical trials in antiepileptogenesis
    • Mani R, Pollard J, Dichter MA. Human clinical trials in antiepileptogenesis. Neurosci Lett 2011; 497:251-256.
    • (2011) Neurosci Lett , vol.497 , pp. 251-256
    • Mani, R.1    Pollard, J.2    Dichter, M.A.3
  • 72
    • 84885022384 scopus 로고    scopus 로고
    • Schmidt D.New avenues for antiepileptic drug discovery and development
    • Löscher W, Klitgaard H, Twyman RE, Schmidt D.New avenues for antiepileptic drug discovery and development. Nat Rev Drug Discov 2013; 12:757-776.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 757-776
    • Löscher, W.1    Klitgaard, H.2    Twyman, R.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.