The ALDH2 rs671 polymorphism affects post-stroke epilepsy susceptibility and plasma 4-HNE levels

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Yang, Heng ^a   Song, Zhi ^a   Yang, Guo Ping ^a   Zhang, Bi Kui ^a   Chen, Min ^a   Wu, Tian ^a   Guo, Ren ^a  

^a THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; MALONALDEHYDE; PROTEIN KINASE C EPSILON; REACTIVE OXYGEN METABOLITE; 4-HYDROXY-2-NONENAL; ALDEHYDE; ALDEHYDE DEHYDROGENASE; ALDH2 PROTEIN, HUMAN;

ADULT; ALDH2 GENE; ALLELE; ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CASE CONTROL STUDY; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME ACTIVITY; EPILEPSY; FEMALE; GENE FREQUENCY; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PC12 CELL LINE; POST STROKE EPILEPSY; RAT; SIGNAL TRANSDUCTION; AGED; ANIMAL; BLOOD; COMPLICATION; GENETIC PREDISPOSITION; GENETICS; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ALDEHYDE DEHYDROGENASE; ALDEHYDES; ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; CELL SURVIVAL; EPILEPSY; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; OXIDATIVE STRESS; PC12 CELLS; POLYMORPHISM, SINGLE NUCLEOTIDE; RATS; RISK FACTORS;

EID: 84907970843     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109634     Document Type: Article

References (32)

1. Scharfman HE (2007) The neurobiology of epilepsy. Curr Neurol Neurosci Rep 7: 348-354.
2. Forsgren L, Bucht G, Eriksson S, Bergmark L (1996) Incidence and clinical characterization of unprovoked seizures in adults: a prospective population-based study. Epilepsia 37: 224-229.
3. Li X, Breteler MM, de Bruyne MC, Meinardi H, Hauser WA, et al. (1997) Vascular determinants of epilepsy: the Rotterdam Study. Epilepsia 38: 1216-1220.
4. Burneo JG, Fang J, Saposnik G (2010) Impact of seizures on morbidity and mortality after stroke: a Canadian multi-centre cohort study. Eur J Neurol 17: 52-58.
5. Cherubini A, Polidori MC, Bregnocchi M, Pezzuto S, Cecchetti R, et al. (2000) Antioxidant profile and early outcome in stroke patients. Stroke 31: 2295-2300.
6. Li SY, Li Q, Shen JJ, Dong F, Sigmon VK, et al. (2006) Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling. J Mol Cell Cardiol 40: 283-294.
7. Guo JM, Liu AJ, Zang P, Dong WZ, Ying L, et al. (2013) ALDH2 protects against stroke by clearing 4-HNE. Cell Res 23: 915-930.
8. Lee WC, Wong HY, Chai YY, Shi CW, Amino N, et al. (2012) Lipid peroxidation dysregulation in ischemic stroke: plasma 4-HNE as a potential biomarker. Biochem Biophys Res Commun 425: 842-847.
9. Renner A, Sagstetter MR, Harms H, Lange V, Gotz ME, et al. (2005) Formation of 4-hydroxy-2-nonenal protein adducts in the ischemic rat heart after transplantation. J Heart Lung Transplant 24: 730-736.
10. Lagranha CJ, Deschamps A, Aponte A, Steenbergen C, Murphy E (2010) Sex differences in the phosphorylation of mitochondrial proteins result in reduced production of reactive oxygen species and cardioprotection in females. Circ Res 106: 1681-1691.
11. Stewart MJ, Malek K, Crabb DW (1996) Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J Investig Med 44: 42-46.
12. Crabb DW, Edenberg HJ, Bosron WF, Li TK (1989) Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. J Clin Invest 83: 314-316.
13. Yoshida A, Huang IY, Ikawa M (1984) Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci U S A 81: 258-261.
14. Guo YJ, Chen L, Bai YP, Li L, Sun J, et al. (2010) The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels. Atherosclerosis 211: 545-550.
15. Xu F, Chen YG, Xue L, Li RJ, Zhang H, et al. (2011) Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome. J Cell Mol Med 15: 1955-1962.
16. Hashimoto Y, Nakayama T, Futamura A, Omura M, Nakarai H, et al. (2002) Relationship between genetic polymorphisms of alcohol-metabolizing enzymes and changes in risk factors for coronary heart disease associated with alcohol consumption. Clin Chem 48: 1043-1048.
17. Nakamura Y, Amamoto K, Tamaki S, Okamura T, Tsujita Y, et al. (2002) Genetic variation in aldehyde dehydrogenase 2 and the effect of alcohol consumption on cholesterol levels. Atherosclerosis 164: 171-177.
18. Budas GR, Disatnik MH, Chen CH, Mochly-Rosen D (2010) Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice. J Mol Cell Cardiol 48: 757-764.
19. Churchill EN, Disatnik MH, Mochly-Rosen D (2009) Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2. J Mol Cell Cardiol 46: 278-284.
20. Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, et al. (2008) Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321: 1493-1495.
21. Wang RS, Nakajima T, Kawamoto T, Honma T (2002) Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver. Drug Metab Dispos 30: 69-73.
22. He L, Liu B, Dai Z, Zhang HF, Zhang YS, et al. (2012) Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation. Eur J Pharmacol 678: 32-38.
23. Bosron WF, Lumeng L, Li TK (1988) Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease. Mol Aspects Med 10: 147-158.
24. Ferguson RA, Goldberg DM (1997) Genetic markers of alcohol abuse. Clin Chim Acta 257: 199-250.
25. Chen Z, Foster MW, Zhang J, Mao L, Rockman HA, et al. (2005) An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. Proc Natl Acad Sci U S A 102: 12159-12164.
26. Mackenzie IS, Maki-Petaja KM, McEniery CM, Bao YP, Wallace SM, et al. (2005) Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans. Arterioscler Thromb Vasc Biol 25: 1891-1895.
27. Ma H, Guo R, Yu L, Zhang Y, Ren J (2011) Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. Eur Heart J 32: 1025-1038.
28. Li Y, Zhang D, Jin W, Shao C, Yan P, et al. (2006) Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. J Clin Invest 116: 506-511.
29. Nagasawa H, Wada M, Arawaka S, Kawanami T, Kurita K, et al. (2007) A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study. Eur J Neurol 14: 428-434.
30. Takagi S, Iwai N, Yamauchi R, Kojima S, Yasuno S, et al. (2002) Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Hypertens Res 25: 677-681.
31. Zhou S, Huriletemuer, Wang J, Zhang C, Zhao S, et al. (2010) Absence of association on aldehyde dehydrogenase 2 (ALDH2) polymorphism with Mongolian Alzheimer patients. Neurosci Lett 468: 312-315.
32. Patra J, Taylor B, Irving H, Roerecke M, Baliunas D, et al. (2010) Alcohol consumption and the risk of morbidity and mortality for different stroke types - a systematic review and meta-analysis. BMC Public Health 10: 258.