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Angewandte Chemie - International Edition

Volumn 54, Issue 52, 2015, Pages 15771-15776

Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor

(15) Okude, Junya a Ueda, Takumi a,b Kofuku, Yutaka a Sato, Motohiko a Nobuyama, Naoyuki a Kondo, Keita a Shiraishi, Yutaro a Mizumura, Takuya a Onishi, Kento a Natsume, Mei a Maeda, Masahiro c Tsujishita, Hideki c Kuranaga, Takefumi a Inoue, Masayuki a Shimada, Ichio a

a UNIVERSITY OF TOKYO (Japan)

b JAPAN SCIENCE AND TECHNOLOGY AGENCY (Japan)

c SHIONOGI AND CO LTD (Japan)

Author keywords

G protein coupled receptors; isotopic labeling; lipid bilayers; membrane proteins; NMR spectroscopy

Indexed keywords

AMINO ACIDS; BIOLOGICAL MEMBRANES; CONFORMATIONS; LIGANDS; LIPID BILAYERS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SIGNALING;

CONFORMATIONAL CHANGE; CONFORMATIONAL EQUILIBRIUM; G PROTEIN COUPLED RECEPTORS; INTRACELLULAR CAVITIES; ISOTOPIC LABELING; MEMBRANE PROTEINS; METHIONINE RESIDUES; TRANSMEMBRANE HELICES;

PROTEINS;

MU OPIATE RECEPTOR;

CHEMISTRY; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION;

NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; RECEPTORS, OPIOID, MU;

EID: 84955294050 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201508794 Document Type: Article

Times cited : (112)

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