GRIM-19 inhibition induced autophagy through activation of ERK and HIF-1α not STAT3 in Hela cells

Tumor Biology

Volumn 37, Issue 7, 2016, Pages 9789-9796

  Yue, Xin ^a   Zhao, Peiwei ^a   Wu, Kongming ^b   Huang, Juan ^a   Zhang, Wen ^a   Wu, Yaogui ^c   Liang, Xiaohui ^c   He, Xuelian ^a  

^a Wuhan Medical and Healthcare Center for Women and Children   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c WUHAN UNIVERSITY   (China)

Author keywords

Autophagy; Cervical cancer; Chemotherapy; ERK; GRIM 19; HIF 1a

Indexed keywords

ACETYLCYSTEINE; GRIM 19 PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INITIATION FACTOR 4E BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; STAT3 PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; GRIM19 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; MAPK1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OXIDOREDUCTASE; SMALL INTERFERING RNA; STAT3 PROTEIN, HUMAN; TUMOR MARKER;

ADULT; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER PROGNOSIS; CANCER STAGING; CELL VACUOLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; METABOLIC REGULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION; UTERINE CERVIX CANCER; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CASE CONTROL STUDY; CELL PROLIFERATION; COMPARATIVE STUDY; DRUG EFFECTS; DRUG RESISTANCE; FLUORESCENT ANTIBODY TECHNIQUE; FOLLOW UP; GENETICS; LYMPH NODE METASTASIS; MALE; METABOLISM; PATHOLOGY; PROGNOSIS; SURVIVAL RATE; TUMOR CELL CULTURE; TUMOR INVASION; UTERINE CERVICAL NEOPLASMS; WESTERN BLOTTING;

ADULT; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BIOMARKERS, TUMOR; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FOLLOW-UP STUDIES; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LYMPHATIC METASTASIS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NADH, NADPH OXIDOREDUCTASES; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PACLITAXEL; PROGNOSIS; RNA, SMALL INTERFERING; STAT3 TRANSCRIPTION FACTOR; SURVIVAL RATE; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 84955276281     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-016-4877-5     Document Type: Article

References (29)

1. Angell JE, Lindner DJ, Shapiro PS, Hofmann ER, Kalvakolanu DV. Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach. J Biol Chem. 2000;275:33416–26.
2. Lufei C, Ma J, Huang G, Zhang T, Novotny-Diermayr V, Ong CT. GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction. Embo J. 2003;22:1325–35.
3. Zhang J, Yang J, Roy SK, Tininini S, Hu J, Bromberg JF, et al. The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci U S A. 2003;100:9342–7.
4. He X, Cao X. Identification of alternatively spliced GRIM-19 mRNA in kidney cancer tissues. J Hum Genet. 2010;55:507–11.
5. Máximo V, Botelho T, Capela J, Soares P, Lima J, Taveira A, et al. Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. Br J Cancer. 2005;92:1892–8.
6. Hao M, Shu Z, Sun H, Sun R, Wang Y, Liu T, et al. GRIM-19 expression is a potent prognostic marker in colorectal cancer. Hum Pathol. 2015;46:1815–20.
7. Liu Q, Wang L, Wang Z, Yang Y, Tian J, Liu G, et al. GRIM-19 opposes reprogramming of glioblastoma cell metabolism via HIF1α destabilization. Carcinogenesis. 2013;34:1728–36.
8. Fearnley IM, Carroll J, Shannon RJ, Runswick MJ, Walker JE, Hirst J. GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH:ubiquinone oxidoreductase (complex I). J Biol Chem. 2001;276:38345–8.
9. Huang G, Lu H, Hao A, Ng DC, Ponniah S, Guo K, et al. GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I. Mol Cell Biol. 2004;24:8447–56.
10. Chen Y, Yuen WH, Fu J, Huang G, Melendez AJ, Ibrahim FB, et al. The mitochondrial respiratory chain controls intracellular calcium signaling and NFAT activity essential for heart formation in Xenopus laevis. Mol Cell Biol. 2007;27:6420–32.
11. Chen Y, Lu H, Liu Q, Huang G, Lim CP, Zhang L, et al. Function of GRIM-19, a mitochondrial respiratory chain complex I protein, in innate immunity. J Biol Chem. 2012;287:27227–35.
12. Yeo WM, Isegawa Y, Chow VT. The U95 protein of human herpesvirus 6B interacts with human GRIM-19: silencing of U95 expression reduces viral load and abrogates loss of mitochondrial membrane potential. J Virol. 2008;82:1011–20.
13. Seo T, Lee D, Shim YS, Angell JE, Chidambaram NV, Kalvakolanu DV, et al. Viral interferon regulatory factor 1 of Kaposi’s sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death. J Virol. 2002;76:8797–807.
14. Barnich N, Hisamatsu T, Aguirre JE, Xavier R, Reinecker HC, Podolsky DK. GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells. J Biol Chem. 2005;280:19021–6.
15. Levine B, Ranganathan R. Autophagy: snapshot of the network. Nature. 2010;466:38–40.
16. Mukhopadhyay S, Panda PK, Sinha N, Das DN, Bhutia SK. Autophagy and apoptosis: where do they meet? Apoptosis. 2014;19:555–66.
17. Huang G, Chen Y, Lu H, Cao X. Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death. Cell Death Differ. 2007;14:327–37.
18. Liu Y, Zhou R, Yuan X, Han N, Zhou S, Xu H, et al. DACH1 is a novel predictive and prognostic biomarker in hepatocellular carcinoma as a negative regulator of Wnt/β-catenin signaling. Oncotarget. 2015;6:8621–34.
19. Chu Q, Han N, Yuan X, Nie X, Wu H, Chen Y, et al. DACH1 inhibits cyclin D1 expression, cellular proliferation and tumor growth of renal cancer cells. J Hematol Oncol. 2014;7:73.
20. Han N, Yuan X, Wu H, Xu H, Chu Q, Guo M, et al. DACH1 inhibits lung adenocarcinoma invasion and tumor growth by repressing CXCL5 signaling. Oncotarget. 2015;6:5877–88.
21. Andreux PA, Houtkooper RH, Auwerx J. Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov. 2013;12:465–83.
22. Stefanatos R, Sanz A. Mitochondrial complex I: a central regulator of the aging process. Cell Cycle. 2011;10:1528–32.
23. Okon IS, Zou MH. Mitochondrial ROS and cancer drug resistance: implications for therapy. Pharmacol Res. 2015;100:170–4.
24. Okon IS, Coughlan KA, Zhang M, Wang Q, Zou MH. Gefitinib-mediated reactive oxygen specie (ROS) instigates mitochondrial dysfunction and drug resistance in lung cancer cells. J Biol Chem. 2015;290:9101–10.
25. Trachootham D, Alexandre J, Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov. 2009;8:579–91.
26. He X, Zhou A, Lu H, Chen Y, Huang G, Yue X, et al. Suppression of mitochondrial complex I influences cell metastatic properties. PLoS One. 2013;8:e61677.
27. Sui X, Chen R, Wang Z, Huang Z, Kong N, Zhang M, et al. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis. 2013;4:e838.
28. Yokoyama T, Kondo Y, Kondo S. Roles of mTOR and STAT3 in autophagy induced by telomere 3′ overhang-specific DNA oligonucleotides. Autophagy. 2007;3:496–8.
29. Peng X, Gong F, Chen Y, Jiang Y, Liu J, Yu M, et al. Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1-α-mediated signaling. Cell Death Dis. 2014;5:e1367.