Switching the Regioselectivity of a Cyclohexanone Monooxygenase toward (+)-trans-Dihydrocarvone by Rational Protein Design

ACS Chemical Biology

Volumn 11, Issue 1, 2016, Pages 38-43

  Balke, Kathleen ^a   Schmidt, Sandy ^a   Genz, Maika ^a   Bornscheuer, Uwe T ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CARVONE; CYCLOHEXANONE; ENZYME VARIANT; LACTONE; OXYGEN; PHENYLALANINE; TRANS DIHYDROCARVONE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; VALINE; CYCLOHEXANONE OXYGENASE; DIHYDROCARVONE; OXYGENASE; TERPENE;

ARTHROBACTER; ARTICLE; BIOCATALYSIS; CATALYSIS; CHEMICAL REACTION KINETICS; CONFORMATION; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME CONFORMATION; KINETIC PARAMETERS; MICHAELIS MENTEN KINETICS; NONHUMAN; OXYGEN CONCENTRATION; PH; PRIORITY JOURNAL; REACTION ANALYSIS; REACTION TIME; REGIOSELECTIVITY; SUBSTRATE CONCENTRATION; WHOLE CELL; ACTINOBACTERIA; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR DOCKING; MUTATION; STEREOISOMERISM;

ACTINOBACTERIA; ARTHROBACTER; CATALYTIC DOMAIN; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MONOTERPENES; MUTATION; OXYGENASES; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84955273067     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00723     Document Type: Article

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