Fisetin induces apoptosis and endoplasmic reticulum stress in human non-small cell lung cancer through inhibition of the MAPK signaling pathway

Tumor Biology

Volumn 37, Issue 7, 2016, Pages 9615-9624

  Kang, Kyoung Ah ^a   Piao, Mei Jing ^a   Madduma Hewage, Susara Ruwan Kumara ^a   Ryu, Yea Seong ^a   Oh, Min Chang ^a   Kwon, Taeg Kyu ^b   Chae, Sungwook ^c   Hyun, Jin Won ^a  

^a Jeju National University School of Medicine   (South Korea)

^b Keimyung University School of Medicine   (South Korea)

^c Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

Apoptosis; ER stress; Fisetin; Human non small cell lung cancer; MAPK signaling pathway; Reactive oxygen species

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CALCIUM; CASPASE 12; CCAAT ENHANCER BINDING PROTEIN; FISETIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; INOSITOL REQUIRING KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; X BOX TRANSCRIPTION FACTOR 1; FLAVONOID;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME INDUCTION; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; LUNG CANCER CELL LINE; MITOCHONDRION; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; CARCINOMA, NON-SMALL-CELL LUNG; CELL DEATH; DRUG EFFECTS; ENDOPLASMIC RETICULUM; LUNG NEOPLASMS; METABOLISM; PHOSPHORYLATION;

APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL DEATH; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FLAVONOIDS; HUMANS; LUNG NEOPLASMS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84955248258     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-016-4864-x     Document Type: Article

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