Anticancer activity of novel daphnane diterpenoids from Daphne genkwa through cell-cycle arrest and suppression of Akt/STAT/Src signalings in human lung cancer cells

Biomolecules and Therapeutics

Volumn 20, Issue 6, 2012, Pages 513-519

  Jo, Si Kyoung ^a   Hong, Ji Young ^b   Park, Hyen Joo ^b   Lee, Sang Kook ^b  

^a Ewha Womans University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Akt; Anti proliferation; Cell cycle arrest; Daphnane diterpenoids; Drug resistant; Human lung cancer cells

Indexed keywords

CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN E; DITERPENOID; ERLOTINIB; GEFITINIB; GEMCITABINE; MYC PROTEIN; PROTEIN KINASE B; PROTEIN P53; PROTEIN TYROSINE KINASE; RETINOBLASTOMA PROTEIN; STAT PROTEIN; UNCLASSIFIED DRUG; YUANHUAGINE; YUANHUAHINE; YUANHUALINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CORRELATION ANALYSIS; DAPHNE; DAPHNE GENKNWA; DRUG DETERMINATION; DRUG EFFICACY; DRUG ISOLATION; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME REGULATION; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; LUNG CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TREATMENT RESPONSE;

DAPHNE GENKWA; THYMELAEACEAE;

EID: 84870887601     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2012.20.6.513     Document Type: Article

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