Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ

Aging Cell

Volumn 15, Issue 1, 2016, Pages 128-139

  Pararasa, Chathyan ^a   Ikwuobe, John ^a   Shigdar, Shahjahan ^a   Boukouvalas, Alexis ^a   Nabney, Ian T ^a   Brown, James E ^a   Devitt, Andrew ^a   Bailey, Clifford J ^a   Bennett, Stuart J ^a,b   Griffiths, Helen R ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

Anti inflammatory; Macrophage; Mitochondrial ROS; Oleate; Oxidative phosphorylation; Palmitate

Indexed keywords

GLUTATHIONE; HIGH DENSITY LIPOPROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; MEMBRANE ANTIGEN; MONOUNSATURATED FATTY ACID; MYRISTIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN; CERAMIDE; CYTOKINE; FATTY ACID; TUMOR NECROSIS FACTOR;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CELL AGING; CELL DIFFERENTIATION; CELL METABOLISM; CELL POLARITY; CYTOKINE RELEASE; CYTOKINE RESPONSE; GAS CHROMATOGRAPHY; HUMAN; INFLAMMATORY CELL; LEUKOCYTE; MACROPHAGE; MALE; MONOCYTE; MONONUCLEAR CELL; NORMAL HUMAN; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SECRETION; ADOLESCENT; AGE; CYTOLOGY; INFLAMMATION; LIPID METABOLISM; METABOLISM; PHYSIOLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; CELL DIFFERENTIATION; CELL POLARITY; CERAMIDES; CYTOKINES; FATTY ACIDS; HUMANS; INFLAMMATION; LIPID METABOLISM; MACROPHAGES; MALE; MONOCYTES; PPAR GAMMA; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84955213575     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12416     Document Type: Article

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