Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin

ChemBioChem

Volumn 16, Issue 17, 2015, Pages 2484-2490

  Hirayama, Akane ^a   Miyanaga, Akimasa ^a   Kudo, Fumitaka ^a   Eguchi, Tadashi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

biosynthesis; natural products; pactamycin; PLP dependent enzymes; quinonoid

Indexed keywords

3 AMINOBENZOATE; 3 AMINOBENZOIC ACID; 3 DEHYDROSHIKIMATE; AMINOTRANSFERASE; LYSINE; PACTAMYCIN; PYRIDOXAL 5 PHOSPHATE; PYRIDOXAL 5 PHOSPHATE DEPENDENT ENZYME; QUINONE DERIVATIVE; SYNTHETASE; UNCLASSIFIED DRUG; 3 AMINOBENZOIC ACID DERIVATIVE; 3-AMINOBENZOIC ACID; 3-DEHYDROSHIKIMATE; BENZOATE SYNTHASE; OXIDOREDUCTASE; SHIKIMIC ACID;

AROMATIZATION; ARTICLE; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME STRUCTURE; FLOW MEASUREMENT; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; REACTION ANALYSIS; X RAY CRYSTALLOGRAPHY; ANALOGS AND DERIVATIVES; BINDING SITE; BIOCATALYSIS; BIOSYNTHESIS; CHEMISTRY; GENETICS; KINETICS; METABOLISM; MOLECULAR DYNAMICS; SITE DIRECTED MUTAGENESIS; ULTRAVIOLET SPECTROPHOTOMETRY;

BINDING SITES; BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; KINETICS; META-AMINOBENZOATES; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES; PACTAMYCIN; PYRIDOXAL PHOSPHATE; SHIKIMIC ACID; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 84955183142     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201500426     Document Type: Article

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