Genetic dysfunction of serotonin 2A receptor hampers response to antidepressant drugs: A translational approach

Neuropharmacology

Volumn 105, Issue , 2016, Pages 142-153

  Qesseveur, Gaël ^a   Petit, Anne Cécile ^a,b   Nguyen, Hai Thanh ^a   Dahan, Lionel ^c   Colle, Romain ^a,b   Rotenberg, Samuel ^a,b   Seif, Isabelle ^a   Robert, Pauline ^d   David, Denis ^a   Guilloux, Jean Philippe ^a   Gardier, Alain M ^a   Verstuyft, Céline ^b,e   Becquemont, Laurent ^b,e   Corruble, Emmanuelle ^a,b   Guiard, Bruno P ^a,c  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b BICÊTRE HOSPITAL   (France)

^c Université Paul Sabatier   (France)

^d IPSIT   (France)

^e INSERM U1184   (France)

Author keywords

5 HT transporter; 5 HT2A receptor; 5 HT1A receptor; Antidepressant; Electrophysiology; Genetic; Hippocampus; MDD: major depressive disorder; MDE: major depressive episode; Polymorphism; SSRI

Indexed keywords

AGOMELATINE; ANTIDEPRESSANT AGENT; ESCITALOPRAM; FLUOXETINE; IPRONIAZID; MIANSERIN; MIRTAZAPINE; MOCLOBEMIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 2A RECEPTOR; TIANEPTINE; VOLINANSERIN; CITALOPRAM; SEROTONIN UPTAKE INHIBITOR;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL ACTIVITY; COHORT ANALYSIS; CONTROLLED STUDY; DRUG EFFICACY; GENE; GENE INACTIVATION; GENE LOSS; GENETIC DISORDER; GENETIC VARIABILITY; HTR2A GENE; HUMAN; IN VIVO STUDY; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MONOTHERAPY; MOUSE; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; ADOLESCENT; ANIMAL; CELL SURVIVAL; DEPRESSIVE DISORDER, MAJOR; DORSAL RAPHE NUCLEUS; DRUG EFFECTS; GENETICS; GENOTYPE; HIPPOCAMPUS; KNOCKOUT MOUSE; MIDDLE AGED; NERVE CELL; PHYSIOLOGY; TRANSLATIONAL RESEARCH; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANIMALS; ANTIDEPRESSIVE AGENTS; CELL SURVIVAL; CITALOPRAM; DEPRESSIVE DISORDER, MAJOR; DORSAL RAPHE NUCLEUS; FLUOXETINE; GENOTYPE; HIPPOCAMPUS; HUMANS; MICE; MICE, KNOCKOUT; MIDDLE AGED; NEURONS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN UPTAKE INHIBITORS; TRANSLATIONAL MEDICAL RESEARCH; YOUNG ADULT;

EID: 84955110711     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.12.022     Document Type: Article

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