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Angewandte Chemie - International Edition

Volumn 54, Issue 52, 2015, Pages 15888-15891

Selective Inhibition of the Immunoproteasome by Structure-Based Targeting of a Non-catalytic Cysteine

(5) Dubiella, Christian a Baur, Regina a Cui, Haissi a Huber, Eva M a Groll, Michael a

a TECHNICAL UNIVERSITY OF MUNICH (Germany)

Author keywords

drug design; immunology; immunoproteasome; selective inhibitors; structure activity relationships

Indexed keywords

AMINO ACIDS; CELL DEATH; CYTOTOXICITY; IMMUNOLOGY;

ANTI-INFLAMMATORY AGENTS; DRUG DESIGN; IMMUNOPROTEASOME; INFLAMMATORY CYTOKINES; PROTEASOME INHIBITORS; SELECTIVE INHIBITION; SELECTIVE INHIBITORS; STRUCTURE ACTIVITY RELATIONSHIPS;

STRUCTURAL OPTIMIZATION;

CYSTEINE; CYSTEINE PROTEINASE INHIBITOR; PROTEASOME;

CATALYSIS; CHEMISTRY; DRUG EFFECTS;

CATALYSIS; CYSTEINE; CYSTEINE PROTEINASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 84955107386 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201506631 Document Type: Article

Times cited : (25)

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