-
1
-
-
23044466047
-
Specificity and versatility in tgf-beta signaling through Smads
-
Feng, X. H., Derynck, R. Specificity and versatility in tgf-beta signaling through Smads. Annual review of cell and developmental biology 21, 659-693, doi: 10.1146/annurev.cellbio.21.022404.142018 (2005).
-
(2005)
Annual Review of Cell and Developmental Biology
, vol.21
, pp. 659-693
-
-
Feng, X.H.1
Derynck, R.2
-
2
-
-
0031685620
-
TGF-beta signal transduction
-
Massague, J. TGF-beta signal transduction. Annual review of biochemistry 67, 753-791, doi: 10.1146/annurev.biochem.67.1.753 (1998).
-
(1998)
Annual Review of Biochemistry
, vol.67
, pp. 753-791
-
-
Massague, J.1
-
3
-
-
84886897989
-
Adult-specific systemic over-expression reveals novel in vivo effects of the soluble forms of ActRIIA, ActRIIB and BMPRII
-
Yamawaki, K. et al. Adult-specific systemic over-expression reveals novel in vivo effects of the soluble forms of ActRIIA, ActRIIB and BMPRII. PloS one 8, e78076, doi: 10.1371/journal.pone.0078076 (2013).
-
(2013)
PloS One
, vol.8
, pp. e78076
-
-
Yamawaki, K.1
-
4
-
-
0036904895
-
Genetic analysis of the mammalian transforming growth factor-beta superfamily
-
Chang, H., Brown, C. W., Matzuk, M. M. Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocrine reviews 23, 787-823 (2002).
-
(2002)
Endocrine Reviews
, vol.23
, pp. 787-823
-
-
Chang, H.1
Brown, C.W.2
Matzuk, M.M.3
-
5
-
-
0037250476
-
Consequences of knocking out BMP signaling in the mouse
-
(New York NY: 2000)
-
Zhao, G. Q. Consequences of knocking out BMP signaling in the mouse. Genesis (New York, NY: 2000) 35, 43-56, doi: 10.1002/gene.10167 (2003).
-
(2003)
Genesis
, vol.35
, pp. 43-56
-
-
Zhao, G.Q.1
-
7
-
-
29144466479
-
Regulation of muscle growth by multiple ligands signaling through activin type II receptors
-
Lee, S. J. et al. Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proceedings of the National Academy of Sciences of the United States of America 102, 18117-18122, doi: 10.1073/pnas.0505996102 (2005).
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, pp. 18117-18122
-
-
Lee, S.J.1
-
8
-
-
77956032509
-
A soluble activin receptor type IIb prevents the effects of androgen deprivation on body composition and bone health
-
Koncarevic, A. et al. A soluble activin receptor type IIb prevents the effects of androgen deprivation on body composition and bone health. Endocrinology 151, 4289-4300, doi: 10.1210/en.2010-0134 (2010).
-
(2010)
Endocrinology
, vol.151
, pp. 4289-4300
-
-
Koncarevic, A.1
-
9
-
-
76649106431
-
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth
-
Mitchell, D. et al. ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth. Molecular cancer therapeutics 9, 379-388, doi: 10.1158/1535-7163.MCT-09-0650 (2010).
-
(2010)
Molecular Cancer Therapeutics
, vol.9
, pp. 379-388
-
-
Mitchell, D.1
-
10
-
-
84864353942
-
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength
-
Baud'huin, M. et al. A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength. Proceedings of the National Academy of Sciences of the United States of America 109, 12207-12212, doi: 10.1073/pnas.1204929109 (2012).
-
(2012)
Proceedings of the National Academy of Sciences of the United States of America
, vol.109
, pp. 12207-12212
-
-
Baud'Huin, M.1
-
11
-
-
84892903671
-
Multiple-dose, safety, pharmacokinetic, and pharmacodynamic study of sotatercept (ActRIIA-IgG1), a novel erythropoietic agent, in healthy postmenopausal women
-
Sherman, M. L. et al. Multiple-dose, safety, pharmacokinetic, and pharmacodynamic study of sotatercept (ActRIIA-IgG1), a novel erythropoietic agent, in healthy postmenopausal women. Journal of clinical pharmacology 53, 1121-1130, doi: 10.1002/jcph.160 (2013).
-
(2013)
Journal of Clinical Pharmacology
, vol.53
, pp. 1121-1130
-
-
Sherman, M.L.1
-
12
-
-
84892774957
-
Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with advanced cancer
-
Bendell, J. C. et al. Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with advanced cancer. Clinical cancer research: an official journal of the American Association for Cancer Research 20, 480-489, doi: 10.1158/1078-0432.CCR-13-1840 (2014).
-
(2014)
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
, vol.20
, pp. 480-489
-
-
Bendell, J.C.1
-
13
-
-
84902829071
-
A phase 1 study of ACE-536, a regulator of erythroid differentiation, in healthy volunteers
-
Attie, K. M. et al. A phase 1 study of ACE-536, a regulator of erythroid differentiation, in healthy volunteers. American journal of hematology 89, 766-770, doi: 10.1002/ajh.23732 (2014).
-
(2014)
American Journal of Hematology
, vol.89
, pp. 766-770
-
-
Attie, K.M.1
-
14
-
-
84901692001
-
Sotatercept in patients with osteolytic lesions of multiple myeloma1
-
Abdulkadyrov, K. M. et al. Sotatercept in patients with osteolytic lesions of multiple myeloma. British Journal of Haematology 165, 814-823, doi: 10.1111/bjh.12835 (2014).
-
(2014)
British Journal of Haematology
, vol.165
, pp. 814-823
-
-
Abdulkadyrov, K.M.1
-
15
-
-
25444529969
-
Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses
-
Mazerbourg, S. et al. Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. The Journal of biological chemistry 280, 32122-32132, doi: 10.1074/jbc.M504629200 (2005).
-
(2005)
The Journal of Biological Chemistry
, vol.280
, pp. 32122-32132
-
-
Mazerbourg, S.1
-
16
-
-
79151473137
-
Bone morphogenetic proteins: A critical review
-
Bragdon, B. et al. Bone morphogenetic proteins: a critical review. Cellular signalling 23, 609-620, doi: 10.1016/j.cellsig.2010.10.003 (2011).
-
(2011)
Cellular Signalling
, vol.23
, pp. 609-620
-
-
Bragdon, B.1
-
17
-
-
17044364765
-
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo
-
Yoon, B. S. et al. Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proceedings of the National Academy of Sciences of the United States of America 102, 5062-5067, doi: 10.1073/pnas.0500031102 (2005).
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, pp. 5062-5067
-
-
Yoon, B.S.1
-
18
-
-
77954831976
-
Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development
-
Edson, M. A. et al. Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development. Molecular endocrinology (Baltimore, Md.) 24, 1251-1266, doi: 10.1210/me.2009-0461 (2010).
-
(2010)
Molecular Endocrinology (Baltimore, Md.)
, vol.24
, pp. 1251-1266
-
-
Edson, M.A.1
-
19
-
-
84857374828
-
A covalently dimerized recombinant human bone morphogenetic protein-15 variant identifies bone morphogenetic protein receptor type 1B as a key cell surface receptor on ovarian granulosa cells
-
Pulkki, M. M. et al. A covalently dimerized recombinant human bone morphogenetic protein-15 variant identifies bone morphogenetic protein receptor type 1B as a key cell surface receptor on ovarian granulosa cells. Endocrinology 153, 1509-1518, doi: 10.1210/en.2010-1390 (2012).
-
(2012)
Endocrinology
, vol.153
, pp. 1509-1518
-
-
Pulkki, M.M.1
-
20
-
-
76149085535
-
BMPR1a and BMPR1b signaling exert opposing effects on gliosis after spinal cord injury
-
Sahni, V. et al. BMPR1a and BMPR1b signaling exert opposing effects on gliosis after spinal cord injury. The Journal of neuroscience: the official journal of the Society for Neuroscience 30, 1839-1855, doi: 10.1523/JNEUROSCI.4459-09.2010 (2010).
-
(2010)
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience
, vol.30
, pp. 1839-1855
-
-
Sahni, V.1
-
21
-
-
56749149761
-
Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass
-
Kamiya, N. et al. Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass. Journal of Bone and Mineral Research 23, 2007-2017, doi: 10.1359/jbmr.080809 (2008).
-
(2008)
Journal of Bone and Mineral Research
, vol.23
, pp. 2007-2017
-
-
Kamiya, N.1
-
22
-
-
0242363225
-
Identification of the haematopoietic stem cell niche and control of the niche size
-
Zhang, J. et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836-841, doi: 10.1038/nature02041 (2003).
-
(2003)
Nature
, vol.425
, pp. 836-841
-
-
Zhang, J.1
-
23
-
-
0033960316
-
The type i BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
-
Yi, S. E., Daluiski, A., Pederson, R., Rosen, V., Lyons, K. M. The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development 127, 621-630 (2000).
-
(2000)
Development
, vol.127
, pp. 621-630
-
-
Yi, S.E.1
Daluiski, A.2
Pederson, R.3
Rosen, V.4
Lyons, K.M.5
-
24
-
-
0037054548
-
Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation
-
Zhao, M. et al. Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. The Journal of cell biology 157, 1049-1060, doi: 10.1083/jcb.200109012 (2002).
-
(2002)
The Journal of Cell Biology
, vol.157
, pp. 1049-1060
-
-
Zhao, M.1
-
25
-
-
40449084522
-
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
-
Hilton, M. J. et al. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nature medicine 14, 306-314, doi: 10.1038/nm1716 (2008).
-
(2008)
Nature Medicine
, vol.14
, pp. 306-314
-
-
Hilton, M.J.1
-
27
-
-
27244453009
-
A novel transgenic chimaeric mouse system for the rapid functional evaluation of genes encoding secreted proteins
-
Kakitani, M. et al. A novel transgenic chimaeric mouse system for the rapid functional evaluation of genes encoding secreted proteins. Nucleic acids research 33, e85, doi: 10.1093/nar/gni083 (2005).
-
(2005)
Nucleic Acids Research
, vol.33
, pp. e85
-
-
Kakitani, M.1
-
28
-
-
23844455584
-
Mitogenic influence of human R-spondin1 on the intestinal epithelium
-
Kim, K. A. et al. Mitogenic influence of human R-spondin1 on the intestinal epithelium. Science (New York, NY) 309, 1256-1259, doi: 10.1126/science.1112521 (2005).
-
(2005)
Science (New York, NY)
, vol.309
, pp. 1256-1259
-
-
Kim, K.A.1
-
29
-
-
0036087521
-
Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects
-
Yang, Y. A. et al. Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects. The Journal of clinical investigation 109, 1607-1615, doi: 10.1172/jci15333 (2002).
-
(2002)
The Journal of Clinical Investigation
, vol.109
, pp. 1607-1615
-
-
Yang, Y.A.1
-
30
-
-
12344286014
-
A comparison of mechanical properties derived from multiple skeletal sites in mice
-
Schriefer, J. L. et al. A comparison of mechanical properties derived from multiple skeletal sites in mice. Journal of biomechanics 38, 467-475, doi: 10.1016/j.jbiomech.2004.04.020 (2005).
-
(2005)
Journal of Biomechanics
, vol.38
, pp. 467-475
-
-
Schriefer, J.L.1
-
31
-
-
3142746721
-
The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations
-
Howe, J. R. The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. Journal of Medical Genetics 41, 484-491, doi: 10.1136/jmg.2004.018598 (2004).
-
(2004)
Journal of Medical Genetics
, vol.41
, pp. 484-491
-
-
Howe, J.R.1
-
32
-
-
84885186411
-
Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis
-
Voorneveld, P. W. et al. Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis. British journal of cancer 109, 1805-1812, doi: 10.1038/bjc.2013.486 (2013).
-
(2013)
British Journal of Cancer
, vol.109
, pp. 1805-1812
-
-
Voorneveld, P.W.1
-
33
-
-
34548580322
-
Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice
-
Bleuming, S. A. et al. Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice. Cancer research 67, 8149-8155, doi: 10.1158/0008-5472.CAN-06-4659 (2007).
-
(2007)
Cancer Research
, vol.67
, pp. 8149-8155
-
-
Bleuming, S.A.1
-
34
-
-
6944224156
-
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
-
He, X. C. et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nature genetics 36, 1117-1121, doi: 10.1038/ng1430 (2004).
-
(2004)
Nature Genetics
, vol.36
, pp. 1117-1121
-
-
He, X.C.1
-
35
-
-
66649097584
-
Sagopilone inhibits breast cancer bone metastasis and bone destruction due to simultaneous inhibition of both tumor growth and bone resorption
-
Strube, A. et al. Sagopilone inhibits breast cancer bone metastasis and bone destruction due to simultaneous inhibition of both tumor growth and bone resorption. Clinical cancer research: an official journal of the American Association for Cancer Research 15, 3751-3759, doi: 10.1158/1078-0432.CCR-08-3123 (2009).
-
(2009)
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
, vol.15
, pp. 3751-3759
-
-
Strube, A.1
-
36
-
-
54549102135
-
Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway
-
Katsuno, Y. et al. Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway. Oncogene 27, 6322-6333, doi: 10.1038/onc.2008.232 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 6322-6333
-
-
Katsuno, Y.1
-
37
-
-
84884336670
-
BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment
-
Ampuja, M. et al. BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment. BMC cancer 13, 429, doi: 10.1186/1471-2407-13-429 (2013).
-
(2013)
BMC Cancer
, vol.13
, pp. 429
-
-
Ampuja, M.1
-
38
-
-
61949213192
-
Humoral bone morphogenetic protein 2 is sufficient for inducing breast cancer microcalcification
-
Liu, F. et al. Humoral bone morphogenetic protein 2 is sufficient for inducing breast cancer microcalcification. Molecular imaging 7, 175-186 (2008).
-
(2008)
Molecular Imaging
, vol.7
, pp. 175-186
-
-
Liu, F.1
-
39
-
-
21344473027
-
First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptorpositive breast cancer
-
Helms, M. W. et al. First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptorpositive breast cancer. The Journal of pathology 206, 366-376, doi: 10.1002/path.1785 (2005).
-
(2005)
The Journal of Pathology
, vol.206
, pp. 366-376
-
-
Helms, M.W.1
-
40
-
-
18844424225
-
Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts
-
Kakeda, M. et al. Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts. Gene Ther 12, 852-856 (2005).
-
(2005)
Gene Ther
, vol.12
, pp. 852-856
-
-
Kakeda, M.1
|