Hemagglutinin protease secreted by V. cholerae induced apoptosis in breast cancer cells by ROS mediated intrinsic pathway and regresses tumor growth in mice model

Apoptosis

Volumn 21, Issue 2, 2016, Pages 143-154

  Ray, Tanusree ^a   Chakrabarti, Monoj Kumar ^a   Pal, Amit ^a  

^a NATIONAL INSTITUTE OF CHOLERA AND ENTERIC DISEASES   (India)

Author keywords

Apoptosis; HAP; ROS; Tumor regression

Indexed keywords

HEMAGGLUTININ; HEMAGGLUTININ PROTEASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; PROTEINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BACTERIAL PROTEIN; HEMAGGLUTININ-PROTEASE; METALLOPROTEINASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL; CANCER GROWTH; CANCER REGRESSION; CANCER SURVIVAL; CANCER THERAPY; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; EHRLICH ASCITES TUMOR; ENZYME RELEASE; EX VIVO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SURVIVAL RATE; TREATMENT OUTCOME; TUMOR VOLUME; VIBRIO CHOLERAE; WESTERN BLOTTING; ANIMAL; BREAST TUMOR; CANCER TRANSPLANTATION; CARCINOMA, EHRLICH TUMOR; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; FEMALE; HUMAN; METABOLISM; PATHOLOGY; RAW 264.7 CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BACTERIAL PROTEINS; BREAST NEOPLASMS; CARCINOMA, EHRLICH TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; METALLOENDOPEPTIDASES; MICE; NEOPLASM TRANSPLANTATION; OXIDATIVE STRESS; RAW 264.7 CELLS; REACTIVE OXYGEN SPECIES; TUMOR BURDEN; VIBRIO CHOLERAE;

EID: 84954551081     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-015-1194-1     Document Type: Article

References (39)

1. Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B (1975) An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci 72:3666-3670
2. Kokai KJF, Mcclane BA (1997) Determination of functional regions of Clostridium perfringens enterotoxin through deletion analysis. Clin Infect Dis 25:S165-S167. doi: 10.1086/516246
3. Kokai KJF, Benton K, Wieckowski EU, Mcclane BA (1999) Identification of a Clostridium perfringens enterotoxin region required for large complex formation and cytotoxicity by random mutagenesis. Infect Immun 67:5634-5641
4. Michl P, Buchholz M, Rolke M, Kunsch S, Löhr M, McClane B et al (2001) Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin. Gasrtoenterology 121:678-684. doi: 10.1053/gast.2001.27124
5. Hough CD, Sherman- Baust CA, Pizer ES, Montz FJ, Im DD, Rosenshein NB (2000) Large scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer. Cancer Res 60:6281-6287
6. Kominsky SL, Vali M, Korz D, Gabig TG, Weitzman SA, Argani P et al (2004) Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4. Am J Pathol 164:1627-1633. doi: 10.1016/S0002-9440(10)63721-2
7. Nougayrede JP, Taieb F, De Rycke J, Oswald E (2005) Cyclomodulins: bacterial effectors that modulate the eukaryotic cell cycle. Trends Microbiol 13:103-110. doi: 10.1016/j.tim.2005.01.002
8. Mohamed MM, Sloane BF (2006) Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 6:764-775. doi: 10.1038/nrc1949
9. Maeda H, Matsumura Y, Molla A (1987) Antitumor activity of some bacterial proteases: eradication of solid tumors in mice by intratumor injection. Cancer Res 47:563-566
10. Ghosh A, Saha DR, Hoque KM, Asakuna M, Yamasaki S, Koley H et al (2006) Enterotoxigenicity of mature 45-kilodalton and processed 35-kilodalton forms of hemagglutinin protease purified from a cholera toxin gene-negative Vibrio cholerae non-O1, non-O139 strain. Infect Immun 74(5):2937-2946. doi: 10.1128/IAI.74.5.2937-2946.2006
11. Syngkon A, Sridhar Elluri S, Koley H, Rompikuntal PK, Rani Saha DR, Chakrabarti MK et al (2010) Studies on a novel serine protease of a ΔhapaΔprtv vibrio cholerae o1 strain and its role in hemorrhagic response in the rabbit ileal loop model. PLoS One. doi: 10.1371/journal.pone.0013122
12. Nomura F, Akashi S, Sakao Y, Sato S, Kawai T, Matsumoto M et al (2000) Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol 164:3476-3479. doi: 10.4049/jimmunol.164.7.3476
13. Chattopadhyay S, Das T, Sa G, Ray PK (2002) Protein A-activated macrophages induce apoptosis in Ehrlich's ascites carcinoma through a nitric oxide-dependent pathway. Apoptosis 7:49-57
14. Bhattacharyya A, Choudhuri T, Pal S, Chattopadhyay S, Datta GK, Sa G et al (2003) Apoptogenic effects of black tea on Ehrlich's ascites carcinoma cell. Carcinogenesis 24(1):75-80. doi: 10.1093/carcin/24.1.75
15. Roy T, Paul S, Baral RN, Chattopadhyay U, Biswas R (2007) Tumor associated release of interleukin-10 alters the prolactin receptor and down-regulates prolactin responsiveness of immature cortical thymocytes. J Neuroimmunol 186(1-2):112-120. doi: 10.1016/j.jneuroim.2007.03.011
16. McLiman WF, Dairs EV, Glover FL, Rake GW (1957) The submerged culture of mammalian cells. The spinner culture. J Immunol 79:428
17. Secades P, Guijarro JA (1999) Purification and characterization of an extracellular protease from the fish pathogen Yersinia ruckeri and effect of culture conditions on production. Appl Environ Microbiol 65(9):3969-3975
18. Pal S, Choudhuri T, Chattopadhyay S, Bhattacharya A, Datta GK, Das T et al (2001) Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites carcinoma cells. Biochem Biophys Res Commun 288:658-665. doi: 10.1006/bbrc.2001.5823
19. Das T, Sa G, Chattopadhyay S, Ray PK (2002) Protein A-induced apoptosis of cancer cells is affected by soluble immune mediators. Cancer Immunol Immunother 51:376-380. doi: 10.1007/s00262-002-0288-0
20. Gannon JV, Lane DP (1987) p63 and DNA polymerase a compete for the binding to SV40 T antigen. Nature 329:456-458
21. D'Armour FE, Blood FR, Belden DA (1965) The manual for laboratory work in mammalian physiology, 3rd edn. The University of Chicago Press, Chicago, pp 4-6
22. Sharma S, Panjamurthy K, Choudhary B, Srivastava M, Shahabuddin MS, Giri R (2011) A novel DNA intercalator, 8-methoxy pyrimido[4′,5′:4,5]thieno (2,3- b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor. Mol Carcinog 52(6):413-425. doi: 10.1002/mc.21867
23. Kumagai H, Mukaisho K, Sugihara H, Miwa K, Yamamoto G, Hattori T (2004) Thioproline inhibits development of esophageal adenocarcinoma induced by gastroduodenal reflux in rats. Carcinogenesis 25:723-727. doi: 10.1093/carcin/bgh067
24. Ribble D, Goldstein NB, Norris DA, Shellman YG (2005) A simple technique for quantifying apoptosis in 96-well plates. BMC Biotechnol 10:5-12. doi: 10.1186/1472-6750-5-12
25. Sannino P, Shousha S (1994) Demonstration of oestrogen receptors in paraffin wax sections of breast carcinoma using the monoclonal antibody 1D5 and microwave oven processing. J Clin Pathol 47:90-92
26. Ray T, Maity PC, Banerjee S, Deb S, Dasgupta AK, Sarkar S et al (2010) Vitamin C prevents cigarette smoke induced atherosclerosis in guinea pig model. J Atheroscler Thromb 17(8):817-827. doi: 10.5551/jat.2881
27. Cragg GM, Kingston D, Newman DJ (2005) Anticancer agents from natural products. Brunner-Routledge Psychology Press, London, pp 186-205
28. Newman DJ, Cragg GM, Snader KM (2003) Natural products as a source of new drugs over the period 1981-2002. J Nat Prod 66:1022-1037. doi: 10.1021/np030096l
29. Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, Oers MHV (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84:1415-1420
30. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J et al (1997) Prevention of apoptosis by Bcl-2: release of cytochrome C from mitochondria blocked. Science 275:1129-1132. doi: 10.1126/science.275.5303.1129
31. Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC (2012) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice. PLoS One 7(10):1-11. doi: 10.1371/journal.pone.0047021
32. Srivastava M, Nambiar M, Sharma S, Karki SS, Goldsmith G, Hegde M et al (2012) An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell 151:1474-1487. doi: 10.1016/j.cell.2012.11.054
33. Klaunig JE, Kamendulis LM, Hocevar BA (2010) Oxidative stress and oxidative damage in carcinogenesis. Toxicol Pathol 38:96-109. doi: 10.1177/0192623309356453
34. Trachootham D, Alexandre J, Huang P (2009) Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8:579-591. doi: 10.1038/nrd2803
35. Higuchi M, Honda T, Proske RJ, Yeh ET (1998) Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases. Oncogene 17:2753-2760
36. Harsdorf RV, Li PF, Dietz R (1999) Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation 99:2934-2941. doi: 10.1161/01.CIR.99.22.2934
37. Zamzami N, Hirsch T, Dallaporta B, Petit PX, Kroemer G (1997) Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J Bioenerg Biomembr 29:185-193. doi: 10.1023/A:1022694131572
38. Marzo I, Brenner C, Zamzami N, Jurgensmeier JM, Susin SA, Vieira HL et al (1998) Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 281:2027-2031. doi: 10.1126/science.281.5385.2027
39. Shimizu S, Narita M, Tsujimoto Y (1999) Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399:483-487. doi: 10.1038/20959