Enterotoxigenicity of mature 45-kilodalton and processed 35-kilodalton forms of hemagglutinin protease purified from a cholera toxin gene-negative Vibrio cholerae non-O1, non-O139 strain

Infection and Immunity

Volumn 74, Issue 5, 2006, Pages 2937-2946

  Ghosh, A ^a   Saha, D R ^a   Hoque, K M ^a   Asakuna, M ^b   Yamasaki, S ^b   Koley, H ^a   Das, S S ^a   Chakrabarti, M K ^a   Pal, A ^a  

^a NATIONAL INSTITUTE OF CHOLERA AND ENTERIC DISEASES   (India)

^b Osaka Prefecture University   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; EDETIC ACID; HEMAGGLUTININ PROTEASE; SECRETORY PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; BLEEDING; CHOLERA; CONTROLLED STUDY; DOSE RESPONSE; ENZYME PURIFICATION; ERYTHROCYTE; HELA CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; ILEUM; INFLAMMATION; INTESTINE VILLUS; LAMINA PROPRIA; NECROSIS; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; TISSUE CULTURE; VIBRIO CHOLERAE;

ANIMALS; CHOLERA TOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; ILEUM; METALLOENDOPEPTIDASES; MOLECULAR WEIGHT; RABBITS; RATS; VIBRIO CHOLERAE;

EID: 33646355412     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.74.5.2937-2946.2006     Document Type: Article

References (39)

1. Banerjee, K. K., A. N. Ghosh, K. Dutta-Roy, S. C. Pal, and A. C. Ghosh. 1990. Purification and characterization of a novel hemagglutinin from Vibrio cholerae. Infect. Immun. 58:3698-3705.
2. Benítez, J. A., L. Garcia, A. Silva, H. García, R. Fando, B. Cedré, A. Pérez, J. Campos, B. L. Rodríguez, J. L. Pérez, T. Valmaseda, O. Pérez, A. Pérez, M. Ramírez, T. Ledón, M. D. Jidy, M. Lastre, L. Bravo, and G. Sierra. 1999. Preliminary assessment of the safety and immunogenicity of a new CTXφ-negative, hemagglutinin/protease-defective El Tor strain as a cholera vaccine candidate. Infect. Immun. 67:539-545.
3. Booth, B. A., and R. A. Finkelstein. 1986. Presence of the HA/protease and other potential virulence factors in O1 and non-O1 Vibrio cholerae. J. Infect. Dis. 154:183-186.
4. De, S. N., and D. N. Chatterjee. 1953. An experimental study of the mechanism of action of Vibrio cholerae on the intestinal mucous membranes. J. Pathol. Bacteriol. 66:559-562.
5. Dubois, M., K. A. Gilles, J. K. Hamilton, P. A. Rebers, and F. Smith. 1956. Colorimetric method for determination of sugar and related substances. Anal. Chem. 28:350-356.
6. Faruque, S. M., N. Chowdhury, M. Kamruzzaman, M. Dziejman, M. H. Rahman, D. A. Sack, G. B. Nair, and J. J. Mekalanos. 2004. Genetic diversity and virulence potential of environmental Vibrio cholerae population in a cholera-endemic area. Proc. Natl. Acad. Sci. USA 101:2123-2128.
7. Field, M., M. C. Rao, and E. B. Chang. 1989. Intestinal electrolyte transport and diarrhoeal disease. N. Engl. J. Med. 21:879-883.
8. Field, M., and I. McCall. 1971. Ion transport in rabbit ileal mucus: I, Na and Cl fluxes and short-circuit current. Am. J. Physiol. 220:1388-1396.
9. Finkelstein, R. A., and L. F. Hanne. 1982. Purification and characterization of the soluble hemagglutinin (cholera lectin) produced by Vibrio cholerae. Infect. Immun. 36:1199-1208.
10. Fullner, K. J., J. C. Boucher, M. A. Hanes, G. K. Haines, B. M. Meehan, C. Walchle, P. J. Sansonetti, and J. J. Mekalonos. 2003. The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model. J. Exp. Med. 195:1455-1462.
11. Geboes, K., R. Riddell, A. Ost, B. Jensfelt, T. Persson, and R. Lofberg. 2000. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis. Gut 47:404-409.
12. Guanalini, S., J. F. Kechur, P. L. Smith, and M. Field. 1980. Somatostatin effects on ion transport in rabbit intestine. Am. J. Physiol. 240:G26-G32.
13. Gyobu, Y., H. Kodama, and H. Uetake. 1988. Production and partial purification of a fluid accumulating factor of non-O1 Vibrio cholerae. Microbiol. Immunol. 32:565-577.
14. Hase, C. H., and R. A. Finkelstein. 1991. Cloning and nucleotide sequence of the Vibrio cholerae hemagglutinin/protease (HA/protease) gene and construction of an HA/protease-negative strain. J. Bacteriol. 173:3311-3317.
15. Janda, J. M., C. Powers, R. G. Bryant, and S. L. Ahhott. 1988. Current perspectives on the epidemiology and pathogenesis of clinically significant Vibrio spp. Clin. Microbiol. Rev. 1:245-267.
16. Jones, G. W., G. D. Abrams, and R. Freter. 1976. Adhesive properties of Vibrio cholerae: adhesion to isolated rabbit brush border membranes and hemagglutinating activity. Infect. Immun. 14:232-239.
17. Kimsey, H. H., and M. K. Waldor. 1998. Vibrio cholerae hemagglutinin/protease inactivates CTXφ. Infect. Immun. 66:4025-4029.
18. Laemmli, U. K. 1970. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
19. Lu, L., M. E. Baldear, T. Savidge, C. Pothoulakis, and W. A. Walker. 2003. Development of microbial-human enterocyte interaction: cholera toxin. Pediatr. Res. 54:211-218.
20. Lyerly, D. M., D. E. Lockwood, S. H. Richardson, and T. D. Wilkins. 1982. Biological activities of toxins A and B of Clostridium difficile. Infect. Immun. 35:1147-1150.
21. Mel, S. F., K. A. Fullner, S. Wimer-Mackin, W. I. Lencer, and J. J. Mekalanos. 2000. Association of protease activity in Vibrio cholerae vaccine strains with decrease in transcellular epithelial resistance of polarized T84 intestinal epithelial cells. Infect. Immun. 68:6487-6492.
22. Morris, J. G., Jr. 1994. Non-O group 1 Vibrio cholerae strains not associated with epidemic disease, p. 103-115. In I. K. Wachsmuth, P. A. Blake, and O. Olsvik (ed.), Vibrio cholerae and cholera: molecular to global perspectives. American Society for Microbiology, Washington, D.C.
23. Mukhopadhyay, A. K., P. K. Saha, S. Garg, S. K. Bhattacharya, T. Shimada, T. Takeda, Y. Takeda, and G. B. Nair. 1995. Distribution and virulence of Vibrio cholerae belonging to serogroups other than O1 and O139: a nationwide survey. Epidemiol. Infect. 114:65-70.
24. Norqvist, A., B. Norman, and H. Wolf-Watz. 1990. Identification and characterization of a zinc metalloprotease associated with invasion by the fish pathogen Vibrio anguillarum. Infect. Immun. 58:3731-3736.
25. Osibo, R. J., D. M. Lyerly, R. L. Van Tassell, and T. D. Wilkins. 1995. Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vitro. Infect. Immun. 63:3820-3826.
26. Prescott, J. M., and S. H. Wilkes. 1976. Aeromonas aminopeptidase. Methods Enzymol. 45:530-543.
27. Qadri, F., T. R. Bhuiyan, K. K. Dutta, R. Raqib, M. S. Alam, N. H. Alam, A.-M. Svennerholm, and M. M. Mathan. 2004. Acute dehydrating disease caused by Vibrio cholerae serogroups O1 and O139 induce increases in innate cells and inflammatory mediators at the mucosal surfaces of the gut. Gut 53:62-69.
28. Qadri, F., R. Raquib, F. Ahmed, T. Rahman, C. Wennerae, S. K. Das, N. H. Alam, M. M. Mathan, and A. M. Svennerholm. 2002. Increased levels of inflammatory mediators in children and adults infected with Vibrio cholerae O1 and O139. Clin. Diagn. Lab. Immunol. 9:221-229.
29. Qing, X., M. Dziejman, and J. J. Mekalanos. 2003. Determination of the transcriptome of Vibrio cholerae during intraintestinal growth and midcx-ponential phase in vitro. Proc. Natl. Acad. Sci. USA 100:1286-1291.
30. Rodriguez, B. L., A. Rojas, J. Campus, T. Ledon, E. Valle, W. Toledo, and R. Fando. 2001. Differential interleukin-8 response of intestinal epithelial cell line to reactogenic and nonreactogenic candidate vaccine strains of Vibrio cholerae. Infect. Immun. 69:613-616.
31. Saha, D. R., S. K. Niyogi, G. B. Nair, B. Manna, and S. K. Bhattacharya. 2000. Detection of faecal leucocytes and erythrocytes from stools of cholera patients suggesting an evidence of an inflammatory response in cholera. Indian J. Med. Res. 112:5-8.
32. Saha, P. K., H. Koley, A. K. Mukhopadhyay, S. K. Bhattacharya, G. B. Nair, B. S. Ramakrishnan, S. Krishnan, T. Takeda, and Y. Takeda. 1996. Non-toxigenic Vibrio cholerae O1 serotype Inaba biotype El Tor associated with a cluster of cases of cholera in southern India. J. Clin. Microbiol. 34:1114-1117.
33. Saha, P. K., H. Koley, and G. B. Nair. 1996. Purification and characterization of an extracellular secretogenic non-membrane-damaging cytotoxin production by clinical strains of Vibrio cholerae non-O1. Infect. Immun. 64:3101-3108.
34. Sandkvist, M., L. O. Michel, L. P. Hough, V. M. Morales, M. Bagdasarian, M. Koomey, V. J. DiRita, and M. Bagdasarian. 1997. General secretion pathway (esp) genes required for toxin secretion and outer membrane biogenesis in Vibrio cholerae. J. Bacteriol. 179:6994-7003.
35. Schneider, D. R., and C. D. Parker. 1978. Isolation and characterization of protease-deficient mutant of Vibrio cholerae. J. Infect. Dis. 138:143-151.
36. Silva, T. M., M. A. Schleupner, C. O. Tacket, T. S. Steiner, J. B. Kaper, R. Edelman, and R. L. Gurrant. 1996. New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and O139 Vibrio cholerae. Infect. Immun. 64:2362-2364.
37. Toma, C., and Y. Honma. 1996. Cloning and genetic analysis of the Vibrio cholerae aminopeptidase gene. Infect. Immun. 64:4495-4500.
38. Wu, Z., D. Milton, P. Nybom, A. Sjo, and K.-E. Magnusson. 1996. Vibrio cholerae hemagglutinin/protease (HA/protease) causes morphological changes in cultured epithelial cells and perturbs their paracellular barrier function. Microb. Pathog. 21:111-123.
39. Zhou, X., D. Q. Gas, J. Michalski, J. A. Benitez, and J. B. Kaper. 2004. Induction of interleukin-8 in T84 cells by Vibrio cholerae. Infect. Immun. 72:389-397.