Mouse models for the discovery of colorectal cancer driver genes

World Journal of Gastroenterology

Volumn 22, Issue 2, 2016, Pages 815-822

  Clark, Christopher R ^a   Starr, Timothy K ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cancer genes; Colorectal cancer; Insertional mutagenesis; Mouse models; Transposable elements

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; MISMATCH REPAIR PROTEIN PMS2; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN MLH1; PROTEIN MSH2; PROTEIN P53; SMAD4 PROTEIN; SLEEPING BEAUTY TRANSPOSASE, HUMAN; TRANSPOSASE; TUMOR MARKER;

APC GENE; AUTOSOMAL DOMINANT INHERITANCE; CANCER MORTALITY; CARCINOGENESIS; CHROMOSOME 2P; COLORECTAL CANCER; CONTROLLED CLINICAL TRIAL (TOPIC); GENE; GENE DOSAGE; GENE EXPRESSION; GENE FUNCTION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; LINKAGE ANALYSIS; LOSS OF FUNCTION MUTATION; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MLH1 GENE; MOLECULARLY TARGETED THERAPY; MOUSE; MOUSE MODEL; MSH6 GENE; MUTAGENESIS; NEXT GENERATION SEQUENCING; NONHUMAN; ONCOGENE K RAS; PMS1 GENE; PMS2 GENE; PTEN GENE; REVIEW; RSPO2 GENE; SMAD4 GENE; TP53 GENE; TRANSPOSON; TUMOR GENE; TUMOR MODEL; TUMOR SUPPRESSOR GENE; VIRUS GENOME; ANIMAL; CELL TRANSFORMATION; COLON POLYPOSIS; EXPERIMENTAL NEOPLASM; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; HUMAN; METABOLISM; MUTATION; PATHOLOGY; PHENOTYPE;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; BIOMARKERS, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MICE; MUTATION; NEOPLASMS, EXPERIMENTAL; PHENOTYPE; TRANSPOSASES;

EID: 84954448812     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v22.i2.815     Document Type: Review

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