Adenoma development in familial adenomatous polyposis and MUTYH -associated polyposis: Somatic landscape and driver genes

Journal of Pathology

Volumn 238, Issue 1, 2016, Pages 98-108

  Rashid, Mamunur ^a   Fischer, Andrej ^a   Wilson, Cathy H ^a   Tiffen, Jessamy ^a   Rust, Alistair G ^a   Stevens, Philip ^a   Idziaszczyk, Shelley ^b   Maynard, Julie ^b   Williams, Geraint T ^b   Mustonen, Ville ^a   Sampson, Julian R ^b   Adams, David J ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

adenoma development; APC; colorectal neoplasms; driver genes; exome sequencing; MUTYH; somatic landscape; WTX

Indexed keywords

APC PROTEIN; ATTRACTIN LIKE 1 PROTEIN; BETA CATENIN; DNA GLYCOSYLASE MUTY; K RAS PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; PEPTIDES AND PROTEINS; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOLIPASE C GAMMA1; PHOSPHOLIPASE C GAMMA2; PROTEIN P53; UNCLASSIFIED DRUG; WT1 PROTEIN; WTX PROTEIN; DNA GLYCOSYLTRANSFERASE; TRANSCRIPTOME;

ARTICLE; CLINICAL ARTICLE; COLON POLYPOSIS; COLORECTAL ADENOMA; CPG ISLAND; EXOME; EXON; FAMILIAL COLON POLYPOSIS; FEMALE; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; INTRON; LOSS OF FUNCTION MUTATION; MALE; MISSENSE MUTATION; MUTATION RATE; MUTYH ASSOCIATED POLYPOSIS; NONSENSE MUTATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ACETYLATION; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; WNT SIGNALING PATHWAY; DNA MUTATIONAL ANALYSIS; GASTROINTESTINAL POLYPOSIS; GENETICS; HEREDITARY TUMOR; PATHOLOGY;

ADENOMATOUS POLYPOSIS COLI; DNA GLYCOSYLASES; DNA MUTATIONAL ANALYSIS; HUMANS; INTESTINAL POLYPOSIS; NEOPLASTIC SYNDROMES, HEREDITARY; TRANSCRIPTOME;

EID: 84954447035     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4643     Document Type: Article

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