APC and the three-hit hypothesis

Oncogene

Volumn 28, Issue 1, 2009, Pages 146-155

  Segditsas, S ^a   Rowan, A J ^a   Howarth, K ^a   Jones, A ^a   Leedham, S ^a   Wright, N A ^a   Gorman, P ^a   Chambers, W ^a,b   Domingo, E ^a   Roylance, R R ^a   Sawyer, E J ^a   Sieber, O M ^a,d   Tomlinson, I P M ^a,c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

'Just right'; APC; Copy number change; Tumour suppressor; Two hits; Wnt

Indexed keywords

MESSENGER RNA;

ARTICLE; CANCER SCREENING; COLORECTAL CANCER; DIPLOIDY; DISEASE COURSE; GENOMIC INSTABILITY; HETEROZYGOSITY; HUMAN; HUMAN CELL; HYPOTHESIS; KARYOTYPE; MUTANT; MUTATION; POLYPLOIDY; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ADENOMA; ADENOMATOUS POLYPOSIS COLI PROTEIN; ALLELES; CARCINOMA; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DIPLOIDY; GENE DOSAGE; GENOMICS; HUMANS; LOSS OF HETEROZYGOSITY; MODELS, GENETIC; MUTATION; POLYPLOIDY; WNT PROTEINS;

EID: 58149337352     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.361     Document Type: Article

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