β-Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP-activated protein kinase-dependent increase in autophagy

Aging Cell

Volumn 14, Issue 6, 2015, Pages 1024-1033

  Yang, Si ^a   Long, Li Hong ^a,b,c   Li, Di ^a   Zhang, Jian Kang ^a   Jin, Shan ^d   Wang, Fang ^a,b,c   Chen, Jian Guo ^a,b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d HUBEI UNIVERSITY   (China)

Author keywords

Drosophila; AMP activated protein kinase; Autophagy; Autophagy related protein 1; Lifespan; guanidinopropionic acid

Indexed keywords

ATG8 PROTEIN; AUTOPHAGY PROTEIN 5; GUANIDINOPROPIONIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MICROTUBULE ASSOCIATED PROTEIN 1; PROTEIN; UNCLASSIFIED DRUG; ATG1 PROTEIN, DROSOPHILA; ATG5 PROTEIN, DROSOPHILA; ATG8A PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; GUANIDINE DERIVATIVE; HYDROGEN PEROXIDE; PROPIONIC ACID DERIVATIVE; PROTEIN SERINE THREONINE KINASE; SERINE THREONINE PROTEIN KINASE ULK1; SMALL INTERFERING RNA;

ADULT; ARTICLE; AUTOPHAGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET RESTRICTION; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GLYCOLYSIS; LIFE EXTENSION; LIGHT CHAIN; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RESEARCH; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; AGING; ANIMAL; BIOSYNTHESIS; CALORIC RESTRICTION; DRUG EFFECTS; ENZYME ACTIVATION; GENETICS; LONGEVITY; METABOLISM; OXIDATIVE STRESS; PHOSPHORYLATION; PHYSIOLOGY;

AGING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN-1 HOMOLOG; CALORIC RESTRICTION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENZYME ACTIVATION; FEMALE; GUANIDINES; HYDROGEN PEROXIDE; LONGEVITY; MALE; OXIDATIVE STRESS; PHOSPHORYLATION; PROPIONATES; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84954389207     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12371     Document Type: Article

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