Assessing the Utility of Circular Dichroism and FTIR Spectroscopy in Monoclonal-Antibody Comparability Studies

Journal of Pharmaceutical Sciences

Volumn 104, Issue 12, 2015, Pages 4459-4466

  Lin, Jasper C ^a   Glover, Zephania Kwong ^a   Sreedhara, Alavattam ^a  

^a GENENTECH INC   (United States)

Author keywords

biophysical characterization of proteins; circular dichroism; comparability; electronic circular dichroism; FTIR; HPLC; monoclonal antibodies; protein structure; proteins higher order structure

Indexed keywords

MONOCLONAL ANTIBODY; PROTEIN;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; INFRARED SPECTROSCOPY; INTERMETHOD COMPARISON; ION EXCHANGE CHROMATOGRAPHY; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN STRUCTURE; SIZE EXCLUSION CHROMATOGRAPHY; CHEMISTRY; PROCEDURES; PROTEIN CONFORMATION;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, ION EXCHANGE; CIRCULAR DICHROISM; PROTEIN CONFORMATION; PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84954387452     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24683     Document Type: Article

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