Hippocampal Shape Abnormalities Predict Symptom Progression in Neuroleptic-Free Youth at Ultrahigh Risk for Psychosis

Schizophrenia Bulletin

Volumn 42, Issue 1, 2016, Pages 161-169

  Dean, Derek J ^a,b   Orr, Joseph M ^a   Bernard, Jessica A ^a   Gupta, Tina ^a   Pelletier Baldelli, Andrea ^a,b   Carol, Emily E ^a   Mittal, Vijay A ^c  

^a UNIVERSITY OF COLORADO   (United States)

^b Center for Neuroscience   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Hippocampus; MRI; psychosis; shape analysis; ultra high risk; vertex analysis

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FOLLOW UP; HIGH RISK POPULATION; HIPPOCAMPUS; HUMAN; IMAGE ANALYSIS; MALE; NEGATIVE SYNDROME; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITIVE SYNDROME; PRIORITY JOURNAL; PSYCHOSIS; STRUCTURED INTERVIEW; SYMPTOMATOLOGY; CASE CONTROL STUDY; ORGAN SIZE; PATHOLOGY; PRODROMAL SYMPTOM; PROGNOSIS; RISK; SCHIZOPHRENIA; YOUNG ADULT;

ADOLESCENT; CASE-CONTROL STUDIES; DISEASE PROGRESSION; FEMALE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; ORGAN SIZE; PRODROMAL SYMPTOMS; PROGNOSIS; PSYCHOTIC DISORDERS; RISK; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84954349356     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbv086     Document Type: Article

References (58)

1. Csernansky JG, Wang L, Jones D, et al. Hippocampal deformities in schizophrenia characterized by high dimensional brain mapping. Am J Psychiatry. 2002;159:2000-2006.
2. Harrison PJ. The hippocampus in schizophrenia: A review of the neuropathological evidence and its pathophysiological implications. Psychopharmacology (Berl). 2004;174:151-162.
3. Narr KL, Thompson PM, Szeszko P, et al. Regional specificity of hippocampal volume reductions in first-episode schizophrenia. Neuroimage. 2004;21:1563-1575.
4. Phillips LJ, McGorry PD, Garner B, et al. Stress, the hippocampus and the hypothalamic-pituitary-adrenal axis: implications for the development of psychotic disorders. Aust N Z J Psychiatry. 2006;40:725-741.
5. Ebner F, Tepest R, Dani I, et al. The hippocampus in families with schizophrenia in relation to obstetric complications. Schizophr Res. 2008;104:71-78.
6. Mittal VA, Dhruv S, Tessner KD, Walder DJ, Walker EF. The relations among putative biorisk markers in schizotypal adolescents: minor physical anomalies, movement abnormalities, and salivary cortisol. Biol Psychiatry. 2007;61:1179-1186.
7. Fusar-Poli P, Bonoldi I, Yung AR, et al. Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk. Arch Gen Psychiatry. 2012;69:220-229.
8. Ho BC, Andreasen NC, Ziebell S, Pierson R, Magnotta V. Long-term antipsychotic treatment and brain volumes: A longitudinal study of first-episode schizophrenia. Arch Gen Psychiatry. 2011;68:128-137.
9. Lipska BK, Jaskiw GE, Weinberger DR. Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: A potential animal model of schizophrenia. Neuropsychopharmacology. 1993;9:67-75.
10. Mittal VA, Ellman LM, Cannon TD. Gene-environment interaction and covariation in schizophrenia: The role of obstetric complications. Schizophr Bull. 2008;34:1083-1094.
11. Walker E, Mittal V, Tessner K. Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia. Annu Rev Clin Psychol. 2008;4:189-216.
12. Walker EF, Diforio D. Schizophrenia: A neural diathesisstress model. Psychol Rev. 1997;104:667-685.
13. van Erp TG, Saleh PA, Huttunen M, et al. Hippocampal volumes in schizophrenic twins. Arch Gen Psychiatry. 2004;61:346-353.
14. Van Erp TG, Saleh PA, Rosso IM, et al. Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers. Am J Psychiatry. 2002;159:1514-1520.
15. McNeil TF, Cantor-Graae E, Weinberger DR. Relationship of obstetric complications and differences in size of brain structures in monozygotic twin pairs discordant for schizophrenia. Am J Psychiatry. 2000;157:203-212.
16. Wood SJ, Pantelis C, Velakoulis D, Yücel M, Fornito A, McGorry PD. Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk. Schizophr Bull. 2008;34:322-329.
17. Witthaus H, Kaufmann C, Bohner G, et al. Gray matter abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls. Psychiatry Res. 2009;173:163-169.
18. Buehlmann E, Berger GE, Aston J, et al. Hippocampus abnormalities in at risk mental states for psychosis? A crosssectional high resolution region of interest magnetic resonance imaging study. J Psychiatr Res. 2010;44:447-453.
19. Phillips LJ, Velakoulis D, Pantelis C, et al. Non-reduction in hippocampal volume is associated with higher risk of psychosis. Schizophr Res. 2002;58:145-158.
20. Pantelis C, Velakoulis D, McGorry PD, et al. Neuroanatomical abnormalities before and after onset of psychosis: A crosssectional and longitudinal MRI comparison. Lancet. 2003;361:281-288.
21. Wood SJ, Yücel M, Velakoulis D, et al. Hippocampal and anterior cingulate morphology in subjects at ultra-high-risk for psychosis: The role of family history of psychotic illness. Schizophr Res. 2005;75:295-301.
22. Borgwardt SJ, McGuire PK, Aston J, et al. Reductions in frontal, temporal and parietal volume associated with the onset of psychosis. Schizophr Res. 2008;106:108-114.
23. Wood SJ, Kennedy D, Phillips LJ, et al. Hippocampal pathology in individuals at ultra-high risk for psychosis: A multi-modal magnetic resonance study. Neuroimage. 2010;52:62-68.
24. Job DE, Whalley HC, Johnstone EC, Lawrie SM. Grey matter changes over time in high risk subjects developing schizophrenia. Neuroimage. 2005;25:1023-1030.
25. Lawrie SM, Whalley HC, Abukmeil SS, et al. Temporal lobe volume changes in people at high risk of schizophrenia with psychotic symptoms. Br J Psychiatry. 2002;181:138-143.
26. Velakoulis D, Wood SJ, Wong MT, et al. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: A magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Arch Gen Psychiatry. 2006;63:139-149.
27. Sowell ER, Thompson PM, Tessner KD, Toga AW. Mapping continued brain growth and gray matter density reduction in dorsal frontal cortex: Inverse relationships during postadolescent brain maturation. J Neurosci. 2001;21:8819-8829.
28. Andersen SL, Teicher MH. Stress, sensitive periods and maturational events in adolescent depression. Trends Neurosci. 2008;31:183-191.
29. Strange BA, Fletcher PC, Henson RN, Friston KJ, Dolan RJ. Segregating the functions of human hippocampus. Proc Natl Acad Sci U S A. 1999;96:4034-4039.
30. Gogtay N, Nugent TF 3rd, Herman DH, et al. Dynamic mapping of normal human hippocampal development. Hippocampus. 2006;16:664-672.
31. Morey RA, Petty CM, Xu Y, et al. A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes. Neuroimage. 2009;45:855-866.
32. Fischl B, Salat DH, Busa E, et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron. 2002;33:341-355.
33. Tepest R, Wang L, Miller MI, Falkai P, Csernansky JG. Hippocampal deformities in the unaffected siblings of schizophrenia subjects. Biol Psychiatry. 2003;54:1234-1240.
34. Styner M, Lieberman JA, Pantazis D, Gerig G. Boundary and medial shape analysis of the hippocampus in schizophrenia. Med Image Anal. 2004;8:197-203.
35. Ho BC, Magnotta V. Hippocampal volume deficits and shape deformities in young biological relatives of schizophrenia probands. Neuroimage. 2010;49:3385-3393.
36. Biomedical NCftPoHSoB, Behavioral Research. The Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects of Research. Bethesda, MD: ERIC Clearinghouse; 1978.
37. Mittal VA, Gupta T, Orr JM, et al. Physical activity level and medial temporal health in youth at ultra high-risk for psychosis. J Abnorm Psychol. 2013;122:1101-1110.
38. Miller TJ, McGlashan TH, Woods SW, et al. Symptom assessment in schizophrenic prodromal states. Psychiatr Q. 1999;70:273-287.
39. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition, January 1995 FINAL: SCID-I/P Version 2.0). New York, NY: Biometrics Research Department, New York State Psychiatric Institute; 1995.
40. Patenaude B, Smith SM, Kennedy DN, Jenkinson M. A Bayesian model of shape and appearance for subcortical brain segmentation. Neuroimage. 2011;56:907-922.
41. Smith SM, Nichols TE. Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage. 2009;44:83-98.
42. Stefanis N, Frangou S, Yakeley J, et al. Hippocampal volume reduction in schizophrenia: effects of genetic risk and pregnancy and birth complications. Biol Psychiatry. 1999;46:697-702.
43. Sun D, Phillips L, Velakoulis D, et al. Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals. Schizophr Res. 2009;108:85-92.
44. Borgwardt SJ, Riecher-Rössler A, Dazzan P, et al. Regional gray matter volume abnormalities in the at risk mental state. Biol Psychiatry. 2007;61:1148-1156.
45. Bookstein FL. "Voxel-based morphometry" should not be used with imperfectly registered images. Neuroimage. 2001;14:1454-1462.
46. Achterberg HC, van der Lijn F, den Heijer T, et al. Hippocampal shape is predictive for the development of dementia in a normal, elderly population. Hum Brain Mapp. 2014;35:2359-2371.
47. Zarei M, Mataix-Cols D, Heyman I, et al. Changes in gray matter volume and white matter microstructure in adolescents with obsessive-compulsive disorder. Biol Psychiatry. 2011;70:1083-1090.
48. Lee JM, Kim SH, Jang DP, et al. Deformable model with surface registration for hippocampal shape deformity analysis in schizophrenia. Neuroimage. 2004;22:831-840.
49. Tepest R, Wang L, Miller MI, Falkai P, Csernansky JG. Hippocampal deformities in the unaffected siblings of schizophrenia subjects. Biol Psychiatry. 2003;54:1234-1240.
50. Shenton ME, Gerig G, McCarley RW, Székely G, Kikinis R. Amygdala-hippocampal shape differences in schizophrenia: The application of 3D shape models to volumetric MR data. Psychiatry Res. 2002;115:15-35.
51. Csernansky JG, Joshi S, Wang L, et al. Hippocampal morphometry in schizophrenia by high dimensional brain mapping. Proc Natl Acad Sci U S A. 1998;95:11406-11411.
52. Schobel SA, Lewandowski NM, Corcoran CM, et al. Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders. Arch Gen Psychiatry. 2009;66:938-946.
53. Théberge J. Perfusion magnetic resonance imaging in psychiatry. Top Magn Reson Imaging. 2008;19:111-130.
54. Talati P, Rane S, Kose S, et al. Increased hippocampal CA1 cerebral blood volume in schizophrenia. Neuroimage Clin. 2014;5:359-364.
55. Talati P, Rane S, Skinner J, Gore J, Heckers S. Increased hippocampal blood volume and normal blood flow in schizophrenia. Psychiatry Res. 2015.
56. Stone JM, Howes OD, Egerton A, et al. Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosis. Biol Psychiatry. 2010;68:599-602.
57. Stone JM, Day F, Tsagaraki H, et al.; OASIS. Glutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volume. Biol Psychiatry. 2009;66:533-539.
58. Cannon TD, Cadenhead K, Cornblatt B, et al. Prediction of psychosis in youth at high clinical risk: A multisite longitudinal study in North America. Arch Gen Psychiatry. 2008;65:28-37.