PH-responsive thiolated chitosan nanoparticles for oral low-molecular weight heparin delivery: In vitro and in vivo evaluation

Drug Delivery

Volumn 23, Issue 1, 2016, Pages 238-247

  Fan, Bo ^a   Xing, Yang ^a   Zheng, Ying ^a   Sun, Chuan ^a   Liang, Guixian ^a  

^a SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

Low molecular weight heparin; mucoadhesive; oral drug delivery; pH responsive; thiolated chitosan nanoparticles

Indexed keywords

ACID; CHITOSAN NANOPARTICLE; ENOXAPARIN; FLUORESCENT DYE; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; PEPSIN A; THIOGLYCOLIC ACID; THIOL GROUP; ANTICOAGULANT AGENT; CHITOSAN; EXCIPIENT; LOW MOLECULAR WEIGHT HEPARIN; NANOPARTICLE; THIOL DERIVATIVE; TISSUE ADHESIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; CARP; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RELEASE; DRUG SCREENING; DRUG STABILITY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE MUCOSA; INTESTINE MUCOSA PERMEABILITY; MALE; MUCOADHESION; NANOENCAPSULATION; NANOFABRICATION; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PARTICLE SIZE; PH; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; ZETA POTENTIAL; ANIMAL; BIOAVAILABILITY; CHEMISTRY; MEDICINAL CHEMISTRY; METABOLISM; MOUTH MUCOSA; SPRAGUE DAWLEY RAT;

ANIMALS; ANTICOAGULANTS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DRUG DELIVERY SYSTEMS; EXCIPIENTS; HEPARIN, LOW-MOLECULAR-WEIGHT; HYDROGEN-ION CONCENTRATION; INTESTINAL MUCOSA; MALE; MOUTH MUCOSA; NANOPARTICLES; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL COMPOUNDS; TISSUE ADHESIVES;

EID: 84954312236     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2014.909908     Document Type: Article

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